메뉴 건너뛰기




Volumn 2, Issue 3, 2009, Pages 251-256

Toxic and chemopreventive ligands preferentially activate distinct aryl hydrocarbon receptor pathways: Implications for cancer prevention

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3,3' DIINDOLYLMETHANE; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450; ESTROGEN RECEPTOR ALPHA; SMALL INTERFERING RNA;

EID: 68349093856     PISSN: 19406207     EISSN: None     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-08-0146     Document Type: Article
Times cited : (43)

References (41)
  • 1
    • 30944469849 scopus 로고    scopus 로고
    • Estrogen carcinogenesis in breast cancer
    • Yager JD, Davidson NE. Estrogen carcinogenesis in breast cancer. N Engl J Med 2006;354:270-282
    • (2006) N Engl J Med , vol.354 , pp. 270-282
    • Yager, J.D.1    Davidson, N.E.2
  • 2
    • 25844509783 scopus 로고    scopus 로고
    • Steroid hormone receptor signaling in tumorigenesis
    • DOI 10.1002/jcb.20566
    • Singh RR, Kumar R. Steroid hormone receptor signaling in tumorigenesis. J Cell Biochem 2005;96:490-505. (Pubitemid 41504648)
    • (2005) Journal of Cellular Biochemistry , vol.96 , Issue.3 , pp. 490-505
    • Singh, R.R.1    Kumar, R.2
  • 6
    • 34047136753 scopus 로고    scopus 로고
    • Cruciferous vegetables and human cancer risk: Epidemiologic evidence and mechanistic basis
    • DOI 10.1016/j.phrs.2007.01.009, PII S1043661807000321, Nutritional Pharmacology
    • Higdon JV, Delage B, Williams DE, Dashwood RH. Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacol Res 2007;55:224-236 (Pubitemid 46518152)
    • (2007) Pharmacological Research , vol.55 , Issue.3 , pp. 224-236
    • Higdon, J.V.1    Delage, B.2    Williams, D.E.3    Dashwood, R.H.4
  • 8
    • 0030954304 scopus 로고    scopus 로고
    • Changes in levels of urinary estrogen metabolites after oral indole-3- Carbinol treatment in humans
    • Michnovicz JJ, Adlercreutz H, Bradlow HL. Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans. J Natl Cancer Inst 1997;89:718-723 (Pubitemid 27229860)
    • (1997) Journal of the National Cancer Institute , vol.89 , Issue.10 , pp. 718-723
    • Michnovicz, J.J.1    Adlercreutz, H.2    Bradlow, H.L.3
  • 9
    • 0018137952 scopus 로고
    • Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles
    • Wattenberg LW, Loub WD. Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles. Cancer Res 1978;38:1410-1413 (Pubitemid 8323347)
    • (1978) Cancer Research , vol.38 , Issue.5 , pp. 1410-1413
    • Wattenberg, L.W.1    Loub, W.D.2
  • 10
    • 0031715037 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane
    • DOI 10.1093/carcin/19.9.1631
    • Chen I, McDougal A, Wang F, Safe S. Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane. Carcinogenesis 1998;19:1631-1639 (Pubitemid 28441867)
    • (1998) Carcinogenesis , vol.19 , Issue.9 , pp. 1631-1639
    • Chen, I.1    McDougal, A.2    Wang, F.3    Safe, S.4
  • 12
    • 0026046412 scopus 로고
    • Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: Comparisons with 2,3,7,8- tetrachlorodibenzo-p-dioxin
    • Bjeldanes LF, Kim JY, Grose KR, Bartholomew JC, Bradfield CA. Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Proc Natl Acad Sci U S A 1991;88:9543-9547
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 9543-9547
    • Bjeldanes, L.F.1    Kim, J.Y.2    Grose, K.R.3    Bartholomew, J.C.4    Bradfield, C.A.5
  • 13
    • 0038768712 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals
    • Denison MS, Nagy SR. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol 2003;43:309-334
    • (2003) Annu Rev Pharmacol Toxicol , vol.43 , pp. 309-334
    • Denison, M.S.1    Nagy, S.R.2
  • 14
    • 0020010617 scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity
    • Poland A, Knutson JC. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu Rev Pharmacol Toxicol 1982;22:517-554
    • (1982) Annu Rev Pharmacol Toxicol , vol.22 , pp. 517-554
    • Poland, A.1    Knutson, J.C.2
  • 15
    • 34447530842 scopus 로고    scopus 로고
    • An aryl hydrocarbon receptor odyssey to the shores of toxicology: The Deichmann Lecture, International Congress of Toxicology-XI
    • Okey AB. An aryl hydrocarbon receptor odyssey to the shores of toxicology: the Deichmann Lecture, International Congress of Toxicology-XI. Toxicol Sci 2007;98:5-38.
    • (2007) Toxicol Sci , vol.98 , pp. 5-38
