Statin Use, Clinical Fracture, and Bone Density in Postmenopausal Women: Results from the Women's Health Initiative Observational Study

Annals of Internal Medicine

Volumn 139, Issue 2, 2003, Pages

  LaCroix, Andrea Z ^a   Cauley, Jane A ^b   Pettinger, Mary ^b   Hsia, Judith ^b   Bauer, Douglas C ^b   McGowan, Joan ^b   Chen, Zhao ^b   Lewis, Cora E ^b   McNeeley, S Gene ^b   Passaro, Maureen D ^b   Jackson, Rebecca D ^b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; ANTILIPEMIC AGENT; ATORVASTATIN; CORTICOSTEROID; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; PRAVASTATIN; PSYCHOTROPIC AGENT; SIMVASTATIN;

ADULT; AGED; ARM FRACTURE; ARTICLE; BONE DENSITY; CLINICAL STUDY; DRUG USE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FOLLOW UP; FRACTURE; HIP FRACTURE; HUMAN; MAJOR CLINICAL STUDY; OSTEOPOROSIS; POSTMENOPAUSE; PRIORITY JOURNAL; RISK; WRIST FRACTURE; ARM INJURY; DRUG EFFECT; EPIDEMIOLOGY; INCIDENCE; MIDDLE AGED; PHYSIOLOGY; POSTMENOPAUSE OSTEOPOROSIS; PROSPECTIVE STUDY; WRIST INJURY;

AGED; BONE DENSITY; CONFOUNDING FACTORS (EPIDEMIOLOGY); FEMALE; FOLLOW-UP STUDIES; FOREARM INJURIES; FRACTURES, BONE; HIP FRACTURES; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INCIDENCE; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; POSTMENOPAUSE; PROSPECTIVE STUDIES; WRIST INJURIES;

EID: 1642461391     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-139-2-200307150-00009     Document Type: Article

References (22)

1. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994;344:1383-9. [PMID: 7968073]
2. Downs JR, Clearfield M, Weis S, Whitney E, Shapiro DR, Beere PA, et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA. 1998;279:1615-22. [PMID: 9613910]
3. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. N Engl J Med. 1998;339:1349-57. [PMID: 9841303]
4. LaRosa JC, He J, Vupputuri S. Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials. JAMA. 1999;282:2340-6. [PMID: 10612322]
5. Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, et al. Stimulation of bone formation in vitro and in rodents by statins. Science. 1999;286:1946-9. [PMID: 10583956]
6. Bauer DC, Mundy GR, Jamel SA, Black DM, Cauley JA, Harris F, et al. Statin use, bone mass and fracture: an analysis of two prospective studies [Abstract]. J Bone Miner Res. 1999;14(Suppl):S179.
7. Meier CR, Schlienger RG, Kraenzlin ME, Schlegel B, Jick H. HMG-CoA reductase inhibitors and the risk of fractures. JAMA. 2000;283:3205-10. [PMID: 10866867]
8. Wang PS, Solomon DH, Mogun H, Avom J. HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients. JAMA. 2000;283:3211-6. [PMID: 10866868]
9. Chan KA, Andrade SE, Boles M, Buist DS, Chase GA, Donahue JG, et al. Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women. Lancet. 2000;355:2185-8. [PMID: 10881890]
10. van Staa TP, Wegman S, de Vries F, Leufkens B, Cooper C. Use of statins and risk of fractures. JAMA. 2001;285:1850-5. [PMID: 11308398]
11. Reid IR, Hague W, Emberson J, Baker J, Tonkin A, Hunt D, et al. Effect of pravastatin on frequency of fracture in the LIPID study: secondary analysis of a randomised controlled trial. Long-term Intervention with Pravastatin in Ischaemic Disease. Lancet. 2001;357:509-12. [PMID: 11229669]
12. Pasco JA, Kotowicz MA, Henry MJ, Sanders KM, Nicholson GC. Statin use, bone mineral density, and fracture risk: Geelong Osteoporosis Study. Arch Intern Med. 2002;162:537-40. [PMID: 11871921]
13. Design of the Women's Health Initiative clinical trial and observational study. The Women's Health Initiative Study Group. Control Clin Trials. 1998;19:61-109. [PMID: 9492970]
14. Jones P, Kafonek S, Laurora I, Hunninghake D. Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study). Am J Cardiol. 1998;81:582-7. [PMID: 9514454]
15. Kristal AR, Feng Z, Coates RJ, Oberman A, George V. Associations of race/ethnicity, education, and dietary intervention with the validity and reliability of a food frequency questionnaire: the Women's Health Trial Feasibility Study in Minority Populations. Am J Epidemiol. 1997;146:856-69. [PMID: 9384206]
16. Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30:473-83. [PMID: 1593914]
17. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: executive summary. Expert Panel on the Identification, Evaluation, and Treatment of Overweight in Adults. Am J Clin Nutr. 1998;68:899-917. [PMID: 9771869]
18. Mundy GR. Statins and their potential for osteoporosis. IBMS BoneKEy. 2001:1 June;1-5. Accessed at www.bonekey-ibms.org on 21 May 2003.
19. Garrett IR, Esparza J, Chen D, Zhao M, Gutierrez G, Escobedo A, et al. Statins mediate their effects on osteoblasts by inhibition of HMG-CoA reductase and ultimately BMP-2 [Abstract]. J Bone Miner Res. 2000;15(Suppl):S225.
20. Chung YS, Lee MD, Lee SK, Kim HM, Fitzpatrick LA. HMG-CoA reductase inhibitors increase BMD in type 2 diabetes mellitus patients. J Clin Endocrinol Metab. 2000;85:1137-42. [PMID: 10720052]
21. Edwards CJ, Hart DJ, Spector TD. Oral statins and increased bone-mineral density in postmenopausal women [Letter]. Lancet. 2000;355:2218-9. [PMID: 10881898]
22. Watanabe S, Fukumoto S, Takeuchi Y, Nakano T, Fujita T. Effects of one year treatment with statins on bone mass and metabolism [Abstract]. J Bone Miner Res. 2000;15(Suppl):S194.