The implication of alterations in leukocyte subset counts on immune function

Exercise Immunology Review

Volumn 12, Issue , 2006, Pages 54-71

  Nagatomi, Ryoichi ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

EXERCISE; HUMAN; IMMUNOLOGY; LEUKOCYTE; LEUKOCYTE COUNT; LYMPHOCYTE; NATURAL KILLER CELL; NEUTROPHIL; PHYSIOLOGY; REVIEW;

EXERCISE; HUMANS; KILLER CELLS, NATURAL; LEUKOCYTE COUNT; LEUKOCYTES; LYMPHOCYTES; NEUTROPHILS;

EID: 33947512732     PISSN: 10775552     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (106)

1. McCarthy, D. A., and M. M. Dale. 1988. The leucocytosis of exercise. A review and model. Sports Med 6:333-363. (Pubitemid 19011137)
2. Kuijpers, T. W. 2002. Clinical symptoms and neutropenia: the balance of neutrophil development, functional activity, and cell death. Eur J Pediatr 161 Suppl 1:S75-82.
3. Andres, E., E. Noel, J. E. Kurtz, N. Henoun Loukili, G. Kaltenbach, and F. Maloisel. 2004. Life-threatening idiosyncratic drug-induced agranulocytosis in elderly patients. Drugs Aging 21:427-435. (Pubitemid 38736888)
4. Bhatt, V., and A. Saleem. 2004. Review: Drug-induced neutropenia- pathophysiology, clinical features, and management. Ann Clin Lab Sci 34:131-137. (Pubitemid 38685904)
5. Donowitz, G. R., D. G. Maki, C. J. Crnich, P. G. Pappas, and K. V. Rolston. 2001. Infections in the neutropenic patient - new views of an old problem. Hematology (Am Soc Hematol Educ Program):113-139.
6. Baldwin, C., and S. Roath. 1983. The evaluation of neutropenia: the use of the granulocyte mobilization test. Clin Lab Haematol 5:353-360. (Pubitemid 14179743)
7. Selig, C., and W. Nothdurft. 1995. Cytokines and progenitor cells of granulocytopoiesis in peripheral blood of patients with bacterial infections. Infect Immun 63:104-109.
8. Ulich, T. R., J. del Castillo, K. Guo, and L. Souza. 1989. The hematologic effects of chronic administration of the monokines tumor necrosis factor, interleukin-1, and granulocyte-colony stimulating factor on bone marrow and circulation. Am J Pathol 134:149-159. (Pubitemid 19054988)
9. Okajima, K., N. Harada, M. Uchiba, and M. Mori. 2004. Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats. Am J Physiol Gastroin-test Liver Physiol 287:G1116-1123. (Pubitemid 39551840)
10. Bonder, C. S., D. Knight, D. Hernandez-Saavedra, J. M. McCord, and P. Kubes. 2004. Chimeric SOD2/3 inhibits at the endothelial-neutrophil interface to limit vascular dysfunction in ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol 287:G676-684. (Pubitemid 39096635)
11. Mizutani, A., K. Okajima, M. Uchiba, H. Isobe, N. Harada, S. Mizutani, and T. Noguchi. 2003. Antithrombin reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation through promotion of prostacyclin production. Blood 101:3029-3036. (Pubitemid 36857991)
12. Zeiher, B. G., S. Matsuoka, K. Kawabata, and J. E. Repine. 2002. Neutrophil elastase and acute lung injury: prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics. Crit Care Med 30:S281-287. (Pubitemid 34508004)
13. Yamasaki, Y., Y. Matsuo, J. Zagorski, N. Matsuura, H. Onodera, Y. Itoyama, and K. Kogure. 1997. New therapeutic possibility of blocking cytokine-induced neutrophil chemoattractant on transient ischemic brain damage in rats. Brain Res 759:103-111. (Pubitemid 27286349)
14. Palluy, O., L. Morliere, J. C. Gris, C. Bonne, and G. Modat. 1992. Hypoxia/reoxygenation stimulates endothelium to promote neutrophil adhesion. Free Radic Biol Med 13:21-30.
