Conformational change in the Bacillus subtilis RNase P holoenzyme-pre-tRNA complex enhances substrate affinity and limits cleavage rate

RNA

Volumn 15, Issue 8, 2009, Pages 1565-1577

  Hsieh, John ^a   Fierke, Carol A ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Mechanism; Ribonuclease P; Transient kinetics

Indexed keywords

CALCIUM; HOLOENZYME; MAGNESIUM; NUCLEOTIDE; RIBONUCLEASE P; TRANSFER RNA;

ARTICLE; BACILLUS SUBTILIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN INTERACTION; RNA BINDING; RNA CLEAVAGE; THERMODYNAMICS; TURNOVER TIME;

BACILLUS SUBTILIS; FLUORESCEIN; FLUORESCENT DYES; HOLOENZYMES; KINETICS; MODELS, BIOLOGICAL; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; RIBONUCLEASE P; RNA PRECURSORS; RNA, BACTERIAL; SUBSTRATE SPECIFICITY;

BACILLUS SUBTILIS;

EID: 67651007225     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.1639409     Document Type: Article

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