Kinetic isotope effects in hydroxylation reactions effected by cytochrome P450 compounds I implicate multiple electrophilic oxidants for P450-catalyzed oxidations

Biochemistry

Volumn 48, Issue 7, 2009, Pages 1620-1627

  Sheng, Xin ^a   Zhang, Haoming ^b   Hollenberg, Paul F ^b   Newcomb, Martin ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING CONSTANTS; CATALYZED OXIDATIONS; COMPOUND I; CYTOCHROME P-450; FIRST ORDERS; ISOTOPOMERS; KINETIC ISOTOPE EFFECTS; METHYL GROUPS; ORDER OF MAGNITUDES; OXIDATION RATES; SATURATION KINETICS;

CARRIER MOBILITY; CATALYSTS; DEUTERIUM; DEUTERIUM COMPOUNDS; ENZYMES; HYDROCARBONS; HYDROGEN; HYDROGEN PEROXIDE; HYDROXYLATION; OXIDANTS; RATE CONSTANTS; SUBSTRATES;

OXIDATION;

CYTOCHROME P450; ELECTROPHILE; HYDROGEN PEROXIDE; ISOTOPE;

ARTICLE; BINDING AFFINITY; CATALYSIS; HYDROXYLATION; KINETICS; OXIDATION; PRIORITY JOURNAL; BIOCATALYSIS; ENZYME SPECIFICITY; METABOLISM; OXIDATION REDUCTION REACTION; ULTRAVIOLET SPECTROPHOTOMETRY;

BIOCATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; HYDROXYLATION; ISOTOPES; KINETICS; OXIDATION-REDUCTION; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBSTRATE SPECIFICITY;

EID: 61749088916     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi802279d     Document Type: Article

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