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Volumn 192, Issue 2, 2003, Pages 199-203

Overexpression of the peroxisome proliferator activated receptor α or the human c-Ha-ras transgene is not involved in tumorigenesis induced by di(2-ethylhexyl)phthalate in rasH2 mice

Author keywords

Di(2 ethylhexyl)phthalate; Human c Ha ras; Peroxisome proliferator activated receptor ; RasH2 mice

Indexed keywords

ANTIBODY; KI 67 ANTIGEN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER;

EID: 0037474702     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(02)00714-0     Document Type: Article
Times cited : (4)

References (19)
  • 1
    • 0002333521 scopus 로고
    • Hepatic changes associated with peroxisome proliferation
    • G. Gibson, & B. Lake. London: Taylor and Francis Ltd
    • Grasso P. Hepatic changes associated with peroxisome proliferation. Gibson G., Lake B. Peroxisomes: Biology and Importance in Toxicology and Medicine. 1993;639-652 Taylor and Francis Ltd, London.
    • (1993) Peroxisomes: Biology and Importance in Toxicology and Medicine , pp. 639-652
    • Grasso, P.1
  • 2
    • 0030002143 scopus 로고    scopus 로고
    • Hepatocarcinogenic potential of di(2-ethylhexyl)phthalate in rodents and its implications on human risk
    • Huber W.W., Grasl-Kraupp B., Schulte-Hermann R. Hepatocarcinogenic potential of di(2-ethylhexyl)phthalate in rodents and its implications on human risk. Crit. Rev. Toxicol. 26:1996;365-481.
    • (1996) Crit. Rev. Toxicol. , vol.26 , pp. 365-481
    • Huber, W.W.1    Grasl-Kraupp, B.2    Schulte-Hermann, R.3
  • 3
    • 0020444298 scopus 로고
    • The carcinogenicity of dietary di(2-ethylhexyl)phthalate (DEHP) in Fischer 344 rats and B6C3F1 mice
    • Kluwe W.M., Haseman J.K., Douglas J.F., Huff J.E. The carcinogenicity of dietary di(2-ethylhexyl)phthalate (DEHP) in Fischer 344 rats and B6C3F1 mice. J. Toxicol. Environ. Health. 10:1982;797-815.
    • (1982) J. Toxicol. Environ. Health , vol.10 , pp. 797-815
    • Kluwe, W.M.1    Haseman, J.K.2    Douglas, J.F.3    Huff, J.E.4
  • 5
    • 0034677853 scopus 로고    scopus 로고
    • Central role of PPARα in the mechanism of action of hepatocarcinogenic peroxisome proliferators
    • Corton J.C., Lapinskas P.J., Gonzalez F.J. Central role of PPARα in the mechanism of action of hepatocarcinogenic peroxisome proliferators. Mutat. Res. 448:2000;139-151.
    • (2000) Mutat. Res. , vol.448 , pp. 139-151
    • Corton, J.C.1    Lapinskas, P.J.2    Gonzalez, F.J.3
  • 7
    • 0026503353 scopus 로고
    • Chemically induced forestomach papillomas in transgenic mice carry mutant human c-Ha-ras transgenes
    • Ando K., Saitoh A., Hino O., Takahashi R., Kimura M., Katsuki M. Chemically induced forestomach papillomas in transgenic mice carry mutant human c-Ha-ras transgenes. Cancer Res. 52:1992;978-982.
    • (1992) Cancer Res. , vol.52 , pp. 978-982
    • Ando, K.1    Saitoh, A.2    Hino, O.3    Takahashi, R.4    Kimura, M.5    Katsuki, M.6
  • 8
    • 0031279409 scopus 로고    scopus 로고
    • Susceptibility of transgenic mice carrying human prototype c-Ha-ras gene in a short-term carcinogenicity study of vinyl carbamate and ras gene analyses of the induced tumors
    • Mitsumori K., Wakana S., Yamamoto S., Kodama Y., Yasuhara K., Nomura T., Hayashi Y., Maronpot R.R. Susceptibility of transgenic mice carrying human prototype c-Ha-ras gene in a short-term carcinogenicity study of vinyl carbamate and ras gene analyses of the induced tumors. Mol. Carcinog. 20:1997;298-307.
    • (1997) Mol. Carcinog. , vol.20 , pp. 298-307
    • Mitsumori, K.1    Wakana, S.2    Yamamoto, S.3    Kodama, Y.4    Yasuhara, K.5    Nomura, T.6    Hayashi, Y.7    Maronpot, R.R.8
  • 9
    • 0031848163 scopus 로고    scopus 로고
    • Point mutations of the c-Ha-ras gene in spontaneous liver tumors of transgenic mice carrying the human c-Ha-ras gene
    • Hayashi S., Mori I., Nonoyama T., Mitsumori K. Point mutations of the c-Ha-ras gene in spontaneous liver tumors of transgenic mice carrying the human c-Ha-ras gene. Toxicol. Pathol. 26:1998;556-561.
    • (1998) Toxicol. Pathol. , vol.26 , pp. 556-561
    • Hayashi, S.1    Mori, I.2    Nonoyama, T.3    Mitsumori, K.4
  • 10
    • 0034729149 scopus 로고    scopus 로고
