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Volumn 5, Issue 2, 2006, Pages 175-184

Metabolic therapeutics in angina pectoris: History revisited with perhexiline

Author keywords

Etomoxir; Nursing management; Perhexiline; Pharmacology; Ranolazine; Refractory angina; Trimetazidine

Indexed keywords

ETOMOXIR; INSULIN; PERHEXILINE MALEATE; RANOLAZINE; SEROTONIN UPTAKE INHIBITOR; TRIMETAZIDINE;

EID: 33646188203     PISSN: 14745151     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcnurse.2006.01.001     Document Type: Article
Times cited : (28)

References (59)
  • 1
    • 0043169580 scopus 로고    scopus 로고
    • The current cost of angina pectoris to the National Health Service in the UK
    • Stewart S., Murphy N., Walker A., McGuire A., and McMurray J.J. The current cost of angina pectoris to the National Health Service in the UK. Heart 89 (2003) 848-853
    • (2003) Heart , vol.89 , pp. 848-853
    • Stewart, S.1    Murphy, N.2    Walker, A.3    McGuire, A.4    McMurray, J.J.5
  • 2
    • 2942709737 scopus 로고    scopus 로고
    • Hospital discharge rates for suspected acute coronary syndromes between 1990-2000: population based analysis
    • Murphy N.F., MacIntyre K., Capewell S., Stewart S., Pell J., Chalmers J., et al. Hospital discharge rates for suspected acute coronary syndromes between 1990-2000: population based analysis. BMJ 328 (2004) 1413-1414
    • (2004) BMJ , vol.328 , pp. 1413-1414
    • Murphy, N.F.1    MacIntyre, K.2    Capewell, S.3    Stewart, S.4    Pell, J.5    Chalmers, J.6
  • 3
    • 0141459006 scopus 로고    scopus 로고
    • Refractory to medical treatment but not to nursing care: can we do more for patients with chronic angina pectoris?
    • Stewart S. Refractory to medical treatment but not to nursing care: can we do more for patients with chronic angina pectoris?. Eur J Cardiovasc Nurs 2 (2003) 169-170
    • (2003) Eur J Cardiovasc Nurs , vol.2 , pp. 169-170
    • Stewart, S.1
  • 4
    • 0036522084 scopus 로고    scopus 로고
    • The problem of chronic refractory angina. Report from the ESC joint study group on the treatment of refractory angina
    • Mannheimer C., Camici P., Chester M.R., Collins A., DeJongste M., Eliasson T., et al. The problem of chronic refractory angina. Report from the ESC joint study group on the treatment of refractory angina. Eur Heart J 23 (2002) 355-370
    • (2002) Eur Heart J , vol.23 , pp. 355-370
    • Mannheimer, C.1    Camici, P.2    Chester, M.R.3    Collins, A.4    DeJongste, M.5    Eliasson, T.6
  • 5
    • 0032749807 scopus 로고    scopus 로고
    • Improving quality of life in patients with angina
    • Lewin R.J. Improving quality of life in patients with angina. Heart 82 (1999) 654-655
    • (1999) Heart , vol.82 , pp. 654-655
    • Lewin, R.J.1
  • 6
    • 0036191427 scopus 로고    scopus 로고
    • A randomised controlled trial of a self-management plan for patients with newly diagnosed angina
    • Lewin R.J., Furze G., Robinson J., Griffith K., Wiseman S., Pye M., et al. A randomised controlled trial of a self-management plan for patients with newly diagnosed angina. Br J Gen Pract 52 (2002) 194-201
    • (2002) Br J Gen Pract , vol.52 , pp. 194-201
    • Lewin, R.J.1    Furze, G.2    Robinson, J.3    Griffith, K.4    Wiseman, S.5    Pye, M.6
  • 7
    • 0037139277 scopus 로고    scopus 로고
    • Refractory angina pectoris mechanism and therapeutic options
