Glycemic control and therapeutic effect of Nigella sativa and Curcuma longa on rats with streptozotocin-induced diabetic hepatopathy

Journal of Pharmacology and Toxicology

Volumn 4, Issue 2, 2009, Pages 45-57

  Mohamed, Azza Mostafa ^a   El Sharkawy, F Z ^b   Ahmed, S A A ^a   Aziz, W M ^a   Badary, O A ^c  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b Ein Helwan   (Egypt)

^c Ain Shams University   (Egypt)

Author keywords

Antidiabetic; Glycation; Glycolytic enzymes; Oxidative stress; Plants

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; CATALASE; FRUCTOSAMINE; GLICLAZIDE; GLUCOSE; GLUTATHIONE; GLUTATHIONE REDUCTASE; HEMOGLOBIN; HERBACEOUS AGENT; HEXOKINASE; LACTATE DEHYDROGENASE; MALONALDEHYDE; NITRIC OXIDE; PHOSPHOENOLPYRUVATE CARBOXYLASE; PYRUVATE KINASE; STREPTOZOCIN; SUPEROXIDE DISMUTASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLACK CUMIN; CONTROLLED STUDY; CURCUMA LONGA; DIABETES MELLITUS; DIABETIC HEPATOPATHY; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FRUCTOSAMINE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; LIPID PEROXIDATION; LIVER DISEASE; LIVER FUNCTION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; STREPTOZOCIN DIABETES;

EID: 68049089616     PISSN: 1816496X     EISSN: None     Source Type: Journal    
DOI: 10.3923/jpt.2009.45.57     Document Type: Article

References (81)

