Genes and the dynamics of pain control

Functional Neurology

Volumn 24, Issue 1, 2009, Pages 9-15

  Hunt, Stephen P ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Descending control; Local translation; MeCP2; Pain; Sensitisation

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NERVE GROWTH FACTOR; NEUROPEPTIDE; VANILLOID RECEPTOR 1;

CHRONIC PAIN; DNA SEQUENCE; ENVIRONMENTAL FACTOR; EPIGENETICS; GENDER; GENE; GENETIC POLYMORPHISM; HOMEOSTASIS; HUMAN; HYPERALGESIA; LONG TERM POTENTIATION; NERVE CELL PLASTICITY; NERVE FIBER C; NOCICEPTION; NOCICEPTIVE RECEPTOR; NONHUMAN; PAIN; PROTEIN PHOSPHORYLATION; REVIEW; SEX DIFFERENCE; SPINAL CORD DORSAL HORN; ANIMAL; GENETICS; PAIN THRESHOLD; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SENSORY NERVE; SEXUAL DEVELOPMENT;

AFFERENT PATHWAYS; ANIMALS; GENES; HUMANS; PAIN; PAIN THRESHOLD; SEX CHARACTERISTICS;

EID: 67651018925     PISSN: 03935264     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (73)

1. Hunt SP, Mantyh PW. The molecular dynamics of pain control. Nat Rev Neurosci 2001;2:83-91
2. Scholz J, Woolf CJ. The neuropathic pain triad: neurons, immune cells and glia. Nat Neurosci 2007;10:1361-1368 (Pubitemid 350014681)
3. Sindrup SH, Jensen TS. Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action. Pain 1999;83:389-400
4. Greenspan JD, Craft RM, LeResche L et al. Studying sex and gender differences in pain and analgesia: a consensus report. Pain 2007;132 (Suppl 1):S26-45 (Pubitemid 350026210)
5. Krafte DS, Bannon AW. Sodium channels and nociception: recent concepts and therapeutic opportunities. Curr Opin Pharmacol 2008;8:50-56
6. Julius D, Basbaum AI. Molecular mechanisms of nociception. Nature 2001;413:203-210
7. Huang J, Zhang X, McNaughton PA. Inflammatory pain: the cellular basis of heat hyperalgesia. Curr Neuropharmacol 2006;4:197-206 (Pubitemid 44237160)
8. Hunt SP, Rossi J. Peptide- and non-peptide-containing unmyelinated primary afferents: the parallel processing of nociceptive information. Philos Trans R Soc Lond B Biol Sci 1985;308:283-289
9. Nagy JI, Hunt SP. Fluoride-resistant acid phosphatase-containing neurones in dorsal root ganglia are separate from those containing substance P or somatostatin. Neuroscience 1982;7:89-97
10. Michael GJ, Averill S, Shortland PJ, Yan Q, Priestley JV. Axotomy results in major changes in BDNF expression by dorsal root ganglion cells: BDNF expression in large trkB and trkC cells, in pericellular baskets, and in projections to deep dorsal horn and dorsal column nuclei. Eur J Neurosci 1999;11:3539-3551 (Pubitemid 29484251)
11. Sevcik MA, Ghilardi JR, Peters CM et al. Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization. Pain 2005;115:128-141 (Pubitemid 40503972)
12. Doods H, Arndt K, Rudolf K, Just S. CGRP antagonists: unravelling the role of CGRP in migraine. Trends Pharmacol Sci 2007;28:580-587 (Pubitemid 350026615)
13. Zylka MJ, Sowa NA, Taylor-Blake B et al. Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine. Neuron 2008;60:111-122
14. Boucher TJ, Okuse K, Bennett DL, Munson JB, Wood JN, McMahon SB. Potent analgesic effects of GDNF in neuropathic pain states. Science 2000;290:124-127
15. Magerl W, Fuchs PN, Meyer RA, Treede RD. Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia. Brain 2001;124:1754-1764 (Pubitemid 32845437)
16. Jiménez-Diaz L, Géranton SM, Passmore GM et al. Local translation in primary afferent fibers regulates nociception. PLoS ONE 2008;3:e1961
17. Oshiro N, Yoshino K, Hidayat S et al. Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. Genes Cells 2004;9:359-366 (Pubitemid 38514871)
18. Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004;18:1926-1945
19. Takei N, Inamura N, Kawamura M et al. Brain-derived neurotrophic factor induces mammalian target of rapamycindependent local activation of translation machinery and protein synthesis in neuronal dendrites. J Neurosci 2004; 24:9760-9769 (Pubitemid 39463557)
20. Chan AW, MacFarlane IA, Bowsher D, Campbell JA. Weighted needle pinprick sensory thresholds: a simple test of sensory function in diabetic peripheral neuropathy. J Neurol Neurosurg Psychiatry 1992;55:56-59