    • Kim M.C., Kini A., and Sharma S.K. Refractory angina pectoris mechanism and therapeutic options. J Am Coll Cardiol 39 6 (2002) 923-934
    • (2002) J Am Coll Cardiol , vol.39 , Issue.6 , pp. 923-934
    • Kim, M.C.1    Kini, A.2    Sharma, S.K.3
  • 8
    • 0016998022 scopus 로고
    • Grading of angina pectoris (letter)
    • Campeau L. Grading of angina pectoris (letter). Circulation 54 (1976) 522-523
    • (1976) Circulation , vol.54 , pp. 522-523
    • Campeau, L.1
  • 9
    • 2342526006 scopus 로고    scopus 로고
    • Metabolic manipulation in ischaemic heart disease, a novel approach to treatment
    • Lee L., Horowitz J.D., and Frenneaux M. Metabolic manipulation in ischaemic heart disease, a novel approach to treatment. Eur Heart J 25 (2004) 634-641
    • (2004) Eur Heart J , vol.25 , pp. 634-641
    • Lee, L.1    Horowitz, J.D.2    Frenneaux, M.3
  • 10
    • 0030891048 scopus 로고    scopus 로고
    • Perhexiline improves symptomatic status in elderly patients with aortic stenosis
    • Unger S.A., Robinson M.A., and Horowitz J.D. Perhexiline improves symptomatic status in elderly patients with aortic stenosis. Aust N Z J Med 27 1 (1997) 24-28
    • (1997) Aust N Z J Med , vol.27 , Issue.1 , pp. 24-28
    • Unger, S.A.1    Robinson, M.A.2    Horowitz, J.D.3
  • 12
    • 0015396223 scopus 로고
    • Perhexiline maleate in angina pectoris
    • Bleifer D.J., Bleifer S.B., and Okun R. Perhexiline maleate in angina pectoris. Geriatrics 27 9 (1972) 109-115
    • (1972) Geriatrics , vol.27 , Issue.9 , pp. 109-115
    • Bleifer, D.J.1    Bleifer, S.B.2    Okun, R.3
  • 13
    • 0015616229 scopus 로고
    • Perhexiline maleate in the treatment of angina pectoris: a double blind trial
    • [Apr Suppl.]
    • Gitlin N., and Nellen M. Perhexiline maleate in the treatment of angina pectoris: a double blind trial. Postgrad Med J (1973) 100-104 [Apr Suppl.]
    • (1973) Postgrad Med J , pp. 100-104
    • Gitlin, N.1    Nellen, M.2
  • 14
    • 0020574240 scopus 로고
    • Antianginal efficacy of perhexiline maleate in patients refractory to beta-adrenoreceptor blockade
    • White H.D., and Lowe J.B. Antianginal efficacy of perhexiline maleate in patients refractory to beta-adrenoreceptor blockade. Int J Cardiol 3 (1983) 145-155
    • (1983) Int J Cardiol , vol.3 , pp. 145-155
    • White, H.D.1    Lowe, J.B.2
  • 15
    • 33646166888 scopus 로고
    • A comparative study of perhexiline, beta-adrenergic blocking agents and placebos in the management of angina pectoris
    • Armstrong M.L. A comparative study of perhexiline, beta-adrenergic blocking agents and placebos in the management of angina pectoris. Postgrad Med J 3 49 Suppl. (1973 (Apr.)) 108-111
    • (1973) Postgrad Med J , vol.3 , Issue.49 SUPPL , pp. 108-111
    • Armstrong, M.L.1
  • 16
    • 0020075333 scopus 로고
    • Impaired oxidation of debrisoquine in patients with perhexiline neuropathy
    • Shah R.R., Oates N.S., Idle J.R., Smith R.L., and Lockhart J.D.F. Impaired oxidation of debrisoquine in patients with perhexiline neuropathy. Br Med J 284 (1982) 295-299
    • (1982) Br Med J , vol.284 , pp. 295-299
    • Shah, R.R.1    Oates, N.S.2    Idle, J.R.3    Smith, R.L.4    Lockhart, J.D.F.5
  • 17
    • 0021146282 scopus 로고
    • Impaired oxidation of debrisoquine in patients with perhexiline liver injury
    • Morgan M.Y., Reshef R., Shah R.R., Oates N.S., Smith R.L., and Sherlock S. Impaired oxidation of debrisoquine in patients with perhexiline liver injury. Gut 25 (1984) 1057-1064
