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Volumn 34, Issue 3, 2009, Pages 454-458

Toll-like receptor signalling induced by endurance exercise

Author keywords

Cytokines; Diabetes; Fatty acids; Insulin resistance; LPS; MAPK; NF B; Skeletal muscle; TLR2; TLR4

Indexed keywords

FATTY ACID; TOLL LIKE RECEPTOR;

EID: 67651208167     PISSN: 17155312     EISSN: None     Source Type: Journal    
DOI: 10.1139/H09-036     Document Type: Review
Times cited : (28)

References (38)
  • 1
    • 0242351615 scopus 로고    scopus 로고
    • Toll-like receptors and their signaling mechanisms
    • doi:10.1080/00365540310015683. PMID:14620134
    • Akira, S., and Sato, S. 2003. Toll-like receptors and their signaling mechanisms. Scand. J. Infect. Dis. 35: 555-562. doi:10.1080/00365540310015683. PMID:14620134.
    • (2003) Scand. J. Infect. Dis. , vol.35 , pp. 555-562
    • Akira, S.1    Sato, S.2
  • 3
    • 0037643536 scopus 로고    scopus 로고
    • Effects of free fatty acids (FFA) on glucose metabolism: significance for insulin resistance and type 2 diabetes
    • doi:10.1055/s-2003-39781. PMID:12784183
    • Boden, G. 2003. Effects of free fatty acids (FFA) on glucose metabolism: significance for insulin resistance and type 2 diabetes. Exp. Clin. Endocrinol. Diabetes, 111: 121-124. doi:10.1055/s-2003-39781. PMID:12784183.
    • (2003) Exp. Clin. Endocrinol. Diabetes , vol.111 , pp. 121-124
    • Boden,, G.1
  • 4
    • 33644667633 scopus 로고    scopus 로고
    • Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal muscle fat oxidative genes
    • doi:10.1152/ajpendo.00193.2005. PMID:16030063
    • Civitarese, A.E., Hesselink, M.K., Russell, A.P., Ravussin, E., and Schrauwen, P. 2005. Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal muscle fat oxidative genes. Am. J. Physiol. Endocrinol. Metab. 289: E1023-E1029. doi:10.1152/ajpendo.00193.2005. PMID:16030063.
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.289
    • Civitarese, A.E., Hesselink, M.K., Russell, A.P., Ravussin, E., and Schrauwen,, P.1
  • 5
    • 4344701247 scopus 로고    scopus 로고
    • The multi-dimensional regulation of gene expression by fatty acids: polyunsaturated fats as nutrient sensors
    • doi:10.1097/00041433-200402000-00004. PMID:15166803
    • Clarke, S.D. 2004. The multi-dimensional regulation of gene expression by fatty acids: polyunsaturated fats as nutrient sensors. Curr. Opin. Lipidol. 15: 13-18. doi:10.1097/00041433-200402000-00004. PMID:15166803.
    • (2004) Curr. Opin. Lipidol. , vol.15 , pp. 13-18
    • Clarke, S.D.1
  • 6
    • 33749842958 scopus 로고    scopus 로고
    • Toll-like receptor 4: link to the anti-inflammatory effects of exercise? Exerc
    • doi:10.1249/01.jes.0000240027.22749.14. PMID:17031256
    • Flynn, M.G., and McFarlin, B.K. 2006. Toll-like receptor 4: link to the anti-inflammatory effects of exercise? Exerc. Sport Sci. Rev. 34: 176-181. doi:10.1249/01.jes.0000240027.22749.14. PMID:17031256.
