-
1
-
-
0016701474
-
Synthesis of 5-alkyl-2'-deoxyuridines
-
1. Szabolcs A, Sági I, Ötvös L. Synthesis of 5-alkyl-2'-deoxyuridines. Carbohydrates, Nucleosides, Nucleotides 1975; 2: 197-211.
-
(1975)
Carbohydrates, Nucleosides, Nucleotides
, vol.2
, pp. 197-211
-
-
Szabolcs, A.1
Sági, I.2
Ötvös, L.3
-
3
-
-
0022625159
-
5-ethyl-2'-deoxyuridine: An explanation for its lack of cytotoxic action in vivo
-
3. Jeney A, Barre E, Taylor GA, et al. 5-ethyl-2'-deoxyuridine: an explanation for its lack of cytotoxic action in vivo. Eur J Cancer Clin Oncol 1986; 12: 557-62.
-
(1986)
Eur J Cancer Clin Oncol
, vol.12
, pp. 557-562
-
-
Jeney, A.1
Barre, E.2
Taylor, G.A.3
-
4
-
-
0019334899
-
A study of substrate specificity of mammalian and bacterial DNA polymerases with 5-alkyl-2'-deoxyuridine 5 triphosphates
-
4. Sági J, Nowak R, Zmudzka B, et al. A study of substrate specificity of mammalian and bacterial DNA polymerases with 5-alkyl-2'-deoxyuridine 5 triphosphates. Biochim Biophys Acta 1980, 606: 196-202.
-
(1980)
Biochim Biophys Acta
, vol.606
, pp. 196-202
-
-
Sági, J.1
Nowak, R.2
Zmudzka, B.3
-
5
-
-
0021236644
-
Potentiation of the antitumor action of 5-fluorouracil with 5-ethyl-2'-deoxyuridine in human colon tumor xenografts
-
5. Kopper L, Magyarosy E, Jeney A, et al. Potentiation of the antitumor action of 5-fluorouracil with 5-ethyl-2'-deoxyuridine in human colon tumor xenografts. Oncology 1984; 41: 155-8.
-
(1984)
Oncology
, vol.41
, pp. 155-158
-
-
Kopper, L.1
Magyarosy, E.2
Jeney, A.3
-
6
-
-
0024347268
-
Biochemical modulation of 5-fluorouracil: Evidence of significant improvement of survival and quality of life in patients with advanced colorectal cancer
-
6. Poon MA, O'Connel MJ, Moertel CG, et al. Biochemical modulation of 5-fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal cancer. J Clin Oncol 1989; 7: 1407-18.
-
(1989)
J Clin Oncol
, vol.7
, pp. 1407-1418
-
-
Poon, M.A.1
O'Connel, M.J.2
Moertel, C.G.3
-
7
-
-
0024578398
-
Reversal of 5-fluorouracil induced myelosuppression by prolonged administration of high dose uridine
-
7. Van Groeningen J, Peters GJ, Leyva A, et al. Reversal of 5-fluorouracil induced myelosuppression by prolonged administration of high dose uridine. J Natl Cancer Inst 1989; 81: 157-62.
-
(1989)
J Natl Cancer Inst
, vol.81
, pp. 157-162
-
-
Van Groeningen, J.1
Peters, G.J.2
Leyva, A.3
-
8
-
-
0030958101
-
Phase I trial of PN-401, an oral prodrug of uridine, to prevent toxicity from fluorouracil in patients with advanced cancer
-
H. Kelsen DP, Martin D, O'Neil J, et al. Phase I trial of PN-401, an oral prodrug of uridine, to prevent toxicity from fluorouracil in patients with advanced cancer. J Clin Oncol 1997; 15: 1511-7.
-
(1997)
J Clin Oncol
, vol.15
, pp. 1511-1517
-
-
H Kelsen, D.P.1
Martin, D.2
O'Neil, J.3
-
9
-
-
0028577327
-
Dihydropyrimidine dehydrogenase (DPD) and clinical pharmacology of 5-fluorouracil
-
9 Milano G, Etienne MC. Dihydropyrimidine dehydrogenase (DPD) and clinical pharmacology of 5-fluorouracil. Anticancer Res 1994; 14: 2295-8.
