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Volumn 4, Issue 3-4, 2007, Pages

Finding the way in the jungle of kinase drug targets

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; BCR ABL PROTEIN; DASATINIB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; FLT3 LIGAND; GEFITINIB; IMATINIB; LAPATINIB; NILOTINIB; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE; PROTEIN TYROSINE KINASE; SORAFENIB; STEM CELL FACTOR; SUNITINIB; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

EID: 68049137636     PISSN: 17406749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddtec.2008.07.001     Document Type: Review
Times cited : (3)

References (39)
  • 1
    • 33745679123 scopus 로고    scopus 로고
    • Targeting signal transduction as a strategy to treat inflammatory diseases
    • O'neill L.A. Targeting signal transduction as a strategy to treat inflammatory diseases. Nat. Rev. Drug Discov. 5 (2006) 549-563
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 549-563
    • O'neill, L.A.1
  • 2
    • 33745325007 scopus 로고    scopus 로고
    • Mechanisms of drug inhibition of signalling molecules
    • Sebolt-Leopold J.S., and English J.M. Mechanisms of drug inhibition of signalling molecules. Nature 441 (2006) 457-462
    • (2006) Nature , vol.441 , pp. 457-462
    • Sebolt-Leopold, J.S.1    English, J.M.2
  • 3
    • 0036490442 scopus 로고    scopus 로고
    • Smart drugs: tyrosine kinase inhibitors in cancer therapy
    • Shawver L.K., et al. Smart drugs: tyrosine kinase inhibitors in cancer therapy. Cancer Cell 1 (2002) 117-123
    • (2002) Cancer Cell , vol.1 , pp. 117-123
    • Shawver, L.K.1
  • 4
    • 33751106653 scopus 로고    scopus 로고
    • New approaches to molecular cancer therapeutics
    • Collins I., and Workman P. New approaches to molecular cancer therapeutics. Nat. Chem. Biol. 2 (2006) 689-700
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 689-700
    • Collins, I.1    Workman, P.2
  • 5
    • 34548721023 scopus 로고    scopus 로고
    • Protein kinases as targets for cancer treatment
    • Giamas G., et al. Protein kinases as targets for cancer treatment. Pharmacogenomics 8 (2007) 1005-1016
    • (2007) Pharmacogenomics , vol.8 , pp. 1005-1016
    • Giamas, G.1
  • 6
    • 33947596504 scopus 로고    scopus 로고
    • Why is cancer drug discovery so difficult?
    • Kamb A., et al. Why is cancer drug discovery so difficult?. Nat. Rev. Drug Discov. 6 (2007) 115-120
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 115-120
    • Kamb, A.1
  • 7
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola I., and Landis J. Can the pharmaceutical industry reduce attrition rates?. Nat. Rev. Drug Discov. 3 (2004) 711-715
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 8
    • 20844432908 scopus 로고    scopus 로고
    • Can cell systems biology rescue drug discovery?
    • Butcher E.C. Can cell systems biology rescue drug discovery?. Nat. Rev. Drug Discov. 4 (2005) 461-467
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 461-467
    • Butcher, E.C.1
  • 9
    • 33747812085 scopus 로고    scopus 로고
    • Applying computational modeling to drug discovery and development
    • Kumar N., et al. Applying computational modeling to drug discovery and development. Drug Discov. Today 11 (2006) 806-811
    • (2006) Drug Discov. Today , vol.11 , pp. 806-811
    • Kumar, N.1
  • 10
    • 32044451325 scopus 로고    scopus 로고
    • Cancer: a Systems Biology disease
    • Hornberg J.J., et al. Cancer: a Systems Biology disease. Biosystems 83 (2006) 81-90
    • (2006) Biosystems , vol.83 , pp. 81-90
    • Hornberg, J.J.1
  • 11
    • 0033614998 scopus 로고    scopus 로고
    • Creation of human tumour cells with defined genetic elements