    • (2006) Sport Sci. Rev. , vol.34 , pp. 176-181
    • Flynn, M.G.1    McFarlin, B.K.2
  • 7
    • 0035127960 scopus 로고    scopus 로고
    • Resistance exercise decreases skeletal muscle tumor necrosis factor alpha in frail elderly humans
    • doi:10.1096/fj.00-0274com. PMID:11156963
    • Greiwe, J.S., Cheng, B., Rubin, D.C., Yarasheski, K.E., and Semenkovich, C.F. 2001. Resistance exercise decreases skeletal muscle tumor necrosis factor alpha in frail elderly humans. FASEB J. 15: 475-482. doi:10.1096/fj.00-0274com. PMID:11156963.
    • (2001) FASEB J. , vol.15 , pp. 475-482
    • Greiwe, J.S.1    Cheng, B.2    Rubin, D.C.3    Yarasheski, K.E.4    Semenkovich, C.F.5
  • 8
    • 0037153158 scopus 로고    scopus 로고
    • A central role for JNK in obesity and insulin resistance
    • doi:10.1038/nature01137. PMID:12447443
    • Hirosumi, J., Tuncman, G., Chang, L., Gorgun, C.Z., Uysal, K.T., Maeda, K., et al. 2002. A central role for JNK in obesity and insulin resistance. Nature, 420: 333-336. doi:10.1038/nature01137. PMID:12447443.
    • (2002) Nature , vol.420 , pp. 333-336
    • Hirosumi, J.1    Tuncman, G.2    Chang, L.3    Gorgun, C.Z.4    Uysal, K.T.5    Maeda, K.6
  • 9
    • 25444492611 scopus 로고    scopus 로고
    • Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle
    • doi:10.1152/ajpcell.00632.2004. PMID:15888549
    • Ho, R.C., Hirshman, M.F., Li, Y., Cai, D., Farmer, J.R., Aschenbach, W.G., et al. 2005. Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle. Am. J. Physiol. Cell Physiol. 289: C794-C801. doi:10.1152/ajpcell.00632.2004. PMID:15888549.
    • (2005) Am. J. Physiol. Cell Physiol. , vol.289
    • Ho, R.C.1    Hirshman, M.F.2    Li, Y.3    Cai, D.4    Farmer, J.R.5    Aschenbach, W.G.6
  • 10
    • 33644846005 scopus 로고    scopus 로고
    • Skeletal muscle lipid metabolism in exercise and insulin resistance
    • doi:10.1152/physrev.00023.2004. PMID:16371598
    • Kiens, B. 2006. Skeletal muscle lipid metabolism in exercise and insulin resistance. Physiol. Rev. 86: 205-243. doi:10.1152/physrev.00023.2004. PMID:16371598.
    • (2006) Physiol. Rev. , vol.86 , pp. 205-243
    • Kiens, B.1
  • 11
    • 3442878145 scopus 로고    scopus 로고
    • HSP60 induces self-tolerance to repeated HSP60 stimulation and cross-tolerance to other pro-inflammatory stimuli
    • doi:10. 1002/eji.200425108. PMID:15214052
    • Kilmartin, B., and Reen, D.J. 2004. HSP60 induces self-tolerance to repeated HSP60 stimulation and cross-tolerance to other pro-inflammatory stimuli. Eur. J. Immunol. 34: 2041-2051. doi:10. 1002/eji.200425108. PMID:15214052.
    • (2004) Eur. J. Immunol. , vol.34 , pp. 2041-2051
    • Kilmartin, B.1    Reen, D.J.2
  • 12
    • 33745822807 scopus 로고    scopus 로고
    • Interaction between signalling pathways involved in skeletal muscle responses to endurance exercise
    • doi:10.1007/s00424-005-0030-9. PMID:16437222
    • Koulmann, N., and Bigard, A.X. 2006. Interaction between signalling pathways involved in skeletal muscle responses to endurance exercise. Pflugers Arch. 452: 125-139. doi:10.1007/s00424-005-0030-9. PMID:16437222.
