Mutations reveal voltage gating of CNGA1 channels in saturating cGMP

Journal of General Physiology

Volumn 134, Issue 2, 2009, Pages 151-164

  Martínez François, Juan Ramón ^a   Xu, Yanping ^a   Lu, Zhe ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CATION CHANNEL; CYCLIC GMP; PROTEIN; PROTEIN CNGA1; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; NONHUMAN; PHOTORECEPTOR; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; VERTEBRATE; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CYCLIC GMP; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; ELECTROPHYSIOLOGY; ION CHANNEL GATING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, VOLTAGE-GATED; XENOPUS LAEVIS;

EID: 67749099494     PISSN: 00221295     EISSN: 15407748     Source Type: Journal    
DOI: 10.1085/jgp.200910240     Document Type: Article

References (50)

1. + channel. Neuron. 16:1169-1177.
2. + channels. Biophys. J. 85:300-312.
3. Almers, W. 1978. Gating currents and charge movements in excitable membranes. Rev. Physiol. Biochem. Pharmacol. 82:96-190.
4. Armstrong, C.M. 1971. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons. J. Gen. Physiol. 58:413-437.
5. 2+ of substituted cysteine residues within the Ploop. Pflügers Arch. 440:556-565.
6. Becchetti, A., K. Gamel, and V. Torre. 1999. Cyclic nucleotidegated channels. Pore topology studied through the accessibility of reporter cysteines. J. Gen. Physiol. 114:377-392.
7. Benndorf, K., R. Koopmann, E. Eismann, and U.B. Kaupp. 1999. Gating by cyclic GMP and voltage in the α subunit of the cyclic GMPgated channel from rod photoreceptors. J. Gen. Physiol. 114:477-490.
8. Blunck, R., J.F. CorderoMorales, L.G. Cuello, E. Perozo, and F. Bezanilla. 2006. Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction. J. Gen. Physiol. 128:569-581.
9. Bucossi, G., E. Eismann, F. Sesti, M. Nizzari, M. Seri, U.B. Kaupp, and V. Torre. 1996. Timedependent current decline in cyclic GMPon gated bovine channels caused by point mutations in the pore region expressed in Xenopus oocytes. J. Physiol. 493:409-418.
10. Bucossi, G., M. Nizzari, and V. Torre. 1997. Singlechannel properties of ionic channels gated by cyclic nucleotides. Biophys. J. 72:1165-1181.
11. Contreras, J.E., D. Srikumar, and M. Holmgren. 2008. Gating at the selectivity filter in cyclic nucleotidegated channels. Proc. Natl. Acad. Sci. USA. 105:3310-3314.
12. CorderoMorales, J.F., L.G. Cuello, and E. Perozo. 2006a. Voltagedependent gating at the KcsA selectivity filter. Nat. Struct. Mol. Biol. 13:319-322.
13. CorderoMorales, J.F., L.G. Cuello, Y. Zhao, V. Jogini, D.M. Cortes, B. Roux, and E. Perozo. 2006b. Molecular determinants of gating at the potassiumchannel selectivity filter. Nat. Struct. Mol. Biol. 13:311-318.
14. CorderoMorales, J.F., V. Jogini, A. Lewis, V. Vásquez, D.M. Cortes, B. Roux, and E. Perozo. 2007. Molecular driving forces determining potassium channel slow inactivation. Nat. Struct. Mol. Biol. 14:1062-1069.
15. + conduction and selectivity. Science. 280:69-77.
16. 2+ blockage, and ionic selectivity. Proc. Natl. Acad. Sci. USA. 91:1109-1113.
17. Flynn, G.E., and W.N. Zagotta. 2001. Conformational changes in S6 coupled to the opening of cyclic nucleotidegated channels. Neuron. 30:689-698.
18. Fodor, A.A., K.D. Black, and W.N. Zagotta. 1997. Tetracaine reports a conformational change in the pore of cyclic nucleotidegated channels. J. Gen. Physiol. 110:591-600.
19. Gordon, S.E., and W.N. Zagotta. 1995. Localization of regions affecting an allosteric transition in cyclic nucleotideactivated channels. Neuron. 14:857-864.
20. Goulding, E.H., G.R. Tibbs, and S.A. Siegelbaum. 1994. Molecular mechanism of cyclicnucleotidegated channel activation. Nature. 372:369-374.