21. Craner MJ, Klein JP, Black JA, Waxman SG. Preferential expression of IGF-I in small DRG neurons and down-regulation following injury. Neuroreport 2002;13:1649-1652
22. Ji RR, Woolf CJ. Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain. Neurobiol Dis 2001; 8:1-10
23. Ji RR, Strichartz G. Cell signaling and the genesis of neuropathic pain. Sci STKE 2004 Sep 28;2004(252):reE14
24. Brenner GJ, Ji RR, Shaffer S, Woolf CJ. Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons. Eur J Neurosci 2004;20:375-384 (Pubitemid 38969623)
25. Galan A, Laird JM, Cervero F. In vivo recruitment by painful stimuli of AMPA receptor subunits to the plasma membrane of spinal cord neurons. Pain 2004;112:315-323
26. Wisden W, Errington ML, Williams S et al. Differential expression of immediate early genes in the hippocampus and spinal cord. Neuron 1990;4:603-614 (Pubitemid 20160849)
27. Williams S, Evan G, Hunt SP. C-fos Induction in the spinal cord after peripheral nerve lesion. Eur J Neurosci 1991;3:887-894
28. Rygh LJ, Suzuki R, Rahman W et al. Local and descending circuits regulate long-term potentiation and zif268 expression in spinal neurons. Eur J Neurosci 2006;24:761-772 (Pubitemid 44232522)
29. Hunt SP, Pini A, Evan G. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature 1987;328:632-634 (Pubitemid 17103967)
30. Géranton SM, Morenilla-Palao C, Hunt SP. A role for transcriptional repressor methyl-CpG-binding protein 2 and plasticity-related gene serum- and glucocorticoid-inducible kinase 1 in the induction of inflammatory pain states. J Neurosci 2007;27:6163-6173 (Pubitemid 46890014)
31. Géranton SM, Fratto V, Tochiki KK, Hunt SP. Descending serotonergic controls regulate inflammation-induced mechanical sensitivity and methyl-CpG-binding protein 2 phosphorylation in the rat superficial dorsal horn. Mol Pain 2008;4:35
32. Duanmu Z, Kocarek TA, Runge-Morris M. Transcriptional regulation of rat hepatic aryl sulfotransferase (SULT1A1) gene expression by glucocorticoids. Drug Metab Dispos 2001;29:1130-1135 (Pubitemid 32660532)
33. Denny WB, Prapapanich V, Smith DF, Scammell JG. Structure-function analysis of squirrel monkey FK506-binding protein 51, a potent inhibitor of glucocorticoid receptor activity. Endocrinology 2005;146:3194-3201
34. Nuber UA, Kriaucionis S, Roloff TC et al. Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome. Hum Mol Genet 2005;14:2247-2256
35. Chen WG, Chang Q, Lin Y et al. Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 2003;302:885-889
36. Chahrour M, Zoghbi HY. The story of Rett syndrome: from clinic to neurobiology. Neuron 2007;56:422-437
37. Todd AJ, McGill MM, Shehab SA. Neurokinin 1 receptor expression by neurons in laminae I, III and IV of the rat spinal dorsal horn that project to the brainstem. Eur J Neurosci 2000;12:689-700
38. Ikeda H, Stark J, Fischer H et al. Synaptic amplifier of inflammatory pain in the spinal dorsal horn. Science 2006;312:1659-1662
39. Koutsikou S, Parry DM, MacMillan FM, Lumb BM. Laminar organization of spinal dorsal horn neurones activated by C- vs. A-heat nociceptors and their descending control from the periaqueductal grey in the rat. Eur J Neurosci 2007;26:943-952
40. Gauriau C, Bernard JF. A comparative reappraisal of projections from the superficial laminae of the dorsal horn in the rat: the forebrain. J Comp Neurol 2004;468:24-56
41. Craig AD. How do you feel? Interoception: the sense of the physiological condition of the body. Nat Rev Neurosci 2002;3:655-666
42. Nichols ML, Allen BJ, Rogers SD et al. Transmission of chronic nociception by spinal neurons expressing the substance P receptor. Science 1999;286:1558-1561
43. Porreca F, Ossipov MH, Gebhart GF. Chronic pain and medullary descending facilitation. Trends Neurosci 2002;25:319-325
44. Urban MO, Gebhart GF. Supraspinal contributions to hyperalgesia. Proc Natl Acad Sci U S A 1999;96:7687-7692
45. Heinricher MM, Tavares I, Leith JL, Lumb BM. Descending control of nociception: Specificity, recruitment and plasticity. Brain Res Rev 2008 [Epub ahead of print]
