Discovery of a muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors among 2-[(1S,3S)-3- sulfonylaminocyclopentyl]phenylacetamide derivatives

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 4, 2000, Pages 825-832

  Mitsuya, Morihiro ^a   Ogino, Yoshio ^a   Kawakami, Kumiko ^a   Uchiyama, Minaho ^a   Kimura, Toshifumi ^a   Numazawa, Tomoshige ^a   Hasegawa, Takuro ^a   Ohtake, Norikazu ^a   Noguchi, Kazuhito ^a   Mase, Toshiaki ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

J 107320; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M3 RECEPTOR ANTAGONIST; N [1 (4 METHYL 3 PENTENYL)PIPERIDIN 4 YL] 2 CYCLOPENTENYL 2 HYDROXY 2 PHENYLACETAMIDE; SULFONAMIDE; UNCLASSIFIED DRUG; ALKENE; CYCLOPENTANE DERIVATIVE; J 104129; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; PIPERIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; DOG; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; LIVER MICROSOME; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG EFFECT; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ALKENES; CYCLOPENTANES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MUSCARINIC ANTAGONISTS; PIPERIDINES; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC;

EID: 0033625180     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00008-0     Document Type: Article

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