Adipose tissue lipolysis is increased during a repeated bout of aerobic exercise

Journal of Applied Physiology

Volumn 88, Issue 4, 2000, Pages 1277-1283

  Stich, V ^a   De Glisezinski, I ^b   Berlan, M ^c   Bulow, J ^d   Galitzky, J ^c   Harant, I ^b   Suljkovicova, H ^a   Lafontan, M ^c   Riviere D ^b   Crampes, F ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b CHU PURPAN   (France)

^c INSERM   (France)

^d BISPEBJERG HOSPITAL   (Denmark)

Author keywords

Epinephrine; Growth hormone; Microdialysis; Norepinephrine

Indexed keywords

ADRENALIN; CATECHOLAMINE; FATTY ACID; GLUCOSE; GLYCEROL; GROWTH HORMONE; HYDROCORTISONE; INSULIN; LACTIC ACID; NORADRENALIN;

ADIPOSE TISSUE; ADRENALIN BLOOD LEVEL; ADULT; ARTICLE; CATECHOLAMINE BLOOD LEVEL; EXERCISE; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLYCEROL BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; INSULIN BLOOD LEVEL; LACTATE BLOOD LEVEL; LIPID METABOLISM; LIPOLYSIS; MALE; MICRODIALYSIS; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0034101795     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.88.4.1277     Document Type: Article

References (39)

