A rare null allele potentially encoding a dominant-negative TRIM5α protein in Baka pygmies

Virology

Volumn 391, Issue 1, 2009, Pages 140-147

  Torimiro, Judith N ^a,b   Javanbakht, Hassan ^c   Diaz Griffero, Felipe ^c   Kim, Jonghwa ^c   Carr, Jean K ^d   Carrington, Mary ^e   Sawitzke, Julie ^e   Burke, Donald S ^f   Wolfe, Nathan D ^g,h   Dean, Michael ⁱ   Sodroski, Joseph ^c,j  

^a UNIVERSITY OF YAOUNDÉ I   (Cameroon)

^b Chantal Biya International Reference Centre   (Cameroon)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^e SAIC FREDERICK INC   (United States)

^f UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^g Global Viral Forecasting Initiative   (United States)

^h STANFORD UNIVERSITY   (United States)

ⁱ NATIONAL CANCER INSTITUTE   (United States)

^j HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

more..

Author keywords

Africa; Cross species transmission; HIV 1; Mutant; Polymorphism; Restriction factor; Susceptibility

Indexed keywords

TRIPARTITE MOTIF PROTEIN 5;

ADULT; ANIMAL CELL; ARTICLE; BODY FLUID; CAMEROON; CHIMPANZEE; CONTROLLED STUDY; EXON; FIBROBLAST CULTURE; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MINORITY GROUP; NONHUMAN; NULL ALLELE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RETROVIRUS INFECTION; STOP CODON; THYMOCYTE; VIRUS TRANSMISSION; WILD TYPE;

AFRICAN CONTINENTAL ANCESTRY GROUP; ALLELES; CAMEROON; CARRIER PROTEINS; CELL LINE; EXONS; GENOTYPE; HIV INFECTIONS; HUMANS; SEQUENCE ANALYSIS, DNA;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMALIA; PAN;

EID: 67651026847     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2009.05.038     Document Type: Article

References (83)

