North- and South-bicyclo[3.1.0]hexene nucleosides: The effect of ring planarity on anti-HIV activity

ChemMedChem

Volumn 4, Issue 8, 2009, Pages 1354-1363

  Russ, Pamela L ^a   Gonzalez Moa, Maria J ^a,c   Vu, B Christie ^a   Sigano, Dina M ^a   Kelley, James A ^a   Lai, Christopher C ^a   Deschamps, Jeffrey R ^b   Hughes, Stephen H ^a   Marquez, Victor E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NAVAL RESEARCH LABORATORY   (United States)

^c ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Antiviral agents; Carbocycles; Conformationally locked; Nucleosides; Pseudorotational cycles

Indexed keywords

1 [ 4 ((TERT BUTYLDIPHENYLSILYLOXY)METHYL) 3 HYDROXYBICYCLO[3.1.0]HEXAN 1 YL] 5 METHYLPYRIMIDINE 2,4(1H,3H) DIONE; 1 [ 5 ((TERT BUTYLDIPHENYLSILYLOXY)METHYL)BICYCLO[3.1.0]HEX 3 EN 2 YL) 4 (1H 1,2,4 TRIAZOL 1 YL]PYRIMIDIN 2(1H) ONE; 1 [ 5 ((TERT BUTYLDIPHENYLSILYLOXY)METHYL)BICYCLO[3.1.0]HEX 3 EN 2 YL]PYRIMIDINE 2,4(1H,3H) DIONE; 3 BENZOYL 1 [ 5 ((TERT BUTYLDIPHENYLSILYLOXY)METHYL)BICYCLO[3.1.0]HEX 3 EN 2 YL]PYRIMIDINE 2,4(1H,3H) DIONE; 4 AMINO 1 [ 5 ((TERT BUTYLDIPHENYLSILYLOXY)METHYLBICYCLO[3.1.0]HEX 3 EN 2 YL]PYRIMIDIN 2(1H) ONE; 4 AMINO 1 [ 5 (HYDROXYMETHYL)BICYCLO[3.1.0]HEX EN 2 YL] PYRIMIDIN 2(1H) ONE; 9 ( 5 [[TERT BUTYLDIPHENYLSILYLOXY]METHYL]BICYCLO[3.1.0]HEX 3 EN 2 YL) 6 CHLORO 9H PURINE; [ 4 (6 AMINO 9H PURIN 9 YL)BICYCLO[3.1.0]HEX 2 EN 1 YL]METHANOL; ANTIRETROVIRUS AGENT; BICYCLO[3.1.0]HEXENE NUCLEOSIDE; NUCLEOSIDE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG EFFECT; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MITSUNOBU REACTION; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ANTI-HIV AGENTS; BICYCLO COMPOUNDS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; HIV REVERSE TRANSCRIPTASE; HUMANS; MOLECULAR CONFORMATION; NUCLEOSIDES;

EID: 68149161250     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900153     Document Type: Article

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