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Volumn 31, Issue 4, 2009, Pages 285-292

Prenatal stress and neurodevelopment of the child: Focus on the HPA axis and role of the placenta

Author keywords

11 HSD2; Cortisol; Fetal programming; Neurodevelopment; Placenta; Prenatal stress

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; CORTICOTROPIN; GLUCOCORTICOID; HYDROCORTISONE;

EID: 67650932296     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000216539     Document Type: Review
Times cited : (390)

References (63)
  • 2
    • 40049105357 scopus 로고    scopus 로고
    • Autism prevalence following prenatal exposure to hurricanes and tropical storms in Louisiana
    • Kinney DK, Miller AM, Crowley DJ, Huang E, Gerber E: Autism prevalence following prenatal exposure to hurricanes and tropical storms in Louisiana. J Autism Dev Disord 2008;38:481-488.
    • (2008) J Autism Dev Disord , vol.38 , pp. 481-488
    • Kinney, D.K.1    Miller, A.M.2    Crowley, D.J.3    Huang, E.4    Gerber, E.5
  • 4
    • 55749095883 scopus 로고    scopus 로고
    • Project Ice Storm: Prenatal maternal stress affects cognitive and linguistic functioning in 5 1/2-year-old children
    • Laplante DP, Brunet A, Schmitz N, Ciampi A, King S: Project Ice Storm: prenatal maternal stress affects cognitive and linguistic functioning in 5 1/2-year-old children. J Am Acad Child Adolesc Psychiatry 2008; 47: 1063-1072.
    • (2008) J Am Acad Child Adolesc Psychiatry , vol.47 , pp. 1063-1072
    • Laplante, D.P.1    Brunet, A.2    Schmitz, N.3    Ciampi, A.4    King, S.5
  • 5
    • 0036260295 scopus 로고    scopus 로고
    • Maternal antenatal anxiety and children's behavioural/emotional problems at 4 years: Report from the Avon Longitudinal Study of Parents and Children
    • O'Connor TG, Heron J, Golding J, Beveridge M, Glover V: Maternal antenatal anxiety and children's behavioural/emotional problems at 4 years: report from the Avon Longitudinal Study of Parents and Children. Br J Psychiatry 2002; 180: 502-508.
    • (2002) Br J Psychiatry , vol.180 , pp. 502-508
    • O'Connor, T.G.1    Heron, J.2    Golding, J.3    Beveridge, M.4    Glover, V.5
  • 6
    • 0141887058 scopus 로고    scopus 로고
    • Maternal antenatal anxiety and behavioural/ emotional problems in children: A test of a programming hypothesis
    • O'Connor TG, Heron J, Golding J, Glover V: Maternal antenatal anxiety and behavioural/ emotional problems in children: a test of a programming hypothesis. J Child Psychol Psychiatry 2003;44:1025-1036.
    • (2003) J Child Psychol Psychiatry , vol.44 , pp. 1025-1036
    • O'Connor, T.G.1    Heron, J.2    Golding, J.3    Glover, V.4
  • 8
    • 33646691507 scopus 로고    scopus 로고
    • Maternal psychological distress during pregnancy in relation to child development at age two
    • DiPietro JA, Novak MF, Costigan KA, Atella LD, Reusing SP: Maternal psychological distress during pregnancy in relation to child development at age two. Child Dev 2006; 77: 573-587.
    • (2006) Child Dev , vol.77 , pp. 573-587
    • DiPietro, J.A.1    Novak, M.F.2    Costigan, K.A.3    Atella, L.D.4    Reusing, S.P.5
  • 10
    • 0022828908 scopus 로고
    • Are the effects of gestational stress on motor development and cerebellar cholinesterase activity mediated prenatally?
    • Fride E, Soreq H, Weinstock M: Are the effects of gestational stress on motor development and cerebellar cholinesterase activity mediated prenatally? Int J Dev Neurosci 1986;4:407-413.