1. Arner P, Kriegholm E, Engfeldt P, and Bolinder J. Adrenergic regulation of lipolysis in situ at rest and during exercise. J Clin Invest 85: 893-898, 1990.
2. 3-adrenoceptors in the control of lipolysis and nutritive blood flow in human subcutaneous adipose tissue. Br J Pharmacol 117: 907-913, 1996.
3. Barbe P, Stich V, Galitzky J, Kunesova M, Hainer V, Lafontan M, and Berlan M. In vivo increase in β-adrenergic lipolytic response in subcutaneous adipose tissue of obese subjects submitted to a hypocaloric diet. J Clin Endocrinol Metab 82: 63-69, 1997.
4. Bergman BC, Butterfiled GE, Wolfel EE, Casazza GA, Lopaschuk GD, and Brooks GA. Evaluation of exercise and training on muscle lipid metabolism. Am J Physiol Endocrinol Metab 276: E106-E117, 1999.
5. Bernst E and Gutmann I. Determination of ethanol with alcohol dehydrogenase and NAD. In: Methods of Enzymatic Analysis, edited by Bergmeyer HU. New York: Academic, 1974, p. 1499-1505.
6. Blomstrand E and Saltin B. Effect of muscle glycogen on glucose, lactate and amino acid metabolism during exercise and recovery in human subjects. J Physiol (Lond) 514: 293-302, 1999.
7. Bradley DC and Kaslow HR, Radiometric assays for glycerol, glucose and glycogen. Anal Biochem 180: 11-16, 1989.
8. Brooks GA and Mercier J. Balance of carbohydrates and lipid utilization during exercise: the crossover concept. J Appl Physiol 76: 2253-2261, 1994.
9. Bülow J. Adipose blood flow during exercise. Dan Med Bull 30: 85-100, 1983.
10. Bülow J, Jelnes R, Astrup A, Madsen J, and Vilman P. Tissue/blood partition coefficients for xenon in various adipose tissue depots in man. Scand J Clin Lab Invest 41: 1-3, 1987.
11. Casanueva F, Villanueva L, Penalva A, Vila T, and Cabezas-Cerrato J. Free fatty acid of exercise-induced growth hormone secretion. Harm Metab Res 13:348-350, 1981.
12. De Glisezinski I, Harant I, Crampes F, Trudeau F, Felez A, Cottet-Émard JM, Garrigues M, and Riviere D. Effect of carbohydrate ingestion on adipose tissue lipolysis during long-lasting exercise in trained men. J Appl Physiol 84: 1627-1632, 1998.
13. Eisele R, Hannig M, Bremer J, Zimmermann E, and Simon G. Energy supply during cycle endurance exercise after carbohydrate-exhausting preload (Abstract). Int J Sports Med 2: S125, 1996.
14. Enocksson S, Nordenstrom J, Bolinder J, and Arner P. Influence of local blood flow on glycerol levels in human adipose tissue. Int J Obes 19: 350-354, 1995.
15. Felländer G, Linde B, and Bollinder J. Evaluation of the microdialysis ethanol technique for monitoring of subcutaneous adipose tissue blood flow in humans. Int J Obes 20: 220-226, 1996.
16. Frayn K. Fat as fuel for exercise. In: Nutrition and Fitness: Metabolic and Behavioral Aspects in Health And Disease, edited by SimopoulosAP and Pavlou KN. Basel: Karger, 1997, p. 46-62.
17. Galbo H. Hormonal and Metabolic Adaptations to Exercise. Stuttgart, Germany: Thieme, 1983.
18. Galbo H, Christensen NJ, and Holst JJ. Glucose induced decrease in glucagon and epinephrine responses to exercise in man. J Appl Physiol 42: 525-530, 1977.
19. Galbo H, Holst JJ, and Christensen NJ. The effect of different diets and of insulin on the hormonal response to prolonged exercise. Acta Physiol Scand 107: 19-32, 1979.
20. Harant I, Beauville M, Crampes F, Riviere D, Tauber MT, Tauber JP, and Garrigues M. Response of fat cells to growth hormone (GH): effect of long term treatment with recombinant human GH in GH-deficient adults. J Clin Endocrinol Metab 78: 1392-1395, 1994.
21. Hirsch IB, Marker JC, Smith LJ, Spina R, Parvin CA, Holloszy JO, and Cryer PE. Insulin and glucagon in prevention of hypoglycemia during exercise in humans. Am J Physiol Endocrinol Metab 260: E695-E704, 1991.
22. Jansson E and Kaijser L. Effect of diet on the utilization of blood borne and intramuscular substrates during exercise in man. Acta Physiol Scand 115: 19-30, 1982.
23. Jarhult J and Holst J. The role of the adrenergic innervation to the pancreatic islets in the control of insulin release during exercise in man. Pflugers Arch 383: 41-45, 1979.
24. Kanaley JA, Weatherup-Dentes MM, Jaynes EM, and Hartman ML. Obesity supresses the GH response to exercise (Abstract). Med Sci Sports Exerc 30, Suppl 5: S49, 1998.
25. Kanaley JA, Weltman JY, Veldhuis JD, Rogol AD, Hartman ML, and Weltman A. Human growth hormone response to repeated bouts of aerobic exercise. J Appl Physiol 83: 1756-1761, 1997.
26. Kempen KPG, Saris WHM, Senden JMG, Menheere PPCA, Blaak EE, and Van Baak MA. Effect of energy restriction on acute adrenoceptor and metabolic responses to exercise in obese subjects. Am J Physiol Endocrinol Metab 267: E694-E701, 1994.
27. Kjaer M, Secher NH, and Galbo H. Physical stress and catecholamine release. Baillieres Clin Endocinol Metab 1: 279-298, 1987.
28. Klein S, Coyle EF, and Wolfe RR. Fat metabolism during low-intensity exercise in endurance-trained and untrained men. Am J Physiol Endocrinol Metab 267: E934-E940, 1994.
29. Klein S, Coyle EF, and Wolfe RR. Effect of exercise on lipolytic sensitivity in endurance trained athletes. J Appl Physiol 78: 2201-2206, 1995.
30. MacLaren DP, Reuilly T, Campbell IT, and Hopkins C. Hormonal and metabolic responses to maintained hyperglycemia during prolonged exercise. J Appl Physiol 87: 124-131, 1999.
31. Maggs DG, Jacobs R, Rife F, Caprio S, Tamborlane WV, and Sherwin RS. Counterregulation in peripheral tissues. Effect of systemic hypoglycemia on levels of substrates and catecholamines in human skeletal muscle and adipose tissue. Diabetes 46: 70-76, 1997.
32. Millet L, Barbe P, Lafontan M, Berlan M, and Galitzky J. Catecholamine effects on lipolysis and blood flow in human abdominal and femoral adipose. J Appl Physiol 85: 148-157, 1998.
33. Moller N, Jorgensen JOL, Schmitz O, Moller J, Christiansen JS, Alberti KGMM, and Orskov H. Effects of growth hormone pulse on total and forearm substrate fluxes in humans. Am J Physiol Endocrinol Metab 258: E86-E91, 1990.
34. Romijn JA, Coyle EF, Sidossis LS, Gastaledelli A, Horowitz JF, Endert E, and Wolfe RR. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Physiol Endocrinol Metab 265: E380-E391, 1993.
35. Stallknecht B, Bülow J, Frandsen E, and Galbo H. Desensitization of human adipose tissue to epinephrine stimulation studied by microdialysis. J Physiol (Lond) 500: 271-282, 1997.
36. Wahrenberg H, Engfeldt P, Bounder J, and Arner P. Acute adaptation in adrenergic control of lipolysis during physical exercise hi humans. Am J Physiol Endocrinol Metab 253: E383-E390, 1987.
37. Wassermann DH, Lacy DB, Goldstein RE, Williams PE, and Cherrington AD. Exercise induced fall in insulin and the increase in fat metabolism during prolonged exercise. Diabetes 38: 484-490, 1989.
38. Weltan SM, Bosch AN, Dennis SC, and Noakes TD. Preexercise muscle glycogen content affects metabolism during exercise despite maintenance of hyperglycemia. Am J Physiol Endocrinol Metab 274: E83-E88, 1998.
39. Weltman A, Weltman JY, Kanaley JA, Rogol AD, Veldhius JD, and Hartman ML. Repeated bouts of exercise alter the blood lactate-RPE relation. Med Sci Sports Exerc 30: 1113-1117, 1998.