    • (2006) Pflugers Arch. , vol.452 , pp. 125-139
    • Koulmann, N.1    Bigard, A.X.2
  • 13
    • 53449090425 scopus 로고    scopus 로고
    • Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons
    • doi:10.1152/japplphysiol. 00006.2008. PMID:18535122
    • Lambert, C.P., Wright, N.R., Finck, B.N., and Villareal, D.T. 2008. Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons. J. Appl. Physiol. 105: 473-478. doi:10.1152/japplphysiol. 00006.2008. PMID:18535122.
    • (2008) J. Appl. Physiol. , vol.105 , pp. 473-478
    • Lambert, C.P.1    Wright, N.R.2    Finck, B.N.3    Villareal, D.T.4
  • 14
    • 0142064412 scopus 로고    scopus 로고
    • Endotoxin stimulates in vivo expression of inflammatory cytokines tumor necrosis factor alpha,interleukin-1beta, -6, and high-mobility-group protein-1 in skeletal muscle
    • doi:10.1097/01.shk.0000055237.25446.80. PMID:12785009
    • Lang, C.H., Silvis, C., Deshpande, N., Nystrom, G., and Frost, R.A. 2003. Endotoxin stimulates in vivo expression of inflammatory cytokines tumor necrosis factor alpha, interleukin-1beta, -6, and high-mobility-group protein-1 in skeletal muscle. Shock, 19: 538-546. doi:10.1097/01.shk.0000055237.25446.80. PMID:12785009.
    • (2003) Shock , vol.19 , pp. 538-546
    • Lang, C.H.1    Silvis, C.2    Deshpande, N.3    Nystrom, G.4    Frost, R.A.5
  • 15
    • 0038143617 scopus 로고    scopus 로고
    • Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids
    • doi:10. 1194/jlr.M200361-JLR200. PMID:12562875
    • Lee, J.Y., Plakidas, A., Lee, W.H., Heikkinen, A., Chanmugam, P., Bray, G., and Hwang, D.H. 2003. Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. J. Lipid Res. 44: 479-486. doi:10. 1194/jlr.M200361-JLR200. PMID:12562875.
    • (2003) J. Lipid Res. , vol.44 , pp. 479-486
    • Lee, J.Y.1    Plakidas, A.2    Lee, W.H.3    Heikkinen, A.4    Chanmugam, P.5    Bray, G.6    Hwang, D.H.7
  • 16
    • 2342435824 scopus 로고    scopus 로고
    • Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1
    • doi:10.1074/jbc.M312990200. PMID:14966134
    • Lee, J.Y., Zhao, L., Youn, H.S., Weatherill, A.R., Tapping, R., Feng, L., et al. 2004. Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. J. Biol. Chem. 279: 16971-16979. doi:10.1074/jbc.M312990200. PMID:14966134.
    • (2004) J. Biol. Chem. , vol.279 , pp. 16971-16979
    • Lee, J.Y.1    Zhao, L.2    Youn, H.S.3    Weatherill, A.R.4    Tapping, R.5    Feng, L.6
  • 17
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in
    • Cell doi:10.1016/S0092-8674(00)80172-5. PMID:8808632
    • Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J.M., and Hoffmann, J.A. 1996. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell, 86: 973-983. doi:10.1016/S0092-8674(00)80172-5. PMID:8808632.
    • (1996) Drosophila adults , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 18
    • 0035910470 scopus 로고    scopus 로고
    • A novel synthetic acyclic lipid A-like agonist activates cells via the lipopolysaccharide/toll-like receptor 4 signaling pathway
    • doi:10.1074/jbc.M009040200. PMID:11032843
    • Lien, E., Chow, J.C., Hawkins, L.D., McGuinness, P.D., Miyake, K., Espevik, T., et al. 2001. A novel synthetic acyclic lipid A-like agonist activates cells via the lipopolysaccharide/toll-like receptor 4 signaling pathway. J. Biol. Chem. 276: 1873-1880. doi:10.1074/jbc.M009040200. PMID:11032843.