    • (1984) Gut , vol.25 , pp. 1057-1064
    • Morgan, M.Y.1    Reshef, R.2    Shah, R.R.3    Oates, N.S.4    Smith, R.L.5    Sherlock, S.6
  • 18
    • 0022451358 scopus 로고
    • Perhexiline maleate treatment for severe angina pectoris-correlations with pharmacokinetics
    • Horowitz J.D., Sia S.T.B., Macdonald P.S., Goble A.J., and Louis W.J. Perhexiline maleate treatment for severe angina pectoris-correlations with pharmacokinetics. Int J Cardiol 13 (1986) 219-229
    • (1986) Int J Cardiol , vol.13 , pp. 219-229
    • Horowitz, J.D.1    Sia, S.T.B.2    Macdonald, P.S.3    Goble, A.J.4    Louis, W.J.5
  • 19
    • 0025343177 scopus 로고
    • Efficacy and safety of perhexiline maleate in refractory angina: a double-blind placebo-controlled trial of a novel antianginal agent
    • Cole P.L., Beamer A.D., McGowan N., Cantillon C.O., Benfell K., Kelly R.A., et al. Efficacy and safety of perhexiline maleate in refractory angina: a double-blind placebo-controlled trial of a novel antianginal agent. Circulation 81 (1990) 1260-1270
    • (1990) Circulation , vol.81 , pp. 1260-1270
    • Cole, P.L.1    Beamer, A.D.2    McGowan, N.3    Cantillon, C.O.4    Benfell, K.5    Kelly, R.A.6
  • 20
    • 0014914404 scopus 로고
    • Pharmacology of a new antianginal drug: perhexiline coronary circulation and myocardial metabolism
    • Cho Y.W., Belej M., and Aviado D.M. Pharmacology of a new antianginal drug: perhexiline coronary circulation and myocardial metabolism. Chest 56 6 (1970) 577-585
    • (1970) Chest , vol.56 , Issue.6 , pp. 577-585
    • Cho, Y.W.1    Belej, M.2    Aviado, D.M.3
  • 21
    • 0030602865 scopus 로고    scopus 로고
    • Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone
    • Kennedy J.A., Unger S.A., and Horowitz J.D. Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone. Biochem Pharmacol 52 (1996) 273-280
    • (1996) Biochem Pharmacol , vol.52 , pp. 273-280
    • Kennedy, J.A.1    Unger, S.A.2    Horowitz, J.D.3
  • 22
    • 0029829778 scopus 로고    scopus 로고
    • Relationship between plasma perhexiline concentration and symptomatic status during short-term perhexiline therapy
    • Stewart S., Voss D.W., Northey D.L., and Horowitz J.D. Relationship between plasma perhexiline concentration and symptomatic status during short-term perhexiline therapy. Ther Drug Monit 18 (1996) 635-639
    • (1996) Ther Drug Monit , vol.18 , pp. 635-639
    • Stewart, S.1    Voss, D.W.2    Northey, D.L.3    Horowitz, J.D.4
  • 23
    • 0036899544 scopus 로고    scopus 로고
    • Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide
    • Willoughby S.R., Stewart S., Chirkov Y.Y., Kennedy J.A., Holmes A.S., and Horowitz J.D. Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide. Eur Heart J 23 (2002) 1946-1954
    • (2002) Eur Heart J , vol.23 , pp. 1946-1954
    • Willoughby, S.R.1    Stewart, S.2    Chirkov, Y.Y.3    Kennedy, J.A.4    Holmes, A.S.5    Horowitz, J.D.6
  • 24
    • 0035999736 scopus 로고    scopus 로고
    • Partial fatty acid oxidation inhibitors for stable angina
    • Stanley W.C. Partial fatty acid oxidation inhibitors for stable angina. Expert Opin Investig Drugs 11 5 (2002) 615-629
    • (2002) Expert Opin Investig Drugs , vol.11 , Issue.5 , pp. 615-629
    • Stanley, W.C.1
  • 26
    • 0036285606 scopus 로고    scopus 로고
    • Energy metabolism in the normal and failing heart: potential for therapeutic interventions
