CD3ζ expression and T cell proliferation are inhibited by TGF-β1 and IL-10 in cervical cancer patients

Journal of Clinical Immunology

Volumn 29, Issue 4, 2009, Pages 532-544

  Díaz Benítez, Cinthya E ^a   Navarro Fuentes, Karla R ^a   Flores Sosa, Jacqueline A ^a   Juárez Díaz, Janet ^a   Uribe Salas, Felipe J ^a   Román Basaure, Edgar ^b   González Mena, Ludwig E ^b   Alonso De Ruíz, Patricia ^b   López Estrada, Guillermina ^c   Lagunas Martínez, Alfredo ^a   Bermúdez Morales, Victor H ^a   Alcocer González, Juan M ^d   Martínez Barnetche, Jesús ^a   Hernández Pando, Rogelio ^e   Rosenstein, Yvonne ^f   Moreno, José ^g   Madrid Marina, Vicente ^a  

^a INSTITUTO NACIONAL DE SALUD PÚBLICA   (Mexico)

^b SECRETARÍA DE SALUD   (Mexico)

^c Hospital General Parres   (Mexico)

^d UNIVERSIDAD AUTÓNOMA DE NUEVO LEÓN   (Mexico)

^e Instituto Nacional de Ciences Médicas y Nutrición Salvador Zubirán   (Mexico)

^f INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

^g INSTITUTO NACIONAL DE SALUD PÚBLICA   (Mexico)

Author keywords

CD3 expression; cervical cancer; IL 10; Peripheral and infiltrating T cells; TGF 1.

Indexed keywords

CD3 ANTIGEN; CD3 ZETA ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; CD3 ANTIGEN, ZETA CHAIN; IL10 PROTEIN, HUMAN; IL2 PROTEIN, HUMAN; PHYTOHEMAGGLUTININ;

ADULT; AGED; ARTICLE; BLOOD; CANCER GRADING; CANCER PATIENT; CELL INFILTRATION; CELL PROLIFERATION; CONTROL GROUP; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TUMOR ASSOCIATED LEUKOCYTE; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA IN SITU; BIOSYNTHESIS; CULTURE MEDIUM; DRUG EFFECT; HELA CELL; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY; TUMOR CELL LINE; UTERINE CERVIX TUMOR;

ADULT; AGED; ANTIGENS, CD3; CELL LINE, TUMOR; CELL PROLIFERATION; CERVICAL INTRAEPITHELIAL NEOPLASIA; CULTURE MEDIA, CONDITIONED; FEMALE; HELA CELLS; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-2; LYMPHOCYTES, TUMOR-INFILTRATING; MIDDLE AGED; PHYTOHEMAGGLUTININS; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA1; UTERINE CERVICAL NEOPLASMS;

EID: 67651241489     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-009-9279-7     Document Type: Article

References (56)

