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Volumn 272, Issue 24, 2005, Pages 6365-6372

Structure of the substrate complex of thymidine kinase from Ureaplasma urealyticum and investigations of possible drug targets for the enzyme

Author keywords

Bacterial; Crystallography; Deoxythymidine; Nucleoside analogues; Thymidine kinase

Indexed keywords

DEOXYRIBOSE; FLUORINE; NUCLEOSIDE ANALOG; THYMIDINE; THYMIDINE KINASE;

EID: 29144442291     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2005.05030.x     Document Type: Article
Times cited : (30)

References (29)
  • 3
    • 0035872855 scopus 로고    scopus 로고
    • The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis
    • Chambaud I, Heilig R, Ferris S, Barbe V, Samson D, Galisson F, et al. (2001) The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis. Nucleic Acids Res 29, 2145-2153.
    • (2001) Nucleic Acids Res , vol.29 , pp. 2145-2153
    • Chambaud, I.1    Heilig, R.2    Ferris, S.3    Barbe, V.4    Samson, D.5    Galisson, F.6
  • 5
    • 10744222077 scopus 로고    scopus 로고
    • The complete genome sequence of the avian pathogen Mycoplasma gallisepticum strain R (low)
    • Papazisi L, Gorton TS, Kutish G, Markham PF, Browning GF, Nguyen DK, et al. (2003) The complete genome sequence of the avian pathogen Mycoplasma gallisepticum strain R (low). Microbiology 149, 2307-2316.
    • (2003) Microbiology , vol.149 , pp. 2307-2316
    • Papazisi, L.1    Gorton, T.S.2    Kutish, G.3    Markham, P.F.4    Browning, G.F.5    Nguyen, D.K.6
  • 6
    • 0036924517 scopus 로고    scopus 로고
    • The complete genomic sequence of Mycoplasma penetrans an intracellular bacterial pathogen in humans
    • Sasaki Y, Ishikawa J, Yamashita A, Oshima K, Kenri T, Furuya K, et al. (2002) The complete genomic sequence of Mycoplasma penetrans an intracellular bacterial pathogen in humans. Nucleic Acids Res 30, 5293-5300.
    • (2002) Nucleic Acids Res , vol.30 , pp. 5293-5300
    • Sasaki, Y.1    Ishikawa, J.2    Yamashita, A.3    Oshima, K.4    Kenri, T.5    Furuya, K.6
  • 7
    • 1242296870 scopus 로고    scopus 로고
    • The genome sequence of Mycoplasma mycoides subsp mycoides SC type strain PGIT the causative agent of contagious bovine pleuropneumonia (CBPP)
    • Westberg J, Persson A, Holmberg A, Goesmann A, Lundeberg J, Johansson KE, et al. (2004) The genome sequence of Mycoplasma mycoides subsp mycoides SC type strain PGIT the causative agent of contagious bovine pleuropneumonia (CBPP). Genome Res 14, 221-227.
    • (2004) Genome Res , vol.14 , pp. 221-227
    • Westberg, J.1    Persson, A.2    Holmberg, A.3    Goesmann, A.4    Lundeberg, J.5    Johansson, K.E.6
  • 9
    • 23644457964 scopus 로고    scopus 로고
    • Swine and poultry pathogens: The complete genome sequences of two strains of Mycoplasma hyopneumoniae and a strain of Mycoplasma synoviae
    • Vasconcelos AT, Ferreira HB, Bizarro CV, Bonatto SL, Carvalho MO, Pinto PM, et al. (2005) Swine and poultry pathogens: the complete genome sequences of two strains of Mycoplasma hyopneumoniae and a strain of Mycoplasma synoviae. J Bacteriol 187, 5568-5577.
    • (2005) J Bacteriol , vol.187 , pp. 5568-5577
    • Vasconcelos, A.T.1    Ferreira, H.B.2    Bizarro, C.V.3    Bonatto, S.L.4    Carvalho, M.O.5    Pinto, P.M.6
  • 10
    • 0035171667 scopus 로고    scopus 로고
    • Novel deoxynucleoside-phosphorylating enzymes in mycoplasmas: Evidence for efficient utilization of deoxynucleosides
    • Wang L, Westberg J, Bolske G & Eriksson S (2001) Novel deoxynucleoside-phosphorylating enzymes in mycoplasmas: evidence for efficient utilization of deoxynucleosides. Mol Microbiol 42, 1065-1073.
    • (2001) Mol Microbiol , vol.42 , pp. 1065-1073
    • Wang, L.1    Westberg, J.2    Bolske, G.3    Eriksson, S.4
  • 11
    • 0242606204 scopus 로고    scopus 로고
    • Molecular characterization of thymidine kinase from Ureaplasma urealyticum: Nucleoside analogues as potent inhibitors of mycoplasma growth
    • Carnrot C, Wehelie R, Eriksson S, Bolske G & Wang L (2003) Molecular characterization of thymidine kinase from Ureaplasma urealyticum: nucleoside analogues as potent inhibitors of mycoplasma growth. Mol Microbiol 50, 771-780.
    • (2003) Mol Microbiol , vol.50 , pp. 771-780
    • Carnrot, C.1    Wehelie, R.2    Eriksson, S.3    Bolske, G.4    Wang, L.5
  • 17
    • 0038629174 scopus 로고    scopus 로고
    • Structural basis for feedback inhibition of the deoxyribonucleoside salvage pathway: Studies of the Drosophila deoxyribonucleoside kinase
