Nonpolar nucleoside mimics as active substrates for human thymidine kinases

Journal of the American Chemical Society

Volumn 131, Issue 15, 2009, Pages 5488-5494

  Jarchow Choy, Sarah K ^a   Sjuvarsson, Elena ^b   Sintim, Herman O ^a   Eriksson, Staffan ^b   Kool, Eric T ^a  

^a STANFORD UNIVERSITY   (United States)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVE MOLECULES; HIGH EFFICIENCY; HUMAN CELLS; NATURAL SUBSTRATES; NEW DESIGN; NON-POLAR; NUCLEOBASE; NUCLEOSIDE ANALOGUES; NUCLEOTIDE SALVAGE; RECOGNITION MECHANISM; SIZE AND SHAPE; STEADY-STATE KINETICS; THYMIDINE KINASE; THYMINE BASE;

BIOMOLECULES; CATALYSTS; ENZYMES; HYDROGEN; TOLUENE;

SUBSTRATES;

2,4 DIFLUOROTOLUENE DEOXYRIBOSIDE; BROMINE; CHLORINE; FLUORINE; HALOGEN; HYDROGEN; IODINE; NUCLEIC ACID BASE; NUCLEOSIDE; NUCLEOSIDE ANALOG; THYMIDINE; THYMIDINE KINASE; THYMIDINE KINASE 1; THYMIDINE KINASE 2; THYMINE; TOLUENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ELECTRICITY; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; HYDROPHOBICITY; MOLECULAR MECHANICS; MOLECULAR MIMICRY; MOLECULAR PROBE; STEADY STATE; STEREOSPECIFICITY; SUBSTITUTION REACTION; CHEMISTRY; CONFORMATION; ENZYME SPECIFICITY; KINETICS; METABOLISM; PHOSPHORYLATION;

HUMANS; KINETICS; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; NUCLEOSIDES; PHOSPHORYLATION; SUBSTRATE SPECIFICITY; THYMIDINE; THYMIDINE KINASE;

EID: 67849110076     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja808244t     Document Type: Article

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