Mild to moderate early exercise promotes recovery from cerebral ischemia in rats

Canadian Journal of Neurological Sciences

Volumn 36, Issue 4, 2009, Pages 443-449

  Lee, Shi Uk ^a   Kim, Dae Yul ^b   Park, Sung Hye ^c   Choi, Deok Hyung ^c,d   Park, Hee Won ^c,d   Han, Tai Ryoon ^c,d  

^a Seoul National University   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Department of Pathology ^*  (South Korea)

^d Seoul National University Hospital   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

TRIPHENYLTETRAZOLIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN INFARCTION SIZE; CLINICAL EVALUATION; COMPARATIVE STUDY; CONTROLLED STUDY; CONVALESCENCE; IMMUNOHISTOCHEMISTRY; KINESIOTHERAPY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGIC DISEASE; NEUROLOGIC EXAMINATION; NONHUMAN; PRIORITY JOURNAL; RAT; RATING SCALE; SPRAGUE DAWLEY RAT; THICKNESS; TREADMILL EXERCISE; TREATMENT DURATION;

EID: 68349083315     PISSN: 03171671     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0317167100007769     Document Type: Article

References (44)

1. Lambo TA. Stroke--a worldwide health problem. Adv Neurol. 1979;25:1-3.
2. Ernst E. Areview of stroke rehabilitation and physiotherapy. Stroke. 1990;21:1081-5.
3. Stummer W, Weber K, Tranmer B, Baethmann A, Kempski O. Reduced mortality and brain damage after locomotor activity in gerbil forebrain ischemia. Stroke. 1994;25:1862-9.
4. Ding Y, Li J, Lai Q, Rafols JA, Luan X, Clark J, et al. Motor balance and coordination training enhances functional outcome in rat with transient middle cerebral artery occlusion. Neuroscience. 2004;123:667-74.
5. Kim MW, Bang MS, Han TR, Ko YJ, Yoon BW, Kim JH, et al. Exercise increased BDNF and trkB in the contralateral hemisphere of the ischemic rat brain. Brain Res. 2005;1052: 16-21.
6. Richards CL, Malouin F, Wood-Dauphinee S, Williams JI, Bouchard JP, Brunet D. Task-specific physical therapy for optimization of gait recovery in acute stroke patients. Arch Phys Med Rehabil. 1993;74:612-20.
7. Hesse S, Bertelt C, Jahnke MT, Schaffrin A, Baake P, Malezic M, et al. Treadmill training with partial body weight support compared with physiotherapy in nonambulatory hemiparetic patients. Stroke. 1995;26:976-81.
8. Johansson BB, Ohlsson AL. Environment, social interaction, and physical activity as determinants of functional outcome after cerebral infarction in the rat. Exp Neurol. 1996;139:322-7.
9. Ohlsson AL, Johansson BB. Environment influences functional outcome of cerebral infarction in rats. Stroke. 1995;26:644-9.
10. Humm JL, Kozlowski DA, James DC, Gotts JE, Schallert T. Usedependent exacerbation of brain damage occurs during an early post-lesion vulnerable period. Brain Res. 1998;783:286-92.
11. Kozlowski DA, James DC, Schallert T. Use-dependent exaggeration of neuronal injury after unilateral sensorimotor cortex lesions. J Neurosci. 1996;16:4776-86.
12. Yang YR, Wang RY, Wang PS, Yu SM. Treadmill training effects on neurological outcome after middle cerebral artery occlusion in rats. Can J Neurol Sci. 2003;30:252-8.
13. Yang YR, Wang RY, Wang PS. Early and late treadmill training after focal brain ischemia in rats. Neurosci Lett. 2003;339:91-4.
14. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20:84-91.
15. Garcia JH, Wagner S, Liu KF, Hu XJ. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke. 1995;26:627-34; discussion 35.
16. Menzies SA, Hoff JT, Betz AL. Middle cerebral artery occlusion in rats: a neurological and pathological evaluation of a reproducible model. Neurosurgery. 1992;31:100-6; discussion 6-7.
17. Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FR. A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab. 1990;10:290-3.
18. Berne RM, Levy MN. Physiology. 3rd ed. St. Louis: Mosby Year Book; 1993.
19. Auer RN. Non-pharmacologic (physiologic) neuroprotection in the treatment of brain ischemia. Ann N Y Acad Sci. 2001;939: 271-82.
20. Ide K, Horn A, Secher NH. Cerebral metabolic response to submaximal exercise. J Appl Physiol. 1999;87:1604-8.
21. van Praag H, Kempermann G, Gage FH. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci. 1999;2:266-70.