1. Allan J.S., Short M., Taylor M.E., Su S., Hirsch V.M., Johnson P.R., Shaw G.M., and Hahn B.H. Species-specific diversity among simian immunodeficiency viruses from African green monkeys. J. Virol. 655 (1991) 2816-2828
2. Apetrei C., Metzger M.J., Richardson D., Ling B., Telfer P.T., Reed P., Robertson D.L., and Mars P.A. Detection and partial characterization of simian immunodeficiency virus SIVsm strains from bush meat samples from rural Sierra Leone. J. Virol. 79 (2005) 2631-2636
3. Ayouba A., Souquieres S., Njinku B., Martin P.M., Muller-Trutwin M.C., Roques P., Barre-Sinoussi F., Mauclere P., Simon F., and Nerrienet E. HIV-1 group N among HIV-1-seropositive individuals in Cameroon. AIDS 14 (2000) 2623-2625
4. Ayouba A., Mauclere P., Martin P.M., Cunin P., Mfoupouendoun J., Njinku B., Souquieres S., and Simon F. HIV-1 group O infection in Cameroon, 1986-1998. Emerg. Infect. Dis. 7 (2001) 466-467
5. Bibollet-Ruche F., Bailes E., Gao F., Pourrut X., Barlow K.L., Clewley J.P., Mwenda J., Langat D.K., Chege G.K., McClure H.M., Mpoudi-Ngole E., Delaporte E., Peeters M., Shaw G.M., Sharp P.M., and Hahn B.H. New simian immunodeficiency virus infecting De Brazza's monkeys (Cercopithecus neglectus): evidence for a Cercopithecus monkey virus clade. J. Virol. 78 (2004) 7748-7762
6. Bieniasz P.D. Restriction factors: a defense against retroviral infection. Trends Microbiol. 11 (2003) 286-291
7. Brennan G., Kozyrev Y., and Hu S.L. TRIMCyp expression in Old World primates Macaca nemestrina and Macaca fascicularis. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 3569-3574
8. Chen Z., Telfier P., Gettie A., Reed P., Zhang L., Ho D.D., and Marx P.A. Genetic characterization of new West African simian immunodeficiency virus SIVsm: geographic clustering of household-derived SIV strains with human immunodeficiency virus type 2 subtypes and genetically diverse viruses from a single feral sooty mangabey troop. J. Virol. 70 (1996) 3617-3627
9. Chen Z., Luckay A., Sodora D.L., Telfer P., Reed P., Gettie A., Kanu J.M., Sadek R.F., Yee J., Ho D.D., Zhang L., and Marx P.A. Human immunodeficiency virus type 2 (HIV-2) seroprevalence and characterization of a distinct HIV-1 genetic subtype from the natural range of simian immunodeficiency virus-infected sooty mangabeys. J. Virol. 71 (1997) 3953-3960
10. Corbet S., Müller-Trutwin M.C., Versmisse P., Delarue S., Ayouba A., Lewis J., Brunak S., Martin P., Brun-Vezinet F., Simon F., Barre-Sinoussi F., and Mauclere P. env sequences of simian immunodeficiency viruses from chimpanzees in Cameroon are strongly related to those of human immunodeficiency virus group N from the same geographic area. J. Virol. 74 (2000) 529-534
11. Courgnaud V., Abela B., Pournet X., Mpoudi-Ngiole E., Loul S., Delaporte E., and Peeters M. Identification of a new simian immunodeficiency virus lineage with a vpu gene present among different cercopithecus monkeys (C. mona, C. cephus, and C. nictitans) from Cameroon. J. Virol. 77 (2003) 12523-12534
12. Diaz-Griffero F., Li X., Javanbakht H., Song B., Welikala S., Stremlau M., and Sodroski J. Rapid turnover and polyubiquitylation of the retroviral restriction factor TRIM5. Virology 349 (2006) 135-300
13. Diaz-Griffero F., Kar A., Lee M., Stremlau M., Poeschla E., and Sodroski J. Comparative requirements for the restriction of retrovirus infection by TRIM5α and TRIMCyp. Virology 369 (2007) 400-410
14. Diaz-Griffero F., Kar A., Perron M., Xiang S., Javanbakht H., Li H., and Sodroski J. Modulation of retroviral restriction and proteasome inhibitor-resistant turnover by changes in the TRIM5(alpha) B-box 2 domain. J. Virol. 81 (2007) 10362-10378
15. Diaz-Griffero F., Perron M., McGee-Estrada K., Hanna R., Maillard P., Trono D., and Sodroski J. A human TRIM5α B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus. Virology 378 (2008) 233-242