1. Aebi, H., 1984. Catalase in vitro. Methods Enzymol., 105: 121-126.
2. Al-Rawais, N.A., 2002. Herbal medicine in the treatment of diabetes mellitus. Saudi Med, J., 23; 1327-1331.
3. Alberti, K.G. and P.Z. Zimmet, 1998. New diagnostic criteria and classification of diabetes-again? Diabetic Med., 15: 535-536.
4. Ali, B.H., 2004. The effect of Nigella sativa oil on gentamicin nephrotoxicity in rats. Am. J. Chin. Med., 32: 49-55.
5. Araujo, C.A.C. and L.L. Leon, 2001. Biological activities of Curcuma longa L. Mem Inst Oswaido Cruz, 96: 723-728.
6. Arun, N. and N. Nalini, 2002. Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Hum. Nutr., 57: 41-52.
7. Bayrak, O., E. Uz, R. Bayrak, F. Turgut and A.F. Atmaca et al., 2008. Curcumin protects against ischemia/reperfusion injury in rat kidneys. World J. Urol., 26: 285-291.
8. Belcher, G. and G. Schernthaner, 2005. Changes in liver tests during 1 year treatment of patients with type II diabetes with pioglitazone, metformin or gliclazide. Diabetic Med., 22: 973-979.
9. Berger., S, 1985. Incidence of severe side effects during therapy with sulphonylurea and biguanides. Horm. Metab. Res., 17: 111-115.
10. Bergmeyer, H.U., 1975. Determination of lactate dehydrogenase. J. Clin. Chem. Biochem., 13: 269-269.
11. Bergmeyer, H.V., M. Herder and R. Rej, 1986. Approved recommendation (1985) on IFCC methods for the measurement of catalytical concentration of enzymes, Patr 2. IFCC method for aspartate aminotranferase. J. Clin. Chem. Clin. Biochem., 24: 497-497.
12. Bentler, E., O. Duron and B.M. Kelly, 1963. Improved method for the determination of blood glutathione. J. Lab. Clin. Med., 61: 882-888.
13. Bhandari, U., R. Kanojia and K.K. Pillai, 2005. Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats. J. Ethnopharmacol., 97: 227-230.
14. Bourdon, E., N. Loreau and D. Blache, 1999. Glucose and free radicals impair the antioxidant properties of serum albumin. FASEB J., 13: 233-244.
15. Brownlee, M., 2001. Biochemistry and molecular cell biology of diabetic complications. Nature, 414: 813-820.
16. Bradford, M.M., 1976. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem., 72: 248-254.
17. Bucher, T. and G. Pfleiderer, 1955. Pyruvate kinase and phosphoenol pyruvate carboxy kinase activities of ascaris muscle, Hymenolepis diminuta and Schistosoma mansoni. Comparative Biochem. Physiol., 24: 511-518.
18. Buege, J.A. and S.D. Aust, 1978. Microsomal lipid peroxidation. Methods Enzymol., 52: 302-310.
19. Chainani-Wu, N., 2003. Safety and anti-inflammatory activity of curcumin: A component of tumeric (Curcuma longa). J. Altern. Complement Med., 9: 161-168.
20. Cousins, M., J. Adelberg and F. Chenb, 2007. Antioxidant capacity of fresh and dried rhizomes from four clones of turmeric (Curcuma longa L.) grown in vitro. Ind. Crop Prod., 25: 129-135.
21. Dachicourt, N., D. Bailbè, M.N. Gangnerau, P. Serradas, D. Ravel and B. Portha, 1998. Effect of gliclazide treatment on insulin secretion and beta-cell mass in non-insulin dependent diabetic Goto-Kakisaki rats. Eur. J. Pharmacol., 361: 243-251.
22. Deresinski, S., 1995. Infections in the diabetic patient: Strategies for clinicians. Infect. Dis. Rep., 1: 1-12.
23. Doumas, B.T., W.R. Watson and H.G. Biggs, 1971. Albumin standard and measurement of serum albumin with bromocresol green. Clin. Chim. Acta, 31: 87-96.
24. Dourakis, S.P., E. Tzemanakis, C. Sinani and G. Kafiri, 2000. Hadziyannis SJ. Gliclazide-induced acute hepatitis. Eur. J. Gastroenterol. Hepatol., 12: 119-121.
25. Drabkin, D.L. and J.M. Austin, 1932. Spectrophotometric constants for common hemoglobin derivatives in human, dog and rabbit blood. J. Biol. Chem., 98: 719-733.
26. El-Gazzar, M., R. El Mezayen, J.C. Marecki, M.R. Nicolls, A. Canastar and S.C. Dreskin, 2006. Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. Int. Immunopharmacol., 6: 1135-1142.
27. El-Mahmoudy, A., H. Matsuyama, M.A. Borgan, Y. Shimizu and M.G. El-Sayed et al., 2002. Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages. Int. Immunopharmacol., 2: 1603-11611.
28. Erden, M. and N.M. Bor, 1984. Changes in reduced glutathione, glutathione reductase and glutathione peroxidase after radiation in guinea pigs. Biochem. Med., 31: 217-227.
29. Fararh, K.M., Y. Atoji, Y. Shimizu, T. Shiina, H, Nikami and T. Takewaki, 2004. Mechanisms of the hypoglycemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters. Res, Vet. Sci., 77: 123-129.
30. Freeman, B.A. and J.D. Crapo, 1992. Biology of disease: Free radicals and tissue injury. Lab. Invest., 47: 412-426.