1. MF Mitchell WN Hittelman WK Hong R Lotan D Schottenfeld 1994 The natural history of cervical intraepithelial neoplasia: an argument for intermediate endpoint biomarkers Cancer Epidemiol Biomarkers Prev. 3 619 626 (Pubitemid 24314452)
2. JM Walboomers MV Jacobs MM Manos FX Bosch JA Kummer KV Shah PJF Snijders J Peto CJ Meijer N Muñoz 1999 Human papillomavirus is a necessary cause of invasive cervical cancer worldwide J Pathol. 189 12 19 (Pubitemid 29406813)
3. M Melbye J Palefsky J Gonzales LP Ryder H Nielsen O Bergmann J Pindborg RJ Biggar 1990 Immune status as a determinant of human papillomavirus detection and its association with anal epithelial abnormalities Int J Cancer. 46 203 206 (Pubitemid 20252077)
4. G Gentile G Formelli G Orsoni AM Rinaldi P Busacchi 1991 Immunosuppression and human genital papillomavirus infection Eur J Gynaecol Oncol. 12 79 81
5. K Nasiell M Nasiell V Vaćlavinková 1983 Behavior of moderate cervical dysplasia during long-term follow-up Obstet Gynecol. 61 609 614
6. TK Park SN Kim 1989 Cell-mediated immunity in patients with invasive carcinoma of the cervix Yonsei Med J. 30 164 172
7. + effector and memory T cell generation Nat Immunol. 4 835 842 (Pubitemid 37098653)
8. CT Weaver LE Harrington PR Mangan M Gavrieli KM Murphy 2006 Th17: an effector CD4 T cell lineage with regulatory T cell ties Immunity. 24 677 688 (Pubitemid 43867371)
9. J Damoiseaux 2006 Regulatory T cells: back to the future Neth J Med. 64 4 9 (Pubitemid 43168895)
10. SJ Robertson KJ Hasenkrug 2006 The role of virus-induced regulatory T cells in immunopathology Springer Semin Immunopathol. 28 51 62 (Pubitemid 44267959)
11. BC Sheu RH Lin HC Lien HN Ho SM Hsu SC Huang 2001 Predominant Th2/Tc2 polarity of tumor-infiltrating lymphocytes in human cervical cancer J Immunol. 167 2972 2978
12. JM Alcocer-González J Berumen R Taméz-Guerra V Bermúdez-Morales O Peralta-Zaragoza R Hernández-Pando J Moreno P Gariglio V Madrid-Marina 2006 In vivo expression of immunosuppressive cytokines in human papillomavirus-transformed cervical cancer cells Viral Immunol. 19 481 491 (Pubitemid 44735060)
13. G Bellone A Turletti E Artusio K Mareschi A Carbone D Tibaudi A Robecchi G Emanuelli U Rodeck 1999 Tumor-associated transforming growth factor-β and interleukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients Am J Pathol. 155 537 547 (Pubitemid 29370403)
14. TH Inge KM McCoy BM Susskind SK Barrett G Zhao HD Bear 1992 Immunomodulatory effects of transforming growth factor-β on T lymphocytes. Induction of CD8 expression in the CTLL-2 cell line and in normal thymocytes J Immunol. 148 3847 3856
15. T Espevik IS Figari MR Shalaby GA Lackides GD Lewis HM Shepard MA Palladino 1987 Inhibition of cytokine production by cyclosporin A and transforming growth factorβ J Exp Med. 166 571 576 (Pubitemid 17134033)
16. RP Edwards K Kuykendall P Crowley-Nowick EE Partridge HM Shingleton J Mestecky 1995 T lymphocytes infiltrating advanced grades of cervical neoplasia. CD8-positive cells are recruited to invasion Cancer. 76 1411 1415
17. + tumor-infiltrating lymphocytes is associated with the absence of lymph node metastases in patients with large early-stage cervical cancer Cancer Res. 67 354 361 (Pubitemid 46142795)
18. I Kuss T Saito JT Johnson TL Whiteside 1999 Clinical significance of decreased ζ chain expression in peripheral blood lymphocytes of patients with head and neck cancer Clin Cancer Res. 5 329 334 (Pubitemid 29085186)
19. K Kono ME Ressing RM Brandt CJ Melief RK Potkul B Andersson M Petersson WM Kast R Kiessling 1996 Decreased expression of signal-transducing ζ chain in peripheral T cells and natural killer cells in patients with cervical cancer Clin Cancer Res. 2 1825 1828 (Pubitemid 26384148)