    • Carcinogen dose-dependent variation in the transgene mutation spectrum in urethane-induced lung tumors in transgenic mice carrying the human prototype c-Ha-ras gene
    • Mori I., Yasuhara K., Hayashi S., Nonoyama T., Nomura T., Mitsumori K. Carcinogen dose-dependent variation in the transgene mutation spectrum in urethane-induced lung tumors in transgenic mice carrying the human prototype c-Ha-ras gene. Cancer Lett. 153:2000;199-209.
    • (2000) Cancer Lett. , vol.153 , pp. 199-209
    • Mori, I.1    Yasuhara, K.2    Hayashi, S.3    Nonoyama, T.4    Nomura, T.5    Mitsumori, K.6
  • 11
    • 0012734114 scopus 로고    scopus 로고
    • Point mutations of the c-Ha-ras gene in spontaneous pulmonary tumors of transgenic mice carrying the human c-Ha-ras gene
    • Mori I., Hayashi S., Nonoyama T., Yasuhara K., Mitsumori K., Masegi T. Point mutations of the c-Ha-ras gene in spontaneous pulmonary tumors of transgenic mice carrying the human c-Ha-ras gene. J. Toxicol. Pathol. 13:2000;165-172.
    • (2000) J. Toxicol. Pathol. , vol.13 , pp. 165-172
    • Mori, I.1    Hayashi, S.2    Nonoyama, T.3    Yasuhara, K.4    Mitsumori, K.5    Masegi, T.6
  • 12
    • 0034823841 scopus 로고    scopus 로고
    • Di(2-ethylhexyl)phthalate induces hepatocellular adenoma in transgenic mice carrying a human prototype c-Ha-ras gene in a 26-week carcinogenicity study
    • Toyosawa K., Okimoto K., Kobayashi I., Kijima K., Kikawa E., Kohchi M., Koujitani T., Tanaka K., Matsuoka N. Di(2-ethylhexyl)phthalate induces hepatocellular adenoma in transgenic mice carrying a human prototype c-Ha-ras gene in a 26-week carcinogenicity study. Toxicol. Pathol. 29:2001;458-466.
    • (2001) Toxicol. Pathol. , vol.29 , pp. 458-466
    • Toyosawa, K.1    Okimoto, K.2    Kobayashi, I.3    Kijima, K.4    Kikawa, E.5    Kohchi, M.6    Koujitani, T.7    Tanaka, K.8    Matsuoka, N.9
  • 14
    • 0036192051 scopus 로고    scopus 로고
    • Application of genetically altered models as replacement for the lifetime mouse bioassay in pharmaceutical development
    • Alden C., Smith P., Morton D. Application of genetically altered models as replacement for the lifetime mouse bioassay in pharmaceutical development. Toxicol. Pathol. 30:2002;135-138.
    • (2002) Toxicol. Pathol. , vol.30 , pp. 135-138
    • Alden, C.1    Smith, P.2    Morton, D.3
  • 15
    • 0036185655 scopus 로고    scopus 로고
    • The Tg rasH2 mouse in cancer hazard identification
    • Morton D., Alden C.L., Roth A.J., Usui T. The Tg rasH2 mouse in cancer hazard identification. Toxicol. Pathol. 30:2002;139-146.
    • (2002) Toxicol. Pathol. , vol.30 , pp. 139-146
    • Morton, D.1    Alden, C.L.2    Roth, A.J.3    Usui, T.4
  • 16
    • 0003554629 scopus 로고
    • Multistage carcinogenesis of the rat hepatocyte
    • B.E. Butterworth, & T.J. Slaga. New York: Cold Spring Harbor Laboratory
    • Pitot H.C., Beer D.G., Hendrich S. Multistage carcinogenesis of the rat hepatocyte. Butterworth B.E., Slaga T.J. Banbury Report 25: Nongenotoxic Mechanisms in Carcinogenesis. 1987;41-53 Cold Spring Harbor Laboratory, New York.
    • (1987) Banbury Report 25: Nongenotoxic Mechanisms in Carcinogenesis , pp. 41-53
    • Pitot, H.C.1    Beer, D.G.2    Hendrich, S.3
  • 17
    • 0029362901 scopus 로고
    • Role of oxidative stress in non-genotoxic carcinogenesis with special reference to liver tumors induced by peroxisome proliferators
    • Sai-Kato K., Takagi A., Umemura T., Hasegawa R., Kurokawa Y. Role of oxidative stress in non-genotoxic carcinogenesis with special reference to liver tumors induced by peroxisome proliferators. Biomed. Environ. Sci. 8:1995;269-279.
    • (1995) Biomed. Environ. Sci. , vol.8 , pp. 269-279
    • Sai-Kato, K.1    Takagi, A.2    Umemura, T.3    Hasegawa, R.4    Kurokawa, Y.5
  • 18
    • 0023194491 scopus 로고
    • Correlation of the carcinogenic potential of di(2-ethylhexyl)phthalate (DEHP) with induced hyperplasia rather than with genotoxic activity
    • Smith-Oliver T., Butterworth B.E. Correlation of the carcinogenic potential of di(2-ethylhexyl)phthalate (DEHP) with induced hyperplasia rather than with genotoxic activity. Mutat. Res. 188:1987;21-28.
    • (1987) Mutat. Res. , vol.188 , pp. 21-28
    • Smith-Oliver, T.1    Butterworth, B.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.