    • Stanley W.C., and Chandler M. Energy metabolism in the normal and failing heart: potential for therapeutic interventions. Heart Fail Rev 7 (2002) 115-130
    • (2002) Heart Fail Rev , vol.7 , pp. 115-130
    • Stanley, W.C.1    Chandler, M.2
  • 27
    • 0019543906 scopus 로고
    • Alterations of carbohydrate and lipid metabolism in the acutely ischaemic heart
    • Liedtke A.J. Alterations of carbohydrate and lipid metabolism in the acutely ischaemic heart. Prog Cardiovasc Dis 23 5 (1981) 321-336
    • (1981) Prog Cardiovasc Dis , vol.23 , Issue.5 , pp. 321-336
    • Liedtke, A.J.1
  • 28
    • 0028225110 scopus 로고
    • Lack of efforts of trimetazadine on systemic hemodynamics in patients with coronary disease: a placebo-controlled study
    • Pornin M., Harpey C., Allal, Sellier P., and Ourbak P. Lack of efforts of trimetazadine on systemic hemodynamics in patients with coronary disease: a placebo-controlled study. Clin Trials Metaanal 29 1 (1994) 49-56
    • (1994) Clin Trials Metaanal , vol.29 , Issue.1 , pp. 49-56
    • Pornin, M.1    Harpey, C.2    Allal3    Sellier, P.4    Ourbak, P.5
  • 29
    • 0034678082 scopus 로고    scopus 로고
    • The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase
    • Kantor P.F., Lucien A., Kozak R., and Lopaschuk G.D. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res 86 5 (2000) 580-588
    • (2000) Circ Res , vol.86 , Issue.5 , pp. 580-588
    • Kantor, P.F.1    Lucien, A.2    Kozak, R.3    Lopaschuk, G.D.4
  • 30
    • 0141723313 scopus 로고    scopus 로고
    • The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase
    • MacInnes A., Fairman D.A., Binding P., Rhodes J., Wyatt M.J., Phelan A., et al. The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res 93 3 (2003) e33-e37
    • (2003) Circ Res , vol.93 , Issue.3
    • MacInnes, A.1    Fairman, D.A.2    Binding, P.3    Rhodes, J.4    Wyatt, M.J.5    Phelan, A.6
  • 31
    • 0031756448 scopus 로고    scopus 로고
    • Effect of trimetazine on carnitine palmitoyltransferase-1 in the rat heart
    • Kennedy J.A., and Horowitz J.D. Effect of trimetazine on carnitine palmitoyltransferase-1 in the rat heart. Cardiovasc Drugs Ther 12 4 (1998) 359-363
    • (1998) Cardiovasc Drugs Ther , vol.12 , Issue.4 , pp. 359-363
    • Kennedy, J.A.1    Horowitz, J.D.2
  • 32
    • 18244401979 scopus 로고    scopus 로고
    • Combination treatment in stable effort angina using trimetazadine and metoprolol: results of a randomised, double-blind, multicentre study (TRIMPOL II). TRIMetazidine in POLand
    • Szwed H., Sadowski Z., Elikowski W., Koronkiewicz A., Mamcarz A., Orszulak W., et al. Combination treatment in stable effort angina using trimetazadine and metoprolol: results of a randomised, double-blind, multicentre study (TRIMPOL II). TRIMetazidine in POLand. Eur Heart J 22 24 (2001) 2267-2274
    • (2001) Eur Heart J , vol.22 , Issue.24 , pp. 2267-2274
    • Szwed, H.1    Sadowski, Z.2    Elikowski, W.3    Koronkiewicz, A.4    Mamcarz, A.5    Orszulak, W.6
  • 33
    • 0037732581 scopus 로고    scopus 로고
    • Efficacy and tolerability of trimetazidine in stable angina: a meta-analysis of randomised, double-blind, controlled trials
    • Marzilli M., and Klein W.W. Efficacy and tolerability of trimetazidine in stable angina: a meta-analysis of randomised, double-blind, controlled trials. Coron Artery Dis 14 2 (2003) 171-179
    • (2003) Coron Artery Dis , vol.14 , Issue.2 , pp. 171-179