15. Nose, P. S. 1993. Cytokines and reperfusion injury. J Card Surg 8:305-308. (Pubitemid 23108469)
16. Wahn, H., and S. Hammerschmidt. 2001. Influence of cyclooxygenase and lipoxygenase inhibitors on oxidative stress-induced lung injury. Crit Care Med 29:802-807. (Pubitemid 32299720)
17. Turnage, R. H., K. S. Guice, and K. T. Oldham. 1994. Pulmonary microvascular injury following intestinal reperfusion. New Horiz 2:463-475.
18. Gaines, G. C., M. B. Welborn, 3rd, L. L. Moldawer, T. S. Huber, T. R. Harward, and J. M. Seeger. 1999. Attenuation of skeletal muscle ischemia/reperfusion injury by inhibition of tumor necrosis factor. J Vasc Surg 29:370-376. (Pubitemid 29085297)
19. Toledo-Pereyra, L. H., F. Lopez-Neblina, J. S. Reuben, A. H. Toledo, and P. A. Ward. 2004. Selectin inhibition modulates Akt/MAPK signaling and chemokine expression after liver ischemia-reperfusion. J Invest Surg 17:303-313. (Pubitemid 40109632)
20. Teoh, N. C., and G. C. Farrell. 2003. Hepatic ischemia reperfusion injury: Pathogenic mechanisms and basis for hepatoprotection. J Gastroenterol Hepatol 18:891-902. (Pubitemid 37056167)
21. Jaeschke, H., A. Farhood, M. A. Fisher, and C. W. Smith. 1996. Sequestration of neutrophils in the hepatic vasculature during endotoxemia is independent of beta 2 integrins and intercellular adhesion molecule-1. Shock 6:351-356. (Pubitemid 126727114)
22. Kupatt, C., H. Habazettl, A. Goedecke, D. A. Wolf, S. Zahler, P. Boekstegers, R. A. Kelly, and B. F. Becker. 1999. Tumor necrosis factor-alpha contributes to ischemia- and reperfusion-induced endothelial activation in isolated hearts. Circ Res 84:392-400. (Pubitemid 29120004)
23. Oz, M. C., H. Liao, Y. Naka, A. Seldomridge, D. N. Becker, R. E. Michler, C. R. Smith, E. A. Rose, D. M. Stern, and D. J. Pinsky. 1995. Ischemia-induced interleukin- 8 release after human heart transplantation. A potential role for endothelial cells. Circulation 92:II428-432.
24. Ockaili, R., R. Natarajan, F. Salloum, B. J. Fisher, D. Jones, A. A. Fowler, 3rd, and R. C. Kukreja. 2005. HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation. Am J Physiol Heart Circ Physiol 289:H542-548. (Pubitemid 41129367)
25. Kirtane, A. J., A. Bui, S. A. Murphy, D. Karmpaliotis, I. Kosmidou, K. Boundy, A. Rahman, D. S. Pinto, J. M. Aroesty, R. P. Giugliano, C. P. Cannon, E. M. Antman, and C. M. Gibson. 2004. Association of epicardial and tissue-level reperfusion with left ventricular end-diastolic pressures in ST-elevation myocardial infarction. J Thromb Thrombolysis 17:177-184. (Pubitemid 39193984)
26. Prestigiacomo, C. J., S. C. Kim, E. S. Connolly, Jr., H. Liao, S. F. Yan, and D. J. Pinsky. 1999. CD18-mediated neutrophil recruitment contributes to the pathogenesis of reperfused but not nonreperfused stroke. Stroke 30:1110-1117. (Pubitemid 29211635)
27. Seekamp, A., J. S. Warren, D. G. Remick, G. O. Till, and P. A. Ward. 1993. Requirements for tumor necrosis factor-alpha and interleukin-1 in limb ischemia/reperfusion injury and associated lung injury. Am J Pathol 143:453-463. (Pubitemid 24058200)
28. Gute, D. C., T. Ishida, K. Yarimizu, and R. J. Korthuis. 1998. Inflammatory responses to ischemia and reperfusion in skeletal muscle. Mol Cell Biochem 179:169-187. (Pubitemid 28118851)
29. Saxton, J. M., A. E. Donnelly, and H. P. Roper. 1994. Indices of free-radicalmediated damage following maximum voluntary eccentric and concentric muscular work. Eur J Appl Physiol Occup Physiol 68:189-193. (Pubitemid 24106431)
30. Goto, S., A. Nakamura, Z. Radak, H. Nakamoto, R. Takahashi, K. Yasuda, Y. Sakurai, and N. Ishii. 1999. Carbonylated proteins in aging and exercise: immunoblot approaches. Mech Ageing Dev 107:245-253. (Pubitemid 29210227)
31. Radak, Z., A. Nakamura, H. Nakamoto, K. Asano, H. Ohno, and S. Goto. 1998. A period of anaerobic exercise increases the accumulation of reactive carbonyl derivatives in the lungs of rats. Pflugers Arch 435:439-441. (Pubitemid 28066240)
32. Suzuki, K., S. Nakaji, M. Yamada, Q. Liu, S. Kurakake, N. Okamura, T. Kumae, T. Umeda, and K. Sugawara. 2003. Impact of a competitive marathon race on systemic cytokine and neutrophil responses. Med Sci Sports Exerc 35:348-355. (Pubitemid 36184289)
33. Haahr, P. M., B. K. Pedersen, A. Fomsgaard, N. Tvede, M. Diamant, K. Klarlund, J. Halkjaer-Kristensen, and K. Bendtzen. 1991. Effect of physical exercise on in vitro production of interleukin 1, interleukin 6, tumour necrosis factor-alpha, interleukin 2 and interferon-gamma. Int J Sports Med 12:223-227.