21. Guo, D., and Z. Lu. 2000. Mechanism of cGMPgated channel block by intracellular polyamines. J. Gen. Physiol. 115:783-798.
22. + channels: functional asymmetries and sidedness of proton activation. J. Gen. Physiol. 114:551-560.
23. Jan, L.Y., and Y.N. Jan. 1990. A superfamily of ion channels. Nature. 345:672.
24. Karpen, J.W., A.L. Zimmerman, L. Stryer, and D.A. Baylor. 1988. Gating kinetics of the cyclicGMPactivated channel of retinal rods: flash photolysis and voltagejump studies. Proc. Natl. Acad. Sci. USA. 85:1287-1291.
25. Kaupp, U.B., T. Niidome, T. Tanabe, S. Terada, W. Bönigk, W. Stühmer, N.J. Cook, K. Kangawa, H. Matsuo, T. Hirose, et al. 1989. Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMPgated channel. Nature. 342:762-766.
26. Kusch, J., V. Nache, and K. Benndorf. 2004. Effects of permeating ions and cGMP on gating and conductance of rodtype cyclic nucleotidegated (CNGA1) channels. J. Physiol. 560:605-616.
27. + channel determined by construction of multimeric cDNAs. Neuron. 9:861-871.
28. Liu, J., and S.A. Siegelbaum. 2000. Change of pore helix conformational state upon opening of cyclic nucleotidegated channels. Neuron. 28:899-909.
29. + channel. Science. 309:897-903.
30. + channel in a lipid membranelike environment. Nature. 450:376-382.
31. LópezBarneo, J., T. Hoshi, S.H. Heinemann, and R.W. Aldrich. 1993. Effects of external cations and mutations in the pore region on Ctype inactivation of Shaker potassium channels. Receptors Channels. 1:61-71.
32. Nache, V., J. Kusch, V. Hagen, and K. Benndorf. 2006. Gating of cyclic nucleotidegated (CNGA1) channels by cGMP jumps and depolarizing voltage steps. Biophys. J. 90:3146-3154.
33. Park, C.S., and R. MacKinnon. 1995. Divalent cation selectivity in a cyclic nucleotide-gated ion channel. Biochemistry. 34:13328-13333.
34. + channels. Neuron. 11:353-358.
35. Root, M.J., and R. MacKinnon. 1993. Identification of an external divalent cationbinding site in the pore of a cGMPactivated channel. Neuron. 11:459-466.
36. + channel: electrostatic stabilization of monovalent cations. Science. 285:100-102.
37. Schoppa, N.E., K. McCormack, M.A. Tanouye, and F.J. Sigworth. 1992. The size of gating charge in wildtype and mutant Shaker potassium channels. Science. 255:1712-1715.
38. + channel. Neuron. 16:1159-1167.
39. Sesti, F., E. Eismann, U.B. Kaupp, M. Nizzari, and V. Torre. 1995. The multiion nature of the cGMPgated channel from vertebrate rods. J. Physiol. 487:17-36.
40. Sesti, F., M. Nizzari, and V. Torre. 1996. Effect of changing temperature on the ionic permeation through the cyclic GMPgated channel from vertebrate photoreceptors. Biophys. J. 70:2616-2639.
41. + channel. J. Gen. Physiol. 126:123-135.
42. + channel. J. Gen. Physiol. 112:211-221.
43. Stryer, L. 1986. Cyclic GMP cascade of vision. Annu. Rev. Neurosci. 9:87-119.
44. Sun, Z.P., M.H. Akabas, E.H. Goulding, A. Karlin, and S.A. Siegelbaum. 1996. Exposure of residues in the cyclic nucleotidegated channel pore: P region structure and function in gating. Neuron. 16:141-149.
45. Tanaka, J.C., J.F. Eccleston, and R.E. Furman. 1989. Photoreceptor channel activation by nucleotide derivatives. Biochemistry. 28:2776-2784.
46. + channel. J. Gen. Physiol. 109:301-311.
47. Varnum, M.D., and W.N. Zagotta. 1996. Subunit interactions in the activation of cyclic nucleotidegated ion channels. Biophys. J. 70:2667-2679.
48. Yang, Y., Y. Yan, and F.J. Sigworth. 1997. How does the W434F mutation block current in Shaker potassium channels? J. Gen. Physiol. 109:779-789.
49. Yau, K.W., and D.A. Baylor. 1989. Cyclic GMPactivated conductance of retinal photoreceptor cells. Annu. Rev. Neurosci. 12:289-327.
50. + channel-Fab complex at 2.0 A resolution. Nature. 414:43-48. Supplemental material