    • Marzilli, M.1    Klein, W.W.2
  • 34
    • 0030032681 scopus 로고    scopus 로고
    • Ranolazine stimulates glucose oxidation in normotoxic, ischaemic, and reperfused ischaemic rat hearts
    • McCormack J.G., Barr R., Wolff A.A., and Lopaschuk G.D. Ranolazine stimulates glucose oxidation in normotoxic, ischaemic, and reperfused ischaemic rat hearts. Circulation 93 1 (1996) 135-142
    • (1996) Circulation , vol.93 , Issue.1 , pp. 135-142
    • McCormack, J.G.1    Barr, R.2    Wolff, A.A.3    Lopaschuk, G.D.4
  • 35
    • 0000478761 scopus 로고    scopus 로고
    • The MARISA Investigators and CV Therapeutics. MARISA: monotherapy assessment of ranolazine in stable angina
    • Wolff A.A. The MARISA Investigators and CV Therapeutics. MARISA: monotherapy assessment of ranolazine in stable angina. J Am Coll Cardiol 35 Suppl. A (2000) 408A
    • (2000) J Am Coll Cardiol , vol.35 , Issue.SUPPL. A
    • Wolff, A.A.1
  • 36
    • 0348129532 scopus 로고    scopus 로고
    • Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial
    • Chaitman B.R., Pepine C.J., Parker J.O., Skopal J., Chumakova G., Kuch J., et al. Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial. JAMA 291 3 (2004) 309-316
    • (2004) JAMA , vol.291 , Issue.3 , pp. 309-316
    • Chaitman, B.R.1    Pepine, C.J.2    Parker, J.O.3    Skopal, J.4    Chumakova, G.5    Kuch, J.6
  • 37
    • 0023845559 scopus 로고
    • Additive hypoglycaemic effects of drugs that modify free-fatty acid metabolism by different mechanisms in rats with streptozocin-induced diabetes
    • Reaven G.M., Chang H., and Hoffman B.B. Additive hypoglycaemic effects of drugs that modify free-fatty acid metabolism by different mechanisms in rats with streptozocin-induced diabetes. Diabetes 37 1 (1988) 28-32
    • (1988) Diabetes , vol.37 , Issue.1 , pp. 28-32
    • Reaven, G.M.1    Chang, H.2    Hoffman, B.B.3
  • 38
    • 0024262853 scopus 로고
    • Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischaemic injury independent of changes in long chain acylcarnitine
    • Lopascuk G.D., Wall S.R., Olley P.M., and Davies N.J. Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischaemic injury independent of changes in long chain acylcarnitine. Circ Res 63 6 (1988) 1036-1043
    • (1988) Circ Res , vol.63 , Issue.6 , pp. 1036-1043
    • Lopascuk, G.D.1    Wall, S.R.2    Olley, P.M.3    Davies, N.J.4
  • 39
    • 0033910352 scopus 로고    scopus 로고
    • First clinical trail with etomoxir in patients with chronic congestive heart failure
    • Schmidt-Schweda S., and Holubarsch C. First clinical trail with etomoxir in patients with chronic congestive heart failure. Clin Sci (Lond) 99 1 (2000) 27-35
    • (2000) Clin Sci (Lond) , vol.99 , Issue.1 , pp. 27-35
    • Schmidt-Schweda, S.1    Holubarsch, C.2
  • 40
    • 0029069020 scopus 로고
    • Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year
    • Malmberg K., Ryden L., Efendic S., Herlitz J., Nicol P., Waldenstrom A., et al. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. J Am Coll Cardiol 26 (1995) 57-65
    • (1995) J Am Coll Cardiol , vol.26 , pp. 57-65
    • Malmberg, K.1    Ryden, L.2    Efendic, S.3    Herlitz, J.4    Nicol, P.5    Waldenstrom, A.6
  • 41
    • 4644310831 scopus 로고    scopus 로고
    • Role of insulin-glucose infusion in outcomes after acute myocardial infarction: the diabetes and insulin-glucose infusion in acute myocardial infarction (DIGAMI) study