    • (1986) Int J Dev Neurosci , vol.4 , pp. 407-413
    • Fride, E.1    Soreq, H.2    Weinstock, M.3
  • 11
    • 0027637886 scopus 로고
    • Prenatal stress has long-term effects on behavioral responses to stress in juvenile rhesus monkeys
    • Clarke AS, Schneider ML: Prenatal stress has long-term effects on behavioral responses to stress in juvenile rhesus monkeys. Dev Psy- chobiol 1993;26:293-304.
    • (1993) Dev Psy- chobiol , vol.26 , pp. 293-304
    • Clarke, A.S.1    Schneider, M.L.2
  • 13
    • 4344599469 scopus 로고    scopus 로고
    • High antenatal maternal anxiety is related to ADHD symptoms, externalizing problems, and anxiety in 8- and 9-year-olds
    • Van den Bergh BR, Marcoen A: High antenatal maternal anxiety is related to ADHD symptoms, externalizing problems, and anxiety in 8- and 9-year-olds. Child Dev 2004;75:1085-1097.
    • (2004) Child Dev , vol.75 , pp. 1085-1097
    • Van den Bergh, B.R.1    Marcoen, A.2
  • 15
    • 34548755195 scopus 로고    scopus 로고
    • Gender differences in the effects of prenatal stress on brain development and behaviour
    • Weinstock M: Gender differences in the effects of prenatal stress on brain development and behaviour. Neurochem Res 2007; 32: 1730-1740.
    • (2007) Neurochem Res , vol.32 , pp. 1730-1740
    • Weinstock, M.1
  • 16
    • 33747168497 scopus 로고    scopus 로고
    • Microarray analysis of cultured human brain aggregates following cortisol exposure: Implications for cellular functions relevant to mood disorders
    • Salaria S, Chana G, Caldara F, Feltrin E, Al- tieri M, Faggioni F, Domenici E, Merlo-Pich E, Everall IP: Microarray analysis of cultured human brain aggregates following cortisol exposure: implications for cellular functions relevant to mood disorders. Neurobiol Dis 2006;23:630-636.
    • (2006) Neurobiol Dis , vol.23 , pp. 630-636
    • Salaria, S.1    Chana, G.2    Caldara, F.3    Feltrin, E.4    Al- tieri, M.5    Faggioni, F.6    Domenici, E.7    Merlo-Pich, E.8    Everall, I.P.9
  • 17
    • 0030006521 scopus 로고    scopus 로고
    • Maternal glucocorticoid secretion mediates long-term effects of prenatal stress
    • Barbazanges A, Piazza PV, Le Moal M, Mac- cari S: Maternal glucocorticoid secretion mediates long-term effects of prenatal stress. J Neurosci 1996;16:3943-3949.
    • (1996) J Neurosci , vol.16 , pp. 3943-3949
    • Barbazanges, A.1    Piazza, P.V.2    Le Moal, M.3    Mac- cari, S.4
  • 18
    • 0033093394 scopus 로고    scopus 로고
    • Growth and development following prenatal stress exposure in primates: An examination of ontogenetic vulnerability
    • Schneider ML: Growth and development following prenatal stress exposure in primates: an examination of ontogenetic vulnerability. Child Dev 1999;70:263.
    • (1999) Child Dev , vol.70 , pp. 263
    • Schneider, M.L.1
  • 19
    • 0028286546 scopus 로고
    • Prenatal stress increases the hy- pothalamo-pituitary-adrenal axis response in young and adult rats
    • Henry C, Kabbaj M, Simon H, Le Moal M, Maccari S: Prenatal stress increases the hy- pothalamo-pituitary-adrenal axis response in young and adult rats. J Neuroendocrinol 1994;6:341-345.
    • (1994) J Neuroendocrinol , vol.6 , pp. 341-345
    • Henry, C.1    Kabbaj, M.2    Simon, H.3    Le Moal, M.4    Maccari, S.5
  • 20
    • 23744433505 scopus 로고    scopus 로고
    • Short periods of prenatal stress affect growth, behaviour and hypothalamo-pituitary-adrenal axis activity in male guinea pig offspring
    • Kapoor A, Matthews SG: Short periods of prenatal stress affect growth, behaviour and hypothalamo-pituitary-adrenal axis activity in male guinea pig offspring. J Physiol 2005; 566: 967-977.