34. Ullum, H., P. M. Haahr, M. Diamant, J. Palmo, J. Halkjaer-Kristensen, and B. K. Pedersen. 1994. Bicycle exercise enhances plasma IL-6 but does not change IL-1 alpha, IL-1 beta, IL-6, or TNF-alpha pre-mRNA in BMNC. J Appl Physiol 77:93-97. (Pubitemid 24226120)
35. Drenth, J. P., S. H. Van Uum, M. Van Deuren, G. J. Pesman, J. Van der Ven- Jongekrijg, and J. W. Van der Meer. 1995. Endurance run increases circulating IL- 6 and IL-1ra but downregulates ex vivo TNF-alpha and IL-1 beta production. J Appl Physiol 79:1497-1503.
36. Natelson, B. H., X. Zhou, J. E. Ottenweller, M. T. Bergen, S. A. Sisto, S. Drastal, W. N. Tapp, and W. L. Gause. 1996. Effect of acute exhausting exercise on cytokine gene expression in men. Int J Sports Med 17:299-302. (Pubitemid 26187300)
37. Suzuki, K., M. Totsuka, S. Nakaji, M. Yamada, S. Kudoh, Q. Liu, K. Sugawara, K. Yamaya, and K. Sato. 1999. Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics, and muscle damage. J Appl Physiol 87:1360-1367. (Pubitemid 29483120)
38. Turton, E. P., J. I. Spark, K. G. Mercer, D. C. Berridge, P. J. Kent, R. C. Kester, and D. J. Scott. 1998. Exercise-induced neutrophil activation in claudicants: a physiological or pathological response to exhaustive exercise? Eur J Vasc Endovasc Surg 16:192-196. (Pubitemid 28466769)
39. Cloyd, M. W., J. J. Chen, P. Adeqboyega, and L. Wang. 2001. How does HIV cause depletion of CD4 lymphocytes? A mechanism involving virus signaling through its cellular receptors. Curr Mol Med 1:545-550. (Pubitemid 33772034)
40. Moanna, A., R. Dunham, M. Paiardini, and G. Silvestri. 2005. CD4+ T-cell depletion in HIV infection: killed by friendly fire? Curr HIV/AIDS Rep 2:16-23.
41. Appay, V., F. Boutboul, and B. Autran. 2005. The HIV Infection and Immune Activation: "To Fight and Burn ". Curr Infect Dis Rep 7:473-479. (Pubitemid 41671591)
42. Derdeyn, C. A., and G. Silvestri. 2005. Viral and host factors in the pathogenesis of HIV infection. Curr Opin Immunol 17:366-373. (Pubitemid 40848538)
43. Ledergerber, B., M. Egger, V. Erard, R. Weber, B. Hirschel, H. Furrer, M. Battegay, P. Vernazza, E. Bernasconi, M. Opravil, D. Kaufmann, P. Sudre, P. Francioli, and A. Telenti. 1999. AIDS-related opportunistic illnesses occurring after initiation of potent antiretroviral therapy: the Swiss HIV Cohort Study. Jama 282:2220-2226. (Pubitemid 30002965)
44. Braat, M. C., B. Oosterhuis, R. P. Koopmans, J. M. Meewis, and C. J. Van Boxtel. 1992. Kinetic-dynamic modeling of lymphocytopenia induced by the combined action of dexamethasone and hydrocortisone in humans, after inhalation and intravenous administration of dexamethasone. J Pharmacol Exp Ther 262:509-515.
