Expression of CD3-ζ on T-cells in primary cervical carcinoma and in metastasis-positive and -negative pelvic lymph nodes

British Journal of Cancer

Volumn 79, Issue 7-8, 1999, Pages 1127-1132

  De Gruijl, T D ^a   Bontkes, H J ^a   Peccatori, F ^a,d   Gallee, M P W ^b   Helmerhorst, Th J M ^a   Verheijen, R H M ^a   Aarbiou, J ^a   Mulder, W M C ^a   Walboomers, J M M ^a   Meijer, C J L M ^a   Van De Vange, N ^c   Scheper, R J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

Author keywords

chain; Cervical carcinoma; Cervical dysplasia; T lymphocytes

Indexed keywords

CD3 ANTIGEN; CITRATE SODIUM; DIMER; MONOCLONAL ANTIBODY CD3;

ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MICROWAVE IRRADIATION; PELVIS LYMPH NODE; PRIORITY JOURNAL; T LYMPHOCYTE; UTERINE CERVIX CARCINOMA;

ADULT; AGED; ANTIGENS, CD3; CARCINOMA, SQUAMOUS CELL; DOWN-REGULATION; FEMALE; HUMANS; KILLER CELLS, NATURAL; LYMPH NODES; LYMPHOCYTES, TUMOR-INFILTRATING; MIDDLE AGED; T-LYMPHOCYTES; UTERINE CERVICAL NEOPLASMS;

EID: 0032984366     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690179     Document Type: Article

References (26)