    • Malmberg K. Role of insulin-glucose infusion in outcomes after acute myocardial infarction: the diabetes and insulin-glucose infusion in acute myocardial infarction (DIGAMI) study. Endocr Pract 10 S2 (2004) 13-16
    • (2004) Endocr Pract , vol.10 , Issue.SUPPL.2 , pp. 13-16
    • Malmberg, K.1
  • 42
    • 0007619884 scopus 로고    scopus 로고
    • Systematic review of the efficacy and safety of perhexiline in the treatment of ischaemic heart disease
    • Killalea S.M., and Krum H. Systematic review of the efficacy and safety of perhexiline in the treatment of ischaemic heart disease. Am J Cardiovasc Drugs 1 3 (2001) 193-204
    • (2001) Am J Cardiovasc Drugs , vol.1 , Issue.3 , pp. 193-204
    • Killalea, S.M.1    Krum, H.2
  • 43
    • 0018127057 scopus 로고
    • Pharmacokinetics of perhexiline maleate in anginal patients with and without peripheral neuropathy
    • Singlas E., Goujet M.A., and Simon P. Pharmacokinetics of perhexiline maleate in anginal patients with and without peripheral neuropathy. Eur J Clin Pharmacol 14 (1978) 195-201
    • (1978) Eur J Clin Pharmacol , vol.14 , pp. 195-201
    • Singlas, E.1    Goujet, M.A.2    Simon, P.3
  • 44
    • 0021988392 scopus 로고
    • Investigations of long-term treatment with perhexiline maleate using therapeutic monitoring and electromyography
    • Pilcher J., Cooper J.D.H., Turnell D.C., Matenga J., Paul R., and Lockhart J.D. Investigations of long-term treatment with perhexiline maleate using therapeutic monitoring and electromyography. Ther Drug Monit 7 (1985) 54-60
    • (1985) Ther Drug Monit , vol.7 , pp. 54-60
    • Pilcher, J.1    Cooper, J.D.H.2    Turnell, D.C.3    Matenga, J.4    Paul, R.5    Lockhart, J.D.6
  • 45
    • 0028302917 scopus 로고
    • Inhibition by perhexiline of oxidative phosphorylation and β-oxidation of fatty acids: possible role in pseudoalcoholic liver lesions
    • Deschamps D., DeBeco V., Fisch C., Fromenty B., Guillouzo A., and Pessaayre D. Inhibition by perhexiline of oxidative phosphorylation and β-oxidation of fatty acids: possible role in pseudoalcoholic liver lesions. Hepatology 19 4 (1994) 948-961
    • (1994) Hepatology , vol.19 , Issue.4 , pp. 948-961
    • Deschamps, D.1    DeBeco, V.2    Fisch, C.3    Fromenty, B.4    Guillouzo, A.5    Pessaayre, D.6
  • 46
    • 0019475981 scopus 로고
    • High-performance liquid chromatographic assay of perhexiline maleate in plasma
    • Horowitz J.D., Morris P.M., Drummer O.H., Goble A.J., and Louis W.J. High-performance liquid chromatographic assay of perhexiline maleate in plasma. J Pharm Sci 70 3 (1981) 320-322
    • (1981) J Pharm Sci , vol.70 , Issue.3 , pp. 320-322
    • Horowitz, J.D.1    Morris, P.M.2    Drummer, O.H.3    Goble, A.J.4    Louis, W.J.5
  • 47
    • 0022398966 scopus 로고
    • Therapeutic monitoring of the antianginal drug perhexiline maleate
    • Cooper J.D.H., Turnell D.C., Pilcher J., and Lockhart D. Therapeutic monitoring of the antianginal drug perhexiline maleate. Ann Clin Biochem 22 (1985) 614-617
    • (1985) Ann Clin Biochem , vol.22 , pp. 614-617
    • Cooper, J.D.H.1    Turnell, D.C.2    Pilcher, J.3    Lockhart, D.4
  • 48
    • 0015614806 scopus 로고
    • The absorption, excretion and metabolism of perhexiline maleate by the human
    • [April Suppl.]
    • Wright G.J., Leeson G.A., Zeiger A.V., and Lang J.F. The absorption, excretion and metabolism of perhexiline maleate by the human. Postgrad Med J (1973) 8-15 [April Suppl.]
