Probing the role of parasite-specific, distant structural regions on communication and catalysis in the bifunctional thymidylate synthase- dihydrofolate reductase from Plasmodium falciparum

Biochemistry

Volumn 47, Issue 5, 2008, Pages 1336-1345

  Dasgupta, Tina ^a   Anderson, Karen S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; COULOMB INTERACTIONS; DISEASES; LIGANDS; NUCLEOTIDES;

CATALYTIC RATES; MUTATIONAL ANALYSIS; PARASITES;

ENZYME KINETICS;

DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; POLYPEPTIDE; THYMIDYLATE SYNTHASE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CATALYSIS; CROSSING OVER; ELECTRICITY; ENZYME ACTIVITY; ENZYME STRUCTURE; LEISHMANIA MAJOR; MUTATION; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; STEADY STATE;

ANIMALS; CATALYSIS; ENZYME ACTIVATION; FLUORODEOXYURIDYLATE; KINETICS; LEISHMANIA MAJOR; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; PLASMODIUM FALCIPARUM; TETRAHYDROFOLATE DEHYDROGENASE; TETRAHYDROFOLATES; THYMIDYLATE SYNTHASE;

LEISHMANIA MAJOR; PLASMODIUM FALCIPARUM;

EID: 38849173787     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi701624u     Document Type: Article

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