    • (2005) J Physiol , vol.566 , pp. 967-977
    • Kapoor, A.1    Matthews, S.G.2
  • 21
    • 47149109800 scopus 로고    scopus 로고
    • Pregnant women's cortisol is elevated with anxiety and depression - but only when comorbid
    • Evans LM, Myers MM, Monk C: Pregnant women's cortisol is elevated with anxiety and depression - but only when comorbid. Arch Womens Ment Health 2008;11:239-248.
    • (2008) Arch Womens Ment Health , vol.11 , pp. 239-248
    • Evans, L.M.1    Myers, M.M.2    Monk, C.3
  • 23
    • 33745603236 scopus 로고    scopus 로고
    • Maternal anxiety at amniocentesis and plasma cortisol
    • Sarkar P, Bergman K, Fisk NM, Glover V: Maternal anxiety at amniocentesis and plasma cortisol. Prenat Diagn 2006;26: 505-509.
    • (2006) Prenat Diagn , vol.26 , pp. 505-509
    • Sarkar, P.1    Bergman, K.2    Fisk, N.M.3    Glover, V.4
  • 25
    • 51449105653 scopus 로고    scopus 로고
    • Diurnal rhythm of corti- sol during late pregnancy: Associations with maternal psychological well-being and fetal growth
    • Kivlighan KT, DiPietro JA, Costigan KA, Laudenslager ML: Diurnal rhythm of corti- sol during late pregnancy: associations with maternal psychological well-being and fetal growth. Psychoneuroendocrinology 2008; 33: 1225-1235.
    • (2008) Psychoneuroendocrinology , vol.33 , pp. 1225-1235
    • Kivlighan, K.T.1    DiPietro, J.A.2    Costigan, K.A.3    Laudenslager, M.L.4
  • 27
    • 0025351211 scopus 로고
    • The cor- ticotrophin releasing hormone test in late pregnancy: Lack of adrenocorticotrophin and cortisol response
    • Schulte HM, Weisner D, Allolio B: The cor- ticotrophin releasing hormone test in late pregnancy: lack of adrenocorticotrophin and cortisol response. Clin Endocrinol (Oxf) 1990; 33: 99-106.
    • (1990) Clin Endocrinol (Oxf) , vol.33 , pp. 99-106
    • Schulte, H.M.1    Weisner, D.2    Allolio, B.3
  • 31
    • 34250902914 scopus 로고    scopus 로고
    • Role of the placenta in fetal programming: Underlying mechanisms and potential interventional approaches
    • Jansson T, Powell TL: Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches. Clin Sci 2007; 113: 1-13.
    • (2007) Clin Sci , vol.113 , pp. 1-13
    • Jansson, T.1    Powell, T.L.2
  • 33
    • 0030940457 scopus 로고    scopus 로고
    • Placental 11 beta-hydroxysteroid dehydrogenase: A key regulator of fetal glu- cocorticoid exposure
    • Benediktsson R, Calder AA, Edwards CR, Seckl JR: Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glu- cocorticoid exposure. Clin Endocrinol (Oxf) 1997;46:161-166.
    • (1997) Clin Endocrinol (Oxf) , vol.46 , pp. 161-166
    • Benediktsson, R.1    Calder, A.A.2    Edwards, C.R.3    Seckl, J.R.4
  • 34
    • 0031596094 scopus 로고    scopus 로고
    • 11Beta-hydroxysteroid dehydrogenase type 2 in human pregnancy and reduced expression in intrauterine growth restriction
    • Shams M, Kilby MD, Somerset DA, Howie AJ, Gupta A, Wood PJ, Afnan M, Stewart PM: 11Beta-hydroxysteroid dehydrogenase type 2 in human pregnancy and reduced expression in intrauterine growth restriction. Hum Reprod 1998;13:799-804.
