Altered kinetics of interleukin-6 and other inflammatory mediators during exercise in children with type 1 diabetes

Journal of Investigative Medicine

Volumn 56, Issue 4, 2008, Pages 701-713

  Rosa, Jaime S ^a,b,d   Oliver, Stacy R ^a   Mitsuhashi, Masato ^c   Flores, Rebecca L ^a   Pontello, Andria M ^a   Zaldivar, Frank P ^a   Galassetti, Pietro R ^a,b  

^a Institute for Clinical Translational Science   (United States)

^b University of California   (United States)

^c Hitachi Chemical Research Center   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Children; Exercise; Inflammatory cytokine; Type 1 diabetes

Indexed keywords

CHEMOKINE; CYTOKINE; EOTAXIN; GLUCOSE; INTERLEUKIN 12P70; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE COLONY STIMULATING FACTOR; INSULIN;

ADOLESCENT; ARTICLE; BLOOD SAMPLING; CARDIOVASCULAR DISEASE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYCLING; EXERCISE; FEMALE; GLUCOSE BLOOD LEVEL; GRANULOCYTE; HUMAN; IMMUNOMODULATION; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MONOCYTE; PROTEIN DETERMINATION; RISK ASSESSMENT; SCHOOL CHILD; BLOOD; GENETICS; IMMUNOLOGY; LEUKOCYTE; METABOLISM; DIABETIC PATIENT; KINETICS; MACROPHAGE; AGE DISTRIBUTION; CYTOKINE PRODUCTION; DRUG DOSE REDUCTION; GENE EXPRESSION; IMMUNOREGULATION; INSULIN INFUSION; MOLECULAR MECHANICS; PROTEIN BLOOD LEVEL;

ADOLESCENT; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; EXERCISE; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; LEUKOCYTES; MALE;

EID: 67650671872     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.2310/JIM.0b013e31816c0fba     Document Type: Article

References (53)

