Protein import channel of the outer mitochondrial membrane: A highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small Tom proteins, and import receptors

Molecular and Cellular Biology

Volumn 21, Issue 7, 2001, Pages 2337-2348

  Meisinger, C ^a   Ryan, M T ^a   Hill, K ^a   Model, K ^a   Lim, J H ^a   Sickmann, A ^a   Muller H ^a   Meyer, H E ^a   Wagner, R ^a   Pfanner, N ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ION CHANNEL; PROTEIN PRECURSOR;

ARTICLE; ELECTROPHYSIOLOGY; MEMBRANE VESICLE; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; YEAST;

FUNGAL PROTEINS; INTRACELLULAR MEMBRANES; ION CHANNELS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIA; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION;

SACCHAROMYCES CEREVISIAE;

EID: 0035099421     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.7.2337-2348.2001     Document Type: Article

References (57)

1. The TOM core complex: The general protein import pore of the outer membrane of mitochondria
2. Mitochondrial receptor complex from Neurospora crassa and Saccharomyces cerevisiae
3. The mitochondrial receptor complex: The small subunit Mom8b/Isp6 supports association of receptors with the general insertion pore and transfer of preproteins
4. Protein translocation into mitochondria: The role of TIM complexes
5. The essential yeast protein MIM44 (encoded by MPI1) is involved in an early step of preprotein translocation across the mitochondrial inner membrane
6. 2 and cytochrome c peroxidase are located in the intermembrane space of yeast mitochondria
7. The Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70-Tim44
8. Characterization of the preprotein translocase of the outer mitochondrial membrane by blue native electrophoresis
9. Preprotein translocase of the outer mitochondrial membrane: Molecular dissection and assembly of the general import pore complex
10. Tom5 functionally links mitochondrial preprotein receptors to the general import pore
11. Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria
12. Isolation of intracellular membranes by means of sodium carbonate treatment: Application to endoplasmic reticulum
13. A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins
14. Can Hsp70 proteins act as force-generating motors?
15. 5 reductase to two locations within yeast mitochondria
16. Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins
17. Protein import into yeast mitochondria is accelerated by the outer membrane protein MAS70
18. Reconstitution of a chloroplast protein import channel
19. Tom7 modulates the dynamics of the mitochondrial outer membrane translocase and plays a pathway-related role in protein import
20. Mitochondria unfold precursor proteins by unraveling them from their N-termini
21. Unique composition of the preprotein translocase of the outer mitochondrial membrane from plants
22. Protein translocation: Is Hsp70 pulling my chain?
23. Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins
24. Identification of a mitochondrial receptor complex required for recognition and membrane insertion of precursor proteins
25. Import of mitochondrial carriers mediated by essential proteins of the intermembrane space
26. How membrane proteins travel across the mitochondrial intermembrane space
27. The preprotein translocation channel of the outer membrane of mitochondria
28. The isolated complex of the translocase of the outer membrane of mitochondria: Characterization of the cation-selective and voltage-gated preprotein-conducting pore
29. Biogenesis of Tim proteins of the mitochondrial carrier import pathway: Differential targeting mechanisms and crossing-over with the main import pathway
30. Translocation and insertion of precursor proteins into isolated outer membranes of mitochondria
31. Mitochondrial protein import: Reversible binding of the presequence at the trans side of the outer membrane drives partial translocation and unfolding
32. The preprotein translocase of the outer mitochondrial membrane: Receptors and a general import pore
33. Identification of the mitochondrial receptor complex in Saccharomyces cerevisiae
34. Deletion of the receptor MOM19 strongly impairs import of cleavable preproteins into Saccharomyces cerevisiae mitochondria
35. Protein import into mitochondria
36. How do polypeptides cross the mitochondrial membranes?
37. Mitochondrial preprotein translocase
38. DNA of Saccharomyces cerevisiae
39. Functional cooperation of mitochondrial protein import receptors in yeast
40. Dynamics of the TOM complex of mitochondria during binding and translocation of preproteins
41. Translocation arrest by reversible folding of a precursor protein imported into mitochondria. A means to quantitate translocation contact sites
42. Functional staging of ADP/ATP carrier translocation across the outer mitochondrial membrane
43. Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form
44. Just follow the acid chain
45. Common principles of protein translocation across membranes
46. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
47. Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim 12/Mrs5
48. MOM19, an import receptor for mitochondrial precursor proteins
49. A mitochondrial import receptor for the ADP/ATP carrier
50. Recognition of preproteins by the isolated TOM complex of mitochondria
51. Import of ADP/ATP carrier into mitochondria: Two receptors act in parallel
52. Tom22 is a multifunctional organizer of the mitochondrial preprotein translocase
53. Complex interactions between the chaperonin 60 molecular chaperone and dihydrofolate reductase
54. The protein import motor of mitochondria: Unfolding and trapping of preproteins are distinct and separable functions of matrix Hsp70
55. Cyclophilin-promoted folding of mouse dihydrofolate reductase does not include the slow conversion of the late-folding intermediate to the active enzyme
56. Mechanisms of protein translocation into mitochondria
57. Heterologous HIS3 marker and GFP reporter modules for PCR-targeting in Saccharomyces cerevisiae