Inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase reduces leukocyte recruitment and hepatocyte apoptosis in endotoxin-induced liver injury

Journal of Investigative Medicine

Volumn 57, Issue 5, 2009, Pages 645-649

  Slotta, Jan E ^a,b   Laschke, Matthias W ^a,b   Wang, Yusheng ^a   Schilling, Martin K ^c   Menger, Michael D ^b   Thorlacius, Henrik ^a,d  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b SAARLAND UNIVERSITY   (Germany)

^c Department of General Surgery Abdominal and Vascular Surgery and Pediatric Surgery   (Germany)

^d LUND UNIVERSITY   (Sweden)

Author keywords

Apoptosis; Chemokines; Endotoxin; Inflammation; Liver injury; Simvastatin

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; ENDOTOXIN; GALACTOSAMINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIPOPOLYSACCHARIDE; MEVALONIC ACID; MYELOPEROXIDASE; SIMVASTATIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; C57BL 6 MOUSE; CELL INFILTRATION; CONTROLLED STUDY; DRUG EFFECT; ENDOTOXEMIA; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; LEUKOCYTE AGGREGATION; LIVER CELL; LIVER INJURY; MALE; MOUSE; NONHUMAN;

ANIMALIA; ESCHERICHIA COLI; MUS;

EID: 67650673474     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.2310/JIM.0b013e3181a23cb0     Document Type: Article

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