A potential role for notch signaling in the pathogenesis and regulation of hemangiomas

Journal of Craniofacial Surgery

Volumn 20, Issue SUPPL. 1, 2009, Pages 698-702

  Wu, June K ^a,b   Kitajewski, Jan K ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b NONE   (United States)

Author keywords

Angiogenesis; Hemangioma; Notch signaling; Vasculogenesis

Indexed keywords

DELTA LIKE LIGAND 4; JAGGED1; LIGAND; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; NOTCH3 RECEPTOR; NOTCH4 RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 2;

ANALYSIS; CANCER SURGERY; CONGENITAL HEMANGIOMA; DISEASE MODEL; EMBRYOLOGY; EYELID ANGIOMA; FACE HEMANGIOMA; FETUS DEVELOPMENT; GENETIC ANALYSIS; HEMANGIOMA; HISTORY; HUMAN; INFANT DISEASE; INFANTILE HEMANGIOMA; INVOLUTION; LIVER HEMANGIOMA; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW;

ANIMALS; ENDOTHELIUM, VASCULAR; HEMANGIOMA; HUMANS; INFANT; MICE; RECEPTOR CROSS-TALK; RECEPTORS, NOTCH; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN NEOPLASMS;

EID: 68249118019     PISSN: 10492275     EISSN: None     Source Type: Journal    
DOI: 10.1097/SCS.0b013e318193d898     Document Type: Review

References (79)

