Coordinate Regulation of the Human UDP-Glucuronosyltransferase 1A8, 1A9, and 1A10 Genes by Hepatocyte Nuclear Factor 1α and the Caudal-Related Homeodomain Protein 2

Molecular Pharmacology

Volumn 65, Issue 4, 2004, Pages 953-963

  Gregory, Philip A ^a   Lewinsky, Rikke H ^a   Gardner Stephen, Dione A ^a   Mackenzie, Peter I ^a,b  

^a FLINDERS UNIVERSITY   (Australia)

^b FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 1A9; HOMEODOMAIN PROTEIN; NUCLEAR FACTOR I; NUCLEAR FACTOR IALPHA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX2; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; BINDING SITE; CELL STRAIN CACO 2; CONSENSUS SEQUENCE; CONTROLLED STUDY; GASTROINTESTINAL TRACT; GEL MOBILITY SHIFT ASSAY; GENE ACTIVATION; GENE DELETION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; KIDNEY; LIVER; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; TRANSCRIPTION INITIATION SITE;

CACO-2 CELLS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCURONOSYLTRANSFERASE; HEPATOCYTE NUCLEAR FACTOR 1; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HEPATOCYTE NUCLEAR FACTOR 1-BETA; HOMEODOMAIN PROTEINS; HUMANS; LIVER; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 1842480998     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.65.4.953     Document Type: Article

References (40)