1. Nemet D, Oh Y, Kim H-S, et al. Effect of intense exercise on inflammatory cytokines and growth mediators in adolescent boys. Pediatrics. 2002;110:681-689.
2. Petersen AMW, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol. 2005;98:1154-1162.
3. Cooper DM, Nemet D, Galassetti P. Exercise, stress, and inflammation in the growing child: from the bench to the playground. Curr Opin Pediatr. 2004;16:286-292.
4. Lindmark E, Diderholm E, Wallentin L, et al. Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease: effects of an early invasive or noninvasive strategy. JAMA. 2001;286:2107-2113.
5. Cooper DM, Radom-Aizik S, Schwindt C, et al. Dangerous exercise: lessons learned from dysregulated inflammatory responses to physical activity. J Appl Physiol. 2007;103: 700-709.
6. Rosa JS, Flores RL, Oliver SR, et al. Sustained IL-1α, IL-4, and IL-6 Elevations following correction of hyperglycemia in children with type 1 diabetes mellitus. Pediatr Diabetes. 2008;9:9-16.
7. Galassetti PR, Iwanaga K, Pontello AM, et al. Effect of prior hyperglycemia on IL-6 responses to exercise in children with type 1 diabetes. Am J Physiol Endocrinol Metab. 2006;290:E833-E839.
8. Rosa JS, Oliver SR, Flores RL, et al. Kinetic profiles of 18 systemic pro- and anti-inflammatory mediators during and following exercise in children. J Pediatr Endocrinol Metab. 2007;20:1293-1305.
9. Petersen AC, Crockett L, Richards M, et al. A self-report measure of pubertal status: Reliability, validity, and initial norms. J Youth Adolesc. 1988;17:117-133.
10. Cooper DM, Weiler-Ravell D, Whipp BJ, et al. Aerobic parameters of exercise as a function of body size during growth in children. J Appl Physiol. 1984;56:628-634.
11. duPont NC, Wang K, Wadhwa PD, et al. Validation and comparison of luminex multiplex cytokine analysis kits with ELISA: determinations of a panel of nine cytokines in clinical sample culture supernatants. J Reprod Immunol. 2005;66:175-191.
12. Mitsuhashi M, Cooper A, Ogura M, et al. Oligonucleotide probe design-a new approach. Nature. 1994;367:759-761.
13. Mitsuhashi M, Tomozawa S, Endo K, et al. Quantification of mRNA in whole blood by assessing recovery of RNA and efficiency of cDNA synthesis. Clin Chem. 2006;52: 634-642.
14. Steensberg A, van Hall G, Osada T, et al. Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol. 2000;529:237-242.
15. Febbraio MA, Hiscock N, Sacchetti M, et al. Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes. 2004;53:1643-1648.
16. Lyngso D, Simonsen L, Bulow J. Interleukin-6 production in human subcutaneous abdominal adipose tissue: the effect of exercise. J Physiol. 2002;543:373-378.
17. Yudkin JS, Kumari M, Humphries SE, et al. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis. 2000;148:209-214.
18. Pedersen BK, Akerstrom TCA, Nielsen AR, et al. Role of myokines in exercise and metabolism. J Appl Physiol. 2007;103:1093-1098.
19. Drenth JP, Van Uum SH, Van Deuren M, et al. Endurance run increases circulating IL-6 and IL-1ra but downregulates ex vivo TNF-alpha and IL-1 beta production. J Appl Physiol. 1995;79:1497-1503.
20. Galassetti PR, Iwanaga K, Crisostomo M, et al. Inflammatory cytokine, growth factor and counterregulatory responses to exercise in children with type 1 diabetes and healthy controls. Pediatric Diabetes. 2006;7:16-24.
21. Das UN. Anti-inflammatory nature of exercise. Nutrition. 2004;20:323-326.
22. Steensberg A, Fischer CP, Keller C, et al. IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab. 2003;285:E433-E437.
23. Lakka TA, Lakka H-M, Rankinen T, et al. Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study. Eur Heart J. 2005;26:2018-2025.
24. Danesh J, Wheeler JG, Hirschfield GM, et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med. 2004;350:1387-1397.
25. Blake GJ, Ridker PM. Inflammatory bio-markers and cardiovascular risk prediction. J Int Med. 2002;252:283-294.
26. Arend WP. The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev. 2002;13:323-340.
27. Koenders MI, Joosten LAB, van den Berg WB. Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis. Ann Rheum Dis. 2006;65:iii29-iii33.
28. Mukaida N, Harada A, Matsushima K. Interleukin-8 (IL-8) and monocyte chemotactic and activating factor (MCAF/ MCP-1), chemokines essentially involved in inflammatory and immune reactions. Cytokine Growth Factor Rev. 1998;9:9-23.
29. Maurer M, von Stebut E. Macrophage inflammatory protein-1. Int J Biochem Cell Biol. 2004;36:1882-1886.
30. Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell. 2001;104:487-501.
31. Fleetwood AJ, Cook AD, Hamilton JA. Functions of granulocyte-macrophage colony-stimulating factor. Crit Rev Immunol. 2005;25:405.
32. Cook EB, Stahl JL, Graziano FM. Eotaxin: what we know, and what we would like to know. Allergy Asthma Proc. 1998;19:253-255.
33. Jha P, Sohn J-H, Xu Q, et al. The complement system plays a critical role in the development of experimental autoimmune anterior uveitis. Invest Ophthalmol Vis Sci. 2006;47:1030-1038.
34. Christen U, Von Herrath MG. IP-10 and type 1 diabetes: a question of time and location. Autoimmunity. 2004;37:273.
35. Ayan C, Martin V. Systemic lupus erythematosus and exercise. Lupus. 2007;16:5.
36. de Jong Z, Vlieland TP. Safety of exercise in patients with rheumatoid arthritis. Curr Opin Rheum. 2005;17:177.
37. Giannini C. Role of physical exercise in children and adolescents with diabetes mellitus. J Pediatr Endocrinol. 2007;20:173.
38. Valerio G, Spagnuolo MI, Lombardi F, et al. Physical activity and sports participation in children and adolescents with type 1 diabetes mellitus. Nutr Metab Cardiovasc Dis. 2007;17:376-382.
39. Geffken DF, Cushman M, Burke GL, et al. Association between physical activity and markers of inflammation in a healthy elderly population. Am J Epidemiol. 2001;153: 242-250.
40. Carnethon MR, Gulati M, Greenland P. Prevalence and cardiovascular disease correlates of low cardiorespiratory fitness in adolescents and adults. JAMA. 2005;294:2981-2988.
41. Nagatomi R. The implication of alterations in leukocyte subset counts on immune function. Exerc Immunol Rev. 2006;12:54.
42. Targher G, Zenari L, Bertolini L, et al. Elevated levels of interleukin-6 in young adults with type 1 diabetes without clinical evidence of microvascular and macrovascular complications. Diabetes Care. 2001;24:956-957.
43. de Rekeneire N, Peila R, Ding J, et al. Diabetes, hyperglycemia, and inflammation in older individuals: the health, aging and body composition study. Diabetes Care. 2006;29:1902-1908.
44. Esposito K, Nappo F, Marfella R, et al. Inflammatory cytokine concentrations are acutely increased by hypergly-cemia in humans: role of oxidative stress. Circulation 2002;106:2067-2072.
45. Shankar A, Klein R, Klein BEK, et al. Association between glycosylated hemoglobin level and cardiovascular and all-cause mortality in type 1 diabetes. Am J Epidemiol. 2007;166:393-402.
46. Forst T, Forst S, Strunk K, et al. Impact of insulin on microvascular blood flow and endothelial cell function in the postprandial state in patients with type 1 diabetes. J Diabetes Complicat. 2005;19:128-132.
47. Aljada A, Ghanim H, Saadeh R, et al. Insulin inhibits NF-kB and MCP-1 expression in human aortic endothelial cells. J Clin Endocrinol Metab. 2001;86:450-453.
48. Hansen TK, Thiel S, Wouters PJ, et al. Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels. J Clin Endocrinol Metab. 2003;88:1082-1088.
49. Viardot A, Grey ST, Mackay F, et al. Potential antiinflammatory role of insulin via the preferential polarization of effector T cells towards a T-helper 2 phenotype. Endocrinology. 2006;148:346-353.
50. Ertan T, Keskek M, Kilic M, et al. Effects of gender difference in early cytokine levels in trauma patients. Bratislavske Lekarske Listy. 2007;108:128-132.
51. Chiu KM, Arnaud CD, Ju J, et al. Correlation of estradiol, parathyroid hormone, interleukin-6, and soluble interleu-kin-6 receptor during the normal menstrual cycle. Bone. 2000;26:79-85.
52. Makinoda S, Mikuni M, Sogame M, et al. Erythropoietin, granulocyte-colony stimulating factor, interleukin-1b and interleukin-6 during the normal menstrual cycle. Int J Gynecol Obstet. 1996;55:265-271.
53. Fischer CP. Interleukin-6 in acute exercise and training: what is the biological relevance? Exerc Immunol Rev. 2006;12:6-33.