1. Mulliken JB, Fishman SJ, Burrows PE. Vascular anomalies. Curr Probl Surg 2000;37:517-584
2. Frieden IJ, Haggstrom AN, Drolet BA, et al. Infantile hemangiomas: current knowledge, future directions. Proceedings of a research workshop on infantile hemangiomas, April 7-9, 2005, Bethesda, Maryland, USA. Pediatr Dermatol 2005;22:383-406
3. Boon LM, Enjolras O, Mulliken JB. Congenital hemangioma: evidence of accelerated involution. J Pediatr 1996;128:329-335
4. Berenguer B, Mulliken JB, Enjolras O, et al. Rapidly involuting congenital hemangioma: clinical and histopathologic features. Pediatr Dev Pathol 2003;6:495-510
5. Enjolras O, Mulliken JB, Boon LM, et al. Noninvoluting congenital hemangioma: a rare cutaneous vascular anomaly. Plast Reconstr Surg 2001;107:1647-1654
6. Boye E, Yu Y, Paranya G, et al. Clonality and altered behavior of endothelial cells from hemangiomas. J Clin Invest 2001;107:745-752
7. Bischoff J. Monoclonal expansion of endothelial cells in hemangioma: an intrinsic defect with extrinsic consequences? Trends Cardiovasc Med 2002;12:220-224
8. Yu Y, Flint AF, Mulliken JB, et al. Endothelial progenitor cells in infantile hemangioma. Blood 2004;103:1373-1375
9. Khan ZA, Melero-Martin JM, Wu X, et al. Endothelial progenitor cells from infantile hemangioma and umbilical cord blood display unique cellular responses to endostatin. Blood 2006;108:915-921
10. Takahashi K, Mulliken JB, Kozakewich HP, et al. Cellular markers that distinguish the phases of hemangioma during infancy and childhood. J Clin Invest 1994;93:2357-2364
11. Walter JW, North PE, Waner M, et al. Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma. Genes Chromosomes Cancer 2002;33:295-303
12. Iso T, Hamamori Y, Kedes L. Notch signaling in vascular development. Arterioscler Thromb Vasc Biol 2003;23:543-553
13. Karsan A. The role of notch in modeling and maintaining the vasculature. Can J Physiol Pharmacol 2005;83:14-23
14. Uyttendaele H, Soriano JV, Montesano R, et al. Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion. Dev Biol 1998;196:204-217
15. Vorontchikhina MA, Zimmermann RC, Shawber CJ, et al. Unique patterns of Notch1, Notch4 and Jagged1 expression in ovarian vessels during folliculogenesis and corpus luteum formation. Gene Expr Patterns 2005;5:701-709
16. Krebs LT, Xue Y, Norton CR, et al. Notch signaling is essential for vascular morphogenesis in mice. Genes Dev 2000;14:1343-1352
17. Santagata S, Demichelis F, Riva A, et al. JAGGED1 expression is associated with prostate cancer metastasis and recurrence. Cancer Res 2004;64:6854-6857
18. Politi K, Feirt N, Kitajewski J. Notch in mammary gland development and breast cancer. Semin Cancer Biol 2004;14:341-347
19. Callahan R, Egan SE. Notch signaling in mammary development and oncogenesis. J Mammary Gland Biol Neoplasia 2004;9:145-163
20. Zeng Q, Li S, Chepeha DB, et al. Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell 2005;8:13-23
21. Reedijk M, Odorcic S, Chang L, et al. High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res 2005;65:8530-8537
22. Patel NS, Li JL, Generali D, et al. Up-regulation of Delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res 2005;65:8690-8697
23. Leong KG, Karsan A. Recent insights into the role of Notch signaling in tumorigenesis. Blood 2006;107:2223-2233
24. Rehman AO, Wang CY. Notch signaling in the regulation of tumor angiogenesis. Trends Cell Biol 2006;16:293-300
25. Funahashi Y, Hernandez SL, Das I, et al. A Notch1 ectodomain construct inhibits endothelial Notch signaling, tumor growth, and angiogenesis. Cancer Res 2008;68:4727-4735
26. Shawber CJ, Funahashi Y, Francisco E, et al. Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest 2007;117:3369-3382
27. Corella F, Garcia-Navarro X, Ribe A, et al. Abortive or minimal-growth hemangiomas: Immunohistochemical evidence that they represent true infantile hemangiomas. J Am Acad Dermatol 2008;58:685-690
28. Ceisler E, Blei F. Ophthalmic issues in hemangiomas of infancy. Lymphat Res Biol 2003;1:321-330
29. Ceisler EJ, Santos L, Blei F. Periocular hemangiomas: what every physician should know. Pediatr Dermatol 2004;21:1-9
30. Rahbar R, Nicollas R, Roger G, et al. The biology and management of subglottic hemangioma: past, present, future. Laryngoscope 2004;114:1880-1891
31. Boon LM, Burrows PE, Paltiel HJ, et al. Hepatic vascular anomalies in infancy: a twenty-seven-year experience. J Pediatr 1996;129:346-354
32. Howell DM, Gumbiner CH, Martin GE. Congestive heart failure due to giant cutaneous cavernous hemangioma. Clin Pediatr 1984;23:504-506
33. Burrows PE, Robertson RL, Mulliken JB, et al. Cerebral vasculopathy and neurologic sequelae in infants with cervicofacial hemangioma: report of eight patients. Radiology 1998;207:601-607
34. Drolet BA, Dohil M, Golomb MR, et al. Early stroke and cerebral vasculopathy in children with facial hemangiomas and PHACE association. Pediatrics 2006;117:959-964
35. Mulliken JB, Marler JJ, Burrows PE, et al. Reticular infantile hemangioma of the limb can be associated with ventral-caudal anomalies, refractory ulceration, and cardiac overload. Pediatr Dermatol 2007;24:356-362
36. Girard C, Bigorre M, Guillot B, et al. PELVIS Syndrome. Arch Dermatol 2006;142:884-888
37. Xu Q, Zhang ZY, Chen WT, et al. The formation of transgenic mice with hemangiomas (in Chinese). Zhonghua Kou Qiang Yi Xue Za Zhi 2003;38:355-357
38. Rothermel TA, Engelhardt B, Sheibani N. Polyoma virus middle-T-transformed PECAM-1 deficient mouse brain endothelial cells proliferate rapidly in culture and form hemangiomas in mice. J Cell Physiol 2005;202:230-239
