메뉴 건너뛰기




Volumn 92, Issue 2, 2009, Pages 660-666

The effects of oral contraceptives including low-dose estrogen and drospirenone on the concentration of leptin and ghrelin in polycystic ovary syndrome

Author keywords

drospirenone; ghrelin; leptin; oral contraceptive; PCOS

Indexed keywords

ANDROSTENEDIONE; DROSPIRENONE PLUS ETHINYLESTRADIOL; ESTRADIOL; FOLLITROPIN; GHRELIN; LEPTIN; LUTEINIZING HORMONE; PRASTERONE SULFATE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

EID: 67651085354     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2008.07.008     Document Type: Article
Times cited : (19)

References (54)
  • 1
    • 33744509899 scopus 로고    scopus 로고
    • Anovulation and the polycystic ovary. Speroff L., and Fritz M.A. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Anovulation and the polycystic ovary. In: Speroff L., and Fritz M.A. (Eds). Clinical Gynecologic Endocrinology and Infertility (2005), Lippincott Williams & Wilkins, Philadelphia 465-498
    • (2005) Clinical Gynecologic Endocrinology and Infertility , pp. 465-498
  • 2
    • 0023412220 scopus 로고
    • Epidemiology of infertility and polycystic ovarian disease: endocrinological and demographic studies
    • Hull M.G. Epidemiology of infertility and polycystic ovarian disease: endocrinological and demographic studies. Gynecol Endocrinol 1 (1987) 235-245
    • (1987) Gynecol Endocrinol , vol.1 , pp. 235-245
    • Hull, M.G.1
  • 3
    • 0034815278 scopus 로고    scopus 로고
    • Relative risk of conversion from normoglycaemia to impaired glucose tolerance or non-insulin dependent diabetes mellitus in polycystic ovarian syndrome
    • Norman R.J., Masters L., Milner C.R., Wang J.X., and Davies M.J. Relative risk of conversion from normoglycaemia to impaired glucose tolerance or non-insulin dependent diabetes mellitus in polycystic ovarian syndrome. Hum Reprod 16 (2001) 1995-1998
    • (2001) Hum Reprod , vol.16 , pp. 1995-1998
    • Norman, R.J.1    Masters, L.2    Milner, C.R.3    Wang, J.X.4    Davies, M.J.5
  • 4
    • 67651128062 scopus 로고    scopus 로고
    • Speroff L., and Fritz M.A. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Obesity. In: Speroff L., and Fritz M.A. (Eds). Clinical Gynecologic Endocrinology and Infertility (2005), Lippincott Williams & Wilkins, Philadelphia 779-804
    • (2005) Clinical Gynecologic Endocrinology and Infertility , pp. 779-804
    • Obesity1
  • 6
    • 33646120575 scopus 로고    scopus 로고
    • Serum soluble leptin receptor levels and free leptin index in women with polycystic ovary syndrome: relationship to insulin resistance and androgens
    • Sepilian V.P., Crochet J.R., and Nagamani M. Serum soluble leptin receptor levels and free leptin index in women with polycystic ovary syndrome: relationship to insulin resistance and androgens. Fertil Steril 85 (2006) 1441-1447
    • (2006) Fertil Steril , vol.85 , pp. 1441-1447
    • Sepilian, V.P.1    Crochet, J.R.2    Nagamani, M.3
  • 7
    • 7944229911 scopus 로고    scopus 로고
    • Serum leptin levels correlate with obesity parameters but not with hyperinsulinism in women with polycystic ovary syndrome
    • Erturk E., Kuru N., Savci V., Tuncel E., Ersoy C., and Imamoglu S. Serum leptin levels correlate with obesity parameters but not with hyperinsulinism in women with polycystic ovary syndrome. Fertil Steril 82 (2004) 1364-1368
    • (2004) Fertil Steril , vol.82 , pp. 1364-1368
    • Erturk, E.1    Kuru, N.2    Savci, V.3    Tuncel, E.4    Ersoy, C.5    Imamoglu, S.6
  • 8
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 9
    • 0035320623 scopus 로고    scopus 로고
    • Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor
    • Kojima M., Hosoda H., Matsuo H., and Kangawa K. Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocrinol Metab 12 (2001) 118-122
    • (2001) Trends Endocrinol Metab , vol.12 , pp. 118-122
    • Kojima, M.1    Hosoda, H.2    Matsuo, H.3    Kangawa, K.4
  • 10
    • 0037066587 scopus 로고    scopus 로고
    • Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity
    • Muccioli G., Tschop M., Papotti M., Deghenghi R., Heiman M., and Ghigo E. Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur J Pharmacol 440 (2002) 235-254
    • (2002) Eur J Pharmacol , vol.440 , pp. 235-254
    • Muccioli, G.1    Tschop, M.2    Papotti, M.3    Deghenghi, R.4    Heiman, M.5    Ghigo, E.6
  • 11
    • 0035433977 scopus 로고    scopus 로고
    • A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
    • Cummings D.E., Purnell J.Q., Frayo R.S., Schmidova K., Wisse B.E., and Weigle D.S. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50 (2001) 1714-1719
    • (2001) Diabetes , vol.50 , pp. 1714-1719
    • Cummings, D.E.1    Purnell, J.Q.2    Frayo, R.S.3    Schmidova, K.4    Wisse, B.E.5    Weigle, D.S.6
  • 14
    • 0003667408 scopus 로고    scopus 로고
    • Oral Contraception
    • Speroff L., and Fritz M.A. (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Oral Contraception. In: Speroff L., and Fritz M.A. (Eds). Clinical Gynecologic Endocrinology and Infertility (2005), Lippincott Williams & Wilkins, Philadelphia 861-942
    • (2005) Clinical Gynecologic Endocrinology and Infertility , pp. 861-942
  • 15
    • 0025201663 scopus 로고
    • The effects of different formulations of oral contraceptive agents on lipid and carbohydrate metabolism
    • Godsland I.F., Crook D., Simpson R., Proudler T., Felton C., Lees B., et al. The effects of different formulations of oral contraceptive agents on lipid and carbohydrate metabolism. N Engl J Med 323 (1990) 1375-1381
    • (1990) N Engl J Med , vol.323 , pp. 1375-1381
    • Godsland, I.F.1    Crook, D.2    Simpson, R.3    Proudler, T.4    Felton, C.5    Lees, B.6
  • 16
    • 0000275817 scopus 로고    scopus 로고
    • A comparative investigation of contraceptive reliability, cycle control and tolerance of two monophasic oral contraceptives containing either drospirenone or desogestrel
    • Erratum Eur J Contracept Reprod Health Care 2001;6:63
    • Foidart J.M., Wuttke W., Bouw G.M., Gerlinger C., and Heithecker R. A comparative investigation of contraceptive reliability, cycle control and tolerance of two monophasic oral contraceptives containing either drospirenone or desogestrel. Eur J Contracept Reprod Health Care 5 (2000) 124-134 Erratum Eur J Contracept Reprod Health Care 2001;6:63
    • (2000) Eur J Contracept Reprod Health Care , vol.5 , pp. 124-134
    • Foidart, J.M.1    Wuttke, W.2    Bouw, G.M.3    Gerlinger, C.4    Heithecker, R.5
  • 17
    • 0346186090 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19 (2004) 41-47
    • (2004) Hum Reprod , vol.19 , pp. 41-47
  • 18
    • 12644305063 scopus 로고
    • Clinical assessment of body hair growth in women
    • Ferriman D., and Gallwey J.D. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 21 (1961) 1440-1447
    • (1961) J Clin Endocrinol Metab , vol.21 , pp. 1440-1447
    • Ferriman, D.1    Gallwey, J.D.2
  • 19
    • 0021813187 scopus 로고
    • Homeostasis model assessment: insulin resistance and -cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., and Turner R.C. Homeostasis model assessment: insulin resistance and -cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-419
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 20
    • 0015348189 scopus 로고
    • Estimation of the concentration of the low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • Friedewald W.T., Levy R.I., and Fredrickson D.S. Estimation of the concentration of the low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18 (1972) 499-502
    • (1972) Clin Chem , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 21
    • 0028910917 scopus 로고
    • Drospirenone: a novel progestogen with antimineralocorticoid and antiandrogenic activity: pharmacological characterization in animal models
    • Muhn P., Krattenmacher R., Beier S., Elger W., and Schillinger E. Drospirenone: a novel progestogen with antimineralocorticoid and antiandrogenic activity: pharmacological characterization in animal models. Contraception 51 (1995) 99-110
