Biochemical and structural characterization of residue 96 mutants of Plasmodium falciparum triosephosphate isomerase: Active-site loop conformation, hydration and identification of a dimer-interface ligand-binding site

Acta Crystallographica Section D: Biological Crystallography

Volumn 65, Issue 8, 2009, Pages 847-857

  Gayathri, P ^a   Banerjee, Mousumi ^a   Vijayalakshmi, A ^a   Balaram, Hemalatha ^b   Balaram, P ^a   Murthy, M R N ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

3 phosphoglycerate; Active site hydration; Dimer interface binding site; Loop 6 conformation; Plasmodium falciparum triosephosphate isomerase

Indexed keywords

LIGAND; MUTANT PROTEIN; PHENYLALANINE; PROTOZOAL PROTEIN; TRIOSEPHOSPHATE ISOMERASE; WATER;

ANIMAL; ARTICLE; CHEMISTRY; CRYSTALLIZATION; DIMERIZATION; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; METABOLISM; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; X RAY CRYSTALLOGRAPHY;

ANIMALS; CATALYTIC DOMAIN; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; LIGANDS; MUTANT PROTEINS; PHENYLALANINE; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTOZOAN PROTEINS; TRIOSE-PHOSPHATE ISOMERASE; WATER;

PLASMODIUM FALCIPARUM;

EID: 68349139284     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444909018666     Document Type: Article

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