Using Laser Scanning Cytometry to Measure PPAR-Mediated Peroxisome Proliferation and β Oxidation

Toxicologic Pathology

Volumn 33, Issue 1, 2005, Pages 86-91

  Pruimboom Brees, Ingrid M ^a   Brees, Dominique J J E ^a   Shen, Amy C ^a   Keener, Mary ^a   Francone, Omar ^a   Amacher, David E ^a   Loy, James K ^a   Kerlin, Roy L ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Acyl CoA oxidase; Peroxisome; proliferation; PTS1; oxidation

Indexed keywords

ACYL COENZYME A OXIDASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOMETRY; IMMUNOHISTOCHEMISTRY; LASER MICROSCOPY; LIVER CELL; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PEROXISOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RAT;

ACYL-COA OXIDASE; ANIMALS; CATALASE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LASER SCANNING CYTOMETRY; LIVER; MALE; OXIDATION-REDUCTION; PALMITOYL COENZYME A; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PEROXISOME PROLIFERATORS; PEROXISOMES; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS;

ANIMALIA;

EID: 13444252981     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230590881817     Document Type: Article

References (10)

1. Amacher DE, Beck R, Schomaker SJ, Kenny CV Hepatic microsomal enzyme induction, beta-oxidation, and cell proliferation following administration of clofibrate, gemfibrozil, or bezafibrate in the CD rat Toxicol Appl Pharmacol 1997 142 1 143-50
2. Farioli-Vecchioli S, Moreno S, Ceru MP Immunohistochemical localization of acyl CoA oxidase in the rat central nervous system Neurocytol 2001 30 21 33
3. Gould SJ, Krisans GA, Subramani S Antibodies directed against the peroxisomal targeting signal of firefly luciferase recognize multiple mammalian peroxisomal proteins J Cell Biol 1990 110 27 34
4. Kamentsky LA Laser scanning cytometry Meth Cell Biol 2001 63 57 87
5. Lazarow PB Assay of peroxisomal β oxidation of fatty acids Methods in Enzymology 1981 72 315 319
6. Moody DE, Gibson GG, Grant DF, Madgalou J, Rao MS Peroxisome proliferators, a unique set of drug-metabolizing enzyme inducers: commentary on a symposium Drug Metabol Dispos 1992 20 779-91
7. Nemali MR, Usuda N, Reddy MK Comparison of constitutive and inducible levels of expression of peroxisomal beta-oxidation and catalase genes in liver and extrahepatic tissues of rat Cancer Res 1988 48 5316-24
8. Osumi T, Hashimoto T, Ui N Purification and properties of acyl Co A oxidase from rat liver J Biochem (Tokyo) 1980 87 1735-46
9. Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import Mol Cell Biol 2002 22 6 1639-55
10. Usuda N, Johkura K, Hachiya T, Nakazawa A Immunoelectron microscopy of peroxisomes employing the antibody for the SKL sequence PTS1 C-terminus common to peroxisomal enzymes J Histochem Cytochem 1999 47 9 1119-26