Ribonuclease P: A ribonucleoprotein enzyme

Current Opinion in Chemical Biology

Volumn 4, Issue 5, 2000, Pages 553-558

  Kurz, Jeffrey C ^a   Fierke, Carol A ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RIBONUCLEASE P; RIBONUCLEOPROTEIN; TRANSFER RNA;

CATALYSIS; CHEMICAL REACTION; ENZYME ACTIVITY; HYDROLYSIS; PROTEIN STRUCTURE; REVIEW; RNA ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 0033779905     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(00)00131-9     Document Type: Review

References (75)

1. Ribozymes: The characteristics and properties of catalytic RNAs
2. Mechanistic aspects of enzymatic catalysis: Lessons from comparison of RNA and protein enzymes
3. Evolutionary perspective on the structure and function of ribonuclease P, a ribozyme
4. RNase P - A 'Scarlet Pimpernel'
5. Ribonuclease P: Unity and diversity in a tRNA processing ribozyme
6. Ribonuclease P: The diversity of a ubiquitous RNA processing enzyme
7. The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
8. Role of the protein moiety of ribonuclease P, a ribonucleoprotein enzyme
9. Protein component of Bacillus subtilis RNase P specifically enhances the affinity for precursor-tRNA(Asp)
10. E. coli RNAase P has a required RNA component
11. Substrate recognition by RNase P and by the catalytic M1 RNA: Identification of possible contact points in pre-tRNAs
12. Base pairing between Escherichia coli RNase P RNA and its substrate
13. Model substrates for an RNA enzyme
14. Nucleotides in precursor tRNAs that are required intact for catalysis by RNase P RNAs
15. Evolutionary variation in bacterial RNase P RNAs
16. Structure and evolution of ribonuclease P RNA in Gram-positive bacteria
17. The design and catalytic properties of a simplified ribonuclease P RNA
18. Higher order folding and domain analysis of the ribozyme from Bacillus subtilis ribonuclease P
19. Domain structure of the ribozyme from eubacterial ribonuclease P
20. Recognition of the T stem-loop of a pre-tRNA substrate by the ribozyme from Bacillus subtilis ribonuclease P
21. Multiple substrate binding sites in the ribozyme from Bacillus subtilis RNase P
22. The cleavage step of ribonuclease P catalysis is determined by ribozyme-substrate interactions both distal and proximal to the cleavage site
23. Different cleavage sites are aligned differently in the active site of M1 RNA, the catalytic subunit of Escherichia coli RNase P
24. Use of circular permutation and end modification to position photoaffinity probes for analysis of RNA structure
25. Thionucleobases as intrinsic photoaffinity probes of nucleic acid structure and nucleic acid-protein interactions
26. Identification of individual nucleotides in the bacterial ribonuclease P ribozyme adjacent to the pre-tRNA cleavage site by short-range photocrosslinking
27. The track of the pre-tRNA 5' leader in the ribonuclease P ribozyme-substrate complex
28. Multiple binding modes of substrate to the catalytic RNA subunit of RNase P from Escherichia coli
29. Nucleotide analog interference mapping
30. Identification of adenosine functional groups involved in substrate binding by the ribonuclease P ribozyme
31. Secondary structure of the circular form of the Tetrahymena rRNA intervening sequence: A technique for RNA structure analysis using chemical probes and reverse transcriptase
32. 2 groups of Escherichia coli RNase P RNA involved in intramolecular tertiary contacts and direct interactions with tRNA
33. Comparative photocrosslinking analysis of the tertiary structures of Escherichia coli and Bacillus subtilis RNase P RNAs
34. Derivation of the three-dimensional architecture of bacterial ribonuclease P RNAs from comparative sequence analysis
35. Mapping the active site of ribonuclease P RNA using a substrate containing a photoaffinity agent
36. Use of photoaffinity crosslinking and molecular modeling to analyze the global architecture of ribonuclease P RNA