    • (1973) Postgrad Med J , pp. 8-15
    • Wright, G.J.1    Leeson, G.A.2    Zeiger, A.V.3    Lang, J.F.4
  • 49
    • 0023042671 scopus 로고
    • Simultaneous determination of perhexiline and its monohydroxy metabolites in biological fluids by gas chromatography-electron-capture detection
    • Cooper R.G., Harper G., Price A.H., Evans D.A.P., and Lockhart D. Simultaneous determination of perhexiline and its monohydroxy metabolites in biological fluids by gas chromatography-electron-capture detection. J Chromatogr 381 (1986) 305-314
    • (1986) J Chromatogr , vol.381 , pp. 305-314
    • Cooper, R.G.1    Harper, G.2    Price, A.H.3    Evans, D.A.P.4    Lockhart, D.5
  • 50
    • 0021351640 scopus 로고
    • Polymorphic hydroxylation of perhexiline maleate in man
    • Cooper R.G., Evans D.A.P., and Whibley E.J. Polymorphic hydroxylation of perhexiline maleate in man. J Med Genet 21 (1984) 27-33
    • (1984) J Med Genet , vol.21 , pp. 27-33
    • Cooper, R.G.1    Evans, D.A.P.2    Whibley, E.J.3
  • 51
    • 0742286803 scopus 로고    scopus 로고
    • Cytochrome P45 2D6: overview and update on pharmacology, genetics, biochemistry
    • Zanger U.M., Raimundo S., and Eichelbaum M. Cytochrome P45 2D6: overview and update on pharmacology, genetics, biochemistry. Naunyn-Schmiedeberg's Arch Pharmacol 369 (2004) 23-37
    • (2004) Naunyn-Schmiedeberg's Arch Pharmacol , vol.369 , pp. 23-37
    • Zanger, U.M.1    Raimundo, S.2    Eichelbaum, M.3
  • 52
    • 0034638766 scopus 로고    scopus 로고
    • Pharmacogenetics and adverse drug reactions
    • Meyer U.A. Pharmacogenetics and adverse drug reactions. Lancet North Am Ed 356 (2000) 1667-1671
    • (2000) Lancet North Am Ed , vol.356 , pp. 1667-1671
    • Meyer, U.A.1
  • 53
    • 0036204756 scopus 로고    scopus 로고
    • Molecular Genetics of CYP2D6: clinical relevance with focus on psychotrophic drugs
    • Bertilsson L., Dahl M.L., Dalén P., and Al-Shurbaji A. Molecular Genetics of CYP2D6: clinical relevance with focus on psychotrophic drugs. Br J Clin Pharmacol 53 (2002) 111-122
    • (2002) Br J Clin Pharmacol , vol.53 , pp. 111-122
    • Bertilsson, L.1    Dahl, M.L.2    Dalén, P.3    Al-Shurbaji, A.4
  • 54
    • 0030432585 scopus 로고    scopus 로고
    • Frequent distribution of ultrarapid metabolisers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles
    • Aklillu E., Persson I., Bertilsson L., Johansson I., Rodrigues F., and Ingelman-Sundberg M. Frequent distribution of ultrarapid metabolisers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. J Pharmacol Exp Ther 278 1 (1996) 441-446
    • (1996) J Pharmacol Exp Ther , vol.278 , Issue.1 , pp. 441-446
    • Aklillu, E.1    Persson, I.2    Bertilsson, L.3    Johansson, I.4    Rodrigues, F.5    Ingelman-Sundberg, M.6
  • 56
    • 0029297832 scopus 로고
    • Caring for patients with acute myocardial ischaemia: the perhexiline maleate experience
    • Stewart S. Caring for patients with acute myocardial ischaemia: the perhexiline maleate experience. Dimens Crit Care Nurs 14 3 (1995) 127-135
    • (1995) Dimens Crit Care Nurs , vol.14 , Issue.3 , pp. 127-135
    • Stewart, S.1
  • 58
    • 33646196330 scopus 로고    scopus 로고
    • MIMS Australia. Perhexiline maleate MIMS Abbreviated Prescribing Information. [Online] 2003 [cited 2005 Aug 19]. Available from URL: http://mims.hcn.net.au via the University of Queensland Library.
  • 59
    • 0028906242 scopus 로고
    • Is perhexiline essential for the optimal management of angina pectoris?
    • Horowitz J.D., Button I.K., and Wing L. Is perhexiline essential for the optimal management of angina pectoris?. Aust N Z J Med 25 (1995) 111-113
    • (1995) Aust N Z J Med , vol.25 , pp. 111-113
    • Horowitz, J.D.1    Button, I.K.2    Wing, L.3


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