Activation of the mouse TATA-less and human TATA-containing UDP- glucuronosyltransferase 1A1 promoters by hepatocyte nuclear factor 1

Molecular Pharmacology

Volumn 56, Issue 3, 1999, Pages 526-536

  Bernard, Pascal ^a,b   Goudonnet, Hervé ^b   Artur, Yves ^b   Desvergne, Béatrice ^a   Wahli, Walter ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITÉ DE BOURGOGNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCURONOSYLTRANSFERASE; NUCLEAR FACTOR I; TATA BINDING PROTEIN;

ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; GENE EXPRESSION; GLUCURONIDATION; HUMAN; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0032817021     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.56.3.526     Document Type: Article

References (39)

1. Aono S, Adachi Y, Uyama E, Yamada Y, Keino H, Nanno T, Koiwai O and Sato H (1995) Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome. Lancet 345:958-959.
2. Beutler E, Gelbart T and Demina A (1998) Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter-A balanced polymorphism for regulation of bilirubin metabolism. Proc Natl Acad Sci USA 95:8170-8174.
3. Bosma PJ, Chowdhury JR, Bakker C, Gantla S, de Boer A, Oostra BA, Lindhout D, Tytgat GN, Jansen PL, Oude Elferink RP and Chowdhury NR (1995) The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med 333:1171-1175.
4. Bosma PJ, Seppen J, Goldhoorn B, Bakker C, Oude Elferink RP, Chowdhury JR, Chowdhury NR and Jansen PL (1994) Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man. J Biol Chem 269: 17960-17964.
5. Brierley CH, Senafi SB, Clarke D, Hsu MH, Johnson EF and Burchell B (1996) Regulation of the human bilirubin UDP-glucuronosyltransferase gene. Adv Enzyme Regul 36:85-97.
6. Cereghini S (1996) Liver-enriched transcription factors and hepatocyte differentiation. FASEB J 10:267-282.
7. Chouard T, Jeannequin O, Rey-Campos J, Yaniv M and Traincard F (1997) A set of polyclonal and monoclonal antibodies reveals major differences in post-translational modification of the rat HNF1 and vHNF1 homeoproteins. Biochimie 79:707-715.
8. Chu Q, Lei W, Gudehithlu K, Matwyshyn GA, Bocchetta M and Kong ANT (1997) cDNA cloning of the mouse bilirubin/phenol family of UDP-glucuronosyltransferase (mugtbr2-like). Pharm Res 14:662-666.
9. Clarke DJ, Moghrabi N, Monaghan G, Cassidy A, Boxer M, Hume R and Burchell B (1997) Genetic defects of the UDP-glucuronosyltransferase-1 (UGT1) gene that cause familial non-haemolytic unconjugated ayperbilirubinaemias. Clin Chim. Acta 266:63-74.
10. Dignam JD, Lebovitz RM and Roeder RG (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-1489.
11. Emami KH, Burke TW and Smale ST (1998) Sp1 activation of a TATA-less promoter requires a species-specific interaction involving transcription factor HD. Nucleic Acids Res 26:839-846.
12. Emi Y, Ikushiro S and Iyanagi T (1995) Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex. J Biochem 117:392-399.
13. Emi Y, Ikushiro S and Iyanagi T (1996) Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 gene complex. J Biol Chem 271:3952-3958.
14. Gregori C, Kahn A and Pichard AL (1993) Competition between transcription factors HNF1 and HNF3, and alternative cell-specific activation by DBP and C/EBP contribute to the regulation of the liver-specific aldolase B promoter. Nucleic Acids Res 21:897-903.
15. Hansen AJ, Lee YH, Gonzalez FJ and Mackenzie PI (1997) HNF1 alpha activates the rat UDP glucuronosyltransferase UGT2B1 gene promoter. DNA Cell Biol 16:207-214.
16. Hansen AJ, Lee YH, Sterneck E, Gonzalez FJ and Mackenzie PI (1998) C/EBPalpha is a regulator of the UDP glucuronosyltransferase UGT2B1 gene. Mol Pharmacol 53:1027-1033.
17. Hauser SC and Gollan JL (1990) Mechanistic and molecular aspects of hepatic bilirubin glucuronidation. Progress Liver Dis 9:225-235.
