N-MYC promotes cell proliferation through a direct transactivation of neuronal leucine-rich repeat protein-1 (NLRR1) gene in neuroblastoma

Oncogene

Volumn 27, Issue 46, 2008, Pages 6075-6082

  Hossain, M S ^a,b   Ozaki, T ^a,b   Wang, H ^a,c   Nakagawa, A ^d   Takenobu, H ^a   Ohira, M ^a   Kamijo, T ^a   Nakagawara, A ^a,b  

^a CHIBA CANCER CENTER   (Japan)

^b CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c CHINA MEDICAL UNIVERSITY   (China)

^d NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

c myc; N MYC; Neuroblastoma; NLRR1; Proliferation; Transactivation

Indexed keywords

GENE PRODUCT; SMALL INTERFERING RNA;

ARTICLE; CANCER GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; E BOX ELEMENT; FEMALE; GENE; GENE AMPLIFICATION; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRON; NEUROBLASTOMA; NEURONAL LEUCINE RICH REPEAT PROTEIN 1 GENE; ONCOGENE C MYB; PRIORITY JOURNAL; TRANSACTIVATION;

APOPTOSIS; CELL PROLIFERATION; CULTURE MEDIA, SERUM-FREE; HELA CELLS; HUMANS; MEMBRANE PROTEINS; NEOPLASM PROTEINS; NEUROBLASTOMA; PROTO-ONCOGENE PROTEINS C-MYC; RNA, SMALL INTERFERING; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 53649092492     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2008.200     Document Type: Article

References (26)

1. Alex R, Sozeri O, Meyer S, Dildrop R. (1992). Determination of the DNA sequence recognized by the bHLH-zip domain of the N-Myc protein. Nucleic Acids Res 20: 2257-2263.
2. Bando T, Sekine K, Kobayashi S, Watabe AM, Rump A, Tanaka M et al. (2005). Neuronal leucine-rich repeat protein 4 functions in hippocampus-dependent long-lasting memory. Mol Cell Biol 25: 4166-4175.
3. Bernards R, Dessain SK, Weinberg RA. (1986). N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma. Cell 47: 667-674.
4. Blackwood EM, Eisenman RN. (1991). Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA binding complex with Myc. Science 251: 1211-1217.
5. Blackwood EM, Kretzner I, Eisenman RN. (1992). Myc and Max function as a nucleoprotein complex. Curr Opin Genet Dev 2: 227-235.
6. Boon K, Caron HN, van Asperen R, Valentijn L, Hermus MC, van Sluis P et al. (2001). N-myc enhances the expression of a large set of genes functioning ribosome biogenesis and protein synthesis. EMBO J 20: 1383-1393.
7. Brodeur GM, Nakagawara A. (1992). Molecular basis of clinical heterogeneity in neuroblastoma. Am J Pediatr Hematol Oncol 14: 111-116.
8. Degterev A, Boyce M, Yuan J. (2003). A decade of caspases. Oncogene 22: 8543-8567.
9. Fukamachi K, Matsuoka Y, Ohno H, Hamaguchi T, Tsuda H. (2002). Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs. J Biol Chem 277: 43549-43552.
10. Hamano S, Ohira M, Isogai E, Nakada K, Nakagawara A. (2004). Identification of novel human neuronal leucine-rich repeat (hNLRR) family, genes and inverse association of expression of Nbla10449/ hNLRR-1 and Nbla10677/hNLRR-3 with the prognosis of primary neuroblastomas. Int J Oncol 24: 1457-1466.
11. Kohl NE, Kanda N, Schreck RR, Bruns G, Latt SA, Gilbert F et al. (1983). Transposition and amplification of oncogene-related sequences in human neuroblastomas. Cell 35: 359-367.
12. Kouzarides T, Ziff E. (1988). The role of the leucine zipper in the fos-jun interaction. Nature 336: 646-651.
13. Landschulz WH, Johnson PF, McKnight S. (1988). The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 240: 1759-1764.
14. Lasorella A, Noseda M, Beyna M, Iavarone A. (2000). Id2 is a retinoblastoma protein target and mediates signaling by Myc oncoproteins. Nature 407: 592-598.
15. Lutz W, Stohr M, Schurmann J, Wenzel A, Lohr A, Schwab M. (1996). Conditional expression of N-myc in human neuroblastoma cells increases expression of a-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells. Oncogene 13: 803-812.
16. Murre C, Schonleber McCaw P, Baltimore D. (1989). A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56: 777-783.
17. Negroni A, Scarpa S, Romeo A, Ferrari S, Modesti A, Raschella G. (1991). Decrease of proliferation rate and induction of differentiation by a MYCN antisense DNA oligomer in a human neuroblastoma cell line. Cell Growth Differ 2: 511-518.
18. Schwab M, Alitalo K, Klempnauer KH, Varmus HE, Bishop JM, Gilbert F et al. (1983). Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Nature 305: 245-248.
19. Seeger RC, Brodeur GM, Sather H, Dalton A, Siegel SE, Wong KY et al. (1985). Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl J Med 313: 1111-1116.
20. Slack A, Chen Z, Tonelli R, Pule M, Hunt L, Pession A et al. (2005). The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma. Proc Natl Acad Sci USA 102: 731-736.
21. Taguchi A, Wanaka A, Mori T, Matsumoto K, Imai Y, Takagi T et al. (1996). Molecular cloning of novel leucine-rich repeat proteins and their expression in the developing mouse nervous system. Brain Res Mol Brain Res 35: 31-40.
22. Taniguchi H, Tohyama A, Takagi T. (1996). Cloning and expression of a novel gene for a protein with leucine-rich repeats in the developing mouse nervous system. Brain Res Mol Brain Res 36: 45-52.
23. Torres R, Schreiber-Agus N, Morgenbesser SD, DePinho RA. (1992). Myc and Max: a putative transcriptional complex in search of a cellular target. Curr Opin Cell Biol 4: 468-474.
24. Truscott M, Denault JB, Goulet B, Leduy L, Salvesen GS, Nepveu A. (2007). Carboxy-terminal proteolytic processing of CUX1 by a caspase enables transcriptional activation in proliferating cells. J Biol Chem 282: 30216-30226.
25. Wang J, Xie I, Allan S, Beach D, Hannon G. (1998). Myc activates telomerase. Genes Dev 12: 1769-1774.
26. Weiss WA, Aldape K, Mohapatra G, Feuerstein BG, Bishop JM. (1997). Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO J 16: 2985-2995.