    • Hahn W.C., et al. Creation of human tumour cells with defined genetic elements. Nature 400 (1999) 464-468
    • (1999) Nature , vol.400 , pp. 464-468
    • Hahn, W.C.1
  • 12
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 13
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B., and Kinzler K.W. Cancer genes and the pathways they control. Nat. Med. 10 (2004) 789-799
    • (2004) Nat. Med. , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 14
    • 1542515338 scopus 로고    scopus 로고
    • A census of human cancer genes
    • Futreal P.A., et al. A census of human cancer genes. Nat. Rev. Cancer 4 (2004) 177-183
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 177-183
    • Futreal, P.A.1
  • 15
    • 0033555859 scopus 로고    scopus 로고
    • Emergent properties of networks of biological signaling pathways
    • Bhalla U.S., and Iyengar R. Emergent properties of networks of biological signaling pathways. Science 283 (1999) 381-387
    • (1999) Science , vol.283 , pp. 381-387
    • Bhalla, U.S.1    Iyengar, R.2
  • 16
    • 0037174670 scopus 로고    scopus 로고
    • Network motifs: simple building blocks of complex networks
    • Milo R., et al. Network motifs: simple building blocks of complex networks. Science 298 (2002) 824-827
    • (2002) Science , vol.298 , pp. 824-827
    • Milo, R.1
  • 17
    • 0037047611 scopus 로고    scopus 로고
    • MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network
    • Bhalla U.S., et al. MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297 (2002) 1018-1023
    • (2002) Science , vol.297 , pp. 1018-1023
    • Bhalla, U.S.1
  • 18
    • 4944258252 scopus 로고    scopus 로고
    • Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4 beta-phorbol 12-myristate 13-acetate
    • Hornberg J.J., et al. Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4 beta-phorbol 12-myristate 13-acetate. Eur. J. Biochem. 271 (2004) 3905-3913
    • (2004) Eur. J. Biochem. , vol.271 , pp. 3905-3913
    • Hornberg, J.J.1
  • 19
    • 0029790351 scopus 로고    scopus 로고
    • Ultrasensitivity in the mitogen-activated protein kinase cascade
    • Huang C.Y., and Ferrell Jr. J.E. Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 10078-10083
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 10078-10083
    • Huang, C.Y.1    Ferrell Jr., J.E.2
  • 20
    • 0034019315 scopus 로고    scopus 로고
    • Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades
    • Kholodenko B.N. Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades. Eur. J. Biochem. 267 (2000) 1583-1588
    • (2000) Eur. J. Biochem. , vol.267 , pp. 1583-1588
    • Kholodenko, B.N.1
  • 21
    • 4143110020 scopus 로고    scopus 로고
    • Hysteresis vs. graded responses: the connections make all the difference
    • Ninfa A.J., and Mayo A.E. Hysteresis vs. graded responses: the connections make all the difference. Sci. STKE 2004 (2004) e20
    • (2004) Sci. STKE , vol.2004
    • Ninfa, A.J.1    Mayo, A.E.2
  • 22
    • 33644524741 scopus 로고    scopus 로고
    • Cell-signalling dynamics in time and space
    • Kholodenko B.N. Cell-signalling dynamics in time and space. Nat. Rev. Mol. Cell Biol. 7 (2006) 165-176
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 165-176
    • Kholodenko, B.N.1
  • 23
    • 0041926731 scopus 로고    scopus 로고
    • Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling
    • Pouyssegur J., and Lenormand P. Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling. Eur. J. Biochem. 270 (2003) 3291-3299
    • (2003) Eur. J. Biochem. , vol.270 , pp. 3291-3299
    • Pouyssegur, J.1    Lenormand, P.2
  • 24
    • 0036536713 scopus 로고    scopus 로고
    • MAP kinase cascade signaling and endocytic trafficking: a marriage of convenience?
