Effect of ShanZha, a Chinese herbal product, on obesity and dyslipidemia in hamsters receiving high-fat diet

Journal of Ethnopharmacology

Volumn 124, Issue 3, 2009, Pages 544-550

  Kuo, Daih Huang ^a   Yeh, Ching Hua ^b,d   Shieh, Po Chuen ^a   Cheng, Kai Chun ^b   Chen, Fu An ^a   Cheng, Juei Tang ^b,c,d  

^a TAJEN UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c CHI MEI MEDICAL CENTER   (Taiwan)

^d CHANG JUNG CHRISTIAN UNIVERSITY   (Taiwan)

Author keywords

Dyslipidemia; Obesity; PPAR ; Rosaceae; ShanZha (Crataegus pinnatifida)

Indexed keywords

ANTILIPEMIC AGENT; CHINESE DRUG; CLOFIBRATE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BROWN ADIPOSE TISSUE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CRATAEGUS; CRATAEGUS PIMMATIFIDA; DOSE RESPONSE; DYSLIPIDEMIA; FOOD INTAKE; HAMSTER; LIPID DIET; MALE; NONHUMAN; OBESITY; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE;

3T3 CELLS; ADIPOCYTES; ADIPOSITY; ANIMALS; ANTI-OBESITY AGENTS; AZO COMPOUNDS; BLOTTING, WESTERN; BODY WEIGHT; CELL DIFFERENTIATION; COLORING AGENTS; CRICETINAE; DIET; DIETARY FATS; DRUGS, CHINESE HERBAL; DYSLIPIDEMIAS; EATING; HYPOLIPIDEMIC AGENTS; INDICATORS AND REAGENTS; MALE; MESOCRICETUS; MICE; PPAR ALPHA;

CRATAEGUS PINNATIFIDA; CRICETINAE; ROSACEAE;

EID: 67651005118     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.05.005     Document Type: Article

References (39)