16. Gao F., Yue L., White A.T., Pappas P.G., Barchue J., Hanson A.P., Greene B.M., Sharp P.M., Shaw G.M., and Hahn B.H. Human infection by genetically diverse SIVsm-related HIV-2 in west Africa. Nature 358 (1992) 495-499
17. Gao F., Bailes E., Robertson D.L., Chen Y., Rodenburg C.M., Michael S.F., Cummins L.B., Arthur L.O., Peeters M., Shaw G.M., Sharp P.M., and Hahn B.H. Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature 397 (1999) 436-441
18. Goldschmidt V., Bleiber G., May M., Martinez R., Ortiz M., and Telenti A. The Swiss HIV Cohort Study. Role of common human TRIM5alpha variants in HIV-1 disease progression. Retrovirology 22 (2006) 54
19. Grϋtter C., Briand C., Capitani G., Mittl P.R., Papin S., Tschopp J., and Grϋtter M.G. Structure of the PRYSPRY-domain: implications for autoinflammatory diseases. FEBS Lett. 580 (2006) 99-106
20. Hahn B.H., Shaw G.M., De Cock K.M., and Sharp P.M. AIDS as a zoonosis: scientific and public health implications. Science 287 (2000) 607-614
21. Hatziioannou T., Cowan S., Goff S.P., Bieniasz P.D., and Towers G.J. Restriction of multiple divergent retrovirus by Lv1 and Ref1. EMBO J. 22 (2003) 385-394
22. Hatziioannou T., Perez-Caballero D., Yang A., Cowan S., and Bieniasz P.D. Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 10774-10779
23. Hofmann W., Schubert D., LaBonte J., Munson L., Gibson S., Scammell J., Ferrigno P., and Sodroski J. Species-specific, postentry barriers to primate immunodeficiency virus infection. J. Virol. 73 (1999) 10020-10028
24. James L.C., Keeble A.H., Khan Z., Rhodes D.A., and Trowsdale J. Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 6200-6205
25. Javanbakht H., Diaz-Griffero F., Stremlau M., Si Z., and Sodroski J. The contribution of RING and B-box 2 domains to retroviral restriction mediated by monkey TRIM5α. J. Biol. Chem. 280 (2005) 26933-26940
26. Javanbakht H., An P., Gold B., Petersen D., O'hUigin C., O'Brien S., Kirk G., Detels R., Goedert J., Buchbinder S., Donfield S., Shulenin S., Song B., Perron M., Stremlau M., Sodroski J., Dean M., and Winkler C. Effects of human TRIM5α polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection. Virology 354 (2006) 15-27
27. Jolly C., Phillips-Conroy J.E., Turner T.R., Broussard S., and Allan J.S. SIVagm incidence over two decades in a natural population of Ethiopian grivet monkeys (Cercopithecus aethiops aethiops). J. Med. Primatol. 25 (1996) 78-83
28. Kar A.K., Diaz-Griffero F., Li Y., Li X., and Sodroski J. Biochemical and biophysical characterization of a chimeric TRIM21-TRIM5alpha protein. J. Virol. 82 (2008) 11669-11681
29. Keckesova Z., Ylinen L.M., and Towers G.J. The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 10785-107890
30. Keele B.F., Van Heuverswyn F., Li Y., Bailes E., Takehisa J., Santiago M.L., Bibollet-Ruche F., Chen Y., Wain L.V., Liegeois F., Loul S., Ngole E.M., Bienvenue Y., Delaporte E., Brookfield J.F., Sharp P.M., Shaw G.M., Peeters M., and Hahn B.H. Chimpanzee reservoirs of pandemic and nonpandemic HIV-1. Science 313 (2006) 523-526
31. Kondo Y., Mizokami M., Nakano T., Kato T., Ohba K., Orito E., Ueda R., Mukaide M., Hikiji K., Oyunsuren T., and Cooksley W.G. Genotype of GB virus C/hepatitis G virus by molecular evolutionary analysis. Virus Res. 52 (1997) 221-230
32. Konings F.A., Haman G.R., Xue Y., Urbanski M.M., Hertzmark K., Nanfack A., Achkar J.M., Burda S.T., and Nyambi P.N. Genetic analysis of HIV-1 strains in rural eastern Cameroon indicates the evolution of second-generation recombinants to circulating recombinant forms. J. Acquir. Immune Defic. Syndr. 42 (2006) 331-341
33. Kratovac Z., Virgen C.A., Bibollet-Ruche F., Hahn B., Bieniasz P.D., and Hatziioannou T. Primate lentivirus capsid sensitivity to TRIM5 proteins. J. Virol. 82 (2008) 6772-6777
34. In: Kuiken C., Leitner T., Foley B., Hahn B., Marx P., McCutchan F., Wolinsky S., and Korber B. (Eds). HIV Sequence Compendium 2008 (2008), Publisher: Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico. LA-UR 08-03719
