How important is hyperglycemia during acute brain infarction?

Neurologist

Volumn 10, Issue 4, 2004, Pages 195-200

  Bruno, Askiel ^a   Williams, Linda S ^a   Kent, Thomas A ^b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Cerebral infarction; Cerebral perfusion; Hyperglycemia

Indexed keywords

GLUCOSE; INSULIN; POTASSIUM;

BLOOD CLOT LYSIS; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN PERFUSION; CLINICAL TRIAL; DISEASE ASSOCIATION; GLUCOSE INTAKE; HUMAN; HYPERGLYCEMIA; OUTCOMES RESEARCH; PRIORITY JOURNAL; REVIEW;

ACUTE DISEASE; ANIMALS; BRAIN INFARCTION; HUMANS; HYPERGLYCEMIA; REPERFUSION; TREATMENT OUTCOME;

EID: 3242657072     PISSN: 10747931     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.nrl.0000131800.77824.dd     Document Type: Review

References (32)

1. Kent TA, Soukup VM, Fabian RH. Heterogeneity affecting outcome from acute stroke therapy: making reperfusion worse. Stroke. 2001;32: 2318-2327.
2. Gisselsson L, Smith ML, Siesjo BK. Hyperglycemia and focal brain ischemia. J Cereb Blood Flow Metab. 1999;19:288-297.
3. Quast MJ, Wei J, Huang NC, et al, Perfusion deficit parallels exacerbation of cerebral ischemia/reperfusion injury in hyperglycemic rats. J Cereb Blood Flow Metab. 1997;17:553-559.
4. Prado R, Ginsberg MD, Dietrich WD, et al. Hyperglycemia increases infarct size in collaterally perfused but not end-arterial vascular territories. J Cereb Blood Flow Metab. 1988;8:186-192.
5. Kawai N, Keep RF, Betz AL. Hyperglycemia and the vascular effects of cerebral ischemia. Stroke. 1997;28:149-154.
6. Yip PK, He YY, Hsu CY, et al. Effect of plasma glucose on infarct size in focal cerebral ischemia-reperfusion. Neurology. 1991;41:899-905.
7. Li P-A, Shuaib A, Miyashita H, et al. Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia. Stroke. 2000;31:183-192.
8. Warner DS, Gionet TX, Todd MM, et al. Insulin-induced normoglycemia improves ischemic outcome in hyperglycemic rats. Stroke. 1992; 23:1775-1781.
9. Voll CL, Whishaw IQ, Auer RN. Postischemic insulin reduces spatial learning deficit following transient forebrain ischemia in rats. Stroke. 1989;20:646-651.
10. Tyson R, Peeling J, Sutherland G. Metabolic changes associated with altering blood glucose levels in short duration forebrain ischemia. Brain Res. 1993;608:288-298.
11. 3H]nimodipine in focal cerebral ischemia: modulation by hyperglycemia. J Cereb Blood Flow Metab. 1997;17:1057-1065.
12. Alvarez-Sabin J, Molina CA, Montaner J, et al. Effects of admission hyperglycemia on stroke outcome in reperfused tissue plasminogen activator-treated patients * editorial comment. Stroke. 2003;34:1235-1241.
13. Molina CA, Montaner J, Abilleira S, et al. Timing of spontaneous recanalization and risk of hemorrhagic transformation in acute cardioembolic stroke. Stroke. 2001;32:1079-1084.
14. Alexandrov AV, Grotta JC. Arterial reocclusion in stroke patients treated with intravenous tissue plasminogen activator. Neurology. 2002; 59:862-867.
15. Bruno A, Biller J, Adams HP Jr., et al. Acute blood glucose level and outcome from ischemic stroke. Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Investigators. Neurology. 1999;52:280-284.
16. Wass CT, Scheithauer BW, Bronk JT, et al. Insulin treatment of corticosteroid-associated hyperglycemia and its effect on outcome after forebrain ischemia in rats. Anesthesiology. 1996;84:644-651.
17. Voll C, Auer R. The effect of postischemic blood glucose levels on ischemic brain damage in the rat. Ann Neurol. 1988;24:638-646.
18. Dandona P, Aljada A, Bandyopadhyay A. The potential therapeutic role of insulin in acute myocardial infarction in patients admitted to intensive care and in those with unspecified hyperglycemia. Diabetes Care. 2003;26:516-519.
19. Diaz R, Paolasso EA, Piegas LS, et al. Metabolic modulation of acute myocardial infarction. The ECLA (Estudios Cardiologicos Latino-america) Collaborative Group. Circulation. 1998;98:2227-2234.
20. Abu-Zeid HA, Choi NW, Hsu P-H, et al. Prognostic factors in the survival of 1,484 stroke cases observed for 30 to 48 months. Arch Neurol. 1978;35:213-218.
21. Moulin T, Tatu L, Crépin-Leblond T, et al. The Besanqon Stroke Registry: an acute stroke registry of 2,500 consecutive patients. Eur Neurol. 1997;38:10-20.
22. Weir CJ, Murray GD, Dyker AG, et al. Is hyperglycaemia an independent predictor of poor outcome after acute stroke? Results of a long term follow up study. BMJ. 1997;314:1303-1306.
23. Bruno A, Levine SR, Frankel MR, et al. Admission glucose level and clinical outcomes in the NINDS rt-PA. Stroke Trial Neurol. 2002;59: 669-674.
24. Els T, Klisch J, Orszagh M, et al. Hyperglycemia in patients with focal cerebral ischemia after intravenous thrombolysis: influence on clinical outcome and infarct size. Cerebrovasc Dis. 2002;13:89-94.
25. Baird TA, Parsons MW, Phanh T, et al. Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome. Stroke. 2003;34:2208-2214.
26. Parsons MW, Barber PA, Darby DG, et al. Acute hyperglycemia in stroke leads to increased brain lactate production and greater final infarct size. Stroke. 2001;32:331-332.
27. Larrue V, von Kummer RR, Muller A, et al. Risk factors for severe hemorrhagic transformation in ischemic stroke patients treated with recombinant tissue plasminogen activator: a secondary analysis of the European-Australasian Acute Stroke Study (ECASS II). Stroke. 2001; 32:438-441.
28. Scott JF, Robinson GM, French JM, et al. Glucose potassium insulin infusions in the treatment of acute stroke patients with mild to moderate hyperglycemia: the Glucose Insulin in Stroke Trial (GIST). Stroke. 1999;30:793-799.
29. Williams LS, Rotich J, Qi R, et al. Admission hyperglycemia and mortality after stroke: magnitude and management of the problem. Neurology. 2002.
30. Bruno A, Saha C, Williams LS, et al. IV insulin during acute cerebral infarction in patients with diabetes mellitus. Neurology. 2004;62:1441-1442.
31. Malmberg K, Ryden L, Efendic S, et al. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. J Am Coll Cardiol. 1995;26:57-65.
32. Malmberg K, for the DIGAMI (Diabetes Mellitus IGIiAMISG). Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. BMJ. 1997;314:1512-1515.