    • (1995) Contraception , vol.51 , pp. 99-110
    • Muhn, P.1    Krattenmacher, R.2    Beier, S.3    Elger, W.4    Schillinger, E.5
  • 22
    • 2942631366 scopus 로고    scopus 로고
    • Drospirenone for the treatment of hirsute women with polycystic ovary syndrome: a clinical, endocrinological, metabolic pilot study
    • Guido M., Romualdi D., Giuliani M., Suriano R., Selvaggi L., Apa R., et al. Drospirenone for the treatment of hirsute women with polycystic ovary syndrome: a clinical, endocrinological, metabolic pilot study. J Clin Endocrinol Metab 89 (2004) 2817-2823
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2817-2823
    • Guido, M.1    Romualdi, D.2    Giuliani, M.3    Suriano, R.4    Selvaggi, L.5    Apa, R.6
  • 23
    • 11144354560 scopus 로고    scopus 로고
    • Ethinyl estradiol-drospirenone, flutamide-metformin, or both for adolescents and women with hyperinsulinemic hyperandrogenism: opposite effects on adipocytokines and body adiposity
    • Ibanez L., and de Zegher F. Ethinyl estradiol-drospirenone, flutamide-metformin, or both for adolescents and women with hyperinsulinemic hyperandrogenism: opposite effects on adipocytokines and body adiposity. J Clin Endocrinol Metab 89 (2004) 1592-1597
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 1592-1597
    • Ibanez, L.1    de Zegher, F.2
  • 24
    • 0033833321 scopus 로고    scopus 로고
    • Drospirenone: pharmacology and pharmacokinetics of a unique progestogen
    • Krattenmacher R. Drospirenone: pharmacology and pharmacokinetics of a unique progestogen. Contraception 62 (2000) 29-38
    • (2000) Contraception , vol.62 , pp. 29-38
    • Krattenmacher, R.1
  • 25
    • 34447132119 scopus 로고    scopus 로고
    • Influence of a new oral contraceptive with drospirenone on lipid metabolism
    • Taneepanichskul S., and Phupong V. Influence of a new oral contraceptive with drospirenone on lipid metabolism. Gynecol Endocrinol 23 (2007) 347-350
    • (2007) Gynecol Endocrinol , vol.23 , pp. 347-350
    • Taneepanichskul, S.1    Phupong, V.2
  • 26
    • 0029011362 scopus 로고
    • Effects of new oral contraceptive containing an antimineralocorticoid progestogen, drospirenone, on the renin-aldosterone system, body weight, blood pressure, glucose tolerance, and lipid metabolism
    • Oelkers W., Foidart J.M., Dombrovicz N., Welter A., and Heithecker R. Effects of new oral contraceptive containing an antimineralocorticoid progestogen, drospirenone, on the renin-aldosterone system, body weight, blood pressure, glucose tolerance, and lipid metabolism. J Clin Endocrinol Metab 80 (1995) 1816-1821
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 1816-1821
    • Oelkers, W.1    Foidart, J.M.2    Dombrovicz, N.3    Welter, A.4    Heithecker, R.5
  • 27
    • 0034058861 scopus 로고    scopus 로고
    • An open-label, multicenter study to evaluate Yasmin, a low-dose combination oral contraceptive containing drospirenone, a new progestogen
    • Parsey K.S., and Pong A. An open-label, multicenter study to evaluate Yasmin, a low-dose combination oral contraceptive containing drospirenone, a new progestogen. Contraception 61 (2000) 105-111
    • (2000) Contraception , vol.61 , pp. 105-111
    • Parsey, K.S.1    Pong, A.2
  • 28
    • 33947506395 scopus 로고    scopus 로고
    • Efficacy of an oral contraceptive containing drospirenone in the treatment of women with polycystic ovary syndrome
    • Pehlivanov B., and Mitkov M. Efficacy of an oral contraceptive containing drospirenone in the treatment of women with polycystic ovary syndrome. Eur J Contracept Reprod Health Care 12 (2007) 30-35
    • (2007) Eur J Contracept Reprod Health Care , vol.12 , pp. 30-35
    • Pehlivanov, B.1    Mitkov, M.2
  • 29
    • 0037501322 scopus 로고    scopus 로고
    • A randomized study over 13 cycles to assess the influence of oral contraceptives containing ethinyl estradiol combined with drospirenone or desogestrel on carbohydrate metabolism
