Synthesis and Conformational Analysis of a Locked Analogue of Carbovir Built on a Bicyclo[3.1.0]-hex-2-enyl Template

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 12, 2003, Pages 2077-2091

  Choi, Yongseok ^a   Sun, Guangyu ^a   George, Clifford ^b   Nicklaus, Marc C ^a   Kelley, James A ^a   Marquez, Victor E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NAVAL RESEARCH LABORATORY   (United States)

Author keywords

Anti HIV; Bicyclo 3.1.0 hex 2 enyl template; Carbocyclic nucleosides; Carbovir analogue; Conformationally locked

Indexed keywords

2 AMINO 9 [5' (HYDROXYMETHYL)BICYCLO[3.1.0]HEX 3' EN 2' YL]HYDROPURIN 6 ONE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CARBOVIR; CYCLOPENTANE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG CONFORMATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENERGY; HUMAN; HUMAN CELL; ISOMERISM; STRUCTURE ANALYSIS;

ANTI-HIV AGENTS; CRYSTALLOGRAPHY, X-RAY; CYCLOPENTANES; CYCLOPROPANES; DIDEOXYNUCLEOSIDES; GUANOSINE; HIV-1; HIV-2; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; THERMODYNAMICS;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0347481327     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120026631     Document Type: Article

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