    • Okey, A.B.1
  • 18
    • 0038418500 scopus 로고    scopus 로고
    • Plant-derived 3,3′-diindolylmethane is a strong androgen antagonist in human prostate cancer cells
    • DOI 10.1074/jbc.M300588200
    • Le HT, Schaldach CM, Firestone GL, Bjeldanes LF. Plant-derived 3,3′-diindolylmethane is a strong androgen antagonist in human prostate cancer cells. J Biol Chem 2003;278:21136-21145 (Pubitemid 36806427)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.23 , pp. 21136-21145
    • Le, H.T.1    Schaldach, C.M.2    Firestone, G.L.3    Bjeldanes, L.F.4
  • 20
    • 0000317180 scopus 로고    scopus 로고
    • Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis?
    • Zhu BT, Conney AH. Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis? Cancer Res 1998;58:2269-2277
    • (1998) Cancer Res , vol.58 , pp. 2269-2277
    • Zhu, B.T.1    Conney, A.H.2
  • 21
    • 35948958167 scopus 로고    scopus 로고
    • 2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo
    • Cicek M, Iwaniec UT, Goblirsch MJ, et al. 2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo. Cancer Res 2007;67:10106-10111
    • (2007) Cancer Res , vol.67 , pp. 10106-10111
    • Cicek, M.1    Iwaniec, U.T.2    Goblirsch, M.J.3
  • 22
    • 0028987872 scopus 로고
    • The aryl hydrocarbon receptor complex
    • Hankinson O. The aryl hydrocarbon receptor complex. Annu Rev Pharmacol Toxicol 1995;35:307-340
    • (1995) Annu Rev Pharmacol Toxicol , vol.35 , pp. 307-340
    • Hankinson, O.1
  • 24
    • 0142027829 scopus 로고    scopus 로고
    • Agonist and Chemopreventative Ligands Induce Differential Transcriptional Cofactor Recruitment by Aryl Hydrocarbon Receptor
    • DOI 10.1128/MCB.23.21.7920-7925.2003
    • Hestermann EV, Brown M. Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor. Mol Cell Biol 2003;23:7920-7925 (Pubitemid 37271487)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.21 , pp. 7920-7925
    • Hestermann, E.V.1    Brown, M.2
  • 25
    • 38949097735 scopus 로고    scopus 로고
    • The search for endogenous activators of the aryl hydrocarbon receptor
    • Nguyen LP, Bradfield CA. The search for endogenous activators of the aryl hydrocarbon receptor. Chem Res Toxicol 2008;21:102-116
    • (2008) Chem Res Toxicol , vol.21 , pp. 102-116
    • Nguyen, L.P.1    Bradfield, C.A.2
  • 26
    • 2642510760 scopus 로고    scopus 로고
    • Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer
    • Nebert DW, Dalton TP, Okey AB, Gonzalez FJ. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem 2004;279:23847-23850
    • (2004) J Biol Chem , vol.279 , pp. 23847-23850
    • Nebert, D.W.1    Dalton, T.P.2    Okey, A.B.3    Gonzalez, F.J.4
  • 27
    • 0031715037 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane
    • DOI 10.1093/carcin/19.9.1631
    • Chen I, McDougal A, Wang F, Safe S. Aryl hydrocarbon receptor-mediated anti-estrogenic and antitumorigenic activity of diindolylmethane. Carcinogenesis 1998;19:1631-1639 (Pubitemid 28441867)
    • (1998) Carcinogenesis , vol.19 , Issue.9 , pp. 1631-1639
    • Chen, I.1    McDougal, A.2    Wang, F.3    Safe, S.4
  • 28
    • 0034646769 scopus 로고    scopus 로고
    • Inhibition of carcinogen-induced rat mammary tumor growth and other estrogen-dependent responses by symmetrical dihalo-substituted analogs of diindolylmethane
    • DOI 10.1016/S0304-3835(99)00406-1, PII S0304383599004061
    • McDougal A, Gupta MS, Ramamoorthy K, Sun G, Safe SH. Inhibition of carcinogen-induced rat mammary tumor growth and other estrogen-dependent responses by symmetrical dihalo-substituted analogs of diindolylmethane. Cancer Lett 2000;151:169-179 (Pubitemid 30156791)
    • (2000) Cancer Letters , vol.151 , Issue.2 , pp. 169-179
    • McDougal, A.1    Sethi Gupta, M.2    Ramamoorthy, K.3    Sun, G.4    Safe, S.H.5
  • 29
    • 0030731436 scopus 로고    scopus 로고
    • Inhibition of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumor growth by aryl hydrocarbon receptor agonists
    • DOI 10.1016/S0304-3835(97)00299-1, PII S0304383597002991
    • McDougal A, Wilson C, Safe S. Inhibition of 7,12-dimethylbenz[a] anthracene-induced rat mammary tumor growth by aryl hydrocarbon receptor agonists. Cancer Lett 1997;120:53-63. (Pubitemid 27483311)
    • (1997) Cancer Letters , vol.120 , Issue.1 , pp. 53-63
    • McDougal, A.1    Wilson, C.2    Safe, S.3
  • 31