    • (2001) J. Biol. Chem. , vol.276 , pp. 1873-1880
    • Lien, E.1    Chow, J.C.2    Hawkins, L.D.3    McGuinness, P.D.4    Miyake, K.5    Espevik, T.6
  • 19
    • 0034637439 scopus 로고    scopus 로고
    • The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes
    • doi:10. 1074/jbc.M002137200. PMID:10823826
    • Lin, Y., Lee, H., Berg, A.H., Lisanti, M.P., Shapiro, L., and Scherer, P.E. 2000. The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J. Biol. Chem. 275: 24255-24263. doi:10. 1074/jbc.M002137200. PMID:10823826.
    • (2000) J. Biol. Chem. , vol.275 , pp. 24255-24263
    • Lin, Y.1    Lee, H.2    Berg, A.H.3    Lisanti, M.P.4    Shapiro, L.5    Scherer, P.E.6
  • 20
    • 1542315579 scopus 로고    scopus 로고
    • Different skeletal muscle HSP70 responses to high-intensity strength training and low-intensity endurance training
    • doi:10.1007/s00421-003-0976-2. PMID:14595562
    • Liu, Y., Lormes, W., Wang, L., Reissnecker, S., and Steinacker, J.M. 2004. Different skeletal muscle HSP70 responses to high-intensity strength training and low-intensity endurance training. Eur. J. Appl. Physiol. 91: 330-335. doi:10.1007/s00421-003-0976-2. PMID:14595562.
    • (2004) Eur. J. Appl. Physiol. , vol.91 , pp. 330-335
    • Liu, Y.1    Lormes, W.2    Wang, L.3    Reissnecker, S.4    Steinacker, J.M.5
  • 21
    • 8144220343 scopus 로고    scopus 로고
    • TLR4 is lower in resistance-trained older women and related to inflammatory cytokines
    • doi:10.1249/01.MSS.0000145465.71269.10. PMID:15514501
    • McFarlin, B.K., Flynn, M.G., Campbell, W.W., Stewart, L.K., and Timmerman, K.L. 2004. TLR4 is lower in resistance-trained older women and related to inflammatory cytokines. Med. Sci. Sports Exerc. 36: 1876-1883. doi:10.1249/01.MSS.0000145465.71269.10. PMID:15514501.
    • (2004) Med. Sci. Sports Exerc. , vol.36 , pp. 1876-1883
    • McFarlin, B.K.1    Flynn, M.G.2    Campbell, W.W.3    Stewart, L.K.4    Timmerman, K.L.5
  • 22
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • doi:10. 1038/41131. PMID:9237759
    • Medzhitov, R., Preston-Hurlburt, P., and Janeway, C.A., Jr.
    • (1997) Nature , vol.388 , pp. 394-397
  • 23
    • 0034022263 scopus 로고    scopus 로고
    • Toll-like receptors
    • doi:10.1016/S1286-4579(00)00303-8. PMID:10758401
    • Muzio, M., and Mantovani, A. 2000. Toll-like receptors. Microbes Infect. 2: 251-255. doi:10.1016/S1286-4579(00)00303-8. PMID:10758401.
    • (2000) Microbes Infect. , vol.2 , pp. 251-255
    • Muzio, M.1    Mantovani, A.2
  • 25
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
    • doi:10.1126/science.282.5396.2085. PMID:9851930
    • Poltorak, A., He, X., Smirnova, I., Liu, M.Y., Van Huffel, C., Du, X., et al. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science, 282: 2085-2088. doi:10.1126/science.282.5396.2085. PMID:9851930.
    • (1998) Science , vol.282 , pp. 2085-2088
    • Poltorak, A.1    He, X.2    Smirnova, I.3    Liu, M.Y.4    Van Huffel, C.5    Du, X.6
  • 26
    • 37549013749 scopus 로고    scopus 로고
    • Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle
    • doi:10.1007/s00125-007-0861-3. PMID:18060381
    • Radin, M.S., Sinha, S., Bhatt, B.A., Dedousis, N., and O'Doherty, R.M. 2008. Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle. Diabetologia, 51: 336-346. doi:10.1007/s00125-007-0861-3. PMID:18060381.
