Lymphocyte function antigen-1 mediates leukocyte adhesion and subsequent liver damage in endotoxemic mice

British Journal of Pharmacology

Volumn 141, Issue 4, 2004, Pages 709-716

  Li, Xiang ^a   Klintman, Daniel ^a   Weitz Schmidt, Gabriele ^b   Schramm, René ^a,c   Thorlacius, Henrik ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b NOVARTIS PHARMA AG   (Switzerland)

^c SAARLAND UNIVERSITY   (Germany)

Author keywords

Adhesion; Endotoxin; Integrin; Intravital microscopy; LFA703; Sepsis; Statins

Indexed keywords

ENDOTOXIN; GALACTOSAMINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KETAMINE; LFA 703; LIPOPOLYSACCHARIDE; LIVER ENZYME; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 703; UNCLASSIFIED DRUG; XYLAZINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DETECTION; ANTIGEN BINDING; APOPTOSIS; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOTHELIUM CELL; ENDOTOXEMIA; GENE TARGETING; IMMUNOMODULATION; INHIBITION KINETICS; LEUKOCYTE ACTIVATION; LEUKOCYTE ADHERENCE; LIVER CELL DAMAGE; LIVER CIRCULATION; LIVER FAILURE; LIVER INJURY; LYMPHOCYTE FUNCTION; MALE; MICROCIRCULATION; MICROSCOPIC ANATOMY; MOUSE; NONHUMAN; PERFUSION; PRIORITY JOURNAL; SEPSIS;

ANIMALS; ANTIBODIES, BLOCKING; APOPTOSIS; CAPILLARIES; CELL ADHESION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTOXEMIA; GENE TARGETING; HEMODYNAMIC PROCESSES; HEPATITIS, TOXIC; HEPATOCYTES; LEUKOCYTE COUNT; LEUKOCYTES; LIVER; LIVER CIRCULATION; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MALE; MICE; MICE, INBRED C57BL;

EID: 1842506199     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705634     Document Type: Article

References (42)