    • 0032842573 scopus 로고    scopus 로고
    • Development of selective aryl hydrocarbon receptor modulators for treatment of breast cancer
    • DOI 10.1517/13543784.8.9.1385
    • Safe S, Qin C, McDougal A. Development of selective aryl hydrocarbon receptor modulators (SARMs) for treatment of breast cancer. Expert Opin Investig Drugs 1999;8:1385-1396 (Pubitemid 29417622)
    • (1999) Expert Opinion on Investigational Drugs , vol.8 , Issue.9 , pp. 1385-1396
    • Safe, S.1    Qin, C.2    McDougal, A.3
  • 32
    • 0018074887 scopus 로고
    • Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats
    • Kociba RJ, Keyes DG, Beyer JE, et al. Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Toxicol Appl Pharmacol 1978;46:279-303.
    • (1978) Toxicol Appl Pharmacol , vol.46 , pp. 279-303
    • Kociba, R.J.1    Keyes, D.G.2    Beyer, J.E.3
  • 33
    • 0028285283 scopus 로고
    • Inhibition of 7,12-dimethyl-benzanthracene-induced rat mammary tumor growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin
    • Holcomb M, Safe S. Inhibition of 7,12-dimethyl-benzanthracene-induced rat mammary tumor growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Cancer Lett 1994;82:43-47
    • (1994) Cancer Lett , vol.82 , pp. 43-47
    • Holcomb, M.1    Safe, S.2
  • 34
    • 33750541268 scopus 로고    scopus 로고
    • Down-regulation of androgen receptor by 3,3′-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells
    • DOI 10.1158/0008-5472.CAN-06-2011
    • Bhuiyan MM, Li Y, Banerjee S, et al. Down-regulation of androgen receptor by 3,3′-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells. Cancer Res 2006;66:10064-10072 (Pubitemid 44672060)
    • (2006) Cancer Research , vol.66 , Issue.20 , pp. 10064-10072
    • Bhuiyan, M.M.R.1    Li, Y.2    Banerjee, S.3    Ahmed, F.4    Wang, Z.5    Ali, S.6    Sarkar, F.H.7
  • 36
    • 0346121452 scopus 로고    scopus 로고
    • Flavonoids as aryl hydrocarbon receptor agonists/antagonists: Effects of structure and cell context
    • Zhang S, Qin C, Safe SH. Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context. Environ Health Perspect 2003;111:1877-1882 (Pubitemid 37541197)
    • (2003) Environmental Health Perspectives , vol.111 , Issue.16 , pp. 1877-1882
    • Zhang, S.1    Qin, C.2    Safe, S.H.3
  • 37
    • 0034872657 scopus 로고    scopus 로고
    • Molecular identification of potential selective estrogen receptor modulator (SERM) like properties of phytoestrogens in the human breast cancer cell line MCF-7
    • DOI 10.1055/s-2001-16474
    • Diel P, Olff S, Schmidt S, Michna H. Molecular identification of potential selective estrogen receptor modulator (SERM) like properties of phytoestrogens in the human breast cancer cell line MCF-7. Planta Med 2001;67:510-514 (Pubitemid 32800414)
    • (2001) Planta Medica , vol.67 , Issue.6 , pp. 510-514
    • Diel, P.1    Olff, S.2    Schmidt, S.3    Michna, H.4
  • 38
    • 47549100615 scopus 로고    scopus 로고
    • Genistein differentially modulates androgen-responsive gene expression and activates JNK in LNCaP cells
    • Lazarevic B, Karlsen SJ, Saatcioglu F. Genistein differentially modulates androgen-responsive gene expression and activates JNK in LNCaP cells. Oncol Rep 2008;19:1231-1235
    • (2008) Oncol Rep , vol.19 , pp. 1231-1235
    • Lazarevic, B.1    Karlsen, S.J.2    Saatcioglu, F.3
  • 40
    • 52949095784 scopus 로고    scopus 로고
    • Isoflavones and the prevention of breast and prostate cancer: New perspectives opened by nutrigenomics
    • Steiner C, Amould S, Scalbert A, Manach C. Isoflavones and the prevention of breast and prostate cancer: new perspectives opened by nutrigenomics. Br J Nutr 2008;99 E Suppl 1:ES78-108.
    • (2008) Br J Nutr , vol.99 E , Issue.SUPPL. 1
    • Steiner, C.1    Amould, S.2    Scalbert, A.3    Manach, C.4
  • 41
    • 0032842573 scopus 로고    scopus 로고
    • Development of selective aryl hydrocarbon receptor modulators for treatment of breast cancer
    • DOI 10.1517/13543784.8.9.1385
    • Safe S, Qin C, McDougal A. Development of selective aryl hydrocarbon receptor modulators for treatment of breast cancer. Expert Opin Investig Drugs 1999;8:1385-1396 (Pubitemid 29417622)
    • (1999) Expert Opinion on Investigational Drugs , vol.8 , Issue.9 , pp. 1385-1396
    • Safe, S.1    Qin, C.2    McDougal, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.