    • (1998) Hum Reprod , vol.13 , pp. 799-804
    • Shams, M.1    Kilby, M.D.2    Somerset, D.A.3    Howie, A.J.4    Gupta, A.5    Wood, P.J.6    Afnan, M.7    Stewart, P.M.8
  • 35
    • 0035145735 scopus 로고    scopus 로고
    • Fetal hypothalamic-pituitary-ad- renal stress responses to invasive procedures are independent of maternal responses
    • Gitau R, Fisk NM, Teixeira JM, Cameron A, Glover V: Fetal hypothalamic-pituitary-ad- renal stress responses to invasive procedures are independent of maternal responses. J Clin Endocrinol Metab 2001;86:104-109.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 104-109
    • Gitau, R.1    Fisk, N.M.2    Teixeira, J.M.3    Cameron, A.4    Glover, V.5
  • 36
    • 33645582847 scopus 로고    scopus 로고
    • The mother or the fetus? 11Beta-hydroxysteroid dehy- drogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids
    • Holmes MC, Abrahamsen CT, French KL, Paterson JM, Mullins JJ, Seckl JR: The mother or the fetus? 11Beta-hydroxysteroid dehy- drogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids. J Neurosci 2006;26:3840-3844.
    • (2006) J Neurosci , vol.26 , pp. 3840-3844
    • Holmes, M.C.1    Abrahamsen, C.T.2    French, K.L.3    Paterson, J.M.4    Mullins, J.J.5    Seckl, J.R.6
  • 38
    • 0030975923 scopus 로고    scopus 로고
    • Hypertension induced by foetal exposure to a maternal low-protein diet, in the rat, is prevented by pharmacological blockade of maternal glucocorticoid synthesis
    • Langley-Evans SC: Hypertension induced by foetal exposure to a maternal low-protein diet, in the rat, is prevented by pharmacological blockade of maternal glucocorticoid synthesis. J Hypertens 1997;15:537-544.
    • (1997) J Hypertens , vol.15 , pp. 537-544
    • Langley-Evans, S.C.1
  • 39
    • 26044475876 scopus 로고    scopus 로고
    • Chronic maternal stress inhibits the capacity to up-regulate placental 11beta-hydroxyster- oid dehydrogenase type 2 activity
    • Welberg LA, Thrivikraman KV, Plotsky PM: Chronic maternal stress inhibits the capacity to up-regulate placental 11beta-hydroxyster- oid dehydrogenase type 2 activity. J Endocri- nol 2005;186:R7-R12.
    • (2005) J Endocri- nol , vol.186
    • Welberg, L.A.1    Thrivikraman, K.V.2    Plotsky, P.M.3
  • 41
    • 58149125303 scopus 로고    scopus 로고
    • Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: Possible key role of placental 11beta- hydroxysteroid dehydrogenase type 2
    • Lucassen PJ, Bosch OJ, Jousma E, Kromer SA, Andrew R, Seckl JR, Neumann ID: Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: possible key role of placental 11beta- hydroxysteroid dehydrogenase type 2. Eur J Neurosci 2009;29:97-103.
    • (2009) Eur J Neurosci , vol.29 , pp. 97-103
    • Lucassen, P.J.1    Bosch, O.J.2    Jousma, E.3    Kromer, S.A.4    Andrew, R.5    Seckl, J.R.6    Neumann, I.D.7
  • 42
    • 0034740083 scopus 로고    scopus 로고
    • Reduced placental 11beta-hy- droxysteroid dehydrogenase type 2 mRNA levels in human pregnancies complicated by intrauterine growth restriction: An analysis of possible mechanisms
    • McTernan CL, Draper N, Nicholson H, Chal- der SM, Driver P, Hewison M, Kilby MD, Stewart PM: Reduced placental 11beta-hy- droxysteroid dehydrogenase type 2 mRNA levels in human pregnancies complicated by intrauterine growth restriction: an analysis of possible mechanisms. J Clin Endocrinol Metab 2001; 86: 4979-4983.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4979-4983
    • McTernan, C.L.1    Draper, N.2    Nicholson, H.3    Chal- der, S.M.4    Driver, P.5    Hewison, M.6    Kilby, M.D.7    Stewart, P.M.8
  • 43
    • 0034742462 scopus 로고    scopus 로고
    • Course of placental 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxypros- taglandin dehydrogenase mRNA expression during human gestation
    • Schoof E, Girstl M, Frobenius W, Kirsch- baum M, Repp R, Knerr I, Rascher W, Dotsch J: Course of placental 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxypros- taglandin dehydrogenase mRNA expression during human gestation. Eur J Endocrinol 2001;145:187-192.