1. ANDERSON, D.C., SCHMALSTEIG, F.C., FINEGOLD, M.J., HUGHES, B.J., ROTHLEIN, R., MILLER, L.J., KOHL, S., TOSI, M.F., JACOBS, R.L., WALDROP, T.C., GOLDMAN, A.S., SHEARER, W.T. & SPRINGER, T.A. (1985). The severe and moderate phenotypes of heritable Mac-1, LFA-1 deficiency: their quantitative definition and relation to leukocyte dysfunction and clinical features. J. Infect. Dis., 152, 668-689.
2. ARFORS, K.E., LUNDBERG, C., LINDBOM, L., LUNDBERG, K., BEATTY, P.G. & HARLAN, J.M. (1987). A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorpho-nuclear leukocyte accumulation and plasma leakage in vivo. Blood, 69, 338-340.
3. ARGENBRIGHT, L.W., LETTS, L.G. & ROTHLEIN, R. (1991). Monoclonal antibodies to the leukocyte membrane CD18 glyco-protein complex and to intercellular adhesion molecule-1 inhibit leukocyte-endothelial adhesion in rabbits. J. Leukoc. Biol., 49, 253-257.
4. CARLOS, T.M. & HARLAN, J.M. (1994). Leukocyte-endothelial adhesion molecules. Blood, 84, 2068-2101.
5. DIACOVO, T.G., ROTH, S.J., BUCCOLA, J.M., BAINTON, D.F. & SPRINGER, T.A. (1996). Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18. Blood, 88, 146-157.
6. DING, Z.M., BABENSEE, J.E., SIMON, S.I., LU, H., PERRARD, J.L., BULLARD, D.C., DAI, X.Y., BROMLEY, S.K., DUSTIN, M.L., ENTMAN, M.L., SMITH, C.W. & BALLANTYNE, C.M. (1999). Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J. Immunol., 163, 5029-5038.
7. DUNNE, J.L., BALLANTYNE, C.M., BEAUDET, A.L. & LEY, K. (2002). Control of leukocyte rolling velocity in TNF-alpha-induced inflammation by LFA-1 and Mac-1. Blood, 99, 336-341.
8. ESSANI, N.A., BAJT, M.L., FARHOOD, A., VONDERFECHT, S.L. & JAESCHKE, H. (1997). Transcriptional activation of vascular cell adhesion molecule-1 gene in vivo and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock. J. Immunol., 158, 5941-5948.
9. FOX-ROBICHAUD, A. & KUBES, P. (2000). Molecular mechanisms of tumor necrosis factor alpha-stimulated leukocyte recruitment into the murine hepatic circulation. Hepatology, 31, 1123-1127.
10. FRENETTE, P.S., MAYADAS, T.N., RAYBURN, H., HYNES, R.O. & WAGNER, D.D. (1996). Susceptibility to infection and altered hematopoiesis in mice deficient in both P-and E-selectins. Cell, 84, 563-574.
11. GAHMBERG, C.G. (1997). Leukocyte adhesion: CD11/CD18 integrins and intercellular adhesion molecules. Curr. Opin. Cell Biol., 9, 643-650.
12. GIRONELLA, M., MOLLA, M., SALAS, A., SORIANO, A., SANS, M., CLOSA, D., ENGEL, P., SALAS, A., PIQUE, J.M. & PANES, J. (2002). The role of P-selectin in experimental colitis as determined by antibody immunoblockade and genetically deficient mice. J. Leukoc. Biol., 72, 56-64.
13. HARLAN, J.M. (1993). Leukocyte adhesion deficiency syndrome: insights into the molecular basis of leukocyte emigration. Clin. Immunol. Immunopathol., 67, S16-S24.
14. HEWETT, J.A., JEAN, P.A., KUNKEL, S.L. & ROTH, R.A. (1993). Relationship between tumor necrosis factor-alpha and neutrophils in endotoxin-induced liver injury. Am. J. Physiol., 265, G1011-G1015.
15. HOLMAN JR, J.M. & SABA, T.M. (1988). Hepatocyte injury during post-operative sepsis: activated neutrophils as potential mediators. J. Leukoc. Biol., 43, 193-203.
16. ISSEKUTZ, A.C. & ISSEKUTZ, T.B. (1992). The contribution of LFA-1 (CD11a/CD18) and MAC-1 (CD11b/CD18) to the in vivo migration of polymorphonuclear leucocytes to inflammatory reactions in the rat. Immunology, 76, 655-661.
17. JAESCHKE, H., FARHOOD, A., FISHER, M.A. & SMITH, C.W. (1996). Sequestration of neutrophils in the hepatic vasculature during endotoxemia is independent of beta 2 integrins and intercellular adhesion molecule-1. Shock, 6, 351-356.
18. JAESCHKE, H., FARHOOD, A. & SMITH, C.W. (1991). Neutrophil-induced liver cell injury in endotoxin shock is a CD11b/CD18-dependent mechanism. Am. J. Physiol., 261, G1051-G1056.
19. KALLEN, J., WELZENBACH, K., RAMAGE, P., GEYL, D., KRIWACKI, R., LEGGE, G., COTTENS, S., WEITZ-SCHMIDT, G. & HOMMEL, U. (1999). Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain. J. Mol. Biol., 292, 1-9.
20. KLINTMAN, D., SCHRAMM, R., MENGER, M.D. & THORLACIUS, H. (2002). Leukocyte recruitment in hepatic injury: selectin-mediated leukocyte rolling is a prerequisite for CD18-dependent firm adhesion. J. Hepatol., 36, 53-59.
21. KLINTMAN, D., XIANG, L. & THORLACIUS, H. (2004). Important role of P-selectin in leukocyte recruitment, hepatocellular injury and apoptosis in endotoxemic mice. Clin. Diagn. Lab. Immunol., (in press).
22. KROEMER, G., PETIT, P., ZAMZAMI, N., VAYSSIERE, J.L. & MIGNOTTE, B. (1995). The biochemistry of programmed cell death. FASEB J., 9, 1277-1287.