45. Shinkai, S., S. Watanabe, H. Asai, and P. N. Shek. 1996. Cortisol response to exercise and post-exercise suppression of blood lymphocyte subset counts. Int J Sports Med 17:597-603. (Pubitemid 26417746)
46. Okutsu, M., K. Ishii, K. J. Niu, and R. Nagatomi. 2005. Cortisol-induced CXCR4 augmentation mobilizes T lymphocytes after acute physical stress. Am J Physiol Regul Integr Comp Physiol 288:R591-599. (Pubitemid 40250567)
47. Muller, A., B. Homey, H. Soto, N. Ge, D. Catron, M. E. Buchanan, T. McClanahan, E. Murphy, W. Yuan, S. N. Wagner, J. L. Barrera, A. Mohar, E. Verastegui, and A. Zlotnik. 2001. Involvement of chemokine receptors in breast cancer metastasis. Nature 410:50-56. (Pubitemid 32225831)
48. Liles, W. C., H. E. Broxmeyer, E. Rodger, B. Wood, K. Hubel, S. Cooper, G. Hangoc, G. J. Bridger, G. W. Henson, G. Calandra, and D. C. Dale. 2003. Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist. Blood 102:2728-2730. (Pubitemid 37248839)
49. Dhabhar, F. S., and B. S. McEwen. 1999. Enhancing versus suppressive effects of stress hormones on skin immune function. Proc Natl Acad Sci U S A 96:1059-1064. (Pubitemid 29072183)
50. Dhabhar, F. S. 2003. Stress, leukocyte trafficking, and the augmentation of skin immune function. Ann N Y Acad Sci 992:205-217. (Pubitemid 36712197)
51. Castro, M., S. R. Bloch, M. V. Jenkerson, S. DeMartino, D. L. Hamilos, R. B. Cochran, X. E. Zhang, H. Wang, J. P. Bradley, K. B. Schechtman, and M. J. Holtzman. 2004. Asthma exacerbations after glucocorticoid withdrawal reflects T cell recruitment to the airway. Am J Respir Crit Care Med 169:842-849. (Pubitemid 38402461)
52. Ferry, A., B. L. Weill, and M. Rieu. 1990. Immunomodulations induced in rats by exercise on a treadmill. J Appl Physiol 69:1912-1915.
53. Kong, F. K., C. L. Chen, and M. D. Cooper. 2002. Reversible disruption of thymic function by steroid treatment. J Immunol 168:6500-6505.
54. Hilleman, M. R. 1995. Overview: practical insights from comparative immunology and pathogenesis of AIDS, hepatitis B, and measles for developing an HIV vaccine. Vaccine 13:1733-1740. (Pubitemid 26010048)
55. Itoh, H., H. Nakata, Y. Yokoya, S. Nakashima, T. Yamanishi, T. Hara, J. Kawai, H. Miyamoto, K. Higashi, and S. Nishioka. 1996. Efficacy and side effects of intermittent recombinant interferon-alpha 2a in chronic aggressive hepatitis C: with or without initial daily administration. J Gastroenterol Hepatol 11:718-723. (Pubitemid 26252900)
56. Nakayama, K., M. Monma, T. Fukushima, T. Ohrui, and H. Sasaki. 2000. Tuberculin responses and risk of pneumonia in immobile elderly patients. Thorax 55:867-869.
