-
1
-
-
33745679123
-
Targeting signal transduction as a strategy to treat inflammatory diseases
-
O'neill L.A. Targeting signal transduction as a strategy to treat inflammatory diseases. Nat. Rev. Drug Discov. 5 (2006) 549-563
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 549-563
-
-
O'neill, L.A.1
-
2
-
-
33745325007
-
Mechanisms of drug inhibition of signalling molecules
-
Sebolt-Leopold J.S., and English J.M. Mechanisms of drug inhibition of signalling molecules. Nature 441 (2006) 457-462
-
(2006)
Nature
, vol.441
, pp. 457-462
-
-
Sebolt-Leopold, J.S.1
English, J.M.2
-
3
-
-
0036490442
-
Smart drugs: tyrosine kinase inhibitors in cancer therapy
-
Shawver L.K., et al. Smart drugs: tyrosine kinase inhibitors in cancer therapy. Cancer Cell 1 (2002) 117-123
-
(2002)
Cancer Cell
, vol.1
, pp. 117-123
-
-
Shawver, L.K.1
-
4
-
-
33751106653
-
New approaches to molecular cancer therapeutics
-
Collins I., and Workman P. New approaches to molecular cancer therapeutics. Nat. Chem. Biol. 2 (2006) 689-700
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 689-700
-
-
Collins, I.1
Workman, P.2
-
5
-
-
34548721023
-
Protein kinases as targets for cancer treatment
-
Giamas G., et al. Protein kinases as targets for cancer treatment. Pharmacogenomics 8 (2007) 1005-1016
-
(2007)
Pharmacogenomics
, vol.8
, pp. 1005-1016
-
-
Giamas, G.1
-
6
-
-
33947596504
-
Why is cancer drug discovery so difficult?
-
Kamb A., et al. Why is cancer drug discovery so difficult?. Nat. Rev. Drug Discov. 6 (2007) 115-120
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 115-120
-
-
Kamb, A.1
-
7
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola I., and Landis J. Can the pharmaceutical industry reduce attrition rates?. Nat. Rev. Drug Discov. 3 (2004) 711-715
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
8
-
-
20844432908
-
Can cell systems biology rescue drug discovery?
-
Butcher E.C. Can cell systems biology rescue drug discovery?. Nat. Rev. Drug Discov. 4 (2005) 461-467
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 461-467
-
-
Butcher, E.C.1
-
9
-
-
33747812085
-
Applying computational modeling to drug discovery and development
-
Kumar N., et al. Applying computational modeling to drug discovery and development. Drug Discov. Today 11 (2006) 806-811
-
(2006)
Drug Discov. Today
, vol.11
, pp. 806-811
-
-
Kumar, N.1
-
10
-
-
32044451325
-
Cancer: a Systems Biology disease
-
Hornberg J.J., et al. Cancer: a Systems Biology disease. Biosystems 83 (2006) 81-90
-
(2006)
Biosystems
, vol.83
, pp. 81-90
-
-
Hornberg, J.J.1
-
11
-
-
0033614998
-
Creation of human tumour cells with defined genetic elements
-
Hahn W.C., et al. Creation of human tumour cells with defined genetic elements. Nature 400 (1999) 464-468
-
(1999)
Nature
, vol.400
, pp. 464-468
-
-
Hahn, W.C.1
-
12
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
13
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein B., and Kinzler K.W. Cancer genes and the pathways they control. Nat. Med. 10 (2004) 789-799
-
(2004)
Nat. Med.
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
14
-
-
1542515338
-
A census of human cancer genes
-
Futreal P.A., et al. A census of human cancer genes. Nat. Rev. Cancer 4 (2004) 177-183
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 177-183
-
-
Futreal, P.A.1
-
15
-
-
0033555859
-
Emergent properties of networks of biological signaling pathways
-
Bhalla U.S., and Iyengar R. Emergent properties of networks of biological signaling pathways. Science 283 (1999) 381-387
-
(1999)
Science
, vol.283
, pp. 381-387
-
-
Bhalla, U.S.1
Iyengar, R.2
-
16
-
-
0037174670
-
Network motifs: simple building blocks of complex networks
-
Milo R., et al. Network motifs: simple building blocks of complex networks. Science 298 (2002) 824-827
-
(2002)
Science
, vol.298
, pp. 824-827
-
-
Milo, R.1
-
17
-
-
0037047611
-
MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network
-
Bhalla U.S., et al. MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297 (2002) 1018-1023
-
(2002)
Science
, vol.297
, pp. 1018-1023
-
-
Bhalla, U.S.1
-
18
-
-
4944258252
-
Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4 beta-phorbol 12-myristate 13-acetate
-
Hornberg J.J., et al. Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4 beta-phorbol 12-myristate 13-acetate. Eur. J. Biochem. 271 (2004) 3905-3913
-
(2004)
Eur. J. Biochem.
, vol.271
, pp. 3905-3913
-
-
Hornberg, J.J.1
-
19
-
-
0029790351
-
Ultrasensitivity in the mitogen-activated protein kinase cascade
-
Huang C.Y., and Ferrell Jr. J.E. Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 10078-10083
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 10078-10083
-
-
Huang, C.Y.1
Ferrell Jr., J.E.2
-
20
-
-
0034019315
-
Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades
-
Kholodenko B.N. Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades. Eur. J. Biochem. 267 (2000) 1583-1588
-
(2000)
Eur. J. Biochem.