-
(1994)
Anticancer Res
, vol.14
, pp. 2295-2298
-
-
Milano, G.1
Etienne, M.C.2
-
10
-
-
0028982820
-
Response to fluorouracil therapy in cancer patients: The role of tumoral dihydropyrimidine dehydrogenase activity
-
10. Etienne MC, Cheradame S, Fischel JL, et al. Response to fluorouracil therapy in cancer patients: the role of tumoral dihydropyrimidine dehydrogenase activity. J Clin Oncol 1995; 13: 1663-70.
-
(1995)
J Clin Oncol
, vol.13
, pp. 1663-1670
-
-
Etienne, M.C.1
Cheradame, S.2
Fischel, J.L.3
-
11
-
-
0026490284
-
Decreased catabolism of fluorouracil in peripheral blood mononuclear cells during combination therapy with fluorouracil leucovorin and interferon α-2a
-
11. Yee LK, Allegra CJ, Steinberg SM, et al. Decreased catabolism of fluorouracil in peripheral blood mononuclear cells during combination therapy with fluorouracil leucovorin and interferon α-2a. J Natl Cancer Inst 1992; 84: 1820-5.
-
(1992)
J Natl Cancer Inst
, vol.84
, pp. 1820-1825
-
-
Yee, L.K.1
Allegra, C.J.2
Steinberg, S.M.3
-
12
-
-
0031876466
-
Putative role of dihydropyrimidine dehydrogenase in the toxic side effects of 5-fluorouracil in colorectal cancer patients
-
12. Katona Cs, Kralovánszky J, Rosta A, et al. Putative role of dihydropyrimidine dehydrogenase in the toxic side effects of 5-fluorouracil in colorectal cancer patients. Oncology 1998; 55: 468-75.
-
(1998)
Oncology
, vol.55
, pp. 468-475
-
-
Katona, Cs.1
Kralovánszky, J.2
Rosta, A.3
-
13
-
-
0029157545
-
Dihydropyrimidine dehydrogenase: A tumoral target for fluorouracil modulation
-
13. Fischel JL, Etienne MC, Spector T, et al. Dihydropyrimidine dehydrogenase: a tumoral target for fluorouracil modulation. Clin Cancer Res 1995; 1: 991-6.
-
(1995)
Clin Cancer Res
, vol.1
, pp. 991-996
-
-
Fischel, J.L.1
Etienne, M.C.2
Spector, T.3
-
14
-
-
0031900670
-
Phase I clinical and pharmacologic study of eniluracil plus fluorouracil in patients with advanced cancer
-
14. Schilsky RL, Hohneker J, Ratain MJ, et al. Phase I clinical and pharmacologic study of eniluracil plus fluorouracil in patients with advanced cancer. J Clin Oncol 1998; 16: 1450-7.
-
(1998)
J Clin Oncol
, vol.16
, pp. 1450-1457
-
-
Schilsky, R.L.1
Hohneker, J.2
Ratain, M.J.3
-
15
-
-
0009669473
-
Possible mechanisms playing a role in the enhancement of the antitumour effect of 5-FU by 5-ethyl-2'-deoxyuridine
-
15. Kralovánszky J, Pandi E, Katona Cs, et al. Possible mechanisms playing a role in the enhancement of the antitumour effect of 5-FU by 5-ethyl-2'-deoxyuridine. Ann Oncol 1996; 7 (suppl 1): 67.
-
(1996)
Ann Oncol
, vol.7
, Issue.SUPPL. 1
, pp. 67
-
-
Kralovánszky, J.1
Pandi, E.2
Katona, Cs.3
-
16
-
-
0009718329
-
The effect of 5-alkyl-pyrimidines and 5-alkyl pyrimidine nucleosides on the catabolism of 5-fluorouracil in vivo
-
van der Plaas HC, Örvös L, Simonyi M, eds. Amsterdam; Elsevier
-
16. Veres Zs, Szabolcs A, Szinai I, et al. The effect of 5-alkyl-pyrimidines and 5-alkyl pyrimidine nucleosides on the catabolism of 5-fluorouracil in vivo. In: van der Plaas HC, Örvös L, Simonyi M, eds. Bio-organic beterocycles. Amsterdam; Elsevier 1984: 339-43.
