Monoisopropylglutathione ester protects A549 cells from the cytotoxic effects of sulphur mustard

Human and Experimental Toxicology

Volumn 16, Issue 11, 1997, Pages 636-644

  Lindsay, Christopher D ^a   Hambrook, Joy L ^a   Lailey, Alison F ^a  

^a DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

A549 cell line; Monoisopropylglutathione ester; Sulphur mustard

Indexed keywords

CRYSTAL VIOLET; ESTER; GLUTATHIONE DERIVATIVE; MUSTARD GAS; NEUTRAL RED;

ARTICLE; CELL CULTURE; CELL PROTECTION; CELL VIABILITY; CYTOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL;

GENTIANA; VIOLA (ANGIOSPERM);

EID: 0030730317     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/096032719701601102     Document Type: Article

References (38)

1. Haber LF. The Poisonous Cloud: Chemical Warfare in the First World War. Oxford University Press, 1986.
2. Momeni AZ, Enshaeih S, Meghdadi M and Randall RJ. Manifestations of Mustard Gas: A Clinical Study of 535 Patients Exposed to Mustard Gas. Archives of Dermatology 1992; 123: 775-780.
3. Black RM, Clarke RJ, Read RW and Reid MJT. Application of Gas Chromatography, Mass Spectrometry and Gas Chromatography Tandem Mass Spectrometry to the Analysis of Chemical Warfare Samples, Found to Contain Residues of the Nerve Agent Sarin, Sulphur mustard and their Degradation Products. Journal of Chromatography 1994; A 662: 301-321.
4. Black RM, Upshall DG. Assessing the danger. Chemistry in Britain 1988; 659-664.
5. Casarett and Doull's Toxicology. The Basic Science of Poisons. Klassen CD, Amdur MO, Doull J. (Editors), pp. 279-280. Macmillan Publishing Co, Inc, New York, Toronto, London, 1986.
6. Fox M, Scott M. The genetic toxicology of nitrogen and sulphur mustard. Mutation Research 1980; 75: 131-168.
7. Brookes P, Lawley PD. Effects of alkylating agents on T2 and T4 bacteriophage. Biochemical Journal 1963; 89: 138-144.
8. Somani SM, Babu SR. Toxicodynamics of sulfur mustard. International Journal of Clinical Pharmacology. Therapy and Toxicology 1989; 27: 419-435.
9. Papirmeister B, Gross CL, Meier HL, Petrali JP, Johnson JB. Molecular Basis for Mustard-Induced Vesication. Fundamental and Applied Toxicology 1985; 5: S134-S149.
10. Hathaway DE. Importance of Chemical Non-enzymic Reactions in vivo. In: Molecular Aspects of Toxicology: Mode of Action Studies, p. 204. Royal Society of Chemistry, 1984.
11. Wilde PE, Upshall DG. Cysteine esters protect cultured rodent lung slices from sulphur mustard. Human and Experimental Toxicology 1994; 13: 743-748.
12. Gross CL et al. Sulfur mustard (HD) cytotoxicity in lymphocytes can be affected by intracellular glutathione levels. Proceedings of the 1989 Medical Defence Bioscience Review, US Army Medical Research and Development Command, 15-17th August 1989, Aberdeen Proving Ground, Maryland, USA, pp. 415-418, 1989.
13. Gross CL et al. Biochemical manipulation of intracellular glutathione levels influences cytotoxicity to isolated human lymphocytes by sulfur mustard. Cell Biology and Toxicology 1993; 9: 259-267.
14. Asano K et al. Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proceedings of the National Academy of Science USA 1994; 91: 10089-10093.
15. Wu F, Bui KC, Buckley S, Warburton D. Cell Cycle-dependent Expression of Cyclin D1 and a 45 kD Protein in Human A549 Lung Carcinoma Cells. American Journal of Respiratory Cell and Molecular Biology 1994; 10: 437-447.
16. Arnold R et al. Interleukin-8, interleukin-6, and soluble tumour necrosis factor receptor type I released from a human pulmonary epithelial cell line (A549) exposed to respiratory syncytial virus. Immunology 1994; 82: 126-133.