1. Ahmed S.M., Clasen M.E., and Donnelly J.E. Management of dyslipidemia in adults. American Family Physician 57 (1998) 2192-2204
2. Ailhaud G., Grimaldi P., and Negrel R. Cellular and molecular aspects of adipose tissue development. Annual Review of Nutrition 12 (1992) 207-233
3. Akbiyik F., Cinar K., Demirpence E., Ozsullu T., Tunca R., Haziroglu R., Yurdaydin C., Uzunalimoglu O., and Bozkaya H. Ligand-induced expression of peroxisome proliferator-activated receptor alpha and activation of fatty acid oxidation enzymes in fatty liver. European Journal of Clinical Investigation 34 (2004) 429-435
4. Al Makdessi S., Sweidan H., Müllner S., and Jocob R. Myocardial protection by pre-treatment with Crataegus oxyacantha. Arzneimittel-Forschung (Drug Research) 46 (1996) 25-27
5. Ali A.T., Penny C.B., Paiker J.E., Psaras G., Ikram F., and Crowther N.J. The relationship between alkaline phosphatase activity and intracellular lipid accumulation in murine 3T3-L1 cells and human preadipocytes. Analytical Biochemistry 354 (2006) 247-254
6. Ammon H.P., and Handel M. Crataegus, toxicology and pharmacology. Part I. Toxicity. Planta Medica 43 (1981) 105-120
7. Berger J.P., Akiyama T.E., and Meinke P.T. PPARs: therapeutic targets for metabolic disease. Trends in Pharmacological Sciences 26 (2005) 244-251
8. Bergeron R.Y., Woods J., Zycband J.W., Liu E.I., Li C., Adams Z., Berger A., Zhang J.P., Moller B.B., Doebber D.E., and Thomas W. Peroxisome proliferator-activated receptor (PPAR)-alpha agonism prevents the onset of type 2 diabetes in Zucker diabetic fatty rats: a comparison with PPAR gamma agonism. Endocrinology 147 (2006) 4252-4262
9. Bray G.A., and Bellanger T. Epidemiology, trends, and morbidities of obesity and the metabolic syndrome. Endocrine 29 (2006) 109-117
10. Bucher H.C., Griffith L.E., and Guyatt G.H. Systematic review on the risk and benefit of different cholesterol-lowering interventions. Arteriosclerosis, Thrombosis, and Vascular Biology 19 (1999) 187-195
11. Chen J.D., Wu Y.Z., Tao Z.L., Chen Z.M., and Liu X.P. Hawthorn (shan zha) drink and its lowering effect on blood lipid levels in humans and rats. World Review of Nutrition and Dietetics 77 (1995) 147-154
12. Chu C.Y., Lee M.J., Liao C.L., Lin W.L., Yin Y.F., and Tseng T.H. Inhibitory effect of hot-water extract from dried fruit of Crataegus pinnatifida on low-density lipoprotein (LDL) oxidation in cell and cell-free systems. Journal of Argicultural and Food Chemistry 51 (2003) 7583-7588
13. Fan C., Yan J., Qian Y., Wo X., and Gao L. Regulation of lipoprotein lipase expression by effect of hawthorn flavonoids on peroxisome proliferator response element pathway. Journal of Pharmacological Sciences 100 (2006) 51-58
14. Ferreira A.V., Parreira G.G., Green A., and Botion L.M. Effects of fenofibrate on lipid metabolism in adipose tissue of rats. Metabolism: Clinical and Experimental 55 (2006) 731-735
15. Francis G.A., Annicotte J.S., and Auwerx J. PPAR agonists in the treatment of atherosclerosis. Current Opinion in Pharmacology 3 (2003) 186-191
16. Fu J., Gaetani S., Oveisi F., Lo Verme J., Serrano A., Rodriguez De Fonseca F., Rosengarth A., Luecke H., Di Giacomo B., Tarzia G., and Piomelli D. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 425 (2003) 90-93
17. Guerre-Millo M., Gervois P., Raspe E., Madsen L., Poulain P., Derudas B., Herbert J.M., Winegar D.A., Willson T.M., Fruchart J.C., Berge R.K., and Staels B. Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. Journal of Biological Chemistry 275 (2000) 16638-16642
18. Hamilton M. Strategies for the management of patients with obesity. Treatments in Endocrinology 1 (2002) 21-36
19. Hamon N.W. Hawthorns. Canadian Pharmaceutical Journal 708 (1988) 724
20. Kao S.T., Wang S.D., Yu C.K., and Lei H.Y. The effect of Chinese herbal medicine, xiao-qing-long tang (XQLT), on allergen-induced bronchial inflammation in mite-sensitized mice. Allergy 55 (2000) 1127-1133
21. Kwon H.J., Hyun S.H., and Choung S.Y. Traditional Chinese medicine improves dysfunction of peroxisome proliferator-activated receptor alpha and microsomal triglyceride transfer protein on abnormalities in lipid metabolism in ethanol-fed rats. BioFactors 23 (2005) 163-176
22. Lee C.H., Olson P., and Evans R.M. Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology 144 (2003) 2201-2207
23. Lei F., Zhang X.N., Wang W., Xing D.M., Xie W.D., Su H., and Du L.J. Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. International Journal of Obesity 31 (2007) 1023-1029
24. Li Z.Y., Xu G.B., and Xia T.A. Prevalence rate of metabolic syndrome and dyslipidemia in a large professional population in Beijing. Atherosclerosis 184 (2006) 188-192
25. Lin J., Della-Fera M.A., and Baile C.A. Green tea polyphenol epigallocatechin gallate inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes. Obesity Research 13 (2005) 982-990
26. Lo Verme J., Gaetani S., Fu J., Oveisi F., Burton K., and Piomelli D. Regulation of food intake by oleoylethanolamide. Cellular and Molecular Life Sciences 62 (2005) 708-716
27. Luci S., Giemsa B., Kluge H., and Eder K. Clofibrate causes an upregulation of PPARα target genes but does not alter expression of SREBP target genes in liver and adipose tissue of pigs. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 293 (2007) R70-77
28. Pöpping S., Rose H., Ioneseu I., Fisher Y., and Kammermeier H. Effect of a hawthorn extract on contraction and energy turnover of isolated rat cardiomyocytes. Arzneimittel-Forschung (Drug Research) 45 (1995) 1157-1161
29. Rosen E.D. The molecular control of adipogenesis, with special reference to lymphatic pathology. Annals of New York Academy of Sciences 979 (2002) 143-158
30. Schuller H.M., Zhang L., Weddle D.L., Castonguay A., Walker K., and Miller M.S. The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK. Journal of Cancer Research and Clinical Oncology 128 (2002) 525-532
31. Singh R., Artaza J.N., Taylor W.E., Braga M., Yuan X., Gonzalez-Cadavid N.F., and Bhasin S. Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology 147 (2006) 141-154
32. Thuillier P., Baillie R., Sha X., and Clarke S.D. Cytosolic and nuclear distribution of PPARgamma2 in differentiating 3T3-L1 preadipocytes. Journal of Lipid Research 39 (1998) 2329-2338
33. Vibes J., Lasserre B., Gleye J., and Declume C. Inhibition of thromboxane A2 biosynthesis in vitro by the main components of Crataegus oxyacantha (Hawthorn) flower heads. Prostaglandins, Leukotrienes, and Essential Fatty Acids 50 (1994) 173-175
34. Weihmayr T., and Ernst E. Therapeutic effectiveness of Crataegus. Fortschritte der Medizin 114 (1996) 27-29
35. Yang J.Y., Della-Fera M.A., Hartzell D.L., Nelson-Dooley C., Hausman D.B., and Baile C.A. Esculetin induces apoptosis and inhibits adipogenesis in 3T3-L1 cells. Obesity 14 (2006) 1691-1699
36. Yano H., Mizoguchi A., Fukuda K., Haramaki M., Ogasawara S., Momosaki S., and Kojiro M. The herbal medicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase. Cancer Research 54 (1994) 448-454
37. Yeh C.C., Lin C.C., Wang S.D., Chen Y.S., Su B.H., and Kao S.T. Protective and anti-inflammatory effect of a traditional Chinese medicine, Xia-Bai-San, by modulating lung local cytokine in a murine model of acute lung injury. International Immunopharmacology 6 (2006) 1506-1514
38. Yin J., Zhang H., and Ye J. Traditional Chinese medicine in treatment of metabolic syndrome. Endocrine, Metabolic & Immune Disorders Drug Targets 8 (2008) 99-111
39. Zhang Z., Chang Q., Zhu M., Huang Y., Ho W.K., and Chen Z. Characterization of antioxidants present in hawthorn fruits. The Journal of Nutritional Biochemistry 12 (2001) 144-152