    • Gaspard U., Scheen A., Endrikat J., Buicu C., Lefebvre P., Gerlinger C., et al. A randomized study over 13 cycles to assess the influence of oral contraceptives containing ethinyl estradiol combined with drospirenone or desogestrel on carbohydrate metabolism. Contraception 67 (2003) 423-429
    • (2003) Contraception , vol.67 , pp. 423-429
    • Gaspard, U.1    Scheen, A.2    Endrikat, J.3    Buicu, C.4    Lefebvre, P.5    Gerlinger, C.6
  • 30
    • 0036925201 scopus 로고    scopus 로고
    • Plasma ghrelin, obesity, and the polycystic ovary syndrome: correlation with insulin resistance and androgen levels
    • Pagotto U., Gambineri A., Vicennati V., Heiman M.L., Tschöp M., and Pasquali R. Plasma ghrelin, obesity, and the polycystic ovary syndrome: correlation with insulin resistance and androgen levels. J Clin Endocrinol Metab 87 (2002) 5625-5629
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 5625-5629
    • Pagotto, U.1    Gambineri, A.2    Vicennati, V.3    Heiman, M.L.4    Tschöp, M.5    Pasquali, R.6
  • 32
    • 25144516827 scopus 로고    scopus 로고
    • Comparative study of plasma ghrelin levels in women with polycystic ovary syndrome, in hyperandrogenic women and in normal controls
    • Panidis D., Farmakiotis D., Koliakos G., Rousso D., Kourtis A., Katsikis I., et al. Comparative study of plasma ghrelin levels in women with polycystic ovary syndrome, in hyperandrogenic women and in normal controls. Hum Reprod 20 (2005) 2127-2132
    • (2005) Hum Reprod , vol.20 , pp. 2127-2132
    • Panidis, D.1    Farmakiotis, D.2    Koliakos, G.3    Rousso, D.4    Kourtis, A.5    Katsikis, I.6
  • 35
    • 18244391222 scopus 로고    scopus 로고
    • Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion
    • Shiiya T., Nakazato M., Mizuta M., Date Y., Mondal M.S., Tanaka M., et al. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 87 (2002) 240-244
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 240-244
    • Shiiya, T.1    Nakazato, M.2    Mizuta, M.3    Date, Y.4    Mondal, M.S.5    Tanaka, M.6
  • 36
    • 33747633975 scopus 로고    scopus 로고
    • Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS). Adiponectin, ghrelin, leptin and body composition in hirsute PCOS patients and controls
    • Glintborg D., Andersen M., Hagen C., Frystyk J., Hulstrøm V., Flyvbjerg A., et al. Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS). Adiponectin, ghrelin, leptin and body composition in hirsute PCOS patients and controls. Eur J Endocrinol 155 (2006) 337-345
    • (2006) Eur J Endocrinol , vol.155 , pp. 337-345
    • Glintborg, D.1    Andersen, M.2    Hagen, C.3    Frystyk, J.4    Hulstrøm, V.5    Flyvbjerg, A.6
  • 37
    • 0034751526 scopus 로고    scopus 로고
    • Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans
    • Broglio F., Arvat E., Benso A., Gottero C., Muccioli G., Papotti M., et al. Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J Clin Endocrinol Metab 86 (2001) 5083-5086
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5083-5086
    • Broglio, F.1    Arvat, E.2    Benso, A.3    Gottero, C.4    Muccioli, G.5    Papotti, M.6
  • 39
    • 0036896934 scopus 로고    scopus 로고
    • Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents
    • Ikezaki A., Hosoda H., Ito K., Iwama S., Miura N., Matsuoka H., et al. Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents. Diabetes 51 (2002) 3408-3411
    • (2002) Diabetes , vol.51 , pp. 3408-3411
    • Ikezaki, A.1    Hosoda, H.2    Ito, K.3    Iwama, S.4    Miura, N.5    Matsuoka, H.6
  • 42
    • 0037233878 scopus 로고    scopus 로고
    • Serum ghrelin levels in obese patients: the relationship to serum leptin levels and soluble leptin receptors levels
    • Rosicka M., Krsek M., Matoulek M., Jarkovska Z., Marek J., Justova V., et al. Serum ghrelin levels in obese patients: the relationship to serum leptin levels and soluble leptin receptors levels. Physiol Res 52 (2003) 61-66
    • (2003) Physiol Res , vol.52 , pp. 61-66
