UV-DDB: A molecular machine linking DNA repair with ubiquitination

DNA Repair

Volumn 8, Issue 8, 2009, Pages 969-972

  Sugasawa, Kaoru ^a  

^a KOBE UNIVERSITY   (Japan)

Author keywords

DNA damage recognition; Nucleotide excision repair; Ubiquitination; Ultraviolet light; UV DDB; XPC

Indexed keywords

DNA BINDING PROTEIN;

ARTICLE; CRYSTAL STRUCTURE; DNA DAMAGE; DNA REPAIR; EXCISION REPAIR; PRIORITY JOURNAL; PROTEIN ASSEMBLY; UBIQUITINATION; ULTRAVIOLET RADIATION;

ANIMALS; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; GENOME; HUMANS; MODELS, BIOLOGICAL; UBIQUITINATION; ULTRAVIOLET RAYS;

EID: 67650663224     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2009.05.001     Document Type: Article

References (37)

1. Friedberg E.C., Walker G.C., Siede W., Wood R.D., Schultz R.A., and Ellenberger T. DNA Repair and Mutagenesis. second ed. (2006), ASM Press, Washington, DC
2. Gillet L.C., and Scharer O.D. Molecular mechanisms of mammalian global genome nucleotide excision repair. Chem. Rev. 106 (2006) 253-276
3. Riedl T., Hanaoka F., and Egly J.-M. The comings and goings of nucleotide excision repair factors on damaged DNA. EMBO J. 22 (2003) 5293-5303
4. Sugasawa K., Ng J.M.Y., Masutani C., Iwai S., van der Spek P.J., Eker A.P.M., Hanaoka F., Bootsma D., and Hoeijmakers J.H.J. Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. Mol. Cell 2 (1998) 223-232
5. Volker M., Moné M.J., Karmakar P., van Hoffen A., Schul W., Vermeulen W., Hoeijmakers J.H.J., van Driel R., van Zeeland A.A., and Mullenders L.H.F. Sequential assembly of the nucleotide excision repair factors in vivo. Mol. Cell 8 (2001) 213-224
6. Batty D., Rapic'-Otrin V., Levine A.S., and Wood R.D. Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites. J. Mol. Biol. 300 (2000) 275-290
7. Sugasawa K., Okamoto T., Shimizu Y., Masutani C., Iwai S., and Hanaoka F. A multistep damage recognition mechanism for global genomic nucleotide excision repair. Genes Dev. 15 (2001) 507-521
8. Min J.-H., and Pavletich N.P. Recognition of DNA damage by the Rad4 nucleotide excision repair protein. Nature 449 (2007) 570-575
9. Sugasawa K., Shimizu Y., Iwai S., and Hanaoka F. A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex. DNA Repair (Amst.) 1 (2002) 95-107
10. Kusumoto R., Masutani C., Sugasawa K., Iwai S., Araki M., Uchida A., Mizukoshi T., and Hanaoka F. Diversity of the damage recognition step in the global genomic nucleotide excision repair in vitro. Mutat. Res. 485 (2001) 219-227
11. Scrima A., Konickova R., Czyzewski B.K., Kawasaki Y., Jeffrey P.D., Groisman R., Nakatani Y., Iwai S., Pavletich N.P., and Thomä N.H. Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex. Cell 135 (2008) 1213-1223
12. Keeney S., Chang G.J., and Linn S. Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E. J. Biol. Chem. 268 (1993) 21293-21300
13. Wittschieben B.Ø., and Wood R.D. DDB complexities. DNA Repair (Amst.) 2 (2003) 1065-1069
14. Chu G., and Chang E. Xeroderma pigmentosum group E cells lack a nuclear factor that binds to damaged DNA. Science 242 (1988) 564-567
15. Hwang B.J., Toering S., Francke U., and Chu G. p48 Activates a UV-damaged-DNA binding factor and is defective in xeroderma pigmentosum group E cells that lack binding activity. Mol. Cell. Biol. 18 (1998) 4391-4399
16. Itoh T., Linn S., Ono T., and Yamaizumi M. Reinvestigation of the classification of five cell strains of xeroderma pigmentosum group E with reclassification of three of them. J. Invest. Dermatol. 114 (2000) 1022-1029
17. Nichols A.F., Ong P., and Linn S. Mutations specific to the xeroderma pigmentosum group E Ddb- phenotype. J. Biol. Chem. 271 (1996) 24317-24320