1. Bontkes HJ, de Gruijl TD, Walboomers JMM, van den Muysenberg AJC, Gunther AW, Scheper RJ, Meijer CJLM and Kummer JA (1997) Assessment of cytotoxic T-lymphocyte phenotype using the specific markers granzyme B and TIA-1 in cervical neoplastic lesions. Br J Cancer 76: 1353-1360
2. Chouaib S, Asselin-Paturel C, Mami-Chouaib F, Caignard A and Blay JY (1997) The host-tumor immune conflict: from immunosuppression to resistance and destruction. Immunol Today 18: 493-497
3. Correa MR, Ochoa AC, Ghosh P, Mizoguchi H, Harvey L and Longo DL (1997) Sequential development of structural and functional alterations in T cells from tumor-bearing mice. J Immunol 158: 5292-5296
4. Cromme FV, Meijer CJLM, Snijders PJF, Uyterlinde A, Kenemans P, Helmerhorst T, Stern PL, Vandenbrule AJC and Walboomers JMM (1993) Analysis of MHC class-I and class-II expression in relation to presence of HPV genotypes in premalignant and malignant cervical lesions. Br J Cancer 67: 1372-1380
5. Cromme FV, Walboomers JMM, Stukart MJ, de Gruijl TD, Kummer JA, Leonhart AM, Helmerhorst TJM and Meijer CJLM (1995) Lack of granzyme expression in T lymphocytes indicates poor cytotoxic T lymphocyte activation in human papillomavirus-associated cervical carcinomas. Int J Gynecol Cancer 5: 366-373
6. de Gruijl TD, Bontkes HJ, Stukart MJ, Walboomers JMM. Remmink AJ, Verheijen RHM, Helmerhorst TJM, Meijer CJLM and Scheper RJ (1996a) T cell proliferative responses against human papillomavirus type 16 E7 oncoprotein are most prominent in cervical intraepithelial neoplasia patients with a persistent viral infection. J Gen Virol 77: 2183-2191
7. de Gruijl TD, Bontkes HJ, Walboomers JMM, Stukart MJ, Robbesom AAJP, von Blomberg-van der Flier BME, Herbrink P, Remmink AJ, Verheijen RHM, Helmerhorst TJM, Meijer CJLM and Scheper RJ (1996b) Analysis of IgG reactivity against human papillomavirus type-16 E7 in patients with cervical intraepithelial neoplasia indicates an association with clearance of viral infection: results of a prospective study. Int J Cancer 68: 731-738
8. Finke JH, Zea AH Longo DL, Mizoguchi H, Tubbs RR, Wiltrout RH, O'Shea JJ, Kudou S, Klein E, Bukowski RM and Ochoa A (1993) Loss of T-cell receptor zeta chain and P56lck in T-cells infiltrating human renal cell carcinoma. Cancer Res 53: 5613-5616
9. Frazer IH (1996) Immunology of papillomavirus infection. Curr Op Immunol 8: 484-491
10. IARC (1995) Monographs on the Evaluation of the Carcinogenic Risks to Humans, vol. 64, The Human Papillomavirus. International Agency for Research on Cancer: Lyon
11. Kiessling R, Kono K, Petersson M and Wasserman K (1996) Immunosuppression in human tumor-host interaction: role of cytokines and alterations in signal-transducing molecules. Springer Sem Immunopatol 18: 227-242
12. Kono K, Ressing ME, Brandt RMP, Melief CJM, Potkul RK, Andersson B, Petersson M, Kast WM and Kiessling R (1996a) Decreased expression of signal-transducing zeta chain in peripheral T cells and natural killer cells in patients with cervical cancer. Clin Cancer Res 2: 1825-1828
13. Kono K, Salazar-Onfray F, Petersson M, Hansson J, Masucci G, Wasserman K, Nakazawa T, Andersson P and Kiessling R (1996b) Hydrogen peroxide secreted by macrophages/monocytes inhibits tumor specific T-cell and NK mediated cytotoxicity and down-regulates expression expression of signal-transducing molecules. Eur J Immunol 26: 1308-1313
14. Lai P, Rabinowich H, Crowley-Nowick PA, Bell MC, Mantovani G and Whiteside TL (1996) Alterations in expression and function of signal-transducing proteins in tumour-associated T and natural killer cells in patienls with ovarian carcinoma. Clin Cancer Res 2: 161-173
15. Levey DL and Srivastava PK (1996) Alterations in T cells of cancer-bearers: whence specificity? Immunol Today 17: 365-368
16. Matsuda M, Petersson M, Lenkei R, Taupin J-L, Magnusson I, Mellstedt H, Andersson P and Kiessling R (1995) Alterations in the signal-transducing molecules of T cells and NK cells in colorectal tumor-infiltrating, gut mucosal and peripheral lymphocytes: correlation with the stage of the disease. Int J Cancer 61: 765-772
17. Matzinger P (1994) Tolerance, danger and the extended family. Annu Rev Immunol 12: 991-1045
18. Maurice MM, Lankester AC, Bezemer AC, Geertsma MF, Tak PP, Breedveld FC, van Lier RAW and Verweij CL (1998) Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis. J Immunol 159: 2973-2978
19. Mizoguchi H, O'Shea JJ, Longo DL, Loeffler CM, McVicar DW and Ochoa A (1992) Alterations in signal transduction molecules in T-lymphocytes from tumor bearing mice. Science 258: 1795-1798
20. Mulder WMC, Bloemena E, Stukart MJ, Kummer JA, Wagstaff J and Scheper RJ (1997) T cell receptor-zeta and granzyme B expression in mononuclear cell infiltrates in normal colon mucosa and colon carcinoma. Gut 40: 113-119
21. Nakagomi H, Petersson M, Magnusson I, Juhlin C, Matsuda M, Mellstedt H, Taupin J-L, Vivier E, Anderson P and Kiessling R (1993) Decreased expression of the signal-transducing zeta chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma. Cancer Res 53: 5610-5612
22. Robey E and Allison JP (1995) T-cell activation: integration of signals from the antigen receptor and costimulatory molecules. Immunol Today 16: 306-310
23. Rosenberg AS (1996) Development of cancer immunotherapies based on identification of the genes encoding cancer regression antigens. J Natl Cancer Inst 88: 1635-1644
24. Tartour E, Latour S, Mathiot C, Thiounn N, Mosseri V, Joyeux I, D'Enghien CD, Lee R, Derbre B and Fridman WH (1995) Variable expression of CD3-zeta chain in tumor-infiltrating lymphocytes (TIL) derived from renal-cell carcinoma: relationship with TIL phenotype and function. Int J Cancer 63: 205-212
25. Whiteside TL, Jost LM and Herbermann RB (1992) Tumor-infiltrating lymphocytes. Potential and limitations to their use for cancer therapy. Crit Rev Oncol Hematol 12: 25-47
26. Zea AH, Curti BD, Longo CD, Alvord WG, Srobl SL, Mizoguchi H, Creekmore SP, O'Shea JJ, Powers GC, Urba WJ and Ochoa AC (1995) Alteration in T cell receptor and signal transduction molecules in melanoma patients. Clin Cancer Res 1: 1327-1335