39. Tang Y, Liu W, Yu S, et al. A novel in vivo model of human hemangioma: xenograft of human hemangioma tissue on nude mice. Plast Reconstr Surg 2007;120:869-878
40. Peng Q, Liu W, Tang Y, et al. The establishment of the hemangioma model in nude mouse. J Pediatr Surg 2005;40:1167-1172
41. Chang EI, Thangarajah H, Hamou C, et al. Hypoxia, hormones, and endothelial progenitor cells in hemangioma. Lymphat Res Biol 2007;5:237-243
42. Sun ZY, Yang L, Yi CG, et al. Possibilities and potential roles of estrogen in the pathogenesis of proliferation hemangiomas formation. Med Hypotheses 2008;71:286-292
43. Khan ZA, Boscolo E, Picard A, et al. Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice. J Clin Invest 2008;118:2592-2599
44. Mulliken JB, Enjolras O. Congenital hemangiomas and infantile hemangioma: missing links. J Am Acad Dermatol 2004;50:875-882
45. Ritter MR, Butschek RA, Friedlander M, et al. Pathogenesis of infantile haemangioma: new molecular and cellular insights. Expert Rev Mol Med 2007;9:1-19
46. North PE, Waner M, Mizeracki A, et al. A unique microvascular phenotype shared by juvenile hemangiomas and human placenta. Arch Dermatol 2001;137:559-570
47. North PE, Waner M, Brodsky MC. Are infantile hemangiomas of placental origin? Ophthalmology 2002;109:633-634
48. Barnes CM, Christison-Lagay EA, Folkman J. The placenta theory and the origin of infantile hemangioma. Lymphat Res Biol 2007;5:245-255
49. Haggstrom AN, Drolet BA, Baselga E, et al. Prospective study of infantile hemangiomas: demographic, prenatal, and perinatal characteristics. J Pediatr 2007;150:291-294
50. Lopez Gutierrez JC, Avila LF, Sosa G, et al. Placental anomalies in children with infantile hemangioma. Pediatr Dermatol 2007;24:353-355
51. Burton BK, Schulz CJ, Angle B, et al. An increased incidence of haemangiomas in infants born following chorionic villus sampling (CVS). Prenat Diagn 1995;15:209-214
52. Barnes CM, Huang S, Kaipainen A, et al. Evidence by molecular profiling for a placental origin of infantile hemangioma. Proc Natl Acad Sci U S A 2005;102:19097-19102
53. Kleinman ME, Greives MR, Churgin SS, et al. Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma. Arterioscler Thromb Vasc Biol 2007;27:2664-2670
54. Ruas JL, Lendahl U, Poellinger L. Modulation of vascular gene expression by hypoxia. Curr Opin Lipidol 2007;18:508-514
55. Yu Y, Varughese J, Brown LF, et al. Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells. Am J Pathol 2001;159:2271-2280
56. Dadras SS, North PE, Bertoncini J, et al. Infantile hemangiomas are arrested in an early developmental vascular differentiation state. Mod Pathol 2004;17:1068-1079
57. Simons M. Integrative signaling in angiogenesis. Mol Cell Biochem 2004;264:99-102
58. Chang J, Most D, Bresnick S, et al. Proliferative hemangiomas: analysis of cytokine gene expression and angiogenesis. Plast Reconstr Surg 1999;103:1-9
59. Bicknell R, Harris AL. Novel angiogenic signaling pathways and vascular targets. Annu Rev Pharmacol Toxicol 2004;44:219-238
60. Shawber CJ, Kitajewski J. Notch function in the vasculature: insights from zebrafish, mouse and man. Bioessays 2004;26:225-234
61. Weinmaster G, Roberts VJ, Lemke G. A homolog of Drosophila Notch expressed during mammalian development. Development 1991;113:199-205
62. Weinmaster G, Roberts VJ, Lemke G. Notch2: a second mammalian Notch gene. Development 1992;116:931-941
63. Lardelli M, Dahlstrand J, Lendahl U. The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium. Mech Dev 1994;46:123-136
64. Uyttendaele H, Marazzi G, Wu G, et al. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development 1996;122:2251-2259
65. Gallahan D, Callahan R. The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4). Oncogene 1997;14:1883-1890
66. Bettenhausen B, Hrabe de Angelis M, Simon D, et al. Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. Development 1995;121:2407-2418
67. Dunwoodie SL, Henrique D, Harrison SM, et al. Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo. Development 1997;124:3065-3076
68. Shutter JR, Scully S, FanW, et al. Dll4, a novel Notch ligand expressed in arterial endothelium. Genes Dev 2000;14:1313-1318
69. Lindsell CE, Shawber CJ, Boulter J, et al. Jagged: a mammalian ligand that activates Notch1. Cell 1995;80:909-917
70. Shawber C, Boulter J, Lindsell CE, et al. Jagged2: a serrate-like gene expressed during rat embryogenesis. Dev Biol 1996;180:370-376
71. Weinmaster G. Notch signaling: direct or what? Curr Opin Genet Dev 1998;8:436-442
72. Chigurupati S, Arumugam TV, Son TG, et al. Involvement of notch signaling in wound healing. PLoS ONE 2007;2:e1167
73. Lawson ND, Vogel AM, Weinstein BM. sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell 2002;3:127-136
74. Liu ZJ, Shirakawa T, Li Y, et al. Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol 2003;23:14-25
75. Hainaud P, Contreres JO, Villemain A, et al. The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions. Cancer Res 2006;66:8501-8510
76. Hellstrom M, Phng LK, Hofmann JJ, et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 2007;445:776-780
77. Lobov IB, Renard RA, Papadopoulos N, et al. Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci U S A 2007;104:3219-3224
78. Suchting S, Freitas C, le Noble F, et al. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc Natl Acad Sci U S A 2007;104:3225-3230
79. Williams CK, Li JL, Murga M, et al. Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood 2006;107:931-939