, vol.267
, pp. 1583-1588
-
-
Kholodenko, B.N.1
-
21
-
-
4143110020
-
Hysteresis vs. graded responses: the connections make all the difference
-
Ninfa A.J., and Mayo A.E. Hysteresis vs. graded responses: the connections make all the difference. Sci. STKE 2004 (2004) e20
-
(2004)
Sci. STKE
, vol.2004
-
-
Ninfa, A.J.1
Mayo, A.E.2
-
22
-
-
33644524741
-
Cell-signalling dynamics in time and space
-
Kholodenko B.N. Cell-signalling dynamics in time and space. Nat. Rev. Mol. Cell Biol. 7 (2006) 165-176
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 165-176
-
-
Kholodenko, B.N.1
-
23
-
-
0041926731
-
Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling
-
Pouyssegur J., and Lenormand P. Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling. Eur. J. Biochem. 270 (2003) 3291-3299
-
(2003)
Eur. J. Biochem.
, vol.270
, pp. 3291-3299
-
-
Pouyssegur, J.1
Lenormand, P.2
-
24
-
-
0036536713
-
MAP kinase cascade signaling and endocytic trafficking: a marriage of convenience?
-
Kholodenko B.N. MAP kinase cascade signaling and endocytic trafficking: a marriage of convenience?. Trends Cell Biol. 12 (2002) 173-177
-
(2002)
Trends Cell Biol.
, vol.12
, pp. 173-177
-
-
Kholodenko, B.N.1
-
25
-
-
32944463899
-
Angiogenesis
-
Folkman J. Angiogenesis. Annu. Rev. Med. 57 (2006) 1-18
-
(2006)
Annu. Rev. Med.
, vol.57
, pp. 1-18
-
-
Folkman, J.1
-
26
-
-
34249720998
-
Cytokines in the pathogenesis of rheumatoid arthritis
-
McInnes I.B., and Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat. Rev. Immunol. 7 (2007) 429-442
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 429-442
-
-
McInnes, I.B.1
Schett, G.2
-
28
-
-
11444260258
-
Principles behind the multifarious control of signal transduction. ERK phosphorylation and kinase/phosphatase control
-
Hornberg J.J., et al. Principles behind the multifarious control of signal transduction. ERK phosphorylation and kinase/phosphatase control. FEBS J. 272 (2005) 244-258
-
(2005)
FEBS J.
, vol.272
, pp. 244-258
-
-
Hornberg, J.J.1
-
29
-
-
0026000298
-
Control theory of regulatory cascades
-
Kahn D., and Westerhoff H.V. Control theory of regulatory cascades. J. Theor. Biol. 153 (1991) 255-285
-
(1991)
J. Theor. Biol.
, vol.153
, pp. 255-285
-
-
Kahn, D.1
Westerhoff, H.V.2
-
30
-
-
0036285634
-
Mathematical models of protein kinase signal transduction
-
Heinrich R., et al. Mathematical models of protein kinase signal transduction. Mol. Cell 9 (2002) 957-970
-
(2002)
Mol. Cell
, vol.9
, pp. 957-970
-
-
Heinrich, R.1
-
31
-
-
4243067196
-
The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway
-
Lee E., et al. The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol. 1 (2003) E10
-
(2003)
PLoS Biol.
, vol.1
-
-
Lee, E.1
-
32
-
-
17644427530
-
Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kB pathway the roles of IKK and IkBa
-
Ihekwaba A.E., et al. Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kB pathway the roles of IKK and IkBa. Syst. Biol. 1 (2007) 93-103
-
(2007)
Syst. Biol.
, vol.1
, pp. 93-103
-
-
Ihekwaba, A.E.1
-
33
-
-
24644456999
-
Control of MAPK signalling: from complexity to what really matters
-
Hornberg J.J., et al. Control of MAPK signalling: from complexity to what really matters. Oncogene 24 (2005) 5533-5542
-
(2005)
Oncogene
, vol.24
, pp. 5533-5542
-
-
Hornberg, J.J.1
-
34
-
-
0036195958
-
Metabolic control analysis in drug discovery and disease
-
Cascante M., et al. Metabolic control analysis in drug discovery and disease. Nat. Biotechnol. 20 (2002) 243-249
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 243-249
-
-
Cascante, M.1
-
35
-
-
33846917191
-
Metabolic control analysis to identify optimal drug targets
-
189
-
Hornberg J.J., et al. Metabolic control analysis to identify optimal drug targets. Prog. Drug Res. 64 (2007) 171-173 189
-
(2007)
Prog. Drug Res.
, vol.64
, pp. 171-173
-
-
Hornberg, J.J.1
-
36
-
-
33845918111
-
Oncogenes are to lose control on signaling following mutation: should we aim off target?
-
Hornberg J.J., and Westerhoff H.V. Oncogenes are to lose control on signaling following mutation: should we aim off target?. Mol. Biotechnol. 34 (2006) 109-116
-
(2006)
Mol. Biotechnol.
, vol.34
, pp. 109-116
-
-
Hornberg, J.J.1
Westerhoff, H.V.2
-
37
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
-
Wan P.T., et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116 (2004) 855-867
-
(2004)
Cell
, vol.116
, pp. 855-867
-
-
Wan, P.T.1
-
38
-
-
20444411533
-
The silicon cell initiative: working towards a detailed kinetic description at the cellular level
-
Snoep J.L. The silicon cell initiative: working towards a detailed kinetic description at the cellular level. Curr. Opin. Biotechnol. 16 (2005) 336-343
-
(2005)
Curr. Opin. Biotechnol.
, vol.16
, pp. 336-343
-
-
Snoep, J.L.1
-
39
-
-
33749244440
-
Target validation in silico: does the virtual patient cure the pharma pipeline?
-
Alkema W., et al. Target validation in silico: does the virtual patient cure the pharma pipeline?. Expert. Opin. Ther. Targets 10 (2006) 635-638
-
(2006)
Expert. Opin. Ther. Targets
, vol.10
, pp. 635-638
-
-
Alkema, W.1
|