35. Langelier C.R., Sandrin V., Eckert D.M., Christensen D.E., Chandrasekaran V., Alam S.L., Aiken C., Olsen J.C., Kar A.K., Sodroski J.G., and Sundquist W.I. Biochemical characterization of a recombinant TRIM5α protein that restricts HIV-1 replication. J. Virol. 82 (2008) 11682-11694
36. Lemey P., Pybus O.G., Wang B., Saksena N.K., Salemi M., and Vandamme A.M. Tracing the origins and history of the HIV-2 epidemic. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 6588-6592
37. Lemey P., Pybus O.G., Rambaut A., Drummond A.J., Robertson D.L., Roques P., Worobey M., and Vandamme A.M. The molecular population genetics of HIV-1 group O. Genetics 167 (2004) 1059-1068
38. Li X., and Sodroski J. The TRIM5α B-box 2 domain promotes cooperative binding to the retroviral capsid by mediating higher-order self-association. J. Virol. 82 (2008) 11495-11502
39. Li Y., Li X., Stremlau M., Lee M., and Sodroski J. Removal of arginine 332 allows human TRIM5alpha to bind human immunodeficiency virus capsids and to restriction infection. J. Virol. 80 (2006) 6738-6744
40. Liao C.H., Kuang Y.Q., Liu H.L., Zheng Y.T., and Su B. A novel fusion gene, TRIM5-Cyclophilin A in the pig-tailed macaque determines its susceptibility to HIV-1 infection. AIDS Suppl. 8 (2007) S19-S26
41. Marx P.A., Li Y., Lerche N.W., Sutjipto S., Gettie A., Yee J.A., Brotman B.H., Prince A.M., Hanson A., Webster R.G., and Desrosiers R.C. Isolation of a simian immunodeficiency virus related to human immunodeficiency virus type 2 from a West African pet sooty mangabey. J. Virol. 65 (1991) 4480-4485
42. Nakayama E.E., Carpentier W., Costaghola D., Shioda T., Iwamoto A., Debre F., Yoshimura K., Autran B., Matsushita S., and Theodorou I. Wild type and H43Y variant of human TRIM5alpha show similar anti-human immunodeficiency virus type 1 activity both in vivo and in vitro. Immunogenetics 59 (2007) 511-515
43. Nerrienet E., Santiago M.L., Foupouapouognigni Y., Bailes E., Mundy N.I., Njinku B., Kfutwah A., Muller-Trutwin M.C., Barre-Sinoussi F., Shaw G.M., Sharp P.M., Hahn B.H., and Ayouba A. Simian immunodeficiency virus infection in wild-caught chimpanzees from Cameroon. J. Virol. 79 (2005) 1312-1319
44. Newman R.M., Hall L., Kirmaier A., Pozzi L.A., Pery E., Farzan M., O'Neil S.P., and Johnson W. Evolution of a TRIM5-CypA splice isoform in old world monkeys. PloS Pathog. 4 (2008) e1000003
45. Njouom R., Pasquier C., Ayouba A., Gessain A., Froment A., Mfoupouendoun J., Pouillot R., Dubois M., Sandres-Sauné K., Thonnon J., Izopet J., and Nerrienet E. High rate of hepatitis C virus infection and predominance of genotype 4 among elderly inhabitants of a remote village of the rain forest of South Cameroon. J. Med. Virol. 71 (2003) 219-225
46. Peeters M., Janssens W., Fransen K., Brandful J., Heyndrickx L., Koffi K., Delaporte E., Piot P., Gershy-Damet G.M., and van der Groen G. Isolation of simian immunodeficiency viruses from two sooty mangabeys in Côte d'Ivoire: virological and genetic characterization and relationship to other HIV type 2 and SIVsm/mac strains. AIDS Res. Hum. Retrovir. 10 (1994) 1289-1294
47. Peeters M., Toure-Kane C., and Nkengasong J.N. Genetic diversity of HIV in Africa: impact on diagnosis, treatment, vaccine development and trials. AIDS 17 (2003) 2547-2560
48. Perez-Caballero D., Hatziioannou T., Yang A., Cowan S., and Bieniasz P.D. Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity. J. Virol. 79 (2005) 8969-8978
49. Perron M.J., Stremlau M., Song B., Ulm W., Mulligan R.C., and Sodroski J. TRIM5alpha mediates the postentry block to N-tropic murine leukemia viruses in human cells. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 11827-11832
50. Perron M.J., Stremlau M., Lee M., Javanbakht H., Song B., and Sodroski J. The human TRIM5alpha restriction factor mediates accelerated uncoating of the N-tropic murine leukemia virus capsid. J. Virol. 81 (2007) 2138-2148
51. Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., Riganelli D., Zanaria E., Messali S., Cainaraca S., Guffanti A., Minucci S., Pelicci P.G., and Ballabio A. The tripartite motif family identifies cell compartments. EMBO J. 20 (2001) 2140-2151
52. Rho H.M., Poiesz B., Ruscetti F.W., and Gallo R.C. Characterization of the reverse transcriptase from a new retrovirus (HTLV) produced by a human cutaneous T-cell lymphoma cell line. Virology 112 (1981) 355-360
53. Santiago M.L., Rodenburg C.M., Kamenya S., Bibollet-Ruche F., Gao F., Bailes E., Meleth S., Soong S.J., Kilby J.M., Moldoveanu Z., Fahey B., Muller M.N., Ayouba A., Nerrienet E., McClure H.M., Henney J.L., Pussy A.E., Collins D.A., Boesch C., Wrangham R.W., Goodall J., Sharp P.M., Shaw G.M., and Hahn B.H. SIVcpz in wild chimpanzees. Science 295 (2002) 465
54. Santiago M.L., Range F., Keele B.F., Li Y., Bailes E., Bibollet-Ruche F., Fruteau C., Noë R., Peeters M., Brookfield J.F., Shaw G.M., Sharp P.M., and Hahn B.H. Simian immunodeficiency virus infection in free-ranging sooty mangabeys (Cercocebus atys atys) from the Taï Forest, Côte d'Ivoire: implications for the origin of epidemic human immunodeficiency virus type 2. J. Virol. 79 (2005) 12515-12527
55. Sawyer S.L., Wu L.I., Emerman M., and Malik H.S. Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 2832-2837
56. Sawyer S.L., Wu L.I., Akey J.M., Emerman M., and Malik H.S. High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans. Curr. Biol. 16 (2006) 95-100
57. Sawyer S.L., Emerman M., and Malik H.S. Discordant evolution of the adjacent antiretroviral genes TRIM22 and TRIM5 in mammals. PloS Pathog. 3 (2007) e197
58. Seto M.H., Liu H.L., Zajchowski D.A., and Whitlow M. Protein fold analysis of the B30.2-like domain. Proteins 35 (1999) 235-249
59. Song B., Gold B., O'hUigin C., Javanbakht H., Li X., Stremlau M., Winkler C., Dean M., and Sodroski J. The B30.2(SPRY) domain of the retroviral restriction factor TRIM5α exhibits lineage-specific length and sequence variation in primates. J. Virol. 79 (2005) 6111-6121
60. Song B., Javanbakht H., Perron M., Park D., Stremlau M., and Sodroski J. Retrovirus restriction by TRIM5α variants from Old World and New World primates. J. Virol. 79 (2005) 3930-3937
61. Souquière S., Bibollet-Ruche F., Robertson D.L., Makuwa M., Apetrei C., Onanga R., Kornfeld C., Plantier J.C., Gao F., Abernethy K., White L.J., Karesh W., Telfer P., Wickings E.J., Mauclère P., Mars P.A., Barré-Sinoussi F., Hahn B.H., Müller-Trutwin M.C., and Simon F. Wild Mandrillus sphinx are carriers of two types of lentivirus. J. Virol. 75 (2001) 7086-7096
62. Speelmon E.C., Livingston-Rosanoff D., Li S.S., Vu O., Bui J., Geraghty D.E., Zhao L.P., and McElrath M.J. Genetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection. J. Virol. 80 (2006) 2463-2471
63. Stremlau M., Owens C.M., Perron M.J., Kiessling M., Autissier P., and Sodroski J. The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys. [See comment]. Nature 427 (2004) 848-853
64. Stremlau M., Perron M., Welikala S., and Sodroski J. Species-specific variation in the B30.2(SPRY) domain of TRIM5α determines the potency of human immunodeficiency virus (HIV-1) infection. J. Virol. 79 (2005) 3139-3145
65. Stremlau M., Perron M., Lee M., Yuan L., Song B., Javanbakht H., Diaz-Griffero F., Anderson D.J., Sundquist W.I., and Sodroski J. Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5α restriction factor. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 5514-5519
66. Switzer W.M., Qari S.H., Wolfe N.D., Burke D.S., Folks T.M., and Heneine W. Ancient origin and molecular features of the novel human T-lymphotropic virus type 3 revealed by complete genome analysis. J. Virol. 80 (2006) 7427-7438