57. Yamaya, M., M. Yanai, T. Ohrui, H. Arai, and H. Sasaki. 2001. Interventions to prevent pneumonia among older adults. J Am Geriatr Soc 49:85-90. (Pubitemid 32195140)
58. Nakagawa, T., K. Sekizawa, H. Arai, R. Kikuchi, K. Manabe, and H. Sasaki. 1997. High incidence of pneumonia in elderly patients with basal ganglia infarction. Arch Intern Med 157:321-324. (Pubitemid 27066402)
59. Yoneyama, T., M. Yoshida, T. Ohrui, H. Mukaiyama, H. Okamoto, K. Hoshiba, S. Ihara, S. Yanagisawa, S. Ariumi, T. Morita, Y. Mizuno, T. Ohsawa, Y. Akagawa, K. Hashimoto, and H. Sasaki. 2002. Oral care reduces pneumonia in older patients in nursing homes. J Am Geriatr Soc 50:430-433. (Pubitemid 34229396)
60. Sasaki, H., K. Sekizawa, M. Yanai, H. Arai, M. Yamaya, and T. Ohrui. 1997. New strategies for aspiration pneumonia. Intern Med 36:851-855. (Pubitemid 128520072)
61. Ohrui, T. 2005. Preventive strategies for aspiration pneumonia in elderly disabled persons. Tohoku J Exp Med 207:3-12. (Pubitemid 41195353)
62. Targan, S., L. Britvan, and F. Dorey. 1981. Activation of human NKCC by moderate exercise: increased frequency of NK cells with enhanced capability of effector - target lytic interactions. Clin Exp Immunol 45:352-360. (Pubitemid 11079075)
63. Lanier, L. L. 2005. NK cell recognition. Annu Rev Immunol 23:225-274. (Pubitemid 40563170)
64. Bauer, S., V. Groh, J. Wu, A. Steinle, J. H. Phillips, L. L. Lanier, and T. Spies. 1999. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA [see comments]. Science 285:727-729.
65. Steinle, A., P. Li, D. L. Morris, V. Groh, L. L. Lanier, R. K. Strong, and T. Spies. 2001. Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. Immunogenetics 53:279-287. (Pubitemid 32678762)
66. Takai, T., and M. Ono. 2001. Activating and inhibitory nature of the murine paired immunoglobulin-like receptor family. Immunol Rev 181:215-222. (Pubitemid 32703409)
67. Waner, J. L., and J. A. Nierenberg. 1985. Natural killing (NK) of cytomegalovirus (CMV)-infected fibroblasts: a comparison between two strains of CMV, uninfected fibroblasts, and K562 cells. J Med Virol 16:233-244. (Pubitemid 15039667)
68. Routes, J. M., and S. Ryan. 1995. Oncogenicity of human papillomavirus- or adenovirus- transformed cells correlates with resistance to lysis by natural killer cells. J Virol 69:7639-7647.
69. Johnson, D. R., and M. Jondal. 1981. Herpesvirus ateles and herpesvirus saimiri transform marmoset T cells into continuously proliferating cell lines that can mediate natural killer cell-like cytotoxicity. Proc Natl Acad Sci U S A 78:6391-6395. (Pubitemid 12179718)
70. Routes, J. M., and J. L. Cook. 1995. E1A gene expression induces susceptibility to killing by NK cells following immortalization but not adenovirus infection of human cells. Virology 210:421-428.
71. Katz, P., H. Yeager, Jr., G. Whalen, M. Evans, R. P. Swartz, and J. Roecklein. 1990. Natural killer cell-mediated lysis of Mycobacterium-avium complex-infected monocytes. J Clin Immunol 10:71-77. (Pubitemid 20085861)
72. Biron, C. A., K. S. Byron, and J. L. Sullivan. 1989. Severe herpesvirus infections in an adolescent without natural killer cells. N Engl J Med 320:1731-1735. (Pubitemid 19163129)
73. Jawahar, S., C. Moody, M. Chan, R. Finberg, R. Geha, and T. Chatila. 1996. Natural Killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II). Clin Exp Immunol 103:408-413. (Pubitemid 26089945)
74. de Vries, E., H. R. Koene, J. M. Vossen, J. W. Gratama, A. E. von dem Borne, J. L. Waaijer, A. Haraldsson, M. de Haas, and M. J. van Tol. 1996. Identification of an unusual Fc gamma receptor IIIa (CD16) on natural killer cells in a patient with recurrent infections. Blood 88:3022-3027. (Pubitemid 26357384)
75. Orange, J. S. 2002. Human natural killer cell deficiencies and susceptibility to infection. Microbes Infect 4:1545-1558. (Pubitemid 36050824)
76. Zingoni, A., T. Sornasse, B. G. Cocks, Y. Tanaka, A. Santoni, and L. L. Lanier. 2004. Cross-talk between activated human NK cells and CD4+ T cells via OX40- OX40 ligand interactions. J Immunol 173:3716-3724. (Pubitemid 39280732)
77. Zingoni, A., T. Sornasse, B. G. Cocks, Y. Tanaka, A. Santoni, and L. L. Lanier. 2005. NK cell regulation of T cell-mediated responses. Mol Immunol 42:451-454. (Pubitemid 39655952)
78. Azogui, O., M. F. Avril, A. Margulis, M. Guillard, B. Caillou, and M. Prade. 1991. Tumor-infiltrating CD3- NK cells are more effective than CD3+ T cells in killing autologous melanoma cells. J Invest Dermatol 97:425-429.