31. Grover, J.K., S. Yadav and V. Vats, 2002. Medicinal plants of India with anti-diabetic potential. J. Ethnopharmacol., 81: 81-100.
32. Gumaa, K. and P. McLean, 1972. The kinetic quantitation of ATP D-glucose-6-phosphotransferase. FEBS Lett., 27: 293-297.
33. Hamden, H., M.A. Boujbiha, H. Masmoudi, F.M. Ayadi, K. Jamoussi and A. Elfeki, 2008. Combined vitamins (C and E) and insulin improve oxidative stress and pancreatic and hepatic injury in alloxan diabetic rats. Biomed. Pharmacother. (In Press). 10.1016/j.biopha.2008.02.001
34. Hickman, I.J., A.J. Russell, J.B. Prins and G.A. Macdonald, 2008. Should patients with type II diabetes and raised liver enzymes be referred for further evaluation of liver disease? Diabetic Res. Clin. Practice, 80: e10-e12.
35. Hussain, H.E.M.A., 2002. Hypoglycemic, hypolipidemic and antioxidant properties of combination of curcumin from curcuma longa Linn and partially purified product from abroma augusta, Linn. in streptozotocin induced diabetes. Indian J. Clin. Biochem., 17: 33-43.
36. Iqbal, M., S.D. Sharma, Y. Okazaki, M. Fujisawa and S. Okada, 2003. Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: Possible role in protection against chemical carcinogenesis and toxicity. Pharmacol. Toxicol., 92: 33-38.
37. Jackson, R.L., R.L. Hess and J.D. England, 1979. Haemoglobin A1C values in children with over diabetes maintained in varying degree of correct. Diabetes Care, 2: 391-395.
38. Jin, L., H.Y. Xue, L.J. Jin, S.Y. Li and Y.P. Xu, 2008. Antioxidant and pancreas-protective effect of aucubin on rats with streptozotocin-induced diabetes. Eur. J. Pharmacol., 582: 162-167.
39. Kaleem, M., D. Kirmani, M. Asif, Q. Ahmed and B. Bano, 2006. Biochemical effects of Nigella sativa L. seeds in diabetic rats. Indian J. Exp. Biol., 44: 745-748.
40. Kim, S.H., S.H. Hyun and S.Y. Choung, 2006. Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice, J. Ethnopharmacol., 104: 119-123.
41. Klover, P.J. and R.A. Mooney, 2004. Hepatocytes: Critical for glucose homeostasis. Int. J. Biochem. Cell Biol., 36: 753-758.
42. Kumar, G.S., A.K. Shetty, K. Sambaiah and P.V. Salimath, 2005. Antidiabetic property of fenugreek seed mucilage and spent turmeric in streptozotocin-induced diabetic rats. Nutr. Res., 25: 1021-1028.
43. Lapolla, A., P. Traldi and C. Fedele, 2005. Importance of measuring product of non-enzymatic glycation of proteins. Clin. Biochem., 38: 103-115.
44. Latry, P., P. Bioulac-Sage, E. Echinard, H. Gin and L. Boussarie et al., 1987. Perisinusoidal fibrosis and basement membrane-like material in the livers of diabetic patients. Hum. Pathol., 18: 775-780.
45. Lee, Y.T., C.C. Hsu, M.H. Lin, K.S. Lin and M.C. Yin, 2005. Histidine and carnosine delay diabetic detenoration in mice and protect human low-density lipoprotein against oxidation and glycation. Eur. J. Pharmacol., 513: 145-150.
46. Li, W., K. Ota, J. Nakamura, K. Naruse, E. Nakashima, Y. Oiso and Y. Hamada, 2008. Antiglycation effect of gliclazide on in vitro AGE formation from glucose and methylglyoxal. Exp. Biol. Med., 233: 176-179.
47. Liu; Z., J. Li, Z. Zeng, M. Liu and M. Wang, 2008. The antidiabetic effects of cysteinyl metformin, a newly synthesized agent, in alloxan- and streptozocin-induced diabetic rats. Chemico Biol. Interact., 173: 68-75.
48. Mahmoud, M. R., H.S. El-Abhar and S. Saleh, 2002. The effect of Nigella sativa oil against the liver damage induced by Schistosoma mansoni infection in mice. J. Ethnopharmacol., 79: 1-11.
49. Maiti, R., D. Jana, U.K. Das and D. Ghosh, 2004. Antidiabetic effect of aqueous extract of seed of Tamarindus indica in streptozotocin-induced diabetic rats. J. Ethnopharmacol., 92: 85-91.
50. Mansour, H.A., A.A. Newairy, M.I. Yousef and S.A. Sheweita, 2002. Biochemical study on the effect of some Egyptian herbs in alloxan-induced diabetic rats. Toxicology, 170: 221-228.
51. Mansour, M. and S. Tomhamre, 2004. Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood calls by thymoquinone. J. Enzyme Inhib. Med. Chem., 19: 431-436.
52. Milani, E., S. Nikfar, R. Khorasani, M.J. Zamani and M. Abdollahi, 2005. Reduction of diabetes-induced oxidative stress by phosphodiesterase inhibitors in rats. Comparative Biochem. Physiol., 140 C: 251-255.
53. Misciagna, G., G. De Michelle, V. Guerra, A.M. Cisternino, A. Di Leo and J.L. Freudenheim, 2004. Serum Fructosamine and colorectal adenoma. Eur. J. Epidemiol., 19: 425-432.
54. Miwa, I., J. Okuda, K. Maeda and G. Okuda, 1972. Mutarotase effect on colorimetric determination of blood glucose with D-glucose oxidase. Clin. Chem. Acta, 37: 538-540.