17. Li XY, Donaldson K, Rahman I, MacNee W. An Investigation of the Role of Glutathione in Increased Epithelial Permeability Induced by Cigarette Smoke In Vivo and In Vitro. American Journal of Respiratory and Critical Care Medicine 1994; 149: 1518-1525.
18. Rosenthal GJ et al. Asbestos Stimulates IL-8 Production from Human Lung Epithelial Cells. The Journal of Immunology 1994; 153: 3237-3244.
19. Rotin D, Goldstein BJ, Fladd CA. Expression of the tyrosine phosphatase LAR-PTP2 is developmentally regulated in lung epithelia. American Journal of Physiology (Lung Cellular and Molecular Physiology. 11) 1994; 267: L263-L270.
20. Sigurdson SL, Lwebuga-Mukasa JS. Divalent Cation-Dependent Regulation of Rat Alveolar Epithelial Cell Adhesion and Spreading. Experimental Cell Research 1994; 213: 71-79.
21. Venembre P et al. Secretion of α1-antitrypsin by alveolar epithelial cells. FEBS Letters 1994; 346: 171-174.
22. Maniscalco WM, Sinkin RA, Watkins RH, Campbell MH. Transforming growth factor-β1 modulates type II cell fibronectin and surfactant protein C expression. American Journal of Physiology (Lung Cellular and Molecular Physiology. 11) 1994; 267: L569-L577.
23. Griffiths GD, Lindsay CD, Upshall DG. Examination of the toxicity of several protein toxins of plant origin using bovine pulmonary endothelial cells. Toxicology 1994; 90: 11-27.
24. Gillies RJ et al. Determination of cell number in monolayer cultures. Analytical Biochemistry 1986; 159: 109-113.
25. Lailey AF et al. Protection by cysteine esters against chemically induced pulmonary oedema. Biochemical Pharmacology 1991; 42: S47-S54.
26. Brown LA. Glutathione protects signal transduction in type II cells under oxidant stress. American Journal of Physiology (Lung Cellular and Molecular Physiology. 10) 1994; 266: L172-L177.
27. Gentilhomme E et al. Action of bis(betachloroethyl)sulphide (BCES) on human epidermis reconstituted in culture: morphological alterations and biochemical depletion of glutathione. Toxicology in vitro 1992; 6: 139-147.
28. Bump EA, Brown JM. Role of glutathione in the radiation response of mammalian cells in vitro and in vivo. Pharmacology and Therapeutics 1990; 47: 117-136.
29. Joyce-Brady M et al. Synthesis and Release of Amphipathic gamma-Glutamyl Transferase by the Pulmonary Alveolar Type 2 Cell. The Journal of Biological Chemistry 1994; 269: 14219-14226.
30. Brown LAS, Bai C, Jones DP. Glutathione protection in alveolar type II cells from fetal and neonatal rabbits. American Journal of Physiology (Lung Cellular and Molecular Physiology. 6) 1992; 262: L305-L312.
31. Hagen TM, Brown LAS, Jones DP. Protection against paraquat-induced injury by exogenous GSH in pulmonary alveolar type II cells. Biochemical Pharmacology 1986; 35: 4537-4542.
32. Ho T-L. The Hard Soft Acids Bases (HSAB) . Principle and Organic Chemistry. Chemical Reviews 1975; 75: 1-20.
33. Herriott RM. Inactivation of viruses and cells by mustard gas. Journal of General Physiology 1948; 32: 221-227.
34. Ogston AG, Holiday E, Philpot J St L, Stocken L A. The replacement reactions of B-B′-dichlorodiethyl sulphide and of some analogues in aqueous solution: the isolation of B-chloro-B′-hydroxy diethyl sulphide. Journal of the Chemical Society Faraday Transactions 1948; 44: 45-52.
35. Ogston AG. The chemical reactions of mustard gas in aqueous solution. Biochemical Society Symposium 1948; 2: 2-7.
36. Wormser U. Toxicology of mustard gas. TiPS 1991; 12: 164-167.
37. + Levels and Glucose Uptake of Cultured Human Epidermal Cells Exposed to Sulphur Mustard. Toxicology and Applied Pharmacology 1989; 98: 159-165.
38. Kobayashi S, Takehana M and Tohyama C. Glutathione Isopropyl Ester Reduces UVB-Induced Skin Damage in Hairless Mice. Photochemistry and Photobiology 1996; 63: 106-110.