79. Atzpodien, J., S. C. Gulati, C. Shimazaki, C. Buhrer, S. Oz, J. H. Kwon, J. E. Kolitz, and B. D. Clarkson. 1988. Ewing's sarcoma: ex vivo sensitivity towards natural and lymphokine-activated killing. Oncology 45:437-443. (Pubitemid 18260206)
80. Shau, H., H. S. Koren, and J. R. Dawson. 1983. Human natural killing against ovarian carcinoma. Br J Cancer 47:687-695. (Pubitemid 13094906)
81. Vose, B. M., P. Gallagher, M. Moore, and P. F. Schofield. 1981. Specific and nonspecific lymphocyte cytotoxicity in colon carcinoma. Br J Cancer 44:846-855. (Pubitemid 12246008)
82. Pattengale, P. K., M. Gidlund, K. Nilsson, C. Sundstrom, A. Orn, and H. Wigzell. 1981. Lysis of human B-lymphocyte-derived lymphoma/leukemia cells of established cell lines by interferon-activated natural killer (NK) cells. Int J Cancer 28:459-468. (Pubitemid 11007549)
83. Ballas, Z. K., J. M. Turner, D. A. Turner, E. A. Goetzman, and J. D. Kemp. 1990. A patient with simultaneous absence of"classical " natural killer cells (CD3-, CD16+, and NKH1+) and expansion of CD3+, CD4-, CD8-, NKH1+ subset. J Allergy Clin Immunol 85:453-459. (Pubitemid 20075182)
84. Levy, O., J. S. Orange, P. Hibberd, S. Steinberg, P. LaRussa, A. Weinberg, S. B. Wilson, A. Shaulov, G. Fleisher, R. S. Geha, F. A. Bonilla, and M. Exley. 2003. Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells. J Infect Dis 188:948-953. (Pubitemid 37268242)
85. Imai, K., S. Matsuyama, S. Miyake, K. Suga, and K. Nakachi. 2000. Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11- year follow-up study of a general population. Lancet 356:1795-1799.
86. Parham, P. 2005. Immunogenetics of killer cell immunoglobulin-like receptors. Mol Immunol 42:459-462. (Pubitemid 39655954)
87. Maxwell, L. D., O. A. Ross, M. D. Curran, I. M. Rea, and D. Middleton. 2004. Investigation of KIR diversity in immunosenescence and longevity within the Irish population. Exp Gerontol 39:1223-1232. (Pubitemid 39024371)
88. Yawata, M., N. Yawata, L. Abi-Rached, and P. Parham. 2002. Variation within the human killer cell immunoglobulin-like receptor (KIR) gene family. Crit Rev Immunol 22:463-482. (Pubitemid 36548955)
89. Aizawa, H., T. Abo, S. Aiba, S. Sugawara, K. Kumagai, and H. Tagami. 1989. Epidermodysplasia verruciformis accompanied by large granular lymphocytosis. Report of a case and immunological studies. Archives of dermatology 125:660-665. (Pubitemid 19129074)
90. Tokura, Y., Y. Tamura, M. Takigawa, M. Koide, T. Satoh, T. Sakamoto, D. Horiguchi, and M. Yamada. 1990. Severe hypersensitivity to mosquito bites associated with natural killer cell lymphocytosis. Archives of dermatology 126:362-368. (Pubitemid 20094678)
91. Chung, J. S., H. J. Shin, E. Y. Lee, and G. J. Cho. 2003. Hypersensitivity to mosquito bites associated with natural killer cell-derived large granular lymphocyte lymphocytosis: a case report in Korea. The Korean journal of internal medicine 18:50-52.