-
(1984)
Bio-organic Beterocycles
, pp. 339-343
-
-
Veres, Zs.1
Szabolcs, A.2
Szinai, I.3
-
17
-
-
0022400840
-
Enzymes of uracil catabolism in normal and neoplastic human tissues
-
17. Naguib FNM, Kouni MH, Cha S. Enzymes of uracil catabolism in normal and neoplastic human tissues. Cancer Res 1985; 45: 5405-12
-
(1985)
Cancer Res
, vol.45
, pp. 5405-5412
-
-
Naguib, F.N.M.1
Kouni, M.H.2
Cha, S.3
-
18
-
-
0020451764
-
Rapid catabolism of 5-fluorouracil in freshly isolated rat hepatocytes as analyzed by high-performance liquid chromatography
-
18. Sommadossi JP, Gewirtz DA, Diasio RB, et al. Rapid catabolism of 5-fluorouracil in freshly isolated rat hepatocytes as analyzed by high-performance liquid chromatography. J Biol Chem 1982; 257: 8171-6.
-
(1982)
J Biol Chem
, vol.257
, pp. 8171-8176
-
-
Sommadossi, J.P.1
Gewirtz, D.A.2
Diasio, R.B.3
-
19
-
-
0014303663
-
Thymidine kinase in rat liver during development
-
19. Klemperer G, Haynes GR. Thymidine kinase in rat liver during development Biochem J 1968; 108: 541-5.
-
(1968)
Biochem J
, vol.108
, pp. 541-545
-
-
Klemperer, G.1
Haynes, G.R.2
-
20
-
-
0013965282
-
An isotopic assay for thymidylate synthetase
-
20. Roberts DW. An isotopic assay for thymidylate synthetase. Biochemistry 1966; 5: 3546-8.
-
(1966)
Biochemistry
, vol.5
, pp. 3546-3548
-
-
Roberts, D.W.1
-
21
-
-
0028903088
-
Enhancement of 5-fluoro2'-deoxyuridine antitumor efficacy by the uridine phosphorylase inhibitor 5-benzyloxy barbituric acid
-
21. Ashour OM, Naguib NM, Khalifa MM, et al. Enhancement of 5-fluoro2'-deoxyuridine antitumor efficacy by the uridine phosphorylase inhibitor 5-benzyloxy barbituric acid. Cancer Res 1995; 55: 1092-8.
-
(1995)
Cancer Res
, vol.55
, pp. 1092-1098
-
-
Ashour, O.M.1
Naguib, N.M.2
Khalifa, M.M.3
-
22
-
-
0344109583
-
Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer
-
22. Piedbois P, Rougier P, Buyse M, et al, (Meta-analysis Group in Cancer) Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clinw Oncol 1998; 16: 301-8.
-
(1998)
J Clin Oncol
, vol.16
, pp. 301-308
-
-
Piedbois, P.1
Rougier, P.2
Buyse, M.3
-
23
-
-
0031937913
-
Pretreatment of colon carcinoma cells with Tomudex enhances 5-fluorouracil cytotoxicity
-
23. Longo GSA, Izzo J, Chang YM, et al. Pretreatment of colon carcinoma cells with Tomudex enhances 5-fluorouracil cytotoxicity. Clin Cancer Res 1998, 4: 469-73.
-
(1998)
Clin Cancer Res
, vol.4
, pp. 469-473
-
-
Longo, G.S.A.1
Izzo, J.2
Chang, Y.M.3
-
26
-
-
0020315641
-
Improved measurement of thymidilate synthetase activity by a modified tritium-release assay
-
26. Armstrong RD, Diasio RB. Improved measurement of thymidilate synthetase activity by a modified tritium-release assay. J Biochem Biophys Methods 1982; 6: 141-7.
