Structure of the Plasmodium falciparum triosephosphate isomerase - Phosphoglycolate complex in two crystal forms: Characterization of catalytic loop open and closed conformations in the ligand-bound state

Biochemistry

Volumn 41, Issue 44, 2002, Pages 13178-13188

  Parthasarathy, S ^a   Ravindra, G ^a   Balaram, Hemalatha ^b   Balaram, P ^a   Murthy, M R N ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

LIGANDS;

CONFORMATIONS; CRYSTAL STRUCTURE; DIMERS; ENZYME INHIBITION; ENZYMES; PROTOZOA;

BIOCHEMISTRY;

GLYCOLIC ACID DERIVATIVE; LIGAND; TRIOSEPHOSPHATE ISOMERASE;

ARTICLE; BINDING SITE; CATALYSIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; FAST PROTEIN LIQUID CHROMATOGRAPHY; GENE OVEREXPRESSION; GLYCOLYSIS; HUMAN; LIGAND BINDING; MALARIA; MALARIA FALCIPARUM; MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE; PLASMODIUM FALCIPARUM; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CATALYSIS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ENZYME INHIBITORS; GLYCERIC ACIDS; GLYCOLATES; LIGANDS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; PHENYLALANINE; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; TRIOSE-PHOSPHATE ISOMERASE;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0037027339     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi025783a     Document Type: Article

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