23. KUNKEL, E.J., JUNG, U., BULLARD, D.C., NORMAN, K.E., WOLITZKY, B.A., VESTWEBER, D., BEAUDET, A.L. & LEY, K. (1996). Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and intercellular adhesion molecule 1. J. Exp. Med., 183, 57-65.
24. KWAK, B., MULHAUPT, F., MYIT, S. & MACH, F. (2000). Statins as a newly recognized type of immunomodulator. Nat. Med., 6, 1399-1402.
25. LAWRENCE, M.B. & SPRINGER, T.A. (1991). Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell, 65, 859-873.
26. LEY, K., BULLARD, D.C., ARBONES, M.L., BOSSE, R., VESTWEBER, D., TEDDER, T.F. & BEAUDET, A.L. (1995). Sequential contribution of L-and P-selectin to leukocyte rolling in vivo. J. Exp. Med., 181, 669-675.
27. LU, H., SMITH, C.W., PERRARD, J., BULLARD, D., TANG, L., SHAPPELL, S.B., ENTMAN, M.L., BEAUDET, A.L. & BALLANTYNE, C.M. (1997). LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice. J. Clin. Invest., 99, 1340-1350.
28. MARUBAYASHI, S., OSHIRO, Y., MAEDA, T., FUKUMA, K., OKADA, K., HINOI, T., IKEDA, M., YAMADA, K., ITOH, H. & DOHI, K. (1997). Protective effect of monoclonal antibodies to adhesion molecules on rat liver ischemia-reperfusion injury. Surgery, 122, 45-52.
29. MORISAKI, T., GOYA, T., TOH, H., NISHIHARA, K. & TORISU, M. (1991). The anti Mac-1 monoclonal antibody inhibits neutrophil sequestration in lung and liver in a septic murine model. Clin. Immunol. Immunopathol., 61, 365-375.
30. RAMOS, C.L., KUNKEL, E.J., LAWRENCE, M.B., JUNG, U., VESTWEBER, D., BOSSE, R., MCINTYRE, K.W., GILLOOLY, K.M., NORTON, C.R., WOLITZKY, B.A. & LEY, K. (1997). Differential effect of E-selectin antibodies on neutrophil rolling and recruitment to inflammatory sites. Blood, 89, 3009-3018.
31. RAUEN, U., POLZAR, B., STEPHAN, H., MANNHERZ, H.G. & DE GROOT, H. (1999). Cold-induced apoptosis in cultured hepatocytes and liver endothelial cells: mediation by reactive oxygen species. FASEB J., 13, 155-168.
32. RIAZ, A.A., WAN, M.X., SCHAFER, T., SCHRAMM, R., EKBERG, H., MENGER, M.D., JEPPSSON, B. & THORLACIUS, H. (2002). Fundamental and distinct roles of P-selectin and LFA-1 in ischemia/reperfusion-induced leukocyte-endothelium interactions in the colon. Ann. Surg., 236, 777-784.
33. ROMANO, M., DIOMEDE, L., SIRONI, M., MASSIMILIANO, L., SOTTOCORNO, M., POLENTARUTTI, N., GUGLIELMOTTI, A., ALBANI, D., BRUNO, A., FRUSCELLA, P., SALMONA, M., VECCHI, A., PINZA, M. & MANTOVANI, A. (2000). Inhibition of monocyte chemotactic protein-1 synthesis by statins. Lab. Invest., 80, 1095-1100.
34. RUTTER, J., JAMES, T.J., HOWAT, D., SHOCK, A., ANDREW, D., DE BAETSELIER, P., BLACKFORD, J., WILKINSON, J.M., HIGGS, G., HUGHES, B. & ROBINSON, M.K. (1994). The in vivo and in vitro effects of antibodies against rabbit beta 2-integrins. J. Immunol., 153, 3724-3733.
35. SCHMITS, R., KUNDIG, T.M., BAKER, D.M., SHUMAKER, G., SIMARD, J.J., DUNCAN, G., WAKEHAM, A., SHAHINIAN, A., VAN DER HEINDEN, A., BACHMANN, M.F., OHASHI, P.S., MAK, T.W. & HICKSTEIN, D.D. (1996). LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J. Exp. Med., 183, 1415-1426.
36. SPRINGER, T.A. (1994). Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell, 76, 301-314.
37. TANAKA, Y., KOBAYASHI, K., TAKAHASHI, A., ARAI, I., HIGUCHI, S., OTOMO, S., HABU, S. & NISHIMURA, T. (1993). Inhibition of inflammatory liver injury by a monoclonal antibody against lymphocyte function-associated antigen-1. J. Immunol., 151, 5088-5095.
38. THORLACIUS, H., VOLLMAR, B., GUO, Y., MAK, T.W., PFREUNDSCHUH, M.M., MENGER, M.D. & SCHMITS, R. (2000). Lymphocyte function antigen 1 (LFA-1) mediates early tumour necrosis factor alpha-induced leucocyte adhesion in venules. Br. J. Haematol., 110, 424-429.
39. VOLLMAR, B., GLASZ, J., MENGER, M.D. & MESSMER, K. (1995). Leukocytes contribute to hepatic ischemia/reperfusion injury via intercellular adhesion molecule-1-mediated venular adherence. Surgery, 117, 195-200.
40. WAN, M.X., SCHRAMM, R., KLINTMAN, D., WELZENBACH, K., WEITZ-SCHMIDT, G. & THORLACIUS, H. (2003). A statin-based inhibitor of lymphocyte function antigen-1 protects against ischemia/reperfusion-induced leukocyte adhesion in the colon. Br. J. Pharmacol., 140, 395-401.
41. WEITZ-SCHMIDT, G., WELZENBACH, K., BRINKMANN, V., KAMATA, T., KALLEN, J., BRUNS, C., COTTENS, S., TAKADA, Y. & HOMMEL, U. (2001). Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat. Med., 7, 687-692.
42. WELZENBACH, K., HOMMEL, U. & WEITZ-SCHMIDT, G. (2002). Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition. J. Biol. Chem., 277, 10590-10598.