Impaired JAK-STAT signal transduction contributes to growth hormone resistance in chronic uremia

Journal of Clinical Investigation

Volumn 108, Issue 3, 2001, Pages 467-475

  Schaefer, Franz ^a,b   Chen, Yu ^a   Tsao, Tanny ^a   Nouri, Pouneh ^a   Rabkin, Ralph ^a,c  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; JANUS KINASE; MESSENGER RNA; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN C; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; SUPPRESSOR FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC DISEASE; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; HORMONE RESISTANCE; LIVER MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UREMIA; WEIGHT GAIN;

EID: 0034908363     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI11895     Document Type: Article

References (48)

1. Endocrine and growth disorders
2. Improvement of growth and food utilization by human recombinant growth hormone in uremia
3. Expression of insulin-like growth factor-1 in uremic rats: Growth hormone resistance and nutritional intake
4. Reduced hepatic growth hormone (GH) receptor gene expression and increase in plasma GH binding protein in experimental uremia
5. Decreased hepatic insulin-like growth factor (IGF)I and increased IGF binding protein-1 and -2 gene expression in experimental uremia
6. Serum insulinlike growth factors (IGFs) and IGF binding proteins 1,2 and 3 in children with chronic renal failure: Relationship to height and glomerular filtration rate
7. Impaired actions of insulin-like growth factor 1 on protein synthesis and degradation in skeletal muscle of rats with chronic renal failure. Evidence for a postreceptor defect
8. Effect of prolonged uremia on insulin-like growth I autophosphorylation and tyrosine kinase activity in muscle
9. Reduced food intake is the main cause of low growth hormone receptor expression in uremic rats
10. Role of the tyrosine kinase JAK2 in signal transduction by growth hormone
11. Negative regulation of cytokine signaling pathways
12. SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms
13. Growth hormone regulation of SOCS-2, SOCS-3, and CIS messenger ribonucleic acid expression in the rat
14. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
15. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
16. Gigantism in mice lacking suppressor of cytokine signaling-2
17. Stimulation of supranormal growth in prepubertal, adult plateaued, and hypophysectomized female rats by large doses of rat growth hormone: Physiological effects and adverse consequences
18. Endotoxin-induced inhibition of growth hormone receptor signaling in rat liver in vivo
19. Impaired secretion of growth hormone in experimental uremia: Relevance of caloric deficiency
20. Binding of human growth hormone to rat liver membrane lactogenic and somatotropic sites
21. Preparation of rat liver plasma membranes in a high yield
22. Isolation of rat liver plasma membranes. Use of nucleotide pyrophosphatase and phosphodiesterase I as marker enzymes
23. Response of the intrarenal insulin-like growth factor I axis to acute ischemic injury and treatment with growth hormone and epidermal growth factor
24. Mouse serum growth hormone (GH) binding protein has GH receptor extracellular and substituted transmembrane domains
25. Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2,-3,-4,-5 and -6)
26. Distribution and regulation of rat insulin-like growth factor 1 messenger ribonucleic acids encoding alternative carboxyterminal E-peptides: Evidence for differential processing and regulation in liver
27. The human 18S ribosomal RNA gene: Evolution and stability
28. Evidence from the use of monoclonal antibody probes for structural heterogeneity of the growth hormone receptor
29. Hepatic exression of growth hormone receptor/binding protein and insulin-like growth factor I genes in uremic rats. Influence of nutritional deficit
30. Lactogenic and somatotropic binding sites in liver membranes of rats with renal insufficiency
31. Growth hormone receptor abundance in ribial growth plates of uremic rats: GH/IGF-I treatment
32. Reduced concentration of serum growth hormone-binding protein in children with chronic renal failure: Correlation with GH insensitivity
33. Modulation of growth factors by growth hormone in children with chronic renal failure
34. Rapid changes in gene expression after in vivo growth hormone treatment
35. Acute nuclear actions of growth hormone (GH): Cycloheximide inhibits inducible activator protein-1 activity, but does not block GH-regulated signal transducer and activator of transcription activation or gene expression
36. Growth hormone-mediated regulation of insulin-like growth factor I promoter activity in C6 glioma cells
37. Growth hormone induces insulin-like growth factor-I gene transcription by a synergistic action of STAT5 and HNF-1 alpha
38. Growth hormone suppression of insulin-like growth factor binding protein-1 promoter activity
39. In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3
40. Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice
41. Differential expression of suppressors of cytokine signaling genes in response to nutrition and growth hormone in the septic rat
42. Signaling mechanisms of cytokine receptors and their perturbances in disease
43. Regulation of expression of the rat SOCS-3 gene in hepatocytes by growth hormone, interleukin-6 and glucocorticoids mRNA analysis and promoter characterization
44. Inhibition of growth hormone action in models of inflammation
45. Potentiation of growth hormone-induced liver suppressors of cytokine signaling messenger ribonucleic acid by cytokines
46. Role of the Suppressor of Cytokine Signaling-3 in mediating the inhibitory effects of interleukin-1 beta on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells
47. Inflammation, nutritional state and outcome in end stage renal disease
48. SH2-B and SIRP: JAK2 binding proteins that modulate the actions of growth hormone