    • (2001) Eur J Endocrinol , vol.145 , pp. 187-192
    • Schoof, E.1    Girstl, M.2    Frobenius, W.3    Kirsch- baum, M.4    Repp, R.5    Knerr, I.6    Rascher, W.7    Dotsch, J.8
  • 44
    • 0029566976 scopus 로고
    • Type 2 11 beta-hydroxysteroid dehydrogenase in foetal and adult life
    • Stewart PM, Whorwood CB, Mason JI: Type 2 11 beta-hydroxysteroid dehydrogenase in foetal and adult life. J Steroid Biochem Mol Biol 1995;55:465-471.
    • (1995) J Steroid Biochem Mol Biol , vol.55 , pp. 465-471
    • Stewart, P.M.1    Whorwood, C.B.2    Mason, J.I.3
  • 45
    • 28844444674 scopus 로고    scopus 로고
    • Corticosterone transfer and metabolism in the dually perfused rat placenta: Effect of 11beta-hydroxysteroid dehydrogenase type 2
    • Staud F, Mazancova K, Miksik I, Pavek P, Fendrich Z, Pacha J: Corticosterone transfer and metabolism in the dually perfused rat placenta: effect of 11beta-hydroxysteroid dehydrogenase type 2. Placenta 2006;27:171-180.
    • (2006) Placenta , vol.27 , pp. 171-180
    • Staud, F.1    Mazancova, K.2    Miksik, I.3    Pavek, P.4    Fendrich, Z.5    Pacha, J.6
  • 46
    • 0031697031 scopus 로고    scopus 로고
    • Placental 11[beta]-hydroxysteroid dehydrogenase activity in normotensive and pre-eclamptic pregnancies
    • McCalla CO, Nacharaju VL, Muneyyirci- Delale O, Glasgow S, Feldman JG: Placental 11[beta]-hydroxysteroid dehydrogenase activity in normotensive and pre-eclamptic pregnancies. Steroids 1998;63:511-515.
    • (1998) Steroids , vol.63 , pp. 511-515
    • McCalla, C.O.1    Nacharaju, V.L.2    Muneyyirci- Delale, O.3    Glasgow, S.4    Feldman, J.G.5
  • 48
    • 33646690514 scopus 로고    scopus 로고
    • Placental 11beta-HSD2 activity, early postnatal clinical course, and adrenal function in extremely low birth weight infants
    • Kajantie E, Dunkel L, Turpeinen U, Stenman UH, Andersson S: Placental 11beta-HSD2 activity, early postnatal clinical course, and adrenal function in extremely low birth weight infants. Pediatr Res 2006; 59: 575-578.
    • (2006) Pediatr Res , vol.59 , pp. 575-578
    • Kajantie, E.1    Dunkel, L.2    Turpeinen, U.3    Stenman, U.H.4    Andersson, S.5
  • 49
    • 38649135775 scopus 로고    scopus 로고
    • Placental 11beta-hydroxys- teroid dehydrogenase type 2 is reduced in pregnancies complicated with idiopathic in- trauterine growth restriction: Evidence that this is associated with an attenuated ratio of cortisone to cortisol in the umbilical artery
    • Dy J, Guan H, Sampath-Kumar R, Richardson BS, Yang K: Placental 11beta-hydroxys- teroid dehydrogenase type 2 is reduced in pregnancies complicated with idiopathic in- trauterine growth restriction: evidence that this is associated with an attenuated ratio of cortisone to cortisol in the umbilical artery. Placenta 2008; 29: 193-200.
    • (2008) Placenta , vol.29 , pp. 193-200
    • Dy, J.1    Guan, H.2    Sampath-Kumar, R.3    Richardson, B.S.4    Yang, K.5
  • 50
    • 0034747418 scopus 로고    scopus 로고
    • 11beta-hydroxysteroid dehydro- genase and its role in the syndrome of apparent mineralocorticoid excess
    • White PC: 11beta-hydroxysteroid dehydro- genase and its role in the syndrome of apparent mineralocorticoid excess. Am J Med Sci 2001;322:308-315.
