In vivo regulation of growth hormone-stimulated gene transcription by STAT5b

American Journal of Physiology - Endocrinology and Metabolism

Volumn 286, Issue 3 49-3, 2004, Pages

  Woelfle, Joachim ^a   Rotwein, Peter ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Insulin like growth factor I; Signal transducers and activators of transcription; Suppressors of cytokine signaling

Indexed keywords

ACID LABILE SUBUNIT; ADENOVIRUS VECTOR; CYTOKINE INDUCED SH2 PROTEIN; GROWTH HORMONE; MUTANT PROTEIN; PROTEIN SH2; PROTEIN SUBUNIT; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT5B PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 2; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY GROWTH; CONTROLLED STUDY; FEEDBACK SYSTEM; GENE ACTIVATION; GENE EXPRESSION; GENE TRANSFER; HYPOPITUITARISM; IN VIVO STUDY; MALE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 1442300760     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00389.2003     Document Type: Article

References (40)

1. Adams TE, Hansen JA, Starr R, Nicola NA, Hilton DJ, and Billestrup N. Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling. J Biol Chem 273: 1285-1287, 1998.
2. Bichell DP, Kikuchi K, and Rotwein P. Growth hormone rapidly activates insulin-like growth factor I gene transcription in vivo. Mol Endocrinol 6: 1899-1908, 1992.
3. Daughaday WH and Rotwein P. Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocr Rev 10: 68-91, 1989.
4. Davey HW, McLachlan MJ, Wilkins RJ, Hilton DJ, and Adams TE. STAT5b mediates the GH-induced expression of SOCS-2 and SOCS-3 mRNA in the liver. Mol Cell Endocrinol 158: 111-116, 1999.
5. D'Ercole AJ, Stiles AD, and Underwood LE. Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action. Proc Natl Acad Sci USA 81: 935-939, 1984.
6. Gosteli-Peter MA, Winterhalter KH, Schmid C, Froesch ER, and Zapf J. Expression and regulation of insulin-like growth factor-I (IGF-I) and IGF-binding protein messenger ribonucleic acid levels in tissues of hypophysectomized rats infused with IGF-I and growth hormone. Endocrinology 135: 2558-2567, 1994.
7. Gronowski AM, Le Stunff C, and Rotwein P. Acute nuclear actions of growth hormone (GH): cycloheximide inhibits inducible activator protein-1 activity, but does not block GH-regulated signal transducer and activator of transcription activation or gene expression. Endocrinology 137: 55-64, 1996.
8. Gronowski AM and Rotwein P. Rapid changes in nuclear protein tyrosine phosphorylation after growth hormone treatment in vivo. Identification of phosphorylated mitogen-activated protein kinase and STAT91. J Biol Chem 269: 7874-7878, 1994.
9. Gronowski AM and Rotwein P. Rapid changes in gene expression after in vivo growth hormone treatment. Endocrinology 136: 4741-4748, 1995.
10. Gronowski AM, Zhong Z, Wen Z, Thomas MJ, Darnell JEJ, and Rotwein P. In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3. Mol Endocrinol 9: 171-177, 1995.
11. Gucev ZS, Oh Y, Kelley KM, Labarta JI, Vorwerk P, and Rosenfeld RG. Evidence for insulin-like growth factor (IGF)-independent transcriptional regulation of IGF binding protein-3 by growth hormone in SKHEP-1 human hepatocarcinoma cells. Endocrinology 138: 1464-1470, 1997.
12. Guler HP, Zapf J, Scheiwiller E, and Froesch ER. Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats. Proc Natl Acad Sci USA 85: 4889-4893, 1988.
13. Herrington J and Carter-Su C. Signaling pathways activated by the growth hormone receptor. Trends Endocrinol Metab 12: 252-257, 2001.
14. Horvath CM. STAT proteins and transcriptional responses to extracellular signals. Trends Biochem Sci 25: 496-502, 2000.
15. Hynes MA, Van Wyk JJ, Brooks PJ, D'Ercole AJ, Jansen M, and Lund PK. Growth hormone dependence of somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II messenger ribonucleic acids. Mol Endocrinol 1: 233-242, 1987.
16. Jones JI and Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 16: 3-34, 1995.
17. Jones WK, Yu-Lee LY, Clift SM, Brown TL, and Rosen JM. The rat casein multigene family. Fine structure and evolution of the beta-casein gene. J Biol Chem 260: 7042-7050, 1985.
18. Krebs DL and Hilton DJ. SOCS: physiological suppressors of cytokine signaling. J Cell Sci 113: 2813-2819, 2000.
19. Kriwacki RW, Schultz SC, Steitz TA, and Caradonna JP. Sequence-specific recognition of DNA by zinc-finger peptides derived from the transcription factor Sp1. Proc Natl Acad Sci USA 89: 9759-9763, 1992.