20. TD de Gruijl HJ Bontkes F Peccatori MP Gallee TJ Helmerhorst RH Verheijen J Aarbiou WM Mulder JM Walboomers CJ Meijer N van de Vange RJ Scheper 1999 Expression of CD3-ζ on T-cells in primary cervical carcinoma and in metastasis-positive and -negative pelvic lymph nodes Br J Cancer. 79 1127 1132 (Pubitemid 29087885)
21. RD Klausner LE Samelson 1991 T cell antigen receptor activation pathways: the tyrosine kinase connection Cell. 64 875 878 (Pubitemid 121001175)
22. TL Whiteside S Miescher HR MacDonald V Von Fliedner 1986 Separation of tumor-infiltrating lymphocytes from tumor cells in human solid tumors. A comparison between velocity sedimentation and discontinuous density gradients J Immunol Methods. 90 221 233 (Pubitemid 16089014)
23. TD de Gruijl HJ Bontkes AJ van den Muysenberg JW van Oostveen MJ Stukart RH Verheijen N van der Vange PJ Snijders CJ Meijer JM Wallboomers RJ Scheper 1999 Differences in cytokine mRNA profiles between pre-malignant and malignant lesions of the uterine cervix Eur J Cancer. 35 490 497 (Pubitemid 29157871)
24. A Bañuelos E Reyes R Ocadiz E Alvarez M Moreno A Monroy P Gariglio 2003 Neocarzinostatin induces an effective p53-dependent response in human papillomavirus-positive cervical cancer cells J Pharmacol Exp Ther. 306 671 680 (Pubitemid 36886167)
25. + T cells compared with lymphocytes from tumor draining lymph nodes and peripheral blood in patients with cancer of the uterine cervix Gynecol Oncol. 81 424 432 (Pubitemid 32494657)
26. LA Verduzca-Rodríguez JA Palet-Guzmán H Aguirre-González E González-Puebla 1997 Cervico-uterine cancer and age Ginecol Obstet Mex. 65 119 122
27. D Matour M Melnicoff D Kaye DM Murasko 1989 The role of T cell phenotypes in decreased lymphoproliferation of the elderly Clin Immunol Immunopathol. 50 82 99 (Pubitemid 19044294)
28. JH Curfs JF Meis JA Hoogkamp-korstanje 1997 A primer on cytokines: sources, receptors, effects and inducers Clin Microbiol Rev. 10 742 780 (Pubitemid 27477733)
29. A Fattorossi A Battaglia G Ferrandina A Buzzonetti F Legge V Salutari G Scambia 2004 Lymphocyte composition of tumor draining lymph nodes from cervical and endometrial cancer patients Gynecol Oncol. 92 106 115 (Pubitemid 38147379)
30. M Clerici M Merola E Ferrario D Trabattoni ML Villa B Stefanon DJ Venzon GM Shearer G De Palo E Clerici 1997 Cytokine production patterns in cervical intraepithelial neoplasia: association with human papillomavirus infection J Natl Cancer Inst. 89 245 250 (Pubitemid 27073762)
31. AG Bais I Beckmann J Lindemans PC Ewing CJ Meijer PJ Snijders TJ Helmerhorst 2005 A shift to a peripheral Th2-type cytokine pattern during the carcinogenesis of cervical cancer becomes manifest in CIN III lesions J Clin Pathol. 58 1096 1100 (Pubitemid 41416062)
32. PE Castle A Hildesheim FP Bowman HD Strickler JL Walker T Pustilnik RP Edwards PA Crowley-Nowick 2002 Cervical concentrations of interleukin-10 and interleukin-12 do not correlate with plasma levels J Clin Immunol. 22 23 27 (Pubitemid 34203125)
33. A Gey P Kumari A Sambandam F Lecuru L Cassard C Badoual C Fridman B Nagarajan WH Fridman E Tartour 2003 Identification and characterisation of a group of cervical carcinoma patients with profound downregulation of intratumoral type 1 (IFNgamma) and Type 2 (IL-4) cytokine mRNA expression Eur J Cancer. 39 595 603 (Pubitemid 36287371)
34. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis Nature. 389 737 742 (Pubitemid 27458961)
35. SJ Robertson KJ Hasenkrug 2006 The role of virus-induced regulatory T cells in immunopathology Springer Semin Immunopathol. 28 51 62 (Pubitemid 44267959)
36. H von Boehmer 2005 Mechanisms of suppression by suppressor T cells Nat Immunol. 6 338 344 (Pubitemid 41716770)
37. + regulatory T cells by TGF-β induction of transcription factor Foxp3 J Exp Med. 198 1875 1886 (Pubitemid 38032120)