37. Circularly permuted tRNAs as specific photoaffinity probes of ribonuclease P RNA structure
38. Interaction of the 3'-end of tRNA with ribonuclease P RNA
39. Mechanisms of signaling and related enzymes
40. A general two-metal-ion mechanism for catalytic RNA
41. Multiple magnesium ions in the ribonuclease P reaction mechanism
42. Magnesium ions are required by Bacillus subtilis ribonuclease P RNA for both binding and cleaving precursor tRNA(Asp)
43. How many catalytic RNAs? Ions and the Cheshire cat conjecture
44. Ribozymes: A distinct class of metalloenzymes
45. Divalent cation-dependent stereospecificity of adenosine 5'-O-(2-thiotriphosphate) in the hexokinase and pyruvate kinase reactions. The absolute stereochemistry of the diastereoisomers of adenosine 5'-O-(2-thiotriphosphate)
46. 2+ complexes of adenine nucleotides and thionucleotides and rate constants for formation and dissociation of MgATP and MgADP
47. Thiophilic metal ion rescue of phosphorothioate interference within the Tetrahymena ribozyme P4-P6 domain
48. 2+ coordinated to the pro-R(p) oxygen of the scissile bond
49. 2+-ribozyme by a single R(p)-phosphorothioate modification in the precursor tRNA at the RNase P cleavage site
50. Role of metal ions in the hydrolysis reaction catalyzed by RNase P RNA from Bacillus subtilis
51. Active site constraints in the hydrolysis reaction catalyzed by bacterial RNase P: Analysis of precursor tRNAs with a single 3'-S-phosphorothiolate internucleotide linkage
52. A new metal ion interaction in the Tetrahymena ribozyme reaction revealed by double sulfur substitution
53. Identification of phosphates involved in catalysis by the ribozyme RNase P RNA
54. Helix P4 is a divalent metal ion binding site in the conserved core or the ribonuclease P ribozyme
55. Identification by modification-interference of purine N-7 and ribose 2'-OH groups critical for catalysis by bacterial ribonuclease P
56. The NMR structure of 31mer RNA domain of Escherichia coli RNase P RNA using its non-uniformly deuterium labelled counterpart [the 'NMR-window' concept]
57. The P15-loop of Escherichia coli RNase P RNA is an autonomous divalent metal ion binding domain
58. 2+ ions by ribonuclease P
59. The protein component of Bacillus subtilis ribonuclease P increases catalytic efficiency by enhancing interactions with the 5' leader sequence of pre-tRNA(Asp)
60. Evolution of enzyme function and the development of catalytic efficiency
61. Kinetics of the processing of the precursor to 4.5 S RNA, a naturally occurring substrate for RNase P from Escherichia coli
62. Differential evolution of substrates for an RNA enzyme in the presence and absence of its protein cofactor
63. Ribonuclease P protein structure: Evolutionary origins in the translational apparatus
64. The structure of ribonuclease P protein from Staphylococcus aureus reveals a unique binding site for single-stranded RNA
65. Protein component of the ribozyme ribonuclease P alters substrate recognition by directly contacting precursor tRNA
66. The Ribonuclease P Database
67. Analysis of the functional role of conserved residues in the protein subunit of ribonuclease P from Escherichia coli
68. Kinetic and thermodynamic analysis of RNA-protein interactions in the RNase P holoenzyme from Escherichia coli
69. Characterization in vitro of the defect in a temperature-sensitive mutant of the protein subunit of RNase P from Escherichia coli
70. Protein-RNA interactions in the RNase P holoenzyme from Escherichia coli
71. Gel retardation analysis of the interaction between C5 protein and M1 RNA in the formation of the ribonuclease P holoenzyme from Escherichia coli
72. Recognition of a pre-tRNA substrate by the Bacillus subtilis RNase P holoenzyme
73. Mapping RNA-protein interactions in ribonuclease P from Escherichia coli using disulfide-linked EDTA-Fe
74. Gel retardation analysis of E. coli M1 RNA-tRNA complexes