Analysis of gene expression profiles of forestomach tumors in rasH2 mice initiated with N-ethyl-N-nitrosourea

Archives of Toxicology

Volumn 78, Issue 12, 2004, Pages 688-696

  Okamura, Miwa ^a   Sumida, Kayo ^b   Muto, Tomoko ^c   Kashida, Yoko ^a   Machida, Noboru ^a   Watanabe, Tomoyuki ^b   Mitsumori, Kunitoshi ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b SUMITOMO CHEMICAL CO LTD   (Japan)

^c KYORIN UNIVERSITY   (Japan)

Author keywords

Forestomach; Gene expression; N Ethyl N nitrosourea; ras Gene; rasH2 Mouse

Indexed keywords

CYCLIN D1; ETHYLNITROSOUREA; MATRIX METALLOPROTEINASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INVASION; CARCINOGENESIS; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; FORESTOMACH; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC ANALYSIS; MALE; METASTASIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE C FOS; ONCOGENE C H RAS; ONCOGENE C MYC; ONCOGENE N RAS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SQUAMOUS CELL CARCINOMA; STOMACH TUMOR; TRANSGENE; TRANSGENIC MOUSE; TUMOR GROWTH; UNINDEXED SEQUENCE; UPREGULATION;

ANIMALS; ETHYLNITROSOUREA; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RAS; GENETIC PREDISPOSITION TO DISEASE; MALE; MICE; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STOMACH NEOPLASMS;

ANIMALIA; MUS MUSCULUS;

EID: 12144278641     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-004-0589-5     Document Type: Article

References (36)