18. Rapic-Otrin V., Navazza V., Nardo T., Botta E., McLenigan M., Bisi D.C., Levine A.S., and Stefanini M. True XP group E patients have a defective UV-damaged DNA binding protein complex and mutations in DDB2 which reveal the functional domains of its p48 product. Hum. Mol. Genet. 12 (2003) 1507-1522
19. Fujiwara Y., Masutani C., Mizukoshi T., Kondo J., Hanaoka F., and Iwai S. Characterization of DNA recognition by the human UV-damaged DNA-binding protein. J. Biol. Chem. 274 (1999) 20027-20033
20. Sugasawa K., Okuda Y., Saijo M., Nishi R., Matsuda N., Chu G., Mori T., Iwai S., Tanaka K., Tanaka K., and Hanaoka F. UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. Cell 121 (2005) 387-400
21. Treiber D.K., Chen Z., and Essigmann J.M. An ultraviolet light-damaged DNA recognition protein absent in xeroderma pigmentosum group E cells binds selectively to pyrimidine (6-4) pyrimidone photoproducts. Nucleic Acids Res. 20 (1992) 5805-5810
22. Wittschieben B.Ø., Iwai S., and Wood R.D. DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA. J. Biol. Chem. 280 (2005) 39982-39989
23. Payne A., and Chu G. Xeroderma pigmentosum group E binding factor recognizes a broad spectrum of DNA damage. Mutat. Res. 310 (1994) 89-102
24. Hwang B.J., Ford J.M., Hanawalt P.C., and Chu G. Expression of the p48 xeroderma pigmentosum gene is p53 dependent and is involved in global genome repair. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 424-428
25. Fitch M.E., Nakajima S., Yasui A., and Ford J.M. In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product. J. Biol. Chem. 278 (2003) 46906-46910
26. Moser J., Volker M., Kool H., Alekseev S., Vrieling H., Yasui A., van Zeeland A.A., and Mullenders L.H.F. The UV-damaged DNA binding protein mediates efficient targeting of the nucleotide excision repair complex to UV-induced photo lesions. DNA Repair (Amst.) 4 (2005) 571-582
27. Wang Q.E., Zhu Q., Wani G., Chen J., and Wani A.A. UV radiation-induced XPC translocation within chromatin is mediated by damaged-DNA binding protein, DDB2. Carcinogenesis 25 (2004) 1033-1043
28. Li T., Chen X., Garbutt K.C., Zhou P., and Zheng N. Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase. Cell 124 (2006) 105-117
29. Angers S., Li T., Yi X., MacCoss M.J., Moon R.T., and Zheng N. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Nature 443 (2006) 590-593
30. Groisman R., Polanowska J., Kuraoka I., Sawada J., Saijo M., Drapkin R., Kisselev A.F., Tanaka K., and Nakatani Y. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Cell 113 (2003) 357-367
31. Lee J., and Zhou P. DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase. Mol. Cell 26 (2007) 775-780
32. Fitch M.E., Cross I.V., Turner S.J., Adimoolam S., Lin C.X., Williams K.G., and Ford J.M. The DDB2 nucleotide excision repair gene product p48 enhances global genomic repair in p53 deficient human fibroblasts. DNA Repair (Amst.) 2 (2003) 819-826
33. Rapic'-Otrin V., McLenigan M.P., Bisi D.C., Gonzalez M., and Levine A.S. Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation. Nucleic Acids Res. 30 (2002) 2588-2598
34. Kapetanaki M.G., Guerrero-Santoro J., Bisi D.C., Hsieh C.L., Rapic-Otrin V., and Levine A.S. The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 2588-2593
35. Wang H., Zhai L., Xu J., Joo H.Y., Jackson S., Erdjument-Bromage H., Tempst P., Xiong Y., and Zhang Y. Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol. Cell 22 (2006) 383-394
36. Yasuda T., Sugasawa K., Shimizu Y., Iwai S., Shiomi T., and Hanaoka F. Nucleosomal structure of undamaged DNA regions suppresses the non-specific DNA binding of the XPC complex. DNA Repair (Amst.) 4 (2005) 389-395
37. Petroski M.D., and Deshaies R.J. Function and regulation of cullin-RING ubiquitin ligases. Nat. Rev. Mol. Cell Biol. 6 (2005) 9-20