    • Kholodenko B.N. MAP kinase cascade signaling and endocytic trafficking: a marriage of convenience?. Trends Cell Biol. 12 (2002) 173-177
    • (2002) Trends Cell Biol. , vol.12 , pp. 173-177
    • Kholodenko, B.N.1
  • 25
  • 26
    • 34249720998 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of rheumatoid arthritis
    • McInnes I.B., and Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat. Rev. Immunol. 7 (2007) 429-442
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 429-442
    • McInnes, I.B.1    Schett, G.2
  • 28
    • 11444260258 scopus 로고    scopus 로고
    • Principles behind the multifarious control of signal transduction. ERK phosphorylation and kinase/phosphatase control
    • Hornberg J.J., et al. Principles behind the multifarious control of signal transduction. ERK phosphorylation and kinase/phosphatase control. FEBS J. 272 (2005) 244-258
    • (2005) FEBS J. , vol.272 , pp. 244-258
    • Hornberg, J.J.1
  • 29
    • 0026000298 scopus 로고
    • Control theory of regulatory cascades
    • Kahn D., and Westerhoff H.V. Control theory of regulatory cascades. J. Theor. Biol. 153 (1991) 255-285
    • (1991) J. Theor. Biol. , vol.153 , pp. 255-285
    • Kahn, D.1    Westerhoff, H.V.2
  • 30
    • 0036285634 scopus 로고    scopus 로고
    • Mathematical models of protein kinase signal transduction
    • Heinrich R., et al. Mathematical models of protein kinase signal transduction. Mol. Cell 9 (2002) 957-970
    • (2002) Mol. Cell , vol.9 , pp. 957-970
    • Heinrich, R.1
  • 31
    • 4243067196 scopus 로고    scopus 로고
    • The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway
    • Lee E., et al. The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol. 1 (2003) E10
    • (2003) PLoS Biol. , vol.1
    • Lee, E.1
  • 32
    • 17644427530 scopus 로고    scopus 로고
    • Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kB pathway the roles of IKK and IkBa
    • Ihekwaba A.E., et al. Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kB pathway the roles of IKK and IkBa. Syst. Biol. 1 (2007) 93-103
    • (2007) Syst. Biol. , vol.1 , pp. 93-103
    • Ihekwaba, A.E.1
  • 33
    • 24644456999 scopus 로고    scopus 로고
    • Control of MAPK signalling: from complexity to what really matters
    • Hornberg J.J., et al. Control of MAPK signalling: from complexity to what really matters. Oncogene 24 (2005) 5533-5542
    • (2005) Oncogene , vol.24 , pp. 5533-5542
    • Hornberg, J.J.1
  • 34
    • 0036195958 scopus 로고    scopus 로고
    • Metabolic control analysis in drug discovery and disease
    • Cascante M., et al. Metabolic control analysis in drug discovery and disease. Nat. Biotechnol. 20 (2002) 243-249
    • (2002) Nat. Biotechnol. , vol.20 , pp. 243-249
    • Cascante, M.1
  • 35
    • 33846917191 scopus 로고    scopus 로고
    • Metabolic control analysis to identify optimal drug targets
    • 189
    • Hornberg J.J., et al. Metabolic control analysis to identify optimal drug targets. Prog. Drug Res. 64 (2007) 171-173 189
    • (2007) Prog. Drug Res. , vol.64 , pp. 171-173
    • Hornberg, J.J.1
  • 36
    • 33845918111 scopus 로고    scopus 로고
    • Oncogenes are to lose control on signaling following mutation: should we aim off target?
    • Hornberg J.J., and Westerhoff H.V. Oncogenes are to lose control on signaling following mutation: should we aim off target?. Mol. Biotechnol. 34 (2006) 109-116
    • (2006) Mol. Biotechnol. , vol.34 , pp. 109-116
    • Hornberg, J.J.1    Westerhoff, H.V.2
  • 37
    • 12144289677 scopus 로고    scopus 로고
    • Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
    • Wan P.T., et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116 (2004) 855-867
    • (2004) Cell , vol.116 , pp. 855-867
    • Wan, P.T.1
  • 38
    • 20444411533 scopus 로고    scopus 로고
    • The silicon cell initiative: working towards a detailed kinetic description at the cellular level
    • Snoep J.L. The silicon cell initiative: working towards a detailed kinetic description at the cellular level. Curr. Opin. Biotechnol. 16 (2005) 336-343
    • (2005) Curr. Opin. Biotechnol. , vol.16 , pp. 336-343
    • Snoep, J.L.1
  • 39
    • 33749244440 scopus 로고    scopus 로고
    • Target validation in silico: does the virtual patient cure the pharma pipeline?
    • Alkema W., et al. Target validation in silico: does the virtual patient cure the pharma pipeline?. Expert. Opin. Ther. Targets 10 (2006) 635-638
    • (2006) Expert. Opin. Ther. Targets , vol.10 , pp. 635-638
    • Alkema, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.