38. + regulatory T cells from human peripheral blood J Immunol. 166 7282 7289 (Pubitemid 32525603)
39. M Baniyash 2004 TCR ζ-chain downregulation: curtailing an excessive inflammatory immune response Nat Rev Immunol. 4 675 687 (Pubitemid 39223074)
40. K Tsuzaka K Nozaki C Kumazawa K Shiraishi Y Setoyama K Yoshimoto T Abe T Takeuchi 2006 TCRζ mRNA splice variant forms observed in the peripheral blood T cells from systemic lupus erythematosus patients Springer Semin Immunopathol. 28 185 193 (Pubitemid 46628483)
41. BR Gastman DE Johnson TL Whiteside H Rabinowich 1999 Caspase-mediated degradation of T-cell receptor ζ-chain Cancer Res. 59 1422 1427 (Pubitemid 29160103)
42. M Otsuji Y Kimura T Aoe Y Okamoto T Saito 1996 Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 ζ chain of T-cell receptor complex and antigen-specific T-cell responses Proc Natl Acad Sci U S A. 93 13119 13124 (Pubitemid 26382779)
43. F Fallarino U Grohmann S You BC McGrath DR Cavener C Vacca C Orabona R Bianchi ML Belladona C Volpi P Santamaria MC Fioretti P Puccetti 2006 The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor ζ-chain and induce a regulatory phenotype in naive T cells J Immunol. 176 6752 6761 (Pubitemid 43787857)
44. L- arginine J Biol Chem. 277 21123 21129 (Pubitemid 34952247)
45. T Nakamura T Shima A Saeki T Hidaka A Nakashima O Takikawa S Saito 2007 Expression of indoleamine 2,3-dioxygenase and the recruitment of Foxp3-expressing regulatory T cells in the development and progression of uterine cervical cancer Cancer Sci. 98 874 881 (Pubitemid 46691826)
46. 2 synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors J Clin Endocrinol Metab. 86 2243 2249 (Pubitemid 32472947)
47. + T regulatory cell activities in lung cancer Cancer Res. 65 5211 5220 (Pubitemid 40827331)
48. K Subbaramaiah AJ Dannenberg 2007 Cyclooxygenase-2 transcription is regulated by human papillomavirus 16 E6 and E7 oncoproteins: evidence of a corepressor/coactivator exchange Cancer Res. 67 3976 3985 (Pubitemid 46762188)
49. MY Tjiong N van der Vange JS ter Schegget MPM Burger FWJ ten Kate TA Out 2001 Cytokines in cervicovaginal washing fluid from patients with cervical neoplasia Cytokine. 14 357 360 (Pubitemid 32730478)
50. W von Bernstorff M Voss S Freichel A Schmid I Vogel C Jöhnk D Henne-Bruns B Kremer H Kalthoff 2001 Systemic and local immunosuppression in pancreatic cancer patients Clin Cancer Res. 7 925s 932s (Pubitemid 33600947)
51. 1 levels in breast cancer patients decrease after surgical removal of the tumor Ann Surg. 222 155 162
52. W Dummer JC Becker A Schwaaf M Leverkus T Moll EB Bröcker 1995 Elevated serum levels of interleukin-10 in patients with metastatic malignant melanoma Melanoma Res. 5 67 68
53. TL Whiteside 2004 Down-regulation of ζ-chain expression in T cell: a biomarker of prognosis in cancer? Cancer Immunol Immunother. 53 865 878 (Pubitemid 39312654)
54. I Arany KG Grattendick SK Tyring 2002 Interleukin-10 induces transcription of the early promoter of human papillomavirus type 16 (HPV16) through the 5'-segment of the upstream regulatory region (URR) Antiviral Res. 55 331 339 (Pubitemid 34718132)
55. O Peralta-Zaragoza V Bermudez-Morales L Gutierrez-Xicotencatl J Alcocer-Gonzalez F Recillas-Targa V Madrid-Marina 2006 E6 and E7 oncoproteins from human papillomavirus type 16 induce activation of human transforming growth factor β1 promoter throughout Sp1 recognition sequence Viral Immunol. 19 468 480 (Pubitemid 44735059)
56. AS Kadish GY Ho RD Burk Y Wang SL Romney R Ledwidge RH Angeletti 1997 Lymphoproliferative responses to human papillomavirus (HPV) type 16 proteins E6 and E7: outcome of HPV infection and associated neoplasia J Natl Cancer Inst. 89 1285 1293 (Pubitemid 27371949)