22. Kleim JA, Cooper NR, VandenBerg PM. Exercise induces angiogenesis but does not alter movement representations within rat motor cortex. Brain Res. 2002;934:1-6.
23. Ding Y, Li J, Luan X, Ding YH, Lai Q, Rafols JA, et al. Exercise pre-conditioning reduces brain damage in ischemic rats that may be associated with regional angiogenesis and cellular overexpression of neurotrophin. Neuroscience. 2004;124: 583-91.
24. Hambrecht R, Wolf A, Gielen S, Linke A, Hofer J, Erbs S, et al. Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med. 2000;342:454-60.
25. Ginsberg MD, Sternau LL, Globus MY, Dietrich WD, Busto R. Therapeutic modulation of brain temperature: relevance to ischemic brain injury. Cerebrovasc Brain Metab Rev. 1992;4:189-225.
26. Borer KT, Bestervelt LL, Mannheim M, Brosamer MB, Thompson M, Swamy U, et al. Stimulation by voluntary exercise of adrenal glucocorticoid secretion in mature female hamsters. Physiol Behav. 1992;51:713-8.
27. Smith-Swintosky VL, Pettigrew LC, Sapolsky RM, Phares C, Craddock SD, Brooke SM, et al. Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures. J Cereb Blood Flow Metab. 1996;16:585-98.
28. DeVries AC, Joh HD, Bernard O, Hattori K, Hurn PD, Traystman RJ, et al. Social stress exacerbates stroke outcome by suppressing Bcl-2 expression. Proc Natl Acad Sci USA. 2001; 98:11824-8.
29. Vanderwolf CH, Cain DP. The behavioral neurobiology of learning and memory: a conceptual reorientation. Brain Res Brain Res Rev. 1994;19:264-97.
30. Qu M, Mittmann T, Luhmann HJ, Schleicher A, Zilles K. Longterm changes of ionotropic glutamate and GABA receptors after unilateral permanent focal cerebral ischemia in the mouse brain. Neuroscience. 1998;85:29-43.
31. Veras-Silva AS, Mattos KC, Gava NS, Brum PC, Negrao CE, Krieger EM. Low-intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats. Am J Physiol. 1997;273:H2627-31.
32. Coven DL, Hu X, Cong L, Bergeron R, Shulman GI, Hardie DG, et al. Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise. Am J Physiol Endocrinol Metab. 2003;285:E629-36.
33. Kinoshita S, Yano H, Tsuji E. An increase in damaged hepatocytes in rats after high intensity exercise. Acta Physiol Scand. 2003; 178:225-30.
34. Kim YP, Kim HB, Jang MH, Lim BV, Kim YJ, Kim H, et al. Magnitude- and time-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats. Int J Sports Med. 2003;24:114-7.
35. Mabuchi T, Kitagawa K, Ohtsuki T, Kuwabara K, Yagita Y, Yanagihara T, et al. Contribution of microglia/macrophages to expansion of infarction and response of oligodendrocytes after focal cerebral ischemia in rats. Stroke. 2000;31:1735-43.
36. Liberto CM, Albrecht PJ, Herx LM, Yong VW, Levison SW. Proregenerative properties of cytokine-activated astrocytes. J Neurochem. 2004;89:1092-100.
37. Aschner M. Astrocytic functions and physiological reactions to injury: the potential to induce and/or exacerbate neuronal dysfunction--a forum position paper. Neurotoxicology. 1998;19:7-17; discussion 37-8.
38. Lin JH, Weigel H, Cotrina ML, Liu S, Bueno E, Hansen AJ, et al. Gap-junction-mediated propagation and amplification of cell injury. Nat Neurosci. 1998;1:494-500.
39. Siushansian R, Bechberger JF, Cechetto DF, Hachinski VC, Naus CC. Connexin43 null mutation increases infarct size after stroke. J Comp Neurol. 2001;440:387-94.
40. Li J, Ding YH, Rafols JA, Lai Q, McAllister JP, 2nd, Ding Y. Increased astrocyte proliferation in rats after running exercise. Neurosci Lett. 2005;386:160-4.
41. Komitova M, Perfilieva E, Mattsson B, Eriksson PS, Johansson BB. Effects of cortical ischemia and postischemic environmental enrichment on hippocampal cell genesis and differentiation in the adult rat. J Cereb Blood Flow Metab. 2002;22:852-60.
42. Alonso G. Proliferation of progenitor cells in the adult rat brain correlates with the presence of vimentin-expressing astrocytes. Glia. 2001;34:253-66.
43. Song H, Stevens CF, Gage FH. Astroglia induce neurogenesis from adult neural stem cells. Nature. 2002;417:39-44.
44. Nakase T, Fushiki S, Naus CC. Astrocytic gap junctions composed of connexin 43 reduce apoptotic neuronal damage in cerebral ischemia. Stroke. 2003;34:1987-93.