18. Ijpenberg A, Jeannin E, Wahli W and Desvergne B (1997) Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/ retinoid X receptor heterodimer binding to DNA. A functional analysis of the malic enzyme gene PPAR response element. J Biol Chem 272:20108-20117.
19. Jansen PL, Mulder GJ, Burchell B and Bock KW (1992) New developments in glucuronidation research: Report of a workshop on "Glucuronidation, its role in health and disease." Hepatology 15:532-544.
20. Jordan M, Schallhorn A and Wurm FM (1996) Transfecting mammalian cells: Optimization of critical parameters affecting calcium-phosphate precipitate formation. Nucleic Acids Res 24:596-601.
21. Kolosha VO and Martin SL (1995) Polymorphic sequences encoding the first open reading frame protein from LINE-1 ribonucleoprotein particles. J Biol Chem 270:2868-2873.
22. Krey G, Mahfoudi A and Wahli W (1995) Functional interactions of peroxisome proliferator-activated receptor, retinoid-X receptor, and Sp1 in the transcriptional regulation of the acyl-coenzyme-A oxidase promoter. Mol Endocrinol 9:219-231.
23. Ktistaki E and Talianidis I (1997) Modulation of hepatic gene expression by hepatocyte nuclear factor 1. Science (Wash DC) 277:109-112.
24. Lee YH, Sauer B, Johnson PF and Gonzalez FJ (1997) Disruption of the C/EBP-alpha gene in adult mouse liver. Mol Cell Biol 17:6014-6022.
25. Lee YH, Yano M, Liu SY, Matsunaga E, Johnson PF and Gonzalez FJ (1994) A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBP beta and an Sp1 factor. Mol Cell Biol 14:1383-1394.
26. Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF and Nebert DW (1997) The UDP glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence. Pharmacogenetics 7:255-269.
27. Mackenzie PI and Rodbourn L (1990) Organization of the rat UDP-glucuronosyltransferase, UDPGTr-2, gene and characterization of its promoter. J Biol Chem 265:11328-11332.
28. Matsui T, Segall J, Weil PA and Roeder RG (1980) Multiple factors required for accurate initiation of transcription by purified RNA polymerase II. J Biol Chem 255:11992-11996.
29. Maxam AM and Gilbert W (1977) A new method for sequencing DNA. Proc Natl Acad Sci USA 74:560-564.
30. McGurk KA, Brierley CH and Burchell B (1998) Drug glucuronidation by human renal UDP-glucuronosyltransferases. Biochem Pharmacol 55:1005-1012.
31. Metz RP and Ritter JK (1998) Transcriptional activation of the UDP-glucuronosyltransferase 1A7 gene in rat liver by aryl hydrocarbon receptor ligands and oltipraz. J Biol Chem 273:5607-5614.
32. Pontoglio M, Barra J, Hadchouel M, Doyen A, Kress C, Bach JP, Babinet C and Yaniv M (1995) Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome. Cell 84:575-585.
33. Rey-Campos J, Chouard T, Yaniv M and Cereghini S (1991) vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1. EMBO J 10:1445-1457.
34. Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT and Owens IS (1992) A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. J Biol Chem 267:3257-3261.
35. Sambrook J, Fritsch EF and Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Plainview, NY.
36. Smit AF, Toth G, Riggs AD and Jurka J (1995) Ancestral, mammalian-wide subfamilies of LINE-1 repetitive sequences. J Mol Biol 246:401-417.
37. Strassburg CP, Manns MP and Tukey RH (1998) Expression of the UDP-glucuronosyltransferase 1A locus in human colon - Identification and characterization of the novel extrahepatic UGT1A8. J Biol Chem 273:8719-8726.
38. Strassburg CP, Oldhafer K, Manns MP and Tukey RH (1997) Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue - Identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue. Mol Pharmacol 52:212-220.
39. Yang Z, Boffelli D, Boonmark N, Schwartz K and Lawn R (1998) Apolipoprotein(a) gene enhancer resides within a LINE element. J Biol Chem 273:891-897.