55. Mohamed, A.A., D.E. Abo-Amou, M.A. Shehata and N.E. El-Ashery, 2001. Glutathione peroxidase and nitric oxide in patients with chronic liver diseases. Egypt. J. Schistosomiasis Infect. Endem. Dis., 23: 27-46.
56. Montilla, P., M. Barcos, M.C. Munoz, J.R.M. Castaneda, I. Bujalance and I. Tunez, 2004. Protective effect of Montilla-Moriles appellation red wine on oxidative stress induced by streptozotocin in the rat. J. Nutr. Biochem., 15: 688-693.
57. Moshage, H., B. Kok, J.R. Huizenga and P.L. Jansen, 1995. Nitrite and nitrate determination in plasma: A critical evaluation. Clin. Chem., 41: 892-896.
58. Paoletti, F., D. Aldinucci, A. Mocali and A. Caparrini, 1986. A sensitive spectrophotometric method for the determination of superoxide dismutase activity in tissue extracts. Anal. Biochem., 154: 536-541.
59. Pari, L. and M.A. Satheesh, 2004. Antidiabetic activity of Boerhaavia diffusa L. effect on hepatic key enzymes in experimental diabetes. J. Ethnopharmacol., 91: 109-113.
60. Pulla Reddy, A. Ch. and B.R. Lokesh, 1994. Effect of dietary turmeric (Curcuma longa) on iron-induced lipid-peroxidation in the rat-liver. Food Chem. Toxicol., 32: 279-283.
61. Ramadan, M.F., L.W. Kroh and J.T. Morsel, 2003. Radical scavenging activity of black cumin (Nigella sativa L.), coriander ( Coriandrum sativum L.) and nigger (Guizotia abyssinica Cass.) crude seed oils and oil fractions. J. Agric. Food Chem., 51: 6961-6969.
62. Ramirez-Tortosa, M.C., M.D. Mesa, M.C. Aguilera, J.L. Quiles and L. Baro et al., 1999. Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis. Atherosclerosis, 147: 371-378.
63. Rendell, M., 2004. The role of sulphonylurease in the management of type 2 diabetes mellitus. Drugs, 64: 1339-1358.
64. Robertson, R.P., 2004, Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes. J. Biol. Chem., 279: 42351-42354.
65. Rukkumani, R., K. Atuna, P.S. Varma, K.N. Rajasekaran and V.P. Menon, 2004. Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress. J. Pharm. Pharmacol. Sci., 7: 274-283.
66. Sabater, J., C. Quereda, I. Herrera, J. Pascual, J.J. Villafruela and J. Ortuno, 1991. Nonenzymatic glycosylation of hemoglobin and total plasmatic proteins in end stage renal disease. Am. J. Nephrol., 11: 37-43.
67. Schleicher, P. and M. Saleh, 1998. Black Seed Cumin: The Magical Egyptian Herb for Allergies, Asthma and Immune Disorders. Healing Arts Press, Rochester, Vermont.
68. Selvaraj, N., Z. Bobby and V. Sathiyapriya, 2006. Effect of lipid peroxides and antioxidants on glycation of hemoglobin an in vitro study on human erythrocytes. Clin. Chim. Acta, 366: 190-195.
69. Sheela, C.G. and K.T. Augusti, 1992. Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn. Indian J. Exp. Biol, 30: 523-526.
70. Sliwinska, A., J. Blasiak, J. Kasznicki and J. Drzewoski, 2008. In vitro effect of gliclazide on DNA damage and repair in patients with type 2 diabetes mellitus (T2DM). Chemico Biol. Interact., 173: 159-165.
71. Sreejayan Rao, M.N., 1994. Curcuminoids as potent inhibitors of lipid peroxidation. J. Pharm. Pharmacol., 46: 1013-1016.
72. Suarez, R.K., M.D. Mallet, C. Doxboeck and P.W. Hochachka, 1986. Enzymes of energy metabolism and gluconeogenesis in specific blue malin, Makaira nigricans. Can. J. Zool., 64: 694-694.
73. Sudnikovich, E.J., Y.Z. Maksimchik, S.V. Zabrodskaya, V.L. Kubyshin and E.A. Lapshina et al., 2007. Melatonin attenuates metabolic disorders due to streptozotocin-induced diabetes in rats. Eur. J. Pharmacol., 569: 180-187.
74. Sun, Y., & Lin, S. Ferguson, L. Wang, P. Klepcyk, J.S. Yun and J.E. Friedman, 2002. Phosphoenolpyruvate cayboxykinase over expression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice. J. Biol. Chem., 277: 23301-23307.
75. Swamy, S.M. and B.K. Tan, 2000. Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds. J. Ethnopharmacol., 70: 1-7.
76. Szkudelski, T., 2001. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol. Res., 50: 537-546.
77. Taniguchi, N., H. Kaneto and M. Asahi, 1996. Involvement of glycation and oxidative stress in diabetic macroangiopathy, Diabetes, 45: S81-S83.
78. Thornalley, P.J., 2002. Glycation in diabetic neuropathy: Characteristics, consequences, causes and therapeutic options, Int. Rev. Neurobiol., 50: 37-57.
79. Tolman, K.G., V. Fonseca, M.H. Tan and A. Dalpiaz, 2004. Narrative review: Hepatobiliary disease in type 2 diabetes mellitus. Ann. Intern. Med., 141: 946-956.
80. Young, I.S. and J.V. Woodside, 2001. Antioxidants in health and disease. J. Clin. Pathol., 54: 176-186.
81. Zafir, A. and N. Banu, 2007. Antioxidant potential of fluoxetine in comparison to Curcuma longa in restraint-stressed rats. Eur. J. Pharmacol., 572: 23-31.