    • Rosicka, M.1    Krsek, M.2    Matoulek, M.3    Jarkovska, Z.4    Marek, J.5    Justova, V.6
  • 44
    • 0031154336 scopus 로고    scopus 로고
    • Leptin concentrations in the polycystic ovary syndrome
    • Mantzoros C.S., Dunaif A., and Flier J.S. Leptin concentrations in the polycystic ovary syndrome. J Clin Endocrinol Metab 82 (1997) 1687-1691
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 1687-1691
    • Mantzoros, C.S.1    Dunaif, A.2    Flier, J.S.3
  • 45
    • 0038545228 scopus 로고    scopus 로고
    • Effect of two modes of antiandrogen treatment on insulin sensitivity and serum leptin in women with PCOS
    • Krotkiewski M., Landin K., Dahlgren E., Janson P.O., and Holm G. Effect of two modes of antiandrogen treatment on insulin sensitivity and serum leptin in women with PCOS. Gynecol Obstet Invest 55 (2003) 88-95
    • (2003) Gynecol Obstet Invest , vol.55 , pp. 88-95
    • Krotkiewski, M.1    Landin, K.2    Dahlgren, E.3    Janson, P.O.4    Holm, G.5
  • 46
    • 0036320671 scopus 로고    scopus 로고
    • Effects of oral contraceptives with low-dose estrogen and desogestrel on leptin concentrations
    • Sagsoz N., Akcay F., and Bayram M. Effects of oral contraceptives with low-dose estrogen and desogestrel on leptin concentrations. J Reprod Med 47 (2002) 545-548
    • (2002) J Reprod Med , vol.47 , pp. 545-548
    • Sagsoz, N.1    Akcay, F.2    Bayram, M.3
  • 48
    • 0037242513 scopus 로고    scopus 로고
    • Metformin versus ethinyl estradiol-cyproterone acetate in the treatment of nonobese women with polycystic ovary syndrome: a randomized study
    • Morin-Papunen L., Vauhkonen I., Koivunen R., Ruokonen A., Martikainen H., and Tapanainen J.S. Metformin versus ethinyl estradiol-cyproterone acetate in the treatment of nonobese women with polycystic ovary syndrome: a randomized study. J Clin Endocrinol Metab 88 (2003) 148-156
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 148-156
    • Morin-Papunen, L.1    Vauhkonen, I.2    Koivunen, R.3    Ruokonen, A.4    Martikainen, H.5    Tapanainen, J.S.6
  • 49
    • 0344826568 scopus 로고    scopus 로고
    • Leptin levels increase during flutamide therapy in women with polycystic ovary syndrome
    • Sahin I., Serter R., Karakurt F., Demirbas B., Guler S., Culha C., et al. Leptin levels increase during flutamide therapy in women with polycystic ovary syndrome. Horm Res 60 (2003) 232-236
    • (2003) Horm Res , vol.60 , pp. 232-236
    • Sahin, I.1    Serter, R.2    Karakurt, F.3    Demirbas, B.4    Guler, S.5    Culha, C.6
  • 50
    • 0142025214 scopus 로고    scopus 로고
    • Anti-androgen treatment increases circulating ghrelin levels in obese women with polycystic ovary syndrome
    • Gambineri A., Pagotto U., Tschop M., Vicennati V., Manicardi E., Carcello A., et al. Anti-androgen treatment increases circulating ghrelin levels in obese women with polycystic ovary syndrome. J Endocrinol Invest 26 (2003) 629-634
    • (2003) J Endocrinol Invest , vol.26 , pp. 629-634
    • Gambineri, A.1    Pagotto, U.2    Tschop, M.3    Vicennati, V.4    Manicardi, E.5    Carcello, A.6
  • 52
    • 27744446021 scopus 로고    scopus 로고
    • Ghrelin improves endothelial function in patients with metabolic syndrome
    • Tesauro M., Schinzari F., Iantorno M., Rizza S., Melina D., Lauro D., et al. Ghrelin improves endothelial function in patients with metabolic syndrome. Circulation 112 (2005) 2986-2992
    • (2005) Circulation , vol.112 , pp. 2986-2992
    • Tesauro, M.1    Schinzari, F.2    Iantorno, M.3    Rizza, S.4    Melina, D.5    Lauro, D.6
  • 54
    • 0141643291 scopus 로고    scopus 로고
    • Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes
    • Pöykkö S.M., Kellokoski E., Hörkkö S., Kauma H., Kesäniemi Y.A., and Ukkola O. Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes 52 (2003) 2546-2553
    • (2003) Diabetes , vol.52 , pp. 2546-2553
    • Pöykkö, S.M.1    Kellokoski, E.2    Hörkkö, S.3    Kauma, H.4    Kesäniemi, Y.A.5    Ukkola, O.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.