Chiral gossypol derivatives: Evaluation of their anticancer activity and molecular modeling

European Journal of Medicinal Chemistry

Volumn 44, Issue 10, 2009, Pages 3961-3972

  Zhang, Long ^a   Jiang, Haixia ^b   Cao, Xingxin ^b   Zhao, Huiyun ^a   Wang, Fan ^a   Cui, Yuxin ^a   Jiang, Biao ^b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

Chemical modification; Chiral gossypol; Cytotoxicity; Schiff bases; Structure activity relationships

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; GOSSYPOL BIS(3 AMINO 1 PROPANOL) SCHIFF BASE; GOSSYPOL BIS(TYROSINE METHYL ESTER) SCHIFF BASE; GOSSYPOL BIS[2 AMINO 1 (4 NITROPHENYL)PROPANE 1,3 DIOL] SCHIFF BASE; GOSSYPOL DERIVATIVE; PROTEIN BCL 2; SCHIFF BASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN; CONTROLLED STUDY; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; HELA CELL; HUMAN; HUMAN CELL; IC 50; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; GOSSYPOL; HELA CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2; SCHIFF BASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67651180554     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.04.025     Document Type: Article

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