20. Le Roith D, Bondy C, Yakar S, Liu JL, and Butler A. The somatomedin hypothesis: 2001. Endocr Rev 22: 53-74, 2001.
21. Lupu F, Terwilliger JD, Lee K, Segre GV, and Efstratiadis A. Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. Dev Biol 229: 141-162, 2001.
22. Meton I, Boot EP, Sussenbach JS, and Steenbergh PH. Growth hormone induces insulin-like growth factor-I gene transcription by a synergistic action of STAT5 and HNF-1alpha. FEBS Lett 444: 155-159, 1999.
23. Murphy LJ, Bell GI, Duckworth ML, and Friesen HG. Identification, characterization, and regulation of a rat complementary deoxyribonucleic acid which encodes insulin-like growth factor-I. Endocrinology 121: 684-691, 1987.
24. Ooi GT, Cohen FJ, Tseng LY, Rechler MM, and Boisclair YR. Growth hormone stimulates transcription of the gene encoding the acid-labile subunit (ALS) of the circulating insulin-like growth factor-binding protein complex and ALS promoter activity in rat liver. Mol Endocrinol 11: 997-1007, 1997.
25. Ooi GT, Hurst KR, Poy MN, Rechler MM, and Boisclair YR. Binding of STAT5a and STAT5b to a single element resembling a gamma-interferon-activated sequence mediates the growth hormone induction of the mouse acid-labile subunit promoter in liver cells. Mol Endocrinol 12: 675-687, 1998.
26. Paul C, Seiliez I, Thissen JP, and Le Cam A. Regulation of expression of the rat SOCS-3 gene in hepatocytes by growth hormone, interleukin-6 and glucocorticoids mRNA analysis and promoter characterization. Eur J Biochem 267: 5849-5857, 2000.
27. Ram PA, Park SH, Choi HK, and Waxman DJ. Growth hormone activation of Stat 1, Stat 3, and Stat 5 in rat liver. Differential kinetics of hormone desensitization and growth hormone stimulation of both tyrosine phosphorylation and serine/threonine phosphorylation. J Biol Chem 271: 5929-5940, 1996.
28. Ribaux P, Gjinovci A, Sadowski HB, and Iynedjian PB. Discrimination between signaling pathways in regulation of specific gene expression by insulin and growth hormone in hepatocytes. Endocrinology 143: 3766-3772, 2002.
29. Rosenfeld MG. POU-domain transcription factors: pou-er-ful developmental regulators. Genes Dev 5: 897-907, 1991.
30. Schoenle E, Zapf J, Humbel RE, and Froesch ER. Insulin-like growth factor I stimulates growth in hypophysectomized rats. Nature 296: 252-253, 1982.
31. Sims NA, Clement-Lacroix P, Da Ponte F, Bouali Y, Binart N, Moriggl R, Goffin V, Coschigano K, Gaillard-Kelly M, Kopchick J, Baron R, and Kelly PA. Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5. J Clin Invest 106: 1095-1103, 2000.
32. Smit LS, Meyer DJ, Billestrup N, Norstedt G, Schwartz J, and Carter-Su C. The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH. Mol Endocrinol 10: 519-533, 1996.
33. Teglund S, McKay C, Schuetz E, van Deursen JM, Stravopodis D, Wang D, Brown M, Bodner S, Grosveld G, and Ihle JN. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93: 841-850, 1998.
34. Thomas MJ, Gronowski AM, Berry SA, Bergad PL, and Rotwein P. Growth hormone rapidly activates rat serine protease inhibitor 2.1 gene transcription and induces a DNA-binding activity distinct from those of Statl, -3, and -4. Mol Cell Biol 15: 12-18, 1995.
35. Tollet-Egnell P, Flores-Morales A, Stavreus-Evers A, Sahlin L, and Norstedt G. Growth hormone regulation of SOCS-2, SOCS-3, and CIS messenger ribonucleic acid expression in the rat. Endocrinology 140: 3693-3704, 1999.
36. Udy GB, Towers RP, Snell RG, Wilkins RJ, Park SH, Ram PA, Waxman DJ, and Davey HW. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc Natl Acad Sci USA 94: 7239-7244, 1997.
37. Umayahara Y, Billiard J, Ji C, Centrella M, McCarthy TL, and Rotwein P. CCAAT/enhancer-binding protein delta is a critical regulator of insulin-like growth factor-I gene transcription in osteoblasts. J Biol Chem 274: 10609-10617, 1999.
38. Woelfle J, Billiard J, and Rotwein P. Acute control of insulin-like growth factor-1 gene transcription by growth hormone through STAT5B. J Biol Chem 278: 22696-22702, 2003.
39. Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell CL, Wu Y, Liu JL, Ooi GT, Setser J, Frystyk J, Boisclair YR, and LeRoith D. Circulating levels of IGF-1 directly regulate bone growth and density. J Clin Invest 110: 771-781, 2002.
40. Yoon JB, Berry SA, Seelig S, and Towle HC. An inducible nuclear factor binds to a growth hormone-regulated gene. J Biol Chem 265: 19947-19954, 1990.