Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase

Journal of Structural Biology

Volumn 146, Issue 3, 2004, Pages 416-424

  Govindasamy, Lakshmanan ^a   Kukar, Thomas ^a   Lian, Wei ^a   Pedersen, Brenda ^a   Gu, Yunrong ^a   Agbandje McKenna, Mavis ^a   Jin, Shouguang ^a   McKenna, Robert ^a   Wu, Donghai ^a,b  

^a UNIVERSITY OF FLORIDA   (United States)

^b Shanghai Institute of Forensic Science   (China)

Author keywords

cation interaction; Binary complex; Carnitine acetyltransferase; Steady state enzyme kinetics; Substrate binding site; X ray structure

Indexed keywords

AMINO ACID; ARGININE; CARBOXYLIC ACID DERIVATIVE; CARNITINE; CARNITINE ACETYLTRANSFERASE; HISTIDINE; NITROGEN; PHENYLALANINE; THREONINE; TYROSINE;

AMINO ACID ANALYSIS; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CRYSTAL STRUCTURE; ELECTRICITY; ENZYME ACTIVITY; ENZYME KINETICS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; R FACTOR; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

BINDING SITES; CARNITINE; CARNITINE O-ACETYLTRANSFERASE; CRYSTALLIZATION; ELECTROSTATICS; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 1942521313     PISSN: 10478477     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsb.2004.01.011     Document Type: Article

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