67. Tomonaga K., Katahira J., Fukasawa M., Hassan M.A., Kawamura M., Akari H., Miura T., Goto T., Nakai M., Suleman M., Isahakia M., and Hayami M. Isolation and characterization of simian immunodeficiency virus from African white-crowned mangabey monkeys (Cerocebus torquatus lunulatus). Arch. Virol. 129 (1993) 77-92
68. Van Heuverswyn F., and Peeters M. The origins of HIV and implications for the global epidemic. Curr. Infect. Dis. Rep. 9 (2007) 338-346
69. Van Heuverswyn F., Li Y., Neel C., Bailes E., Keele B.F., Liu W., Loul S., Butel C., Liegeois F., Bienvenue Y., Mpoudi Ngole E., Sharp P.M., Shaw G.M., Delaporte E., Hahn B.H., and Peeters M. SIV infection in wild gorillas. Nature 444 (2006) 164
70. Van Heuverswyn F., Li Y., Bailes E., Neel C., Lafay B., Keele B.F., Shaw K.S., Takchisa J., Kraus M.H., Loul S., Butel C., Liegeois F., Yangda B., Sharp P.M., Mpoudi-Ngole E., Delaporte E., Hahn B.H., and Peeters M. Genetic diversity and phylogeographic clustering of SIVcpsPtt in wild chimpanzees in Cameroon. Virology 368 (2007) 155-171
71. Van Manen D., Rits M.A., Beurgeling C., vanDort K., Schuitemaker H., and Kootstra N.A. The effect of Trim5 polymorphisms on the clinical course of HIV-1 infection. PloS Pathog. 8 (2008) e18
72. Vergne L., Bourgeois A., Mpoudi-Ngole E., Mougnutou R., Mbuagbaw J., Liegeois F., Lauren C., Butel C., Zekeng L., Delaporte E., and Peeters M. Biological and genetic characteristics of HIV infections in Cameroon reveals dual group M and O infections and a correlation between SI-inducing phenotype of the predominant CRF02_AG variant and disease stage. Virology 310 (2003) 254-266
73. Virgen C.A., Kratovac Z., Bieniasz P.D., and Hatziioannou T. Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate species. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 3563-3568
74. Wilson S.J., Webb B.L., Ylinen L.M., Verschoor E., Heeney J.L., and Towers G.J. Independent evolution of an antiviral TRIMCyp in rhesus macaques. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 3557-3562
75. Wolfe N.D., Switzer W.M., Carr J.K., Bhullar V.B., Shanmugam V., Tamoufe U., Prosser A.T., Torimiro J.N., Wright A., Mpoudi-Ngole E., McCutchan F.E., Birx D.L., Folks T.M., Burke D.S., and Heneine W. Naturally acquired simian retrovirus infections in central African hunters. Lancet 363 (2004) 932-937
76. Woo J.S., Imm J.H., Min C.K., Kim K.J., Cha S.S., and Oh B.H. Structural and functional insights into the B30.2/SPRY domain. EMBO J. 25 (2006) 1353-1363
77. Woo J.S., Suh H.Y., Park S.Y., and Oh B.H. Structural basis for protein recognition by B30.2/SPRY domains. Mol. Cell. 24 (2006) 967-976
78. Worobey M., Gemmel M., Teuwen D.E., Haselkorn T., Kunstman K., Bunce M., Muyembe J.-J., Kabongo J.-M.M., Kalengayi R.M., Van Marck E., Thomas M., Gilbert P., and Wolinsky S.M. Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960. Nature 455 (2008) 661-664
79. Yao S., Liu M.S., Masters S.L., Zhang J.G., Babon J.J., Nicola N.R., Nicholson S.E., and Norton R.S. Dynamics of the SPRY domain-containing SOCS box protein 2: flexibility of key functional loops. Protein Sci. 15 (2006) 2761-2772
80. Yap M.W., Nisole S., Lynch C., and Stoye J.P. Trim5alpha protein restricts both HIV-1 and murine leukemia virus. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 10786-10791
81. Yap M.W., Nisole S., and Stoye J.P. A single amino acid change in the SPRY domain of human TRIM5alpha leads to HIV-1 restriction. Curr. Biol. 15 (2005) 73-78
82. Yee J.K., Friedmann T., and Burns J.C. Generation of high-titer pseudotyped retroviral vectors with very broad host range. Methods Cell Biol. 43 (1994) 99-112
83. Zhong P., Burda S., Konings F., Urbanski M., Ma L., Zekeng L., Ewane L., Agyingi L., Agwara M., Saa D.R., Ze E.A., Kinge T., Zolla-Pazner S., and Nyambi P. Genetic and biological properties of HIV type 1 isolates prevalent in villagers of the Cameroon equatorial rain forests and grass fields: further evidence of broad HIV type 1 genetic diversity. AIDS Research and Hum. Retroviruses 19 (2003) 1167-1178