92. Nagatomi, R., T. Kaifu, M. Okutsu, X. Zhang, O. Kanemi, and H. Ohmori. 2000. Modulation of the immune system by the autonomic nervous system and its implication in immunological changes after training. Exerc Immunol Rev 6:54-74. (Pubitemid 30445602)
93. Klokker, M., T. Mohr, M. Kjaer, H. Galbo, and B. K. Pedersen. 1998. The natural killer cell response to exercise in spinal cord injured individuals. Eur J Appl Physiol Occup Physiol 79:106-109. (Pubitemid 29041381)
94. Nielsen, H. B., N. H. Secher, J. H. Kristensen, N. J. Christensen, K. Espersen, and B. K. Pedersen. 1997. Splenectomy impairs lymphocytosis during maximal exercise. Am J Physiol 272:R1847-1852.
95. Kappel, M., T. D. Poulsen, H. Galbo, and B. K. Pedersen. 1998. Effects of elevated plasma noradrenaline concentration on the immune system in humans. Eur J Appl Physiol Occup Physiol 79:93-98. (Pubitemid 29041379)
96. Hori, T., T. Katafuchi, S. Take, Y. Kaizuka, T. Ichijo, and N. Shimizu. 1995. The hypothalamo-sympathetic nervous system modulates peripheral cellular immunity. Neurobiology (Bp) 3:309-317. (Pubitemid 26194540)
97. Benschop, R. J., F. G. Oostveen, C. J. Heijnen, and R. E. Ballieux. 1993. Beta 2- adrenergic stimulation causes detachment of natural killer cells from cultured endothelium. Eur J Immunol 23:3242-3247.
98. Benschop, R. J., F. P. Nijkamp, R. E. Ballieux, and C. J. Heijnen. 1994. The effects of beta-adrenoceptor stimulation on adhesion of human natural killer cells to cultured endothelium. Br J Pharmacol 113:1311-1316.
99. Kanemi, O., X. Zhang, Y. Sakamoto, M. Ebina, and R. Nagatomi. 2005. Acute stress reduces intraparenchymal lung natural killer cells via beta-adrenergic stimulation. Clin Exp Immunol 139:25-34. (Pubitemid 40066125)
100. Suzuki, S., S. Toyabe, T. Moroda, T. Tada, A. Tsukahara, T. Iiai, M. Minagawa, S. Maruyama, K. Hatakeyama, K. Endoh, and T. Abo. 1997. Circadian rhythm of leucocytes and lymphocytes subsets and its possible correlation with the function of the autonomic nervous system. Clin Exp Immunol 110:500-508. (Pubitemid 27525285)
101. Suzui, M., T. Kawai, H. Kimura, K. Takeda, H. Yagita, K. Okumura, P. N. Shek, and R. J. Shephard. 2004. Natural killer cell lytic activity and CD56(dim) and CD56(bright) cell distributions during and after intensive training. J Appl Physiol 96:2167-2173. (Pubitemid 38661497)
102. Berk, L. S., D. L. Felten, S. A. Tan, B. B. Bittman, and J. Westengard. 2001. Modulation of neuroimmune parameters during the eustress of humor-associated mirthful laughter. Altern Ther Health Med 7:62-72, 74-66.
103. Bennett, M. P., J. M. Zeller, L. Rosenberg, and J. McCann. 2003. The effect of mirthful laughter on stress and natural killer cell activity. Altern Ther Health Med 9:38-45.
104. Takahashi, K., M. Iwase, K. Yamashita, Y. Tatsumoto, H. Ue, H. Kuratsune, A. Shimizu, and M. Takeda. 2001. The elevation of natural killer cell activity induced by laughter in a crossover designed study. Int J Mol Med 8:645-650.
105. Zhang, X., K. Matsuo, A. Farmawati, Y. Higashi, K. Ogawa, K. Nagata, and R. Nagatomi. 2006. Exhaustive Exercise induces Differential Changes in Serum Granulysin and Circulating Number of Natural Killer Cells. Tohoku J Exp Med 210:117-124. (Pubitemid 44575586)
106. Ogawa, K., Y. Takamori, K. Suzuki, M. Nagasawa, S. Takano, Y. Kasahara, Y. Nakamura, S. Kondo, K. Sugamura, M. Nakamura, and K. Nagata. 2003. Granulysin in human serum as a marker of cell-mediated immunity. Eur J Immunol 33:1925-1933. (Pubitemid 37120864)