46. Finn DP, Beckett SR, Richardson D, Kendall DA, Marsden CA, Chapman V. Evidence for differential modulation of conditioned aversion and fear-conditioned analgesia by CB1 receptors. Eur J Neurosci 2004;20:848-852
47. Johansen JP, Fields HL. Glutamatergic activation of anterior cingulate cortex produces an aversive teaching signal. Nat Neurosci 2004;7:398-403
48. Pertovaara A. Plasticity in descending pain modulatory systems. Prog Brain Res 2000;129:231-242
49. Millan MJ. Descending control of pain. Prog Neurobiol 2002;66:355-474
50. Suzuki R, Morcuende S, Webber M, Hunt SP, Dickenson AH. Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways. Nat Neurosci 2002;5:1319-1326 (Pubitemid 35417767)
51. Porreca F, Burgess SE, Gardell LR, Vanderah TW, Malan TP, Jr., Ossipov MH, et al. Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor. J Neurosci 2001;21:5281-5288 (Pubitemid 32622953)
52. Suzuki R, Rahman W, Hunt SP, Dickenson AH. Descending facilitatory control of mechanically evoked responses is enhanced in deep dorsal horn neurones following peripheral nerve injury. Brain Res 2004;1019:68-76 (Pubitemid 39078612)
53. Suzuki R, Rahman W, Rygh LJ, Webber M, Hunt SP, Dickenson AH. Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin. Pain 2005;117:292-303 (Pubitemid 41383525)
54. Zeitz KP, Guy N, Malmberg AB et al. The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J Neurosci 2002;22:1010-1019 (Pubitemid 34141780)
55. Maxwell DJ, Kerr R, Rashid S, Anderson E. Characterisation of axon terminals in the rat dorsal horn that are immunoreactive for serotonin 5-HT3A receptor subunits. Exp Brain Res 2003;149:114-124 (Pubitemid 36286821)
56. Miquel MC, Emerit MB, Nosjean A et al. Differential subcellular localization of the 5-HT3-As receptor subunit in the rat central nervous system. Eur J Neurosci 2002;15:449-457 (Pubitemid 35463663)
57. Cox JJ, Reimann F, Nicholas AK, Thornton G, Roberts E, Springell K, et al. An SCN9A channelopathy causes congenital inability to experience pain. Nature 2006;444:894-898
58. Goldberg YP, MacFarlane J, MacDonald ML, Thompson J, Dube MP, Mattice M, et al. Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations. Clin Genet 2007;71:311-319
59. Diatchenko L, Nackley AG, Tchivileva IE, Shabalina SA, Maixner W. Genetic architecture of human pain perception. Trends Genet 2007;23:605-613
60. Mogil JS, Wilson SG, Chesler EJ et al. The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proc Natl Acad Sci U S A 2003;100:4867-4872
61. Zubieta JK, Heitzeg MM, Smith YR et al. COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science 2003;299:1240-1243
62. Tegeder I, Costigan M, Griffin RS et al. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med 2006;12:1269-1277
63. Schweinhardt P, Sauro KM, Bushnell MC. Fibromyalgia: a disorder of the brain? Neuroscientist 2008;14:415-421
64. Brischoux F, Chakraborty S, Brierley DI, Ungless MA. Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli. Proc Natl Acad Sci U S A. 2009;106:4894-4899
65. Schultz W. Multiple dopamine functions at different time courses. Annu Rev Neurosci 2007;30:259-288
66. Reynolds DV. Surgery in the rat during electrical analgesia induced by focal brain stimulation. Science 1969;164:444-445
67. Fields HL. Understanding how opioids contribute to reward and analgesia. Reg Anesth Pain Med 2007;32:242-246
68. Fields H. State-dependent opioid control of pain. Nat Rev Neurosci 2004;5:565-575
69. Franklin KB. Analgesia and the neural substrate of reward. Neurosci Biobehav Rev 1989;13:149-154
70. Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 2006;9:519-525
71. Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, et al. Epigenetic programming by maternal behavior. Nat Neurosci 2004;7:847-854
72. Walker SM, Franck LS, Fitzgerald M, Myles J, Stocks J, Marlow N. Long-term impact of neonatal intensive care and surgery on somatosensory perception in children born extremely preterm. Pain 2009;141:79-87
73. Beecher HK. Relationship of significance of wound to pain experienced. J Am Med Assoc 1956;161:1609-1613