-
(1982)
J Biochem Biophys Methods
, vol.6
, pp. 141-147
-
-
Armstrong, R.D.1
Diasio, R.B.2
-
27
-
-
0028097137
-
A role of dihydropyrimidine dehydrogenase and thymidylate synthase in tumor sensitivity to fluorouracil
-
27. Beck A, Etienne MC, Chédame JL, et al. A role of dihydropyrimidine dehydrogenase and thymidylate synthase in tumor sensitivity to fluorouracil. Eur J Cancer 1994; 30A: 1517-22.
-
(1994)
Eur J Cancer
, vol.30 A
, pp. 1517-1522
-
-
Beck, A.1
Etienne, M.C.2
Chédame, J.L.3
-
28
-
-
0027945196
-
Dihydropyrimidine dehydrogenase activity and 5-fluorouracil chemotherapy
-
28. Diasio RB, Lu Z. Dihydropyrimidine dehydrogenase activity and 5-fluorouracil chemotherapy. J Clin Oncol 1994; 12: 2239-42.
-
(1994)
J. Clin Oncol
, vol.12
, pp. 2239-2242
-
-
Diasio, R.B.1
Lu, Z.2
-
29
-
-
0031912432
-
Decreased dihydropyrimidine dehydrogenase activity in a population of patients with breast cancer implication for 5-fluorouracil based chemotherapy
-
29. Lu Z, Zhang R, Capenter JT, et al Decreased dihydropyrimidine dehydrogenase activity in a population of patients with breast cancer implication for 5-fluorouracil based chemotherapy. Clin Cancer Res 1998; 4: 325-9.
-
(1998)
Clin Cancer Res
, vol.4
, pp. 325-329
-
-
Lu, Z.1
Zhang, R.2
Capenter, J.T.3
-
30
-
-
0000163968
-
Dihydropyrimidine dehydrogenase deficiency and fluorouracil related toxicity
-
30. Milano G, Etienne MC, Pierrefite V, et al. Dihydropyrimidine dehydrogenase deficiency and fluorouracil related toxicity. Br J Cancer 1999; 79: 627-30.
-
(1999)
Br J Cancer
, vol.79
, pp. 627-630
-
-
Milano, G.1
Etienne, M.C.2
Pierrefite, V.3
-
31
-
-
0028073326
-
Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase
-
31. Peters GJ, Van der Wilt CL, Van Groeningen CJ. Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase. Eur J Cancer 1994; 10: 1408-11.
-
(1994)
Eur J Cancer
, vol.10
, pp. 1408-1411
-
-
Peters, G.J.1
Van Der Wilt, C.L.2
Van Groeningen, C.J.3
-
32
-
-
0031832182
-
Thymidylate synthase expression and activity relation to S-phase parameters and 5-fluorouracil sensitivity
-
32. Mirjolet JF, Barberi-Heyob M, Merlin JL, et al. Thymidylate synthase expression and activity relation to S-phase parameters and 5-fluorouracil sensitivity. Br J Cancer 1998; 78: 62-8.
-
(1998)
Br J Cancer
, vol.78
, pp. 62-68
-
-
Mirjolet, J.F.1
Barberi-Heyob, M.2
Merlin, J.L.3
-
33
-
-
0026701936
-
Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracil
-
33. Porter DJT, Chestnut WG, Merrill BM, et al. Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracil. J Biol Chem 1992; 267: 5236-42.
-
(1992)
J Biol Chem
, vol.267
, pp. 5236-5242
-
-
Porter, D.J.T.1
Chestnut, W.G.2
Merrill, B.M.3
-
34
-
-
0027489763
-
Ethynyluracil (776C85) a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil
-
34. Baccanari DP, Davis ST, Knick VC, et al. 5-Ethynyluracil (776C85) a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil. Proc Natl Acad Sci USA 1993; 90: 11064-8.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 11064-11068
-
-
Baccanari, D.P.1
Davis, S.T.2
Knick, V.C.3
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