    • (2001) Am J Med Sci , vol.322 , pp. 308-315
    • White, P.C.1
  • 52
    • 59249096044 scopus 로고    scopus 로고
    • Association between maternal and amniotic fluid cortisol is moderated by maternal anxiety
    • Glover V, Bergman K, Sarkar P, O'Connor TG: Association between maternal and amniotic fluid cortisol is moderated by maternal anxiety. Psychoneuroendocrinology 2009;34:430-435.
    • (2009) Psychoneuroendocrinology , vol.34 , pp. 430-435
    • Glover, V.1    Bergman, K.2    Sarkar, P.3    O'Connor, T.G.4
  • 53
    • 67649847784 scopus 로고    scopus 로고
    • Altered placental function of 11{beta}-HSD2 knockout mice
    • Wyrwoll CS, Seckl JR, Holmes MC: Altered placental function of 11{beta}-HSD2 knockout mice. Endocrinology 2009;150:1287-1293.
    • (2009) Endocrinology , vol.150 , pp. 1287-1293
    • Wyrwoll, C.S.1    Seckl, J.R.2    Holmes, M.C.3
  • 54
    • 0033573692 scopus 로고    scopus 로고
    • Association between maternal anxiety in pregnancy and increased uterine artery resistance index: Cohort based study
    • Teixeira JMA, Fisk NM, Glover V: Association between maternal anxiety in pregnancy and increased uterine artery resistance index: cohort based study. BMJ 1999; 318: 153-157.
    • (1999) BMJ , vol.318 , pp. 153-157
    • Teixeira, J.M.A.1    Fisk, N.M.2    Glover, V.3
  • 57
    • 15944406789 scopus 로고    scopus 로고
    • Are maternal smoking and stress during pregnancy related to ADHD symptoms in children
    • Rodriguez A, Bohlin G: Are maternal smoking and stress during pregnancy related to ADHD symptoms in children? J Child Psy- chol Psychiatry 2005; 46:246-254.
    • (2005) J Child Psy- chol Psychiatry , vol.46 , pp. 246-254
    • Rodriguez, A.1    Bohlin, G.2
  • 59
    • 38149076376 scopus 로고    scopus 로고
    • Antenatal maternal anxiety is related to HPA-axis dysregulation and self-reported depressive symptoms in adolescence: A prospective study on the fetal origins of depressed mood
    • Van den Bergh BRH, Van Calster B, Smits T, Van Huffel S, Lagae L: Antenatal maternal anxiety is related to HPA-axis dysregulation and self-reported depressive symptoms in adolescence: a prospective study on the fetal origins of depressed mood. Neuropsycho-pharmacology 2008; 33: 536-545.
    • (2008) Neuropsycho-pharmacology , vol.33 , pp. 536-545
    • Van den Bergh, B.R.H.1    Van Calster, B.2    Smits, T.3    Van Huffel, S.4    Lagae, L.5
  • 61
    • 33751163740 scopus 로고    scopus 로고
    • Greater arousal and less attentive- ness to face/voice stimuli by neonates of depressed mothers on the Brazelton Neonatal Behavioral Assessment Scale
    • Hernandez-Reif M, Field T, Diego M, Ruddock M: Greater arousal and less attentive- ness to face/voice stimuli by neonates of depressed mothers on the Brazelton Neonatal Behavioral Assessment Scale. Infant Behav Dev 2006; 29: 594-598.
    • (2006) Infant Behav Dev , vol.29 , pp. 594-598
    • Hernandez-Reif, M.1    Field, T.2    Diego, M.3    Ruddock, M.4
  • 63
    • 33746449165 scopus 로고    scopus 로고
    • The effect of maternal PTSD following in utero trauma exposure on behavior and temperament in the 9-month-old infant
    • Brand SR, Engel SM, Canfield RL, Yehuda R: The effect of maternal PTSD following in utero trauma exposure on behavior and temperament in the 9-month-old infant. Ann NY Acad Sci 2006;1071:454-458.
    • (2006) Ann NY Acad Sci , vol.1071 , pp. 454-458
    • Brand, S.R.1    Engel, S.M.2    Canfield, R.L.3    Yehuda, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.