    • (2008) Diabetologia , vol.51 , pp. 336-346
    • Radin, M.S.1    Sinha, S.2    Bhatt, B.A.3    Dedousis, N.4    O'Doherty, R.M.5
  • 27
    • 58149359307 scopus 로고    scopus 로고
    • Elevated Toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects
    • doi:10.2337/db08-0038. PMID:18633101
    • Reyna, S.M., Ghosh, S., Tantiwong, P., Meka, C.S., Eagan, P., Jenkinson, C.P., et al. 2008. Elevated Toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects. Diabetes, 57: 2595-2602. doi:10.2337/db08-0038. PMID:18633101.
    • (2008) Diabetes , vol.57 , pp. 2595-2602
    • Reyna, S.M.1    Ghosh, S.2    Tantiwong, P.3    Meka, C.S.4    Eagan, P.5    Jenkinson, C.P.6
  • 28
    • 33748755008 scopus 로고    scopus 로고
    • Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes
    • doi:10.1074/jbc.M513304200. PMID:16798732
    • Senn, J.J. 2006. Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes. J. Biol. Chem. 281: 26865-26875. doi:10.1074/jbc.M513304200. PMID:16798732.
    • (2006) J. Biol. Chem. , vol.281 , pp. 26865-26875
    • Senn, J.J.1
  • 29
    • 33750584214 scopus 로고    scopus 로고
    • TLR4 links innate immunity and fatty acid-induced insulin resistance
    • doi:10.1172/JCI28898. PMID:17053832
    • Shi, H., Kokoeva, M.V., Inouye, K., Tzameli, I., Yin, H., and Flier, J.S. 2006. TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 116: 3015-3025. doi:10.1172/JCI28898. PMID:17053832.
    • (2006) J. Clin. Invest. , vol.116 , pp. 3015-3025
    • Shi, H.1    Kokoeva, M.V.2    Inouye, K.3    Tzameli, I.4    Yin, H.5    Flier, J.S.6
  • 30
    • 17944380799 scopus 로고    scopus 로고
    • Up-regulation of uncoupling protein 3 gene expression by fatty acids and agonists for PPARs in L6 myotubes
    • doi:10.1210/en.142.10.4189. PMID:11564673
    • Son, C., Hosoda, K., Matsuda, J., Fujikura, J., Yonemitsu, S., Iwakura, H., et al. 2001. Up-regulation of uncoupling protein 3 gene expression by fatty acids and agonists for PPARs in L6 myotubes. Endocrinology, 142: 4189-4194. doi:10.1210/en.142.10.4189. PMID:11564673.
    • (2001) Endocrinology , vol.142 , pp. 4189-4194
    • Son, C.1    Hosoda, K.2    Matsuda, J.3    Fujikura, J.4    Yonemitsu, S.5    Iwakura, H.6
  • 31
    • 0034101795 scopus 로고    scopus 로고
    • Adipose tissue lipolysis is increased during a repeated bout of aerobic exercise
    • PMID:10749819
    • Stich, V., de Glisezinski, I., Berlan, M., Bulow, J., Galitzky, J., Harant, I., et al. 2000. Adipose tissue lipolysis is increased during a repeated bout of aerobic exercise. J. Appl. Physiol. 88: 1277-1283. PMID:10749819.
    • (2000) J. Appl. Physiol. , vol.88 , pp. 1277-1283
    • Stich, V.1    de Glisezinski, I.2    Berlan, M.3    Bulow, J.4    Galitzky, J.5    Harant, I.6
  • 32
    • 0034922923 scopus 로고    scopus 로고
    • Discrimination of bacterial lipoproteins by Toll-like receptor 6
    • doi:10. 1093/intimm/13.7.933. PMID:11431423
    • Takeuchi, O., Kawai, T., Muhlradt, P.F., Morr, M., Radolf, J.D., Zychlinsky, A., et al. 2001. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int. Immunol. 13: 933-940. doi:10. 1093/intimm/13.7.933. PMID:11431423.