1. Baumhueter S, Mendel DB, Conley PB, Kuo CJ, Turk C, Graves MK, Edwards CA, Courtois G, and Crabtree GR (1990) HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF. Genes Dev 4:372-379.
2. Bernard P, Goudonnet H, Artur Y, Desvergne B, and Wahli W (1999) Activation of the mouse TATA-less and human TATA-containing UDP-glucuronosyltransferase 1A1 promoters by hepatocyte nuclear factor 1. Mol Pharmacol 56:526-536.
3. Blumenfeld M, Maury M, Chouard T, Yaniv M, and Condamine H (1991) Hepatic nuclear factor 1 (HNF1) shows a wider distribution than products of its known target genes in developing mouse. Development 113:589-599.
4. Boudreau F, Rings EHHM, van Wering HM, Kim RK, Swain GP, Krasinski SD, Moffett J, Grand RJ, Suh ER, and Traber PG (2002) Hepatocyte nuclear factor-1α, GATA-4 and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription - implication for the developmental regulation of the sucrase-isomaltase gene. J Biol Chem 277:31909-31917.
5. Cheng Z, Radominska-Pandya A, and Tephly TR (1998) Cloning and expression of human UDP-glucuronosyltransferase (UGT) 1A8. Arch Biochem Biophys 356:301-305.
6. Cheng Z, Radominska-Pandya A, and Tephly TR (1999) Studies on the substrate specificity of human intestinal UDP-glucuronosyltransferases 1A8 and 1A10. Drug Metab Dispos 27:1165-1170.
7. Di Guglielmo MD, Park J, Schulz S, and Waldman SA (2001) Nucleotide requirements for CDX2 binding to the cis promoter element mediating intestine-specific expression of guanylyl cyclase C. FEBS Lett 507:128-132.
8. Drummond F, Sowden J, Morrison K, and Edwards YH (1996) The caudal-type homeobox protein Cdx-2 binds to the colon promoter of the carbonic anhydrase 1 gene. Eur J Biochem 236:670-681.
9. Dutton GJ (1980) Glucuronidation of Drugs and Other Compounds. CRC Press Inc., Boca Raton, FL.
10. Gong QH, Cho JW, Huang T, Potter C, Gholami N, Basu NK, Kubota S, Carvalho S, Pennington MW, Owens IS, et al. (2001) Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. Pharmacogenetics 11:357-368.
11. Gregory PA, Gardner-Stephen DA, Lewinsky RH, Duncliffe KN, and Mackenzie PI (2003) Cloning and characterization of the UDP glucuronsyltransferase 1A8, 1A9 and 1A10 gene promoters. Differential regulation through an initiator-like region. J Biol Chem 278:36107-36114.
12. Gregory PA, Hansen AJ, and Mackenzie PI (2000) Tissue specific differences in the regulation of the UDP glucuronosyltransferase 2B17 gene promoter. Pharmacogenetics 10:809-820.
13. Harding D, Fournel-Gigleux S, Jackson MR, and Burchell B (1988) Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells. Proc Natl Acad Sci USA 85:8381-8385.
14. Ishii Y, Hansen AJ, and Mackenzie PI (2000) Octamer transcription factor-1 enhances hepatic nuclear factor-1a-mediated activation of the human UDP glucuronosyltransferase 2B7 promoter. Mol Pharmacol 57:940-947.
15. James R, Erler T, and Kazenwadel J (1994) Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestinal epithelium. J Biol Chem 269:15229-15237.
16. Krasinski SD, Van Wering HM, Tannemaat MR, and Grand RJ (2001) Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha. Am J Physiol 281:G69-G84.
17. Mackenzie PI (2000) Identification of uridine diphosphate glucuronosyltransferases involved in the metabolism and clearance of mycophenolic acid. Ther Drug Monit 22:10-13.
18. Mendel DB and Crabtree GR (1991) HNF-1, a member of a novel class of dimerizing homeodomain proteins. J Biol Chem 266:677-680.
19. Metz RP, Auyeung DJ, Kessler FK, and Ritter JK (2000) Involvement of hepatocyte nuclear factor 1 in the regulation of the UDP-glucuronosyltransferase 1A7 (UGT1A7) gene in rat hepatocytes. Mol Pharmacol 58:319-327.
20. Mitchelmore C, Troelsen JT, Spodsberg N, Sjostrom H, and Noren O (2000) Interaction between the homeodomain proteins Cdx2 and HNF1alpha mediates expression of the lactase-phlorizin hydrolase gene. Biochem J 346 Pt 2:529-535.
21. Mojarrabi B, Butler R, and Mackenzie PI (1996) cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3. Biochem Biophys Res Commun 225:785-790.
22. Mojarrabi B and Mackenzie PI (1998) Characterization of two UDP-glucuronosyltransferases that are predominantly expressed in human colon. Biochem Biophys Res Commun 247:704-709.
23. Nowell SA, Massengill JS, Williams S, Radominska-Pandya A, Tephly TR, Cheng Z, Strassburg CP, Tukey RH, MacLeod SL, Lang NP, et al. (1999) Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human microsomal UDP-glucuronosyltransferases: identification of specific UGT1A family isoforms involved. Carcinogenesis 20:1107-1114.
24. Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, and Owens IS (1992) A novel complex locus UGT1 encodes human bilirubin, phenol and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. J Biol Chem 267:3257-3261.
25. Ritter JK, Crawford JM, and Owens IS (1991) Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells. J Biol Chem 266:1043-1047.
26. Sakaguchi T, Gu XB, Golden HM, Suh ER, Rhoads DB, and Reinecker HC (2002) Cloning of the human claudin-2 5′-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1 α. J Biol Chem 277:21361-21370.
27. Schreiber E, Matthias P, Muller MM, and Schaffner W (1989) Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res 17:6419.
28. Silberg DG, Swain GP, Suh ER, and Traber PG (2000) Cdx1 and Cdx2 expression during intestinal development. Gastroenterology 119:961-971.
29. Strassburg CP, Kneip S, Topp J, Obermayer-Straub P, Barut A, Tukey RH, and Manns MP (2000) Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine. J Biol Chem 275:36164-36171.
30. Strassburg CP, Manns MP, and Tukey RH (1998a) Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. J Biol Chem 273:8719-8726.
31. Strassburg CP, Nguyen N, Manns MP, and Tukey RH (1998b) Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium. Mol Pharmacol 54:647-654.
32. Strassburg CP, Oldhafer K, Manns MP, and Tukey RH (1997) Differential expression of the UGT1A locus in human liver, biliary and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue. Mol Pharmacol 52:212-220.
33. Strassburg CP, Strassburg A, Nguyen N, Li Q, Manns MP, and Tukey RH (1999) Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus. Biochem J 338 (Pt 2):489-498.
34. Suh E, Chen LL, Taylor J, and Traber PG (1994) A homeodomain protein related to caudal regulates intestine-specific gene-transcription. Mol Cell Biol 14:7340-7351.
35. Suh E and Traber PG (1996) An intestine-specific homeobox gene regulates proliferation and differentiation. Mol Cell Biol 16:619-625.
36. Troelsen JT, Mitchelmore C, Spodsberg N, Jensen AM, Noren O, and Sjostrom H (1997) Regulation of lactase-phlorizin hydrolase gene expression by the caudal-related homoeodomain protein Cdx-2. Biochem J 322:833-838.
37. Tukey RH and Strassburg CP (2001) Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract. Mol Pharmacol 59:405-414.
38. van Wering HM, Huibregtse IL, van der Zwan SM, de Bie MS, Dowling LN, Boudreau F, Rings EHHM, Grand RJ, and Krasinski SD (2002) Physical interaction between GATA-5 and hepatocyte nuclear factor-1 α results in synergistic activation of the human lactase-phlorizin hydrolase promoter. J Biol Chem 277:27659-27667.
39. Watanabe Y, Nakajima M, and Yokoi T (2002) Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos 30:1462-1469.
40. Wooster R, Sutherland L, Ebner T, Clarke D, Da Cruz e Silva O, and Burchell B (1991) Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family. Biochem J 278:465-469.