Investigation of the binding interactions of progesterone using muteins of the human progesterone receptor ligand binding domain designed on the basis of a three-dimensional protein model

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1429, Issue 2, 1999, Pages 391-400

  Letz, Miriam ^a   Bringmann, Peter ^a   Mann, Mario ^a   Mueller Fahrnow, Anke ^a   Reipert, Dania ^a   Scholz, Peter ^a   Wurtz, Jean Marie ^b   Egner, Ursula ^a  

^a BAYER PHARMA AG   (Germany)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Binding characteristic; Comparative modelling; Ligand binding domain; Progesterone receptor; Site directed mutagenesis

Indexed keywords

PROGESTERONE; PROGESTERONE RECEPTOR;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; HUMAN; LIGAND BINDING; MODEL; MUTANT; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; THREE DIMENSIONAL IMAGING;

AMINO ACID SEQUENCE; ANIMALS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROGESTERONE; RECEPTORS, PROGESTERONE; SEQUENCE ALIGNMENT;

EID: 0032924018     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(98)00249-0     Document Type: Article

References (28)

1. Moras D., Gronemeyer H. Curr. Opin. Cell Biol. 10:1998;384-391.
2. Tsai M.J., O'Malley B.W. Annu. Rev. Biochem. 63:1994;451-486.
3. Gronemeyer H., Laudet V. Protein Profile. 2:1995;1173-1308.
4. Mangelsdorf D.J., Thummel C., Beato M., Herrlich P., Schütz G., Umesono K., Blumberg B., Kastner P., Mark M., Chambon P., Evans R.M. Cell. 83:1995;835-839.
5. Bourguet W., Ruff M., Chambon P., Gronemeyer H., Moras D. Nature. 375:1995;377-382.
6. Renaud J.-P., Rochel N., Ruff M., Vivat V., Chambon P., Gronemeyer H., Moras D. Nature. 378:1995;681-689.
7. Wagner R.L., Apriletti J.W., McGrath M.E., West B.L., Baxter J.D., Fletterick R.J. Nature. 378:1995;690-697.
8. Brzozowski A.M., Pike A.C.W., Dauter Z., Hubbard R.E., Bonn T., Engström O., Öhmann L., Greene G.L., Gustafsson J.-Å., Carlquist M. Nature. 389:1997;753-758.
9. Bernstein F.C., Koetzle T.F., Williams G.J., Meyer E.F. Jr., Brice M.D., Rodgers J.R., Kennard O., Shimanouchi T., Tasumi M. Eur. J. Biochem. 80:1977;319-324.
10. Allan G.F., Lombardi E., Haynes-Johnson D., Palmer S., Kiddoe M., Kraft P., Campen C., Rybczynski P., Combs D.W., Phillips A. Mol. Endocrinol. 10:1996;1206-1213.
11. Benhamou B., Garcia T., Lerouge T., Vergezac A., Gofflo D., Bigogne C., Chambon P., Gronemeyer H. Science. 255:1992;206-209.
12. Gong W., Chavez S., Beato M. Mol. Endocrinol. 11:1997;1476-1485.
13. Dobson A.D.W., Conneely O.M., Beattie W., Maxwell B.L., Mak P., Tsai M.-J., Schrader W.T., O'Malley B.W. J. Biol. Chem. 264:1989;4207-4211.
14. Vegeto E., Allan G.F., Schrader W.T., Tsai M.-J., McDonnell D.P., O'Malley B.W. Cell. 69:1992;703-713.
15. Garcia T., Benhamou B., Gofflo D., Vergezac A., Philibert D., Chambon P., Gronemeyer H. Mol. Endocrinol. 6:1992;2071-2078.
16. Williams S.P., Sigler P.B. Nature. 393:1998;392-396.
17. Thompson J.D., Higgins D.G., Gibson T.J. Nucleic Acids Res. 22:1994;4673-4680.
18. Wurtz J.-M., Egner U., Heinrich N., Moras D., Mueller-Fahrnow A. J. Med. Chem. 41:1998;1803-1814.
19. Laskowski R.A., MacArthur M.W., Moss D.S., Thornton J.M. J. Appl. Crystallog. 26:1993;283-291.
20. Insight II/Discover 2.9.7, MSI Inc., San Diego, USA, 1995.
21. Niefind K., Schomburg D. J. Mol. Biol. 219:1991;481-497.
22. Bordo D., Argos P. J. Mol. Biol. 217:1991;721-729.
23. Carlson K.E., Choi I., Gee A., Katzenellenbogen B.S., Katzenellenbogen J.A. Biochemistry. 36:1997;14897-14905.
24. Chen D., Stallcup M.R. J. Biol. Chem. 269:1994;7914-7918.
25. Yu C., Warriar N., Govindan M.V. Biochemistry. 34:1995;14163-14173.
26. Chakraborti P.K., Garabedian M.J., Yamamoto K.R., Simons S.S. Jr. J. Biol. Chem. 267:1992;11366-11373.
27. Fagart J., Wurtz J.-M., Souque A., Hellal-Levy C., Moras D., Rafestin-Oblin M.-E. EMBO J. 17:1998;3317-3325.
28. Barton G.J. Protein Eng. 6:1993;37-40.