    • (2001) Int. Immunol. , vol.13 , pp. 933-940
    • Takeuchi, O.1    Kawai, T.2    Muhlradt, P.F.3    Morr, M.4    Radolf, J.D.5    Zychlinsky, A.6
  • 33
    • 0036644042 scopus 로고    scopus 로고
    • Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
    • PMID:12077222
    • Takeuchi, O., Sato, S., Horiuchi, T., Hoshino, K., Takeda, K., Dong, Z., et al. 2002. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 169: 10-14. PMID:12077222.
    • (2002) J. Immunol. , vol.169 , pp. 10-14
    • Takeuchi, O.1    Sato, S.2    Horiuchi, T.3    Hoshino, K.4    Takeda, K.5    Dong, Z.6
  • 34
    • 20444452139 scopus 로고    scopus 로고
    • Effect of elevated lipid concentrations on human skeletal muscle gene expression
    • doi:10.1016/j.metabol.2005.02.012. PMID:15988707
    • Tunstall, R.J., and Cameron-Smith, D. 2005. Effect of elevated lipid concentrations on human skeletal muscle gene expression. Metabolism, 54: 952-959. doi:10.1016/j.metabol.2005.02.012. PMID:15988707.
    • (2005) Metabolism , vol.54 , pp. 952-959
    • Tunstall, R.J.1    Cameron-Smith, D.2
  • 35
    • 34247241629 scopus 로고    scopus 로고
    • Reduced plasma free fatty acid availability during exercise: effect on gene expression
    • doi:10.1007/s00421-006-0376-5. PMID:17186295
    • Tunstall, R.J., McAinch, A.J., Hargreaves, M., van Loon, L.J., and Cameron-Smith, D. 2007. Reduced plasma free fatty acid availability during exercise: effect on gene expression. Eur. J. Appl. Physiol. 99: 485-493. doi:10.1007/s00421-006-0376-5. PMID:17186295.
    • (2007) Eur. J. Appl. Physiol. , vol.99 , pp. 485-493
    • Tunstall, R.J.1    McAinch, A.J.2    Hargreaves, M.3    van Loon, L.J.4    Cameron-Smith, D.5
  • 36
    • 33751172758 scopus 로고    scopus 로고
    • Recognition and signaling by Toll-like receptors
    • doi:10.1146/annurev.cellbio.21.122303.115827. PMID:16822173
    • West, A.P., Koblansky, A.A., and Ghosh, S. 2006. Recognition and signaling by Toll-like receptors. Annu. Rev. Cell Dev. Biol. 22: 409-437. doi:10.1146/annurev.cellbio.21.122303.115827. PMID:16822173.
    • (2006) Annu. Rev. Cell Dev. Biol. , vol.22 , pp. 409-437
    • West, A.P.1    Koblansky, A.A.2    Ghosh, S.3
  • 37
    • 0038664380 scopus 로고    scopus 로고
    • The role of Toll-like receptor 2 in microbial disease and immunity
    • doi:10. 1016/S0264-410X(03)00201-9. PMID:12763684
    • Wetzler, L.M. 2003. The role of Toll-like receptor 2 in microbial disease and immunity. Vaccine, 21(Suppl 2): S55-S60. doi:10. 1016/S0264-410X(03)00201-9. PMID:12763684.
    • (2003) Vaccine , vol.21 , Issue.SUPPL. 2
    • Wetzler, L.M.1
  • 38
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta.
    • doi:10.1126/science.1061620. PMID:11533494
    • Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.W., Karin, M., and Shoelson, S.E. 2001. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science, 293: 1673-1677. doi:10.1126/science.1061620. PMID:11533494.
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.W.5    Karin, M.6    Shoelson, S.E.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.