11Β-hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess

American Journal of the Medical Sciences

Volumn 322, Issue 6, 2001, Pages 308-315

  White, Perrin C ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Aldosterone; Cortisol; Cortisone; Hypertension; Kidney; Mineralocorticoid receptor

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ALDOSTERONE; CORTISONE; HYDROCORTISONE; MINERALOCORTICOID; MINERALOCORTICOID RECEPTOR; HSD11B2 PROTEIN, HUMAN; HYDROXYSTEROID DEHYDROGENASE; RENIN;

APPARENT MINERALOCORTICOID EXCESS SYNDROME; CLINICAL FEATURE; CONFERENCE PAPER; ELECTROLYTE TRANSPORT; ENZYME ACTIVITY; ENZYME DEFECT; GENE MUTATION; GENOTYPE; HYPERTENSION; HYPOKALEMIA; KIDNEY CORTEX; MOLECULAR CLONING; ONSET AGE; PHENOTYPE; PLASMA RENIN ACTIVITY; POTASSIUM EXCRETION; PROTEIN EXPRESSION; SODIUM ABSORPTION; STEROID BINDING; BLOOD; CHILD; FEMALE; GENETICS; HUMAN; HYPERALDOSTERONISM; REVIEW; SYNDROME;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; CHILD; FEMALE; HUMANS; HYDROXYSTEROID DEHYDROGENASES; HYPERALDOSTERONISM; HYPERTENSION; HYPOKALEMIA; RENIN; SYNDROME;

EID: 0034747418     PISSN: 00029629     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000441-200112000-00003     Document Type: Conference Paper

References (53)

1. Disorders of aldosterone biosynthesis and action
2. Disorders of steroid 11 beta hydroxylase isozymes
3. A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol
4. Metabolic and blood pressure responses to hydrocortisone in the syndrome of apparent mineralocorticoid excess
5. Congenital 11 beta-hydroxysteroid dehydrogenase deficiency associated with juvenile hypertension: Corticosteroid metabolite profiles of four patients and their families
6. Mineralocorticoid activity of liquorice: 11-Beta-hydroxysteroid dehydrogenase deficiency comes of age
7. Licorice inhibits corticosteroid 11 beta-dehydrogenase of rat kidney and liver: In vivo and in vitro studies
8. Cloning of human mineralocorticoid receptor complementary DNA: Structural and functional kinship with the glucocorticoid receptor
9. Renal mineralocorticoid receptors and hippocampal corticosterone binding species have identical intrinsic steroid specificity
10. Localisation of 11 beta-hydroxysteroid dehydrogenase-tissue specific protector of the mineralocorticoid receptor
11. Mineralocorticoid action: Target tissue specificity is enzyme, not receptor, mediated
12. Purification and characterization of the corticosteroid 11 beta-dehydrogenase component of the rat liver 11 beta-hydroxysteroid dehydrogenase complex
13. Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase
14. The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization
15. Defects in the HSD11 gene encoding 11β-hydroxysteroid dehydrogenase are not found in patients with apparent mineralocorticoid excess or 11-oxoreductase deficiency
16. A new isoform of 11 beta-hydroxysteroid dehydrogenase in aldosterone target cells
17. Human placental 11 beta-hydroxysteroid dehydrogenase: Evidence for and partial purification of a distinct NAD-dependent isoform
18. --dependent isoform of 11 beta hydroxysteroid dehydrogenase: Cloning and characterization of cDNA from sheep kidney
19. Cloning and tissue distribution of the human 11-HSD type 2 enzyme
20. Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity
21. Characteristics of shortchain alcohol dehydrogenases and related enzymes
22. Tyr-179 and Lys-183 are essential for enzymatic activity of 11 beta-hydroxysteroid dehydrogenase
23. Three-dimensional structure of holo 3 alpha,20 beta-hydroxysteroid dehydrogenase: A member of a short-chain dehydrogenase family
24. The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane
25. Gene structure and chromosomal localization of the human HSD11K gene encoding the kidney (type 2) isozyme of 11β-hydroxysteroid dehydrogenase
26. + dependent 11β-hydroxysteroid dehydrogenase (HSD11K) gene in JEG-3 human choriocarcinoma cells
27. 17-HSD type 2: Chromosomal assignment and progestin regulation of gene expression in human endometrium
28. Cloning, expression, and tissue distribution of the rat nicotinamide adenine dinucleotide-dependent 11 beta-hydroxysteroid dehydrogenase
29. Cloning of the mouse 11 beta-hydrexysteroid dehydrogenase type 2 gene: Tissue specific expression and localization in distal convoluted tubules and collecting ducts of the kidney
30. Expression cloning of the aldosterone target cell-specific 11 beta-hydroxysteroid dehydrogenase from rabbit collecting duct cells
31. Glucocorticoid receptor, mineralocorticoid receptors, 11 beta-hydroxysteroid dehydrogenase-1 and -2 expression in rat brain and kidney: In situ studies
32. Detection of human 11 beta-hydroxysteroid dehydrogenase isoforms using reverse-transcriptase-polymerase chain reaction and localization of the type 2 isoform to renal collecting ducts
33. Immunohistochemical localization of the 11 beta-hydroxysteroid dehydrogenase type II enzyme in human kidney and placenta
34. Immunolocalization of NAD-dependent 11β-hydroxysteroid dehydrogenase in human kidney and colon
35. Localization of 11β-hydroxysteroid dehydrogenase type 2 in rat tissues: In situ studies
36. Cellular localization of 11 betahydroxysteroid dehydrogenase 2 gene expression in the ovine adrenal gland
37. Hybridization histochemical localization of 11 beta-hydroxysteroid dehydrogenase type 2 in rat brain
38. The ontogeny of 11β-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor gene expression reveal intricate control of glucocorticoid action in development
39. Human hypertension caused by mutations in the kidney isozyme of 11 betahydroxysteroid dehydrogenase
40. A mutation in the HSD11B2 gene in a family with apparent mineralocorticoid excess
41. Several homozygous mutations in the gene for 11β-hydroxysteroid dehydrogenase type 2 in patients with apparent mineralocorticoid excess
42. Hypertension in the syndrome of apparent mineralocorticoid excess due to mutation of the 11β-hydroxysteroid dehydrogenase type 2 gene
43. Apparent mineralocorticoid excess: Genotype is correlated with biochemical phenotype
44. Molecular basis for hypertension in the "type II variant" of apparent mineralocorticoid excess
45. A genetic defect resulting in mild low-renin hypertension
46. Mutants of 11beta-hydroxysteroid dehydrogenase (HSD11B2) with partial activity: Improved correlations between genotype and biochemical phenotype in apparent mineralocorticoid excess
47. Disease expression and molecular genotype in congenital adrenal hyperplasia due to 21-hydroxylase deficiency
48. Expression of 11 beta-hydroxysteroid dehydrogenase using recombinant vaccinia virus
49. Urinary free cortisone and the assessment of 11beta-hydroxysteroid dehydrogenase activity in man
50. Report of the second task force on blood pressure control in children-1987
51. A new polymorphic restriction site in the human 11 beta-hydroxysteroid dehydrogenase type 2 gene
52. 11-Beta-hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess
53. CA-repeat polymorphism in intron 1 of HSD11B2: Effects on gene expression and salt sensitivity