Asp41-His48 region of streptokinase is important in binding to a substrate plasminogen

Thrombosis Research

Volumn 99, Issue 1, 2000, Pages 93-98

  Kim, Dong Min ^a   Lee, Sang Jun ^a   Kim, Il Chul ^a   Kim, Sun Taek ^a   Byun, Si Myung ^a,b  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Res Ctr New Biomaterials in Agric   (South Korea)

Author keywords

Activation; Fibrinolysis; Plasminogen; Streptokinase

Indexed keywords

PLASMINOGEN; PLASMINOGEN ACTIVATOR; STREPTOKINASE;

ARTICLE; BINDING AFFINITY; ESCHERICHIA COLI; FIBRINOLYSIS; IMMUNOBLOTTING; MUTAGENESIS; MUTANT; NONHUMAN; PLASMINOGEN ACTIVATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

AMIDOHYDROLASES; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; CHROMOGENIC COMPOUNDS; CLONING, MOLECULAR; DNA MUTATIONAL ANALYSIS; ENZYME ACTIVATION; HUMANS; PLASMIDS; PLASMINOGEN; POINT MUTATION; PROTEIN BINDING; STREPTOKINASE;

EID: 0033938712     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(00)00225-5     Document Type: Article

References (18)

1. Huang T.T., Malke H., Ferretti J.J. The streptokinase gene of group A streptococci. Mol Biol. 2(3):1989;197-205.
2. De Renzo E.C., Siiteri P.K., Hutchings B.L., Bell P.H. Preparation and certain properties of highly purified streptokinase. J Biol Chem. 243:1967;3648-3654.
3. Reddy K.N.N., Markus G. Mechanism of streptokinase and human plasminogen. J Biol Chem. 247:1972;1683-1691.
4. Buck F.F., Boggiano E. Interaction of streptokinase and human plasminogen. J Biol Chem. 246:1971;2091-2096.
5. Summaria L., Robbins K.C. Dissociation of the equimolar human plasmin-streptokinase complex. J Biol Chem. 246:1971;2136-2141.
6. Shi G.Y., Chang B.I., Chen S.M., Wu D.H., Wu H.L. Function of streptokinase fragments in plasminogen activation. Biochem J. 304:1994;235-241.
7. Young K.C., Shi G.Y., Chang Y.F., Chang B.I., Chang L.C., Lai M.D., Chuang W.J., Wu H.L. Interaction of streptokinase and plasminogen. J Biol Chem. 270:1995;29601-29606.
8. Nihalani D., Sahni G. Streptokinase contains two independent plasminogen-binding sites. Biochem Biophys Res Commun. 217:1995;1245-1254.
9. Wang X., Lin X., Loy J.A., Tang J., Zhang X.C. Crystal structure of the catalytic domain of human plasmin complexed with streptokinase. Science. 281:1998;1662-1665.
10. Ko J.H., Park D.K., Kim I.C., Lee S.H., Byun S.M. High-level expression and secretion of streptokinase in Escherichia coli. Biotech Lett. 17(10):1995;1019-1024.
11. Roh D.C., Kim J.H., Park S.K., Lee J.W., Byun S.M. Molecular cloning of streptokinase gene from Streptococcus equisimilis and its expression in E. coli. Korean Biochem J. 19:1986;391-398.
12. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
13. Sambrook J., Fritsch E.F., Maniatis T. Molecular cloning. A Laboratory manual. 2nd Ed:1989;Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
14. α-CBZ-L-lysine ρ-nitrophenyl ester as substrate. Anal Biochem. 65:1975;500-506.
15. Kim I.C., Kim J.S., Lee S.H., Byun S.M. C-terminal peptide of streptokinase, Met369-Pro373, is important in plasminogen activation. Biochem Mol Biol Int. 40(5):1996;939-945.
16. Lee S.H., Jeong S.T., Kim I.C., Byun S.M. Identification of the functional importance of valine-19 residue in streptokinase by N-terminal deletion and site-directed mutagenesis. Biochem Mol Biol Int. 41:1997;199-207.
17. Summaria L., Wohl R.C., Boreisha I.G., Robbins K.C. A virgin enzyme derived from human plasminogen. specific cleavage of the arginyl-560-valyl peptide bond in the diisopropoxyphosphinyl virgin enzyme by plasminogen activators Biochemistry. 21:1982;2056-2059.
18. Gonzalez-Gronow M., Enghild J.J., Pizzo S.V. Streptokinase and human fibronectin share a common epitope. implications for regulation of fibrinolysis and rheumatoid arthritis Biochim Biophys Acta. 1180:1993;283-288.