    • Mikkelsen NE, Johansson K, Karlsson A, Knecht W, Andersen G, Piskur J, et al. (2003) Structural basis for feedback inhibition of the deoxyribonucleoside salvage pathway: studies of the Drosophila deoxyribonucleoside kinase. Biochemistry 42, 5706-5712.
    • (2003) Biochemistry , vol.42 , pp. 5706-5712
    • Mikkelsen, N.E.1    Johansson, K.2    Karlsson, A.3    Knecht, W.4    Andersen, G.5    Piskur, J.6
  • 18
    • 0029036851 scopus 로고
    • Substrate specificities of mitochondrial thymidine kinase and cytosolic deoxycytidine kinase against 5-aryl substituted pyrimidine-2′-deoxyribose analogues
    • Eriksson S & Wang J (1995) Substrate specificities of mitochondrial thymidine kinase and cytosolic deoxycytidine kinase against 5-aryl substituted pyrimidine-2′-deoxyribose analogues. Nucleosides Nucleotides 14, 507-510.
    • (1995) Nucleosides Nucleotides , vol.14 , pp. 507-510
    • Eriksson, S.1    Wang, J.2
  • 19
    • 3042520589 scopus 로고    scopus 로고
    • The role of thymidine kinases in the activation of pyrimidine nucleoside analogues
    • Al-Madhoun A, Tjarks W & Eriksson S (2004) The role of thymidine kinases in the activation of pyrimidine nucleoside analogues. Mini Rev Med Chem 4, 341-350.
    • (2004) Mini Rev Med Chem , vol.4 , pp. 341-350
    • Al-Madhoun, A.1    Tjarks, W.2    Eriksson, S.3
  • 20
    • 0027185675 scopus 로고
    • Reversible ATP-dependent transition between two forms of human cytosolic thymidine kinase with different enzymatic properties
    • Munch-Petersen B, Tyrsted G & Cloos L (1993) Reversible ATP-dependent transition between two forms of human cytosolic thymidine kinase with different enzymatic properties. J Biol Chem 268, 15621-15625.
    • (1993) J Biol Chem , vol.268 , pp. 15621-15625
    • Munch-Petersen, B.1    Tyrsted, G.2    Cloos, L.3
  • 21
    • 0025916482 scopus 로고
    • Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides
    • Munch-Petersen B, Cloos L, Tyrsted G & Eriksson S (1991) Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides. J Biol Chem 266, 9032-9038.
    • (1991) J Biol Chem , vol.266 , pp. 9032-9038
    • Munch-Petersen, B.1    Cloos, L.2    Tyrsted, G.3    Eriksson, S.4
  • 22
    • 13044283431 scopus 로고    scopus 로고
    • Synthesis of 5-(carboranylalkylmercapto)-2′-deoxyuridines and 3-(carboranylalkyl) thymidines and their evaluation as substrates for human thymidine kinases 1 and 2
    • Lunato AJ, Wang J, Woollard JE, Anisuzzaman AK, Ji W, Rong FG, et al. (1999) Synthesis of 5-(carboranylalkylmercapto)-2′-deoxyuridines and 3-(carboranylalkyl) thymidines and their evaluation as substrates for human thymidine kinases 1 and 2. J Med Chem 42, 3378-3389.
    • (1999) J Med Chem , vol.42 , pp. 3378-3389
    • Lunato, A.J.1    Wang, J.2    Woollard, J.E.3    Anisuzzaman, A.K.4    Ji, W.5    Rong, F.G.6
  • 24
    • 0028103275 scopus 로고
    • The CCP4 suite: Programs for protein crystallography
    • CCP4 (1994) The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr 50, 760-763.
    • (1994) Acta Crystallogr D Biol Crystallogr , vol.50 , pp. 760-763
  • 25
    • 0034517589 scopus 로고    scopus 로고
    • An approach to multicopy search in molecular replacement
    • Vagin A & Teplyakov A (2000) An approach to multicopy search in molecular replacement. Acta Crystallogr D Biol Crystallogr 56, 1622-1624.
    • (2000) Acta Crystallogr D Biol Crystallogr , vol.56 , pp. 1622-1624
    • Vagin, A.1    Teplyakov, A.2
  • 26
    • 0347383760 scopus 로고    scopus 로고
    • ARP/wARP and automatic interpretation of protein electron density maps
    • Morris RJ, Perrakis A & Lamzin VS (2003) ARP/wARP and automatic interpretation of protein electron density maps. Methods Enzymol 374, 229-244.
    • (2003) Methods Enzymol , vol.374 , pp. 229-244
    • Morris, R.J.1    Perrakis, A.2    Lamzin, V.S.3
  • 28
    • 84889120137 scopus 로고
    • Improved methods for building protein models in electron density maps and the location of errors in these models
    • Jones TA, Zou JY, Cowan SW & Kjeldgaard M (1991) Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr D Biol Crystallogr 47, 110-119.
    • (1991) Acta Crystallogr D Biol Crystallogr , vol.47 , pp. 110-119
    • Jones, T.A.1    Zou, J.Y.2    Cowan, S.W.3    Kjeldgaard, M.4
  • 29
    • 0029689120 scopus 로고    scopus 로고
    • Structure-activity relationships for phosphorylation of nucleoside analogs to monophosphates by nucleoside kinases
    • Johansson N & Eriksson S (1996) Structure-activity relationships for phosphorylation of nucleoside analogs to monophosphates by nucleoside kinases. Acta Biochim Pol 43, 143-160.
    • (1996) Acta Biochim Pol , vol.43 , pp. 143-160
    • Johansson, N.1    Eriksson, S.2


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