1. Akhurst RJ, Balmain A (1999) Genetic events and the role of TGFβ in epithelial tumour progression. J Pathol 187:82-90
2. Ando K, Saitoh A, Hino O, Takahashi R, Kimura M, Katsuki M (1992) Chemically induced forestomach papillomas in transgenic mice carry mutant human c-Ha-ras transgene. Cancer Res 52:978-982
3. Chang EH, Furth ME, Scolnick EM, Lowy DR (1982) Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus. Nature 297:479-483
4. Cook SJ, Aziz N, McMahon M (1999) The repertoire of Fos and Jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation. Mol Cell Biol 19:330-341
5. Cook SJ, Balmanno K, Garner A, Miller T, Taverner C, Todd D (2000) Regulation of cell cycle re-entry by growth, survival and stress signaling pathways. Biochem Soc Trans 28:233-240
6. Derynck R, Akhurst RJ, Balmain A (2001) TGF-β signaling in tumor suppression and cancer progression. Nat Genet 29:117-129
7. Hong SD, Hong SP, Lee JI, Lim CY (2000) Expression of matrix metalloproteinase-2 and -9 in oral squamous cell carcinomas with regard to the metastatic potential. Oral Oncol 36: 207-213
8. Hunter T (1997) Oncoprotein networks. Cell 88:333-346
9. Ikenaka Y, Yoshiji H, Kuriyama S, Yoshii J, Noguchi R, Tsujinoue H, Yanase K, Namisaki T, Imazu H, Masaki T, Fukui H (2003) Tissue inhibitor of metalloproteinases-1 (TIMP-1) inhibits tumor growth and angiogenesis in the TIMP-1 transgenic mouse model. Int J Cancer 105:340-346
10. Kanitakis J, Ramirez-Bosca A, Reano A, Viac J, Roche P, Thivolet J (1988) Filaggrin expression in normal and pathological skin. A marker of keratinocyte differentiation. Virchows Arch A Pathol Anat Histopathol 412:375-382
11. Kawano Y, Okamoto I, Murakami D, Itoh H, Yoshida M, Ueda S, Saya H (2000) Ras oncoprotein induces CD44 cleavage through phosphoinositide 3-OH kinase and the rho family of small G protein. J Biol Chem 275: 29628-29635
12. Kominsky SL, Argani P, Korz D, Evron E, Raman V, Garrett E, Rein A, Sauter G, Kallioniemi OP, Sukumar S (2003) Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. Oncogene 22:2021-2033
13. Koshikawa N, Moriyama K, Takamura H, Mizushima H, Nagashima Y, Yanoma S, Miyazaki K (1999) Overexpression of laminin γ2 chain monomer in invading gastric carcinoma cells. Cancer Res 59:5596-5601
14. Lavoie JN, L'Allemain G, Brunet A, Muller R, Pouyssegur J (1996) Cyclin D1 expression is regulated positively by the p42/ p44MAPK and negatively by the p38/HOGMAPK pathway. J Biol Chem 271:20608-20616
15. Lin AW, Barrades M, Stone JC, van Aelst L, Serrano M, Lowe SW (1998) Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev 12:3008-3019
16. Lockhart DJ, Dong H, Byrne MC, Follettie MT, Gallo MV, Chee MS, Mittmann M, Wang C, Kobayashi M, Horton H, Brown EL (1996) Expression monitoring by hybridization to high-sensity oligonucleotide arrays. Nat Biotechnol 14:1675-1680
17. Lukas J, Parry D, Aagaard L, Mann DJ, Bartkove J, Strauss M, Peters G, Bartek J (1995) Retinoblastoma-protein-dependent cell cycle inhibition by the tumor suppressor p16. Nature 375:503-506
18. Maruyama C, Tomisawa M, Wakana S, Yamazaki H, Kijima H, Suemizu H, Ohnishi Y, Urano K, Hioki K, Usui T, Nakayama M, Tsuchida T, Mitsumori K, Nomura T, Tamaoki N, Ueyama Y (2001) Overexpression of human H-ras transgene is responsible for tumors induced by chemical carcinogens in mice. Oncol Rep 8:233-237
19. Meloche S, Seuwen K, Pages G, Pouyssegur J (1992) Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity. Mol Endocrinol 6:845-854
20. Mitsumori K, Wakana S, Yamamoto S, Kodama Y, Yasuhara K, Nomura T, Hayashi Y, Maronpot RR (1997) Susceptibility of transgenic mice carrying human prototype c-Ha-ras gene in a short-term carcinogenicity study of vinyl carbamate and ras gene analyses of the induced tumors. Mol Carcinog 20:298-307
21. Nasi S, Ciarapica R, Jucker R, Rosati J, Soucek L (2001) Making decisions through Myc. FEBS Lett 490:153-162
22. Oft M, Peli J, Rudaz C, Schwarz H, Beug H, Reichmann E (1996) TGF-β1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev 10:2462-2477
23. Okamoto K, Beach D (1994) Cyclin G1 is a transcriptional target of the p53 tumor suppressor protein. EMBO J 13:4816-4822
24. Saez E, Rutberg SE, Mueller E, Oppenheim H, Smoluk J, Yuspa SH, Spiegelman BM (1995) c-fos is required for malignant progression of skin tumors. Cell 82:721-732
25. Saitoh A, Kimura M, Takahashi R, Yokoyama M, Nomura T, Izawa M, Sekiya T, Nishimura S, Katsuki M (1990) Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes. Oncogene 5:1195-1200
26. Sakaguchi M, Fujii Y, Hirabayashi H, Yoon HE, Komoto Y, Oue T, Kusafuka T, Okabe A, Matsuda H (1996) Inversely correlated expression of p16 and Rb protein in non-small cell lung cancers: an immunohistochemical study. Int J Cancer 65:442-445
27. Santibanez JF, Guerrero J, Quintanilla M, Fabra A, Martinez J (2002) Transforming growth factor-β1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes. Biochem Biophys Res Commun 296:267-273
28. Sourvinos G, Tsatsanis C, Spandidos DA (1999) Overexpression of Tp1-2/Cot oncogene in human breast cancer. Oncogene 18:4968-4973
29. Suemizu H, Muguruma K, Maruyama C, Tomisawa M, Kimura M, Hioki K, Shimozawa N, Ohnishi Y, Tamaoki N, Nomura T (2002) Transgene stability and features of rasH2 mice as an animal model for short-term carcinogenicity testing. Mol Carcinog 34:1-9
30. Tamaoki N (2001) The rasH2 transgenic mouse: nature of the model and mechanistic studies on tumorigenesis. Toxicol Pathol 29 [Suppl]: 81-89
31. Toyosawa K, Tanaka K, Imai T, Yasuhara K, Koujitani T, Hirose M, Mitsumori K (2003) Mutation and overexpression of the transgene in ethylnitrosourea-induced tumors in mice carrying a human prototype c-Ha-ras gene. Toxicol Pathol 31:491-495
32. Tsuneoka M, Mekada E (2000) Ras/MEK signaling suppresses Myc-dependent apoptosis in cell transformed by c-myc and activated ras. Oncogene 19:115-123
33. Usui T, Mutai M, Hisada S, Takaoka M, Soper KA, McCullough B, Alden C (2001) CB6F1-rasH2 mouse: overview of available data. Toxicol Pathol 29 [Suppl]:90-108
34. Vojtek AB, Der CJ (1998) Increasing complexity of the Ras signaling pathway. J Biol Chem 273:19925-19928
35. Watnick RS, Cheng YN, Rangarajan A, Ince TA, Weinberg RA (2003) Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. Cancer Cell 3:219-231
36. Yamamoto S, Mitsumori K, Kodama Y, Matsunuma N, Manabe S, Okamiya H, Suzuki H, Fukuda T, Sakamaki Y, Sunaga M, Nomura G, Hioki K, Wakana S, Nomura T